Alex Chang, MD
@alexchangmd.bsky.social
Associate professor, clinician-scientist/dad/husband interested in early prevention/treatment of kidney disease
tweets=personal views #nephsky
tweets=personal views #nephsky
Pinned
Happy to share our paper in @asnpublications.bsky.social examining COL4A5 X-linked Alport Syndrome in an unselected health system-based population. Phenotypic spectrum of X-linked Alport syndrome is wider than previously known. Risk lower for Gly624Asp variant. 1/ journals.lww.com/jasn/fulltex...
Reposted by Alex Chang, MD
I did not know it was this bad
Look at the mortality in younger females (versus males) in CKD 5
jamanetwork.com/journals/jam... in @jamainternalmed.com from Alberta
#NephSky #GenderDisparities
Look at the mortality in younger females (versus males) in CKD 5
jamanetwork.com/journals/jam... in @jamainternalmed.com from Alberta
#NephSky #GenderDisparities
November 25, 2025 at 7:14 PM
I did not know it was this bad
Look at the mortality in younger females (versus males) in CKD 5
jamanetwork.com/journals/jam... in @jamainternalmed.com from Alberta
#NephSky #GenderDisparities
Look at the mortality in younger females (versus males) in CKD 5
jamanetwork.com/journals/jam... in @jamainternalmed.com from Alberta
#NephSky #GenderDisparities
Reposted by Alex Chang, MD
I am encountering yet more men on testosterone having huge heart attacks. Bear in mind I’m only on call 1/12th of the time (ie my rota has 12 consultants) and yet I’ve now seen 5 men in the last couple of months who’ve had STEMIs in their 40s and 50s. All very fit and *externally* in great shape
November 23, 2025 at 9:34 AM
I am encountering yet more men on testosterone having huge heart attacks. Bear in mind I’m only on call 1/12th of the time (ie my rota has 12 consultants) and yet I’ve now seen 5 men in the last couple of months who’ve had STEMIs in their 40s and 50s. All very fit and *externally* in great shape
Reposted by Alex Chang, MD
We’re excited to bring SCM to New Orleans for the very first time. Don’t miss this opportunity to connect with colleagues and learn from experts across the kidney care spectrum.
👉 Secure your registration now: www.kidney.org/spring-clini...
#NKFClinicals #Nephrology #MedEd
👉 Secure your registration now: www.kidney.org/spring-clini...
#NKFClinicals #Nephrology #MedEd
November 22, 2025 at 5:03 PM
We’re excited to bring SCM to New Orleans for the very first time. Don’t miss this opportunity to connect with colleagues and learn from experts across the kidney care spectrum.
👉 Secure your registration now: www.kidney.org/spring-clini...
#NKFClinicals #Nephrology #MedEd
👉 Secure your registration now: www.kidney.org/spring-clini...
#NKFClinicals #Nephrology #MedEd
Saw 2 pts in clinic who had anaplasmosis and AKI this summer, scary ticks…yikes!
November 20, 2025 at 6:50 PM
Saw 2 pts in clinic who had anaplasmosis and AKI this summer, scary ticks…yikes!
Reposted by Alex Chang, MD
I think Aliza Thompson is an unsung hero in this story for spearheading the albuminuria acceptance at FDA
journals.lww.com/cjasn/pages/...
#NephJC
journals.lww.com/cjasn/pages/...
#NephJC
journals.lww.com
November 19, 2025 at 3:00 AM
I think Aliza Thompson is an unsung hero in this story for spearheading the albuminuria acceptance at FDA
journals.lww.com/cjasn/pages/...
#NephJC
journals.lww.com/cjasn/pages/...
#NephJC
Reposted by Alex Chang, MD
From RAAS blockade to regenerative medicine: evolving treatment strategies in #Alport syndrome pubmed.ncbi.nlm.nih.gov/41243004/
November 17, 2025 at 3:54 PM
From RAAS blockade to regenerative medicine: evolving treatment strategies in #Alport syndrome pubmed.ncbi.nlm.nih.gov/41243004/
Reposted by Alex Chang, MD
Great collaboration! So happy that our O'Brien Kidney Center Variant Validation Core could help out with the VUS analyses. @washunephrology.bsky.social @obrienkidney.bsky.social
Sharing our preprint - Multidisciplinary approach w/ biobank/EHR data, functional testing, genetic testing lab collaborations to reclassify 20 VUS in Alport syndrome, pkd. @amoralescgc.bsky.social @jeffminerphd.bsky.social www.medrxiv.org/content/10.1...
