Jeff Miner
@jeffminerphd.bsky.social
Professor of Medicine in Nephrology and Matrix Biologist @ WashU Medicine, focused on glomerular basement membrane and Alport syndrome (+ related diseases)
Great collaboration! So happy that our O'Brien Kidney Center Variant Validation Core could help out with the VUS analyses. @washunephrology.bsky.social @obrienkidney.bsky.social
Sharing our preprint - Multidisciplinary approach w/ biobank/EHR data, functional testing, genetic testing lab collaborations to reclassify 20 VUS in Alport syndrome, pkd. @amoralescgc.bsky.social @jeffminerphd.bsky.social www.medrxiv.org/content/10.1...
Leveraging genomic biobanks to enhance genetic testing outcomes for kidney disease
Chronic kidney disease (CKD) affects 9.1% globally and is associated with significant morbidity and mortality. While up to 10% of CKD cases yield a genetic diagnosis with hundreds of implicated genes ...
www.medrxiv.org
November 14, 2025 at 4:33 PM
Great collaboration! So happy that our O'Brien Kidney Center Variant Validation Core could help out with the VUS analyses. @washunephrology.bsky.social @obrienkidney.bsky.social
Your ASN-AHA Young Investigator Award seems like yesterday! Congratulations on the 2-peat!
Katalin Susztak accepting the Homer W. Smith Award. #KidneyWk
November 11, 2025 at 12:59 AM
Your ASN-AHA Young Investigator Award seems like yesterday! Congratulations on the 2-peat!
This makes me very curious about the COL4A5 variant!
Ah makes sense…working on a one-pager for patients in this setting. Strangely, colleague had a male in 30s with col4a5 asymptomatic without hematuria and proteinuria, normal GFR, detected on reproductive screening genetic test done prior to marriage
November 10, 2025 at 12:43 AM
This makes me very curious about the COL4A5 variant!
Reposted by Jeff Miner
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
November 6, 2025 at 6:39 PM
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Thanks to Julie Inglefinger for this enlightening summary at ASN KidneyCure Week!
November 6, 2025 at 3:32 PM
Thanks to Julie Inglefinger for this enlightening summary at ASN KidneyCure Week!
I’ll be there!
Katalin Susztak will be presented the Homer W. Smith Award on Friday, November 7. Join us at #KidneyWk and read more in #ASNKidneyNews: kidney.pub/KN1710-34
November 4, 2025 at 11:10 PM
I’ll be there!
Spreading the word about the Importance and Power of Podocytes at @asnkidney.bsky.social Kidney Week in Houston. @isgd.bsky.social
November 4, 2025 at 8:09 PM
Spreading the word about the Importance and Power of Podocytes at @asnkidney.bsky.social Kidney Week in Houston. @isgd.bsky.social
Thanks to NIDDK for funding this work! #AlportSyndrome @alportuk.bsky.social @alportalliance.bsky.social
Mouse Alport podocytes are susceptible to AAV9 transduction in vivo
doi.org/10.1016/j.kint.2025.09.027
#MedSky #NephSky
@jeffminerphd.bsky.social @washunephrology.bsky.social @washumedicine.bsky.social
doi.org/10.1016/j.kint.2025.09.027
#MedSky #NephSky
@jeffminerphd.bsky.social @washunephrology.bsky.social @washumedicine.bsky.social
November 4, 2025 at 6:27 PM
Thanks to NIDDK for funding this work! #AlportSyndrome @alportuk.bsky.social @alportalliance.bsky.social
I first presented the data in this paper at the Philly Podocyte meeting in May 2023 (thanks @ksusztak.bsky.social
& Larry Holzman), and a few days ago the paper appeared in
@kidneyint.bsky.social . Promising results for new ways to treat Alport syndrome. kidney-international.org/article/S008...
& Larry Holzman), and a few days ago the paper appeared in
@kidneyint.bsky.social . Promising results for new ways to treat Alport syndrome. kidney-international.org/article/S008...
Mouse Alport podocytes are susceptible to AAV9 transduction in vivo
Alport syndrome features a defective glomerular basement membrane (GBM) due to variants
in COL4A3, COL4A4, and COL4A5. The most severe forms, which lack the GBM’s collagen
α3α4α5(IV) network, progress...
kidney-international.org
November 4, 2025 at 4:11 PM
I first presented the data in this paper at the Philly Podocyte meeting in May 2023 (thanks @ksusztak.bsky.social
& Larry Holzman), and a few days ago the paper appeared in
@kidneyint.bsky.social . Promising results for new ways to treat Alport syndrome. kidney-international.org/article/S008...
& Larry Holzman), and a few days ago the paper appeared in
@kidneyint.bsky.social . Promising results for new ways to treat Alport syndrome. kidney-international.org/article/S008...
Structurally beautiful--and beautifully functional, too!
