Alex Williams
@itsneuronal.bsky.social
Asst Prof at NYU + Flatiron Institute
Computational + Statistical Neuroscience
https://neurostatslab.org/
Computational + Statistical Neuroscience
https://neurostatslab.org/
Reposted by Alex Williams
Intuitive cell types don't necessarily play the ascribed functional role in the overall computation. This is not a message the field wants to hear as it suggests better baselines, controls, and some reflection. elifesciences.org/reviewed-pre... 2/2
elifesciences.org
November 25, 2025 at 7:29 PM
Intuitive cell types don't necessarily play the ascribed functional role in the overall computation. This is not a message the field wants to hear as it suggests better baselines, controls, and some reflection. elifesciences.org/reviewed-pre... 2/2
Reposted by Alex Williams
This week the Trump CDC attacked science — and our health, and our kids’ health — by twisting the truth on the CDC website.
There’s things to say about the playbook they used, and that’s helped by a little explanation about scientific truth in practice.
New vid explainer from me:
🧪 part 1/
There’s things to say about the playbook they used, and that’s helped by a little explanation about scientific truth in practice.
New vid explainer from me:
🧪 part 1/
November 22, 2025 at 12:04 AM
This week the Trump CDC attacked science — and our health, and our kids’ health — by twisting the truth on the CDC website.
There’s things to say about the playbook they used, and that’s helped by a little explanation about scientific truth in practice.
New vid explainer from me:
🧪 part 1/
There’s things to say about the playbook they used, and that’s helped by a little explanation about scientific truth in practice.
New vid explainer from me:
🧪 part 1/
Reposted by Alex Williams
🔔 NEW PREPRINT FROM THE LAB ‼️
We introduce a new ML model, LoRAX, for predicting olfactory responses from chemical features, a tricky problem that benefits from progress in ML for biochem. We combine LoRA fine-tuning with protein and chemical foundation models, www.biorxiv.org/content/10.1...
We introduce a new ML model, LoRAX, for predicting olfactory responses from chemical features, a tricky problem that benefits from progress in ML for biochem. We combine LoRA fine-tuning with protein and chemical foundation models, www.biorxiv.org/content/10.1...
Low rank adaptation of chemical foundation models generate effective odorant representations
Featurizing odorants to enable robust prediction of their properties is difficult due to the complex activation patterns that odorants evoke in the olfactory system. Structurally similar odorants can ...
www.biorxiv.org
November 20, 2025 at 1:38 PM
🔔 NEW PREPRINT FROM THE LAB ‼️
We introduce a new ML model, LoRAX, for predicting olfactory responses from chemical features, a tricky problem that benefits from progress in ML for biochem. We combine LoRA fine-tuning with protein and chemical foundation models, www.biorxiv.org/content/10.1...
We introduce a new ML model, LoRAX, for predicting olfactory responses from chemical features, a tricky problem that benefits from progress in ML for biochem. We combine LoRA fine-tuning with protein and chemical foundation models, www.biorxiv.org/content/10.1...
Reposted by Alex Williams
As a longtime fan of cool papers in @currentbiology.bsky.social, I am really thrilled to see this out!
This study sets the stage for understanding the origins of novel (vocal) behaviors.
Big shout out to the main architects of this work @xmikezheng20.bsky.social and @cliffscience.bsky.social
This study sets the stage for understanding the origins of novel (vocal) behaviors.
Big shout out to the main architects of this work @xmikezheng20.bsky.social and @cliffscience.bsky.social
Great @currentbiology.bsky.social study by @xmikezheng20.bsky.social @cliffscience.bsky.social @arkarupbanerjee.bsky.social 🧪🧠🐭🎶
Vocal repertoire expansion in singing mice by co-opting a conserved midbrain circuit node
www.cell.com/current-biol...
Vocal repertoire expansion in singing mice by co-opting a conserved midbrain circuit node
www.cell.com/current-biol...
Vocal repertoire expansion in singing mice by co-opting a conserved midbrain circuit node
Zheng and Harpole et al. show that singing mice produce two major vocal modes: ancestral
USVs and novel songs that follow a linearly decelerating rhythm. Although acoustically
distinct, songs and USVs...
www.cell.com
November 19, 2025 at 6:42 PM
As a longtime fan of cool papers in @currentbiology.bsky.social, I am really thrilled to see this out!
This study sets the stage for understanding the origins of novel (vocal) behaviors.
Big shout out to the main architects of this work @xmikezheng20.bsky.social and @cliffscience.bsky.social
This study sets the stage for understanding the origins of novel (vocal) behaviors.
