Lightnews — Scholar-powered news

Reposted by ISB

Sean Gibbons 🦠💩 @gibbological.bsky.social · 21h

Rubbing shoulders with a @nobelprize.bsky.social laureate! 🤩What a week!

Couldn’t have happened to a nicer person: isbscience.org/news/press-r...

@isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social

Left to right: Sean Gibbons, Naeha Subramanian, Mary Brunkow, Anna Kuchina, and Sid Venkatesh

5 28

ISB @isbscience.org · 19h

Dr. Mary Brunkow is a 2025 Nobel laureate. In today’s @isbscience.org press conference, she shares the FOXP3 story, from a puzzling mouse to a discovery that reshaped immunology.
🎥 Watch the full video: youtu.be/vg61fbycGEk

Mary Brunkow Wins 2025 Nobel Prize | ISB Press Conference (Full)

YouTube video by Institute for Systems Biology

youtu.be

8 10

ISB @isbscience.org · 2d

This morning, @isbscience.org's Dr. Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine! Dr. Brunkow shares the award with Fred Ramsdell and Shimon Sakaguchi. Read the press release here: www.nobelprize.org/.../medicine....

What a tremendous honor! Congratulations!

11 36

Reposted by ISB

Sid Venkatesh @flash-point.bsky.social · 2d

Many congratulations, Mary Brunkow! Couldn’t be happier for you and @isbscience.org ! ♥️

www.nobelprize.org

The official website of the Nobel Prize - NobelPrize.org

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...

www.nobelprize.org

4 15

Reposted by ISB

Itai Yanai @itaiyanai.bsky.social · 2d

Congratulations to Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for this year's Nobel Prize in Physiology or Medicine. It also demonstrates the fairness of the prize, as Mary Brunkow is a Senior Program Manager (not a professor) at the @isbscience.org
hood.isbscience.org/people/mary-...

2 14 39

Reposted by ISB

Healthcare in Europe @healthcare-europe.bsky.social · 2d

Congratulations! The🏅2025 #NobelPrize in Physiology or #Medicine is awarded to 🇺🇸 Mary E. Brunkow ( @isbscience.org ), 🇺🇸 Fred Ramsdell (Sonoma Biotherapeutics) and 🇯🇵 Shimon Sakaguchi (Osaka University) for their insights into how our #immunesystem is kept from attacking our own body.

Immune system researchers receive Nobel Prize 2025 in Medicine

The body’s powerful immune system must be regulated, or it may attack our own organs. Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi are awarded the Nobel Prize in Physiology or Medicine 2025 for...

healthcare-in-europe.com

1 3

ISB @isbscience.org · 8d

Join us for Ignite STEM at @isbscience.org: 11/6, 6-8pmPT. Celebrating 25 years of ISB Education with stories from teachers & students, time with scientists, and the Valerie Logan Leadership in Science Education Award.
🎟 $25 | Students free | 🚗 Free parking
Register: isbscience.org/events/ignit...

ISB @isbscience.org · 12d

Remembering Dr. Charles “Chuck” Watts (1942–2025). Our tribute: isbscience.org/news/philant...

Remembering Dr. Charles 'Chuck' Watts: A Leader, Friend, and Advocate for ISB

We remember Chuck Watts, beloved board chair and physician whose leadership, curiosity, and advocacy helped shape ISB’s mission.

isbscience.org

ISB @isbscience.org · 20d

It’s #PostdocAppreciation Week!

@isbscience.org Postdoc Dr. Dmitry Sutormin found gut bacteria form 3 guilds:

Stressors
Metabolizers
Growers

A survival “bet-hedging” strategy that helps them adapt.

🎥 Watch Dmitry explain: youtu.be/5LG_Ae0SiFg

Inside the Hidden Lives of Bacteria

YouTube video by Institute for Systems Biology

youtu.be

1 2

ISB @isbscience.org · 21d

Congratulations to Co-founder Dr. Lee Hood, who has been awarded the Michael Sela Prize in Biomedical Sciences by the Weizmann Institute of Science. Dr. Hood, along with Drs. Francis Collins and Eric Lander, are the recipients of the inaugural prize.
isbscience.org/news/press-r....