The kidney slit diaphragm resembles a fishnet
doi.org/10.1016/j.kint.2025.08.028
#OpenAccess #NephSky #MedSky
doi.org/10.1016/j.kint.2025.08.028
#OpenAccess #NephSky #MedSky
October 6, 2025 at 9:47 PM
Structurally beautiful--and beautifully functional, too!
Reposted by Jeff Miner
📢 Ready to take your research further? The 2026 KidneyCure Grant cycle is open. Funding, mentorship, and resources are waiting. Applications close on Thursday, November 20, at 2:00 p.m. EST. Programs support fellows, PhD students, and early-career faculty in kidney care: bit.ly/kcgrantsfund...
September 22, 2025 at 9:14 PM
📢 Ready to take your research further? The 2026 KidneyCure Grant cycle is open. Funding, mentorship, and resources are waiting. Applications close on Thursday, November 20, at 2:00 p.m. EST. Programs support fellows, PhD students, and early-career faculty in kidney care: bit.ly/kcgrantsfund...
Congratulations Stephen! I look forward to hearing your talk in Baltimore in November at ASMB 2025! @amsocmatbio.bsky.social
I am thrilled to share that my abstract focusing on novel humanized mouse models of X-linked Alport Syndrome has been selected as a finalist for the Iozzo Trainee Award, as well as a recipient of a Travel Award to the American Society for Matrix Biology biannual meeting.
August 24, 2025 at 10:41 PM
Congratulations Stephen! I look forward to hearing your talk in Baltimore in November at ASMB 2025! @amsocmatbio.bsky.social
Reposted by Jeff Miner
🚨 Final call: The ASN Loan Mitigation Program closes tomorrow, Wednesday, August 20, at 2:00 p.m. EDT. Get your application in for a chance at $50K over three years toward student loans to reduce your debt and focus on your career in kidney care. 👉 bit.ly/lmp2025
August 19, 2025 at 9:29 PM
🚨 Final call: The ASN Loan Mitigation Program closes tomorrow, Wednesday, August 20, at 2:00 p.m. EDT. Get your application in for a chance at $50K over three years toward student loans to reduce your debt and focus on your career in kidney care. 👉 bit.ly/lmp2025
Reposted by Jeff Miner
Very happy that Kidney News published my call for a kidney care revolution. Thank you to @asnpublications and everyone who has guided me along the way.
In an interview with Arnold Davis, a powerful and motivating patient advocate, #ASNKidneyNews explores his path from diagnosis with ADPKD in 2017 to his advocacy and urgent call for change in kidney care. kidney.pub/KN1708-02 @kidneyrebel.bsky.social
August 9, 2025 at 4:15 PM
Very happy that Kidney News published my call for a kidney care revolution. Thank you to @asnpublications and everyone who has guided me along the way.
Check out my article on Alport syndrome in the July ASN Kidney News: "From Basement Membrane Thinning to Alport Syndrome: An Array of Presentations Caused by COL4A3/A4/A5 Gene Variants" www.kidneynews.org/view/journal...
August 1, 2025 at 4:13 PM
Check out my article on Alport syndrome in the July ASN Kidney News: "From Basement Membrane Thinning to Alport Syndrome: An Array of Presentations Caused by COL4A3/A4/A5 Gene Variants" www.kidneynews.org/view/journal...
Reposted by Jeff Miner
🗳️ Voting for the ASN Council Election is now open! Select the next Executive Councilor and At-Large Councilor. Your voice helps shape what’s next in kidney care.
Deadline: Friday, September 5, at 11:59 p.m. EDT
🔗https://www.asn-online.org/vote
Deadline: Friday, September 5, at 11:59 p.m. EDT
🔗https://www.asn-online.org/vote
July 31, 2025 at 9:13 PM
🗳️ Voting for the ASN Council Election is now open! Select the next Executive Councilor and At-Large Councilor. Your voice helps shape what’s next in kidney care.
Deadline: Friday, September 5, at 11:59 p.m. EDT
🔗https://www.asn-online.org/vote
Deadline: Friday, September 5, at 11:59 p.m. EDT
🔗https://www.asn-online.org/vote
Thrilled to have this finally published! If you are interested in learning about the collagen IV diseases Gould syndrome and Alport syndrome, add this to your reading list. www.nature.com/articles/s41...
Collagen IV in Gould syndrome and Alport syndrome
Nature Reviews Nephrology - In this Review, the authors focus on the role of collagen IV in Gould syndrome and Alport syndrome. They discuss the molecular and phenotypic similarities and...
www.nature.com
July 31, 2025 at 2:44 PM
Thrilled to have this finally published! If you are interested in learning about the collagen IV diseases Gould syndrome and Alport syndrome, add this to your reading list. www.nature.com/articles/s41...
One of my favorite sessions in Hamburg!