Big shout out to the main architects of this work @xmikezheng20.bsky.social and @cliffscience.bsky.social
Reposted by Alex Williams
Like most animals, fish move less at night. Underwater, stable posture requires movement. Find out how fish don't fall down at night in: Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish from @yunluzhu.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish
Most fish are inherently unstable and must swim to stabilize posture. How diurnal fish reduce activity at night while maintaining postural control remains unclear. We defined distinct locomotor strate...
doi.org
November 19, 2025 at 3:24 AM
Like most animals, fish move less at night. Underwater, stable posture requires movement. Find out how fish don't fall down at night in: Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish from @yunluzhu.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Alex Williams
Excited to share this work where we found how fish swim differently to keep balance in the dark / explore more in the light.
Spoiler: ever wonder what they do during “little pauses” between swims? They are counting!
Spoiler: ever wonder what they do during “little pauses” between swims? They are counting!
Like most animals, fish move less at night. Underwater, stable posture requires movement. Find out how fish don't fall down at night in: Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish from @yunluzhu.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish
Most fish are inherently unstable and must swim to stabilize posture. How diurnal fish reduce activity at night while maintaining postural control remains unclear. We defined distinct locomotor strate...
doi.org
November 19, 2025 at 4:11 AM
Excited to share this work where we found how fish swim differently to keep balance in the dark / explore more in the light.
Spoiler: ever wonder what they do during “little pauses” between swims? They are counting!
Spoiler: ever wonder what they do during “little pauses” between swims? They are counting!
Reposted by Alex Williams
The UniReps Workshop accepted papers are out! 🎉
Huge thanks to the authors, reviewers, and incredible AC committee for their dedication and effort in making this happen. 🙏 openreview.net/group?id=Neu...
Huge thanks to the authors, reviewers, and incredible AC committee for their dedication and effort in making this happen. 🙏 openreview.net/group?id=Neu...
NeurIPS 2025 Workshop UniReps
Welcome to the OpenReview homepage for NeurIPS 2025 Workshop UniReps
openreview.net
November 17, 2025 at 9:27 PM
The UniReps Workshop accepted papers are out! 🎉
Huge thanks to the authors, reviewers, and incredible AC committee for their dedication and effort in making this happen. 🙏 openreview.net/group?id=Neu...
Huge thanks to the authors, reviewers, and incredible AC committee for their dedication and effort in making this happen. 🙏 openreview.net/group?id=Neu...
Reposted by Alex Williams
Note: this has a computational scientist track! It’s for you, too, math nerds!
Applications for our Fellows-to-Faculty Award are now open! This program supports early career scientists in #autism or #neuroscience research by facilitating their transition into tenure-track faculty positions. Apply by 1/14/2026: www.simonsfoundation.org/2025/10/31/a... #science
Applications for Fellows-to-Faculty Awards Now Open
Applications for Fellows-to-Faculty Awards Now Open on Simons Foundation
www.simonsfoundation.org
October 31, 2025 at 4:30 PM
Note: this has a computational scientist track! It’s for you, too, math nerds!
Reposted by Alex Williams
Hearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers.
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
November 14, 2025 at 4:17 PM
Hearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers.
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
Reposted by Alex Williams
Our new paper in @natcomms.nature.com introduces improv, a flexible software platform that integrates models with experiments in real-time. Traditional experiments collect all data first, then analyze it later. With improv, models analyze data as it streams in and actively guide what to do next.
November 13, 2025 at 3:45 PM
Our new paper in @natcomms.nature.com introduces improv, a flexible software platform that integrates models with experiments in real-time. Traditional experiments collect all data first, then analyze it later. With improv, models analyze data as it streams in and actively guide what to do next.
Reposted by Alex Williams
I entirely agree.
Research in rodents has enabled remarkable technical advances and deepened our understanding of brainstem circuits and general brain physiology.
However, only NHPs possess cognitive, visual, and motor faculties necessary to advance human-relevant systems neuroscience.
Research in rodents has enabled remarkable technical advances and deepened our understanding of brainstem circuits and general brain physiology.
However, only NHPs possess cognitive, visual, and motor faculties necessary to advance human-relevant systems neuroscience.
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.
#neuroskyence
bit.ly/47MXYLH
#neuroskyence
bit.ly/47MXYLH
Without monkeys, neuroscience has no future
Research in primate brains has been essential for the development of BCIs, ANNs. New funding and policy changes put future such advances at risk.
bit.ly
November 11, 2025 at 1:53 PM
I entirely agree.
Research in rodents has enabled remarkable technical advances and deepened our understanding of brainstem circuits and general brain physiology.
However, only NHPs possess cognitive, visual, and motor faculties necessary to advance human-relevant systems neuroscience.
Research in rodents has enabled remarkable technical advances and deepened our understanding of brainstem circuits and general brain physiology.