ISB @isbscience.org · 23d

Postdocs are the pulse of ISB. They bring passion, vision, and fresh ideas that drive discovery.

In honor of Postdoc Appreciation Week, hear from our postdoctoral fellows and learn more about ISB’s Postdoc Program.

isbscience.org/news/philant...

Behind the Breakthroughs: ISB’s Postdoctoral Fellows in Focus

At ISB, postdocs enter the scientific workforce with passion, vision, and advanced training – bringing the fresh ideas that fuel discovery.

isbscience.org

ISB @isbscience.org · 29d

Congratulations to ISB Co-founder and Professor Dr. Leroy (Lee) Hood for receiving the 2025 Michael Sela Prize in Biomedical Sciences! 🎉
A well-deserved honor for a truly inspiring pioneer in human health and medicine. 🧬✨

Learn more: www.weizmann.ac.il/sela-prize/

1 5

ISB @isbscience.org · Sep 5

Since 2021, Claudia McLaughlin Ludwig @claudiamcl.bsky.social and ISB Education have partnered with AmeriCorps. Join recent @americorps.bsky.social members Sarah Clemente and Faduma Hussein in reflecting on their time at ISB and the importance of this program to their professional development.

Service Meets Science: AmeriCorps at ISB

Learn how the AmeriCorps program as part of ISB Education fosters community development and empowers young professionals to make a difference.

isbscience.org

1

Reposted by ISB

UC Irvine School of Medicine @ucirvinemedschool.bsky.social · Aug 28

Join @ucirvine.bsky.social School of Medicine for the Dean’s Distinguished Lecture Series with Leroy Hood, MD, PhD, CEO of
Phenome Health

📊⚕️ Topic: “How Your Data Can Transform Your Health”
📅 Nov. 12, 7 to 8 p.m.
📍 The Susan & Henry Samueli College of Health Sciences, Irvine, CA
👉 bit.ly/3JyftH4

1 1

Reposted by ISB

Sean Gibbons 🦠💩 @gibbological.bsky.social · Aug 28

Great pop-sci digest by Alex Carr of his recent C. diff modeling work in Cell Systems youtu.be/shp-TjniW48?...

here's the paper --> doi.org/10.1016/j.ce...

@isbscience.org

Forecasting Gut Health: Predicting C. diff Risk with Digital Twins

YouTube video by Institute for Systems Biology

youtu.be

3 8

ISB @isbscience.org · Aug 26

ISB Associate Professor Dr. Sean Gibbons @gibbological.bsky.social was a guest on the Longevity Roadmap podcast, where he discussed the challenges of modifying the microbiome, the potential of precision nutrition, the emerging field of fecal transplants, and more.

www.youtube.com/watch?v=MP0o...

The Microbiome’s Role in Aging and Healthspan

YouTube video by Longevity Roadmap

www.youtube.com

1 3

Reposted by ISB

Science in Seattle @scienceinseattle.com · Aug 14

🦠 @isbscience.org researchers have developed personalized models to predict C. difficile colonization risk and test probiotics, paving the way for precision #microbiome therapies.

Learn more from Drs. Sean Gibbons, Alex Carr, Nitin Baliga, & Christian Diener: bit.ly/46QGAqs

1 2 8

Reposted by ISB

Communications Biology @commsbio.nature.com · Aug 18

Multiomics analysis of placental dysfunction defines on interomics networks and identifies disease-specific signatures, illustrating the power of systems biology in understanding obstetric syndromes. @samanthapiekos.bsky.social

www.nature.com/articles/s42...

