James Pirruccello 🌉
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jamespirruccello.com
James Pirruccello 🌉
@jamespirruccello.com
AI slop (except one) enjoyer
My hips don’t lie (they’re sore from sitting too much)
November 25, 2025 at 2:13 PM
Low-volume machine learning subreddits are becoming a prime candidate for Dead Internet Theory.
November 25, 2025 at 1:23 PM
Formulating annoying new ways to pronounce “Gaussian”
November 25, 2025 at 2:46 AM
Me, when I’m yelling at the TV:
video language action models
November 23, 2025 at 8:58 PM
These tools (like Apple’s FaceID) work well for verification, but not identification. In other words, it is unlikely that some random person who grabs your phone will match. But if you were to centralize the lookup (identification), you’d match thousands of people. Hence OK for verification, not ID.
November 23, 2025 at 4:43 PM
November 22, 2025 at 4:54 PM
Chekov’s Gundam
November 22, 2025 at 6:43 AM
My best guess is that for every 1,500 Waymos you have on the street for a year, you save one additional human life.
November 20, 2025 at 6:23 AM
Well I think the Waymo discourse has dried up. Time to start up some Zoox discourse.
November 20, 2025 at 5:54 AM
Reposted by James Pirruccello 🌉
INCREDIBLE CURVES
November 19, 2025 at 10:43 PM
Late to work because a garbage truck driver pulled so close to my Waymo that it went into collision mode. 🫡
November 17, 2025 at 3:51 PM
Reposted by James Pirruccello 🌉
We are excited to announce EchoPrime is published in Nature. EchoPrime is the first echocardiography AI model capable of evaluating a full transthoracic echocardiogram study, identify the most relevant videos, and produce a comprehensive interpretation!
November 17, 2025 at 2:38 AM
I need San Francisco to have its own satellites.
UPDATE: Since launching our own methane-tracking satellite earlier this year, California has helped close 10 large methane leaks in our state.

That pollution reduction is roughly the same as taking 18,000 gas-powered cars off the road for an entire year.
California is moving forward with a groundbreaking satellite project to track and reduce methane emissions.

With this innovative technology, we’ll be able to move faster to cut methane emissions — protecting Californians and tackling harmful pollution.
November 16, 2025 at 8:00 PM
Losing contrastively.
November 16, 2025 at 7:35 PM
Attention to this matter is all you need.
November 16, 2025 at 5:13 PM
November 16, 2025 at 6:19 AM
If you find a cracked 10x engineer, are you supposed to take them to a hospital, or reassemble them kintsugi-style?
November 15, 2025 at 4:07 PM
Whatever Apple did with unread message necromancy in iOS 26.1, I want them to roll it back.
November 15, 2025 at 3:18 PM
Reposted by James Pirruccello 🌉
3/10 – On average across traits, we estimate that ~23% of our estimated WGS-based heritability is due to rare variants (0.01%<frequency<1%). We also show that coding and non-coding genetic variants account for 21% and 79% of rare-variant WGS-based heritability, respectively.
November 12, 2025 at 5:57 PM
Achievement unlocked: so overwhelmed by emails that I missed a manuscript proofs email.
November 12, 2025 at 5:19 PM
Reposted by James Pirruccello 🌉
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
November 11, 2025 at 1:20 AM
Act of Claude: something you attempt disclaim liability for because it was entirely vibe coded.
November 10, 2025 at 10:56 PM
Reposted by James Pirruccello 🌉
📊 Research Summary from @jama.com: Adults with #AFib who drank at least one cup of caffeinated coffee daily after successful cardioversion had a lower risk of recurrence than those who abstained from coffee and caffeine.

#AHA25 @ahascience.bsky.social

ja.ma/47Nwy8q
November 9, 2025 at 3:20 PM
Soumith Chintala stepping away from PyTorch
soumith.ch
November 7, 2025 at 6:41 AM