Jaw-dropping joint session! Prof. Dr. Florian Grahammer and Prof. Dr. Achilleas Frangakis brilliantly reveal the secrets of slit diaphragm composition and structure. Think fishnet pattern! 🐟 🥅 #PodocyteConference 🐙 tobias-b-huber.bsky.social
June 14, 2025 at 7:21 PM
One of my favorite sessions in Hamburg!
Congratulations Moe!!!
Soooo... did a thing yesterday 🇺🇸
I've been eligible to be a citizen for a long time, but never felt the need (I'm a proud Canadian & always will be ❤️). But these are dark times, and every voice/vote/person counts. Who knows what the 🤡 will try next. #NoKings #NoKingsProtest
I've been eligible to be a citizen for a long time, but never felt the need (I'm a proud Canadian & always will be ❤️). But these are dark times, and every voice/vote/person counts. Who knows what the 🤡 will try next. #NoKings #NoKingsProtest
June 14, 2025 at 6:07 PM
Congratulations Moe!!!
Reposted by Jeff Miner
Joshua's story about living with APOL1-associated diasease inspired Dr. Katalin Susztak to present the connecting bridges from mapping to mechanisms to medicine! 💊 More results at the next #PodocyteConference? 🤩
June 11, 2025 at 1:23 PM
Joshua's story about living with APOL1-associated diasease inspired Dr. Katalin Susztak to present the connecting bridges from mapping to mechanisms to medicine! 💊 More results at the next #PodocyteConference? 🤩
Reposted by Jeff Miner
Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.
“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming
www.nytimes.com
June 3, 2025 at 10:58 AM
Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.
“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
Just attended a terrific meeting on Alport Syndrome So many talented experts in the room + the most involved patients. And so much hope for progress towards new treatments.
May 11, 2025 at 8:33 AM
Just attended a terrific meeting on Alport Syndrome So many talented experts in the room + the most involved patients. And so much hope for progress towards new treatments.
Reposted by Jeff Miner
The OKRA National Forum is happening tomorrow from 12-1pm CST / 1-2pm EST!
Dr. Naoka Murakami (WashU) will be discussing “T cells in Kidney Wells: Lessons from Immunotherapy-associated Kidney Injury.”
Learn more and register at our website: www.uab.edu/okra/trainin...
Dr. Naoka Murakami (WashU) will be discussing “T cells in Kidney Wells: Lessons from Immunotherapy-associated Kidney Injury.”
Learn more and register at our website: www.uab.edu/okra/trainin...
April 2, 2025 at 2:17 PM
The OKRA National Forum is happening tomorrow from 12-1pm CST / 1-2pm EST!
Dr. Naoka Murakami (WashU) will be discussing “T cells in Kidney Wells: Lessons from Immunotherapy-associated Kidney Injury.”
Learn more and register at our website: www.uab.edu/okra/trainin...
Dr. Naoka Murakami (WashU) will be discussing “T cells in Kidney Wells: Lessons from Immunotherapy-associated Kidney Injury.”
Learn more and register at our website: www.uab.edu/okra/trainin...
A bright spot regarding NIH: A colleague whose R01 scored 5% in July 2024, with an expected September 2024 start date, finally received the Notice of Award today, with only a standard administrative budget cut. The wheels really are turning.
March 25, 2025 at 11:27 PM
A bright spot regarding NIH: A colleague whose R01 scored 5% in July 2024, with an expected September 2024 start date, finally received the Notice of Award today, with only a standard administrative budget cut. The wheels really are turning.
Reposted by Jeff Miner
#JOIN us #TOMORROW for an exciting e-symposium exploring the critical role of the #ECM in #womensHealth
Register⏩http://asmb.net/e-symposia #ECMatrixIsEverywhere #WomensHealth
#MeetTheOrganizers: Dr. Pilar de la Puente (@delapuente_lab) & Dr. Maria Gonzalez Porras (@GonzalezPLab)
Register⏩http://asmb.net/e-symposia #ECMatrixIsEverywhere #WomensHealth
#MeetTheOrganizers: Dr. Pilar de la Puente (@delapuente_lab) & Dr. Maria Gonzalez Porras (@GonzalezPLab)
March 25, 2025 at 7:20 PM
#JOIN us #TOMORROW for an exciting e-symposium exploring the critical role of the #ECM in #womensHealth
Register⏩http://asmb.net/e-symposia #ECMatrixIsEverywhere #WomensHealth
#MeetTheOrganizers: Dr. Pilar de la Puente (@delapuente_lab) & Dr. Maria Gonzalez Porras (@GonzalezPLab)
Register⏩http://asmb.net/e-symposia #ECMatrixIsEverywhere #WomensHealth
#MeetTheOrganizers: Dr. Pilar de la Puente (@delapuente_lab) & Dr. Maria Gonzalez Porras (@GonzalezPLab)