Placental network differences among obstetric syndromes identified with an integrated multiomics approach - Communications Biology

Multiomics analysis of placental dysfunction defines interomics networks and identifies disease-specific signatures, illustrating the power of systems biology in understanding obstetric syndromes.

www.nature.com

2 1

Reposted by ISB

Sean Gibbons 🦠💩 @gibbological.bsky.social · Aug 6

💥Personalized C. difficile colonization risk prediction and probiotic therapy assessment in the human gut💥

I'm very excited about this work, driven by Alex Carr & co-supervised by @cdiener.com

@cp-cellsystems.bsky.social @isbscience.org @nitinbaliga.bsky.social

www.cell.com/cell-systems...

🧵...

Personalized Clostridioides difficile colonization risk prediction and probiotic therapy assessment in the human gut

Carr et al. show how microbial community-scale metabolic models (MCMMs) predict personalized Clostridioides difficile colonization risk and probiotic efficacy. MCMMs reveal key metabolic strategies ex...

www.cell.com

6 27 57

ISB @isbscience.org · Aug 6

🦠 New paper out today in @cellpress.bsky.social's Cell Systems! ISB researchers show how personalized gut models can predict – and help prevent – dangerous C. diff infections before they strike.
Cell Systems paper: www.cell.com/cell-systems...
ISB news story: isbscience.org/news/health/...

1 5

Reposted by ISB

Sean Gibbons 🦠💩 @gibbological.bsky.social · Jul 31

For a pop-sci digest of this work, check out the @isbscience.org news story here: isbscience.org/news/health/...

A Simpler, Smarter Way to Measure Gut Bacterial Biomass

ISB has developed a fast, affordable gut bacterial biomass measurement from stool data, advancing microbiome research and health insights.

isbscience.org

2 4

Reposted by ISB

Sean Gibbons 🦠💩 @gibbological.bsky.social · Jul 31

You can get an accurate estimate of total bacterial biomass from stool metagenomes by simply normalizing by host read count, without needing any additional measurements.

Excellent work by UW Master's student Gechlang Tang in @asm.org #mSystems Journal.

journals.asm.org/doi/10.1128/...
🧵

Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization | mSystems

In this study, we asked whether normalization by host reads alone was sufficient to estimate absolute bacterial biomass directly from stool metagenomic data, without the need for synthetic spike-ins, ...

journals.asm.org

7 50 94

ISB @isbscience.org · Jul 30

What’s next for #LongCovid research? RECOVER 2.0 aims to define long-term disease trajectories & test new treatments. Watch @isbscience.org's recent town hall conversation with researchers & coordinators from Providence Swedish, @uwmedicine.bsky.social & Cedars-Sinai. isbscience.org/news/isb-eve...

RECOVER 2.0: New Insights and Next Steps in Long COVID Research

Catch up on ISB’s RECOVER Town Hall for Long COVID research, RECOVER 2.0, clinical trials, plus insights from study participants.

isbscience.org

ISB @isbscience.org · Jul 25

Announcing the initial public release of the Biomedical Data Translator, a powerful open-source knowledge graph-based system designed to integrate and harmonize vast, complex biomedical datasets to accelerate translational science and patient care.
isbscience.org/news/health/...

New Tool Unlocks Biomedical Discovery with Launch of Biomedical Data Translator

Biomedical Data Translator intuitively integrates biomedical datasets, empowering researchers to generate data-driven insights.

isbscience.org

2 1

Reposted by ISB

Gwênlyn Glusman (she/her) ☸️ @gwenlyn.bsky.social · Jul 12

"Announcing the Biomedical Data Translator: Initial Public Release" pubmed.ncbi.nlm.nih.gov/40635371/

Translator is the knowledge-graph integration system we're developing to support hypothesis generation by scientists. Funded by NCATS.
As I said in the past, best consortium ever. Awesome people.
🧪

Announcing the Biomedical Data Translator: Initial Public Release - PubMed

The growing availability of biomedical data offers vast potential to improve human health, but the complexity and lack of integration of these datasets often limit their utility. To address this, the ...

pubmed.ncbi.nlm.nih.gov

5 7