However, only NHPs possess cognitive, visual, and motor faculties necessary to advance human-relevant systems neuroscience.
Reposted by Alex Williams
Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41...
#blueprint 1/7
#blueprint 1/7
Estrogen modulates reward prediction errors and reinforcement learning - Nature Neuroscience
Dopamine encoding of reward prediction errors naturally fluctuates over females’ reproductive cycles with estrogenic signaling due to reduced expression of dopamine reuptake proteins.
www.nature.com
November 11, 2025 at 2:41 PM
Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41...
#blueprint 1/7
#blueprint 1/7
Reposted by Alex Williams
Our next paper on comparing dynamical systems (with special interest to artificial and biological neural networks) is out!! Joint work with @annhuang42.bsky.social , as well as @satpreetsingh.bsky.social , @leokoz8.bsky.social , Ila Fiete, and @kanakarajanphd.bsky.social : arxiv.org/pdf/2510.25943
November 10, 2025 at 4:16 PM
Our next paper on comparing dynamical systems (with special interest to artificial and biological neural networks) is out!! Joint work with @annhuang42.bsky.social , as well as @satpreetsingh.bsky.social , @leokoz8.bsky.social , Ila Fiete, and @kanakarajanphd.bsky.social : arxiv.org/pdf/2510.25943
Reposted by Alex Williams
ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline.
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
October 30, 2025 at 3:59 PM
ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline.
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
Reposted by Alex Williams
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Sensory expectations shape neural population dynamics in motor circuits
Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...
www.nature.com
October 29, 2025 at 4:11 PM
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Reposted by Alex Williams
I wrote an explainer about the mass firings—the RIFs.
The RIFs all year have been clearly illegal. Russell Vought is using them to lawlessly clean out federal agencies. Lower court judges have said so. But the Calvinball Supreme Court has allowed them. 1/
The RIFs all year have been clearly illegal. Russell Vought is using them to lawlessly clean out federal agencies. Lower court judges have said so. But the Calvinball Supreme Court has allowed them. 1/
The mass firings have been lawless: now and all year
The first step in stopping a lawless Supreme Court is being clear about what it’s doing
scienceandfreedomalliance.substack.com
October 29, 2025 at 12:02 PM
I wrote an explainer about the mass firings—the RIFs.
The RIFs all year have been clearly illegal. Russell Vought is using them to lawlessly clean out federal agencies. Lower court judges have said so. But the Calvinball Supreme Court has allowed them. 1/
The RIFs all year have been clearly illegal. Russell Vought is using them to lawlessly clean out federal agencies. Lower court judges have said so. But the Calvinball Supreme Court has allowed them. 1/
Reposted by Alex Williams
Pleased to share new work with @sflippl.bsky.social @eberleoliver.bsky.social @thomasmcgee.bsky.social & undergrad interns at Institute for Pure and Applied Mathematics, UCLA.
Algorithmic Primitives and Compositional Geometry of Reasoning in Language Models
www.arxiv.org/pdf/2510.15987
🧵1/n
Algorithmic Primitives and Compositional Geometry of Reasoning in Language Models
www.arxiv.org/pdf/2510.15987
🧵1/n
October 27, 2025 at 6:13 PM
Pleased to share new work with @sflippl.bsky.social @eberleoliver.bsky.social @thomasmcgee.bsky.social & undergrad interns at Institute for Pure and Applied Mathematics, UCLA.
Algorithmic Primitives and Compositional Geometry of Reasoning in Language Models
www.arxiv.org/pdf/2510.15987
🧵1/n
Algorithmic Primitives and Compositional Geometry of Reasoning in Language Models
www.arxiv.org/pdf/2510.15987
🧵1/n
Reposted by Alex Williams
Fisher meets Feynman! 🤝
We use score matching and a trick from quantum field theory to make a product-of-experts family both expressive and efficient for variational inference.
To appear as a spotlight @ NeurIPS 2025.
#NeurIPS2025 (link below)
We use score matching and a trick from quantum field theory to make a product-of-experts family both expressive and efficient for variational inference.
To appear as a spotlight @ NeurIPS 2025.
#NeurIPS2025 (link below)
October 27, 2025 at 12:51 PM
Fisher meets Feynman! 🤝
We use score matching and a trick from quantum field theory to make a product-of-experts family both expressive and efficient for variational inference.
To appear as a spotlight @ NeurIPS 2025.
#NeurIPS2025 (link below)
We use score matching and a trick from quantum field theory to make a product-of-experts family both expressive and efficient for variational inference.
To appear as a spotlight @ NeurIPS 2025.
#NeurIPS2025 (link below)
Reposted by Alex Williams
Want the freedom of a fancy fellowship, but not the year-long wait or arduous application?