Leveraging genomic biobanks to enhance genetic testing outcomes for kidney disease
Chronic kidney disease (CKD) affects 9.1% globally and is associated with significant morbidity and mortality. While up to 10% of CKD cases yield a genetic diagnosis with hundreds of implicated genes ...
www.medrxiv.org
November 14, 2025 at 4:33 PM
Great collaboration! So happy that our O'Brien Kidney Center Variant Validation Core could help out with the VUS analyses. @washunephrology.bsky.social @obrienkidney.bsky.social
Sharing our preprint - Multidisciplinary approach w/ biobank/EHR data, functional testing, genetic testing lab collaborations to reclassify 20 VUS in Alport syndrome, pkd. @amoralescgc.bsky.social @jeffminerphd.bsky.social www.medrxiv.org/content/10.1...
Leveraging genomic biobanks to enhance genetic testing outcomes for kidney disease
Chronic kidney disease (CKD) affects 9.1% globally and is associated with significant morbidity and mortality. While up to 10% of CKD cases yield a genetic diagnosis with hundreds of implicated genes ...
www.medrxiv.org
November 14, 2025 at 2:54 AM
Sharing our preprint - Multidisciplinary approach w/ biobank/EHR data, functional testing, genetic testing lab collaborations to reclassify 20 VUS in Alport syndrome, pkd. @amoralescgc.bsky.social @jeffminerphd.bsky.social www.medrxiv.org/content/10.1...
Reposted by Alex Chang, MD
Whoah
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 13, 2025 at 11:05 PM
Whoah
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
ABIM LKM chatGPT?
November 13, 2025 at 6:00 PM
ABIM LKM chatGPT?
Reposted by Alex Chang, MD
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
November 6, 2025 at 6:39 PM
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Excellent talk by Emmanuel Letavernier on iatrogenic/environmental causes of kidney stones. Vitamin C supplementation during COVID pandemic, vitamin D supplementation possible risk factor for Randalls plaques, hair straightening products glyoxylic acid and galore #kidneywk
November 8, 2025 at 3:58 AM
Excellent talk by Emmanuel Letavernier on iatrogenic/environmental causes of kidney stones. Vitamin C supplementation during COVID pandemic, vitamin D supplementation possible risk factor for Randalls plaques, hair straightening products glyoxylic acid and galore #kidneywk
Reposted by Alex Chang, MD
And @brendonneuen.bsky.social with another simultaneous pub in @jama.com
jamanetwork.com/journals/jam...
Flozination by GFR/albuminuria
#KidneyWk
jamanetwork.com/journals/jam...
Flozination by GFR/albuminuria
#KidneyWk
SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria
This meta-analysis examines whether estimated glomerular filtration rate or degree of albuminuria, as measured by urinary albumin to creatinine ratio, modifies the effects of sodium-glucose cotranspor...
jamanetwork.com
November 8, 2025 at 12:05 AM
And @brendonneuen.bsky.social with another simultaneous pub in @jama.com
jamanetwork.com/journals/jam...
Flozination by GFR/albuminuria
#KidneyWk
jamanetwork.com/journals/jam...
Flozination by GFR/albuminuria
#KidneyWk
Reposted by Alex Chang, MD
And the GBD analysis on CKD
From @paddymark.bsky.social and colleagues
www.thelancet.com/journals/lan... in @thelancet.com
#KidneyWk
From @paddymark.bsky.social and colleagues
www.thelancet.com/journals/lan... in @thelancet.com
#KidneyWk
Global, regional, and national burden of chronic kidney disease in adults, 1990–2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023
CKD is a major global health issue, with rising prevalence and increasing importance
as a cause of death and as a risk factor for cardiovascular death. A better understating
of aetiology, appropriate ...
www.thelancet.com
November 8, 2025 at 12:14 AM
And the GBD analysis on CKD
From @paddymark.bsky.social and colleagues
www.thelancet.com/journals/lan... in @thelancet.com
#KidneyWk
From @paddymark.bsky.social and colleagues
www.thelancet.com/journals/lan... in @thelancet.com
#KidneyWk
Reposted by Alex Chang, MD
REMODEL is fantastic demonstration of what we can do with collaborative effort to perform what Kathy Tuttle calls mechanistic clinical trials!
Semaglutide provides kidney protection via improvements in inflammation and microvascular function. Lots of data to parse going forward. #KidneyWk
Semaglutide provides kidney protection via improvements in inflammation and microvascular function. Lots of data to parse going forward. #KidneyWk
November 7, 2025 at 11:13 PM
REMODEL is fantastic demonstration of what we can do with collaborative effort to perform what Kathy Tuttle calls mechanistic clinical trials!
Semaglutide provides kidney protection via improvements in inflammation and microvascular function. Lots of data to parse going forward. #KidneyWk
Semaglutide provides kidney protection via improvements in inflammation and microvascular function. Lots of data to parse going forward. #KidneyWk
Cool article on potential of exon skipping therapies for rare genetic kidney diseases like x-linked Alport syndrome. Uses anti-sense oligonucleotides (ASOs). This type of treatment has been in use for in Duchenne muscular dystrophy journals.lww.com/jasn/pages/a...
