Finally, this pilus was reported to be conductive many years ago. However, our structure shows no molecular basis for this, and our bulk measurements confirm the pili are not conductive. It's not surprising—why would a photosynthetic bacterium need to adopt the anaerobic respiration lifestyle?

Intriguingly, we also showed this pilus can bind microcystin on its surface! 😜 This binding may be achieved by a unique glycosylation pattern, allowing the bacteria to enrich these toxins, which could potentially aid in their survival.

These pili are crucial for the bacteria to maintain its water column position. Since we lack genetic knockout tools, we temporarily sheared the pili off. Without them, the bacteria could no longer remain where they were. The cells remained viable, and the pili were regenerated after a few hours.

First time posting on Bluesky! 🥳 We discovered a new pilus family in cyanobacteria. The pilin has a novel protein fold that forms a super-tight double-layer tube. Similar gene clusters exist in a few cyanobacterial orders. A great collaboration with John and others! www.nature.com/articles/s41...

Cannulae paper published in final form. Thanks to the many collaborators and to the reviewers. @jerryknowsnothing.bsky.social @mikesleutel.bsky.social @vikramalva.bsky.social

rdcu.be/eKVlI

I missed the original share on this article since I was locked out of my Bluesky account due to algorithmic impotence. Hate when that happens. Really cool structure from @jerryknowsnothing.bsky.social and co-authors. rdcu.be/eHQ1N

Archaeal pili are wild! In #archaeon Saccharolobus islandicus the same adehesive type 4 pilin exists in 4 different conformations forming two structurally very different pili. Collaboration with the groups of @jerryknowsnothing.bsky.social and Ed Egelman. www.nature.com/articles/s41...

Have a look at our paper on a new group of pleomorphic viruses infecting marine hyperthermophilic #archaea of the class Archaeoglobi. The virus coexists in a stable relationship with its host. Congrats to Diana Baquero and Eduardo Bignon. @ISMEJ doi.org/10.1093/isme...