Come join my lab! Work on neuroscience and AI, explore your creativity, be independent or work closely with me, collaborate widely, and have a lot of fun!
my.corehr.com/pls/uoxrecru...
Come join my lab! Work on neuroscience and AI, explore your creativity, be independent or work closely with me, collaborate widely, and have a lot of fun!
my.corehr.com/pls/uoxrecru...
October 23, 2025 at 10:46 AM
Want the freedom of a fancy fellowship, but not the year-long wait or arduous application?
Come join my lab! Work on neuroscience and AI, explore your creativity, be independent or work closely with me, collaborate widely, and have a lot of fun!
my.corehr.com/pls/uoxrecru...
Come join my lab! Work on neuroscience and AI, explore your creativity, be independent or work closely with me, collaborate widely, and have a lot of fun!
my.corehr.com/pls/uoxrecru...
Hotter take: We should only be reporting nonasymptotic confidence intervals using empirical Bernstein inequality or something similar.
Dividing by sqrt(n) is incorrect unless n = infinity.
(To be clear, I am 100% trolling)
Dividing by sqrt(n) is incorrect unless n = infinity.
(To be clear, I am 100% trolling)
What's with machine learning researchers always reporting standard deviation instead of standard error? My understanding is that the error bars are typically used to back up inferential claims about significant differences between sample means (although statistical tests are rare, another problem).
October 27, 2025 at 1:51 AM
Hotter take: We should only be reporting nonasymptotic confidence intervals using empirical Bernstein inequality or something similar.
Dividing by sqrt(n) is incorrect unless n = infinity.
(To be clear, I am 100% trolling)
Dividing by sqrt(n) is incorrect unless n = infinity.
(To be clear, I am 100% trolling)
Reposted by Alex Williams
Looking for a PhD program where you can study computational neuroscience? NYU has a fantastic array of researchers covering the field:
groups.google.com/g/systems-ne...
groups.google.com/g/systems-ne...
Doctoral studies in Computational/Theoretical Neuroscience at NYU
groups.google.com
October 25, 2025 at 2:19 PM
Looking for a PhD program where you can study computational neuroscience? NYU has a fantastic array of researchers covering the field:
groups.google.com/g/systems-ne...
groups.google.com/g/systems-ne...
Reposted by Alex Williams
A new essay on the crazy, all or nothing approach to work happening in AI today, the looming human costs, and the lack of a finish line.
I wouldn't say it's okay, but I'm not sure how to fix it.
www.interconnects.ai/p/burning-out
I wouldn't say it's okay, but I'm not sure how to fix it.
www.interconnects.ai/p/burning-out
Burning out
The international AI industry's collective risk.
www.interconnects.ai
October 25, 2025 at 2:35 PM
A new essay on the crazy, all or nothing approach to work happening in AI today, the looming human costs, and the lack of a finish line.
I wouldn't say it's okay, but I'm not sure how to fix it.
www.interconnects.ai/p/burning-out
I wouldn't say it's okay, but I'm not sure how to fix it.
www.interconnects.ai/p/burning-out
Reposted by Alex Williams
Excited to share our new work with @engeltatiana.bsky.social!
RNNs are often used to explore how the brain may solve specific tasks. We show that, depending on the architecture, RNNs find distinct circuit solutions, behaving differently when exposed to novel stimuli.
www.nature.com/articles/s42...
RNNs are often used to explore how the brain may solve specific tasks. We show that, depending on the architecture, RNNs find distinct circuit solutions, behaving differently when exposed to novel stimuli.
www.nature.com/articles/s42...
Single-unit activations confer inductive biases for emergent circuit solutions to cognitive tasks - Nature Machine Intelligence
Recurrent neural networks are widely used to model brain dynamics. Tolmachev and Engel show that single-unit activation functions influence task solutions that emerge in trained networks, raising the ...
www.nature.com
October 24, 2025 at 7:14 PM
Excited to share our new work with @engeltatiana.bsky.social!
RNNs are often used to explore how the brain may solve specific tasks. We show that, depending on the architecture, RNNs find distinct circuit solutions, behaving differently when exposed to novel stimuli.
www.nature.com/articles/s42...
RNNs are often used to explore how the brain may solve specific tasks. We show that, depending on the architecture, RNNs find distinct circuit solutions, behaving differently when exposed to novel stimuli.
www.nature.com/articles/s42...
Reposted by Alex Williams
The NIH institute director firing last Friday is very bad.
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
October 23, 2025 at 4:02 AM
The NIH institute director firing last Friday is very bad.
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
Reposted by Alex Williams
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
October 22, 2025 at 8:41 PM
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