November 7, 2025 at 12:55 PM
Cool article on potential of exon skipping therapies for rare genetic kidney diseases like x-linked Alport syndrome. Uses anti-sense oligonucleotides (ASOs). This type of treatment has been in use for in Duchenne muscular dystrophy journals.lww.com/jasn/pages/a...
Reposted by Alex Chang, MD
In the afternoon another late breaking oral session among other things at 4:30 pm
@brendonneuen.bsky.social
Lorundrostat
A new oral GLP1
REMODEL to understand sema mechanism
GBD kidney disease with @paddymark.bsky.social
And
@cervantes-lily1.bsky.social !
#KidneyWk
@brendonneuen.bsky.social
Lorundrostat
A new oral GLP1
REMODEL to understand sema mechanism
GBD kidney disease with @paddymark.bsky.social
And
@cervantes-lily1.bsky.social !
#KidneyWk
November 7, 2025 at 10:39 AM
In the afternoon another late breaking oral session among other things at 4:30 pm
@brendonneuen.bsky.social
Lorundrostat
A new oral GLP1
REMODEL to understand sema mechanism
GBD kidney disease with @paddymark.bsky.social
And
@cervantes-lily1.bsky.social !
#KidneyWk
@brendonneuen.bsky.social
Lorundrostat
A new oral GLP1
REMODEL to understand sema mechanism
GBD kidney disease with @paddymark.bsky.social
And
@cervantes-lily1.bsky.social !
#KidneyWk
Looking for new research opportunities in this challenging environment? Consider joining our Center for Kidney Health Research, pt centered research program in a learning health system, leveraging EHR since 1996, exome sequencing in the MyCode cohort. #kidneywk
jobs.geisinger.org/job/danville...
jobs.geisinger.org/job/danville...
November 6, 2025 at 6:19 PM
Looking for new research opportunities in this challenging environment? Consider joining our Center for Kidney Health Research, pt centered research program in a learning health system, leveraging EHR since 1996, exome sequencing in the MyCode cohort. #kidneywk
jobs.geisinger.org/job/danville...
jobs.geisinger.org/job/danville...
Reposted by Alex Chang, MD
You got it! Packing in the fun!
November 5, 2025 at 11:08 PM
You got it! Packing in the fun!
Reposted by Alex Chang, MD
Looks like he’s gone
www.nytimes.com/2025/11/02/h...
Strange times when a chap accuses VP of approving new drugs to quickly with surrogate outcomes 😏
www.nytimes.com/2025/11/02/h...
Strange times when a chap accuses VP of approving new drugs to quickly with surrogate outcomes 😏
November 2, 2025 at 11:05 PM
Looks like he’s gone
www.nytimes.com/2025/11/02/h...
Strange times when a chap accuses VP of approving new drugs to quickly with surrogate outcomes 😏
www.nytimes.com/2025/11/02/h...
Strange times when a chap accuses VP of approving new drugs to quickly with surrogate outcomes 😏
Looking forward to ASN (American Society of Nephrology) Kidney Week this week! See list of Geisinger neph presentations/posters encompassing: genetic kidney stone disease, EHR clinical decision support for albuminuria screening, home dialysis program education, pharmacoepidemiology in CKD and more!
November 1, 2025 at 7:53 PM
Looking forward to ASN (American Society of Nephrology) Kidney Week this week! See list of Geisinger neph presentations/posters encompassing: genetic kidney stone disease, EHR clinical decision support for albuminuria screening, home dialysis program education, pharmacoepidemiology in CKD and more!
Reposted by Alex Chang, MD
Many of my followers know I'm an absolute retatrutide fanboy. I was on the drug in trial, it changed my life forever. It did something funny to my kidney function. It raised my GFR about 20% in 19 months as seen below Pick a measure it rose. Lilly noticed this too and started a trial looking it 🧵
October 30, 2025 at 11:26 PM
Many of my followers know I'm an absolute retatrutide fanboy. I was on the drug in trial, it changed my life forever. It did something funny to my kidney function. It raised my GFR about 20% in 19 months as seen below Pick a measure it rose. Lilly noticed this too and started a trial looking it 🧵
Reposted by Alex Chang, MD
I am genuinely impressed by large language models - they can absorb disparate components of text into some consolidated view, they can produce extremely good language and - with the right model - translate pretty well between languages and they are an excellent text based UI for humans to use. But..
October 26, 2025 at 7:48 AM
I am genuinely impressed by large language models - they can absorb disparate components of text into some consolidated view, they can produce extremely good language and - with the right model - translate pretty well between languages and they are an excellent text based UI for humans to use. But..
Reposted by Alex Chang, MD
Monty Python understood p-hacking
October 23, 2025 at 8:43 AM
Monty Python understood p-hacking