The Journal of Immunology
@jimmunol.bsky.social
The Journal of Immunology is an official journal of The American Association of Immunologists, journals.aai.org/jimmunol
Editor-in-Chief: Gail A. Bishop, Ph.D.
Editor-in-Chief: Gail A. Bishop, Ph.D.
The January issue of The Journal of Immunology is online now! Featuring updates on #CuttingEdge criteria and research from esteemed colleagues, be sure to give it a read.
🔗 bit.ly/TJI0126
🔗 bit.ly/TJI0126
February 3, 2026 at 2:21 PM
The January issue of The Journal of Immunology is online now! Featuring updates on #CuttingEdge criteria and research from esteemed colleagues, be sure to give it a read.
🔗 bit.ly/TJI0126
🔗 bit.ly/TJI0126
This #BriefReview highlights a T cell intrinsic role for NOD2 downstream of T cell receptor and co-receptor signaling and delineates how NOD2 shapes T cell responses in both homeostasis and disease. Read the full review: ow.ly/gKJs50Y4nNq.
Resolving the field: a role for Nod2 in T cells
Abstract. NOD2 is primarily recognized as a cytosolic bacterial sensor of peptidoglycan, activating a downstream Rip2/NF-κB–mediated antimicrobial signalin
ow.ly
January 27, 2026 at 8:42 PM
This #BriefReview highlights a T cell intrinsic role for NOD2 downstream of T cell receptor and co-receptor signaling and delineates how NOD2 shapes T cell responses in both homeostasis and disease. Read the full review: ow.ly/gKJs50Y4nNq.
Reposted by The Journal of Immunology
#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...
TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates
Abstract. Toll-like receptor 4 (TLR4), a critical pattern recognition receptor, detects microbe- and damage/danger-associated molecular patterns to trigger
academic.oup.com
January 11, 2026 at 3:58 PM
#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...
Calling all authors and readers of The JI and @immunohorizons.bsky.social! Late-breaking abstract submissions for IMMUNOLOGY2026™ close today, January 22. Showcase your groundbreaking #immunology research in Boston this April.
The window for #IMMUNOLOGY2026™ late-breaking abstracts closes tomorrow, January 22! Don’t miss your chance to present your latest data and opt in for the "Findings in 5" theater sessions. Finish those drafts!
🔗 https://ow.ly/IQzJ50XXoPC
🔗 https://ow.ly/IQzJ50XXoPC
January 22, 2026 at 8:12 PM
Calling all authors and readers of The JI and @immunohorizons.bsky.social! Late-breaking abstract submissions for IMMUNOLOGY2026™ close today, January 22. Showcase your groundbreaking #immunology research in Boston this April.
Data show that BRGSF-HIS mice possess human myeloid and lymphoid cell compartments in the lung interstitium comparable to humans, providing an opportunity for studying immune mechanisms of human lung diseases. This #TopRead is a collaboration led by Dr. Doumet Georges Helou: ow.ly/c5JL50XYaBP.
January 21, 2026 at 3:50 PM
Data show that BRGSF-HIS mice possess human myeloid and lymphoid cell compartments in the lung interstitium comparable to humans, providing an opportunity for studying immune mechanisms of human lung diseases. This #TopRead is a collaboration led by Dr. Doumet Georges Helou: ow.ly/c5JL50XYaBP.
Data indicate that human CD4+ mucosal-associated invariant T cell TCRs may be selected by alternative MR1 ligands in addition to canonical riboflavin intermediates. Find this #TopRead article from @charlesvorkas.bsky.social and team online: ow.ly/hcNc50XYarT.
January 19, 2026 at 3:54 PM
Data indicate that human CD4+ mucosal-associated invariant T cell TCRs may be selected by alternative MR1 ligands in addition to canonical riboflavin intermediates. Find this #TopRead article from @charlesvorkas.bsky.social and team online: ow.ly/hcNc50XYarT.
Reposted by The Journal of Immunology
#ICYMI: From Dr. Kristin Hogquist at the Center for Immunology-UMN focuses on interferon (IFN) production within the thymus and its effects on thymic APCs and developing thymocyte while also examining the importance of T-cell tolerance to IFN. The Journal of Immunology: https://ow.ly/UEMw50VEIEx
December 29, 2025 at 8:00 PM
#ICYMI: From Dr. Kristin Hogquist at the Center for Immunology-UMN focuses on interferon (IFN) production within the thymus and its effects on thymic APCs and developing thymocyte while also examining the importance of T-cell tolerance to IFN. The Journal of Immunology: https://ow.ly/UEMw50VEIEx
Researchers developed optimized detection and inference of names in scRNA-seq data (scODIN) to enhance the understanding of immune cell heterogeneity and immune regulation. Read more to see the broad implications for immunology and personalized medicine: ow.ly/InOb50XS9k2.
Optimized detection and inference of immune cell type names in single-cell RNA sequencing data
Abstract. Accurate identification of immune cell subsets in single-cell RNA sequencing (scRNA-seq) data is critical for understanding immune responses in a
ow.ly
January 5, 2026 at 7:57 PM
Researchers developed optimized detection and inference of names in scRNA-seq data (scODIN) to enhance the understanding of immune cell heterogeneity and immune regulation. Read more to see the broad implications for immunology and personalized medicine: ow.ly/InOb50XS9k2.
Female Malat1-/- mice demonstrated altered Th2 cytokine expression, evidenced by a reduction in IL-10+ Th2 cells in both lung and spleen, while male Malat1-/- mice did not, revealing Malat1 as a novel determinant of immune sexual dimorphism. Read more: ow.ly/RgN050XQCz8.
Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2
Abstract. Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is
ow.ly
December 31, 2025 at 2:28 PM
Female Malat1-/- mice demonstrated altered Th2 cytokine expression, evidenced by a reduction in IL-10+ Th2 cells in both lung and spleen, while male Malat1-/- mice did not, revealing Malat1 as a novel determinant of immune sexual dimorphism. Read more: ow.ly/RgN050XQCz8.
Awesome @altmetric.com trending research from The Journal of Immunology & @immunohorizons.bsky.social is featured in this year's #immunologywrapped! From the "Impact of sleep deprivation on monocyte subclasses and function" to "TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni".
🧬 2025 was a MOOD. From Hawaii to Capitol Hill, AAI has been busy advancing the field! Check out our #ImmunologyWrapped to see our highlights in research, advocacy, and community.
Which 2025 #Immunology moment was your favorite? ⬇️
https://ow.ly/ulsv50XMEsf
Which 2025 #Immunology moment was your favorite? ⬇️
https://ow.ly/ulsv50XMEsf
December 19, 2025 at 7:44 PM
Awesome @altmetric.com trending research from The Journal of Immunology & @immunohorizons.bsky.social is featured in this year's #immunologywrapped! From the "Impact of sleep deprivation on monocyte subclasses and function" to "TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni".
Researchers evaluated SB834Fc, an IL-2 mutated variant, for its anti-tumor properties. Their results support SB834Fc as a candidate to develop a new IL-2 based cancer #immunotherapy with less toxicity than other IL-2 treatments. Read more online: ow.ly/7Axz50XIyeG.
Enhanced affinity for the IL-2 receptor β subunit potently increases antitumor efficacy of IL-2 across various tumor models by reshaping the tumor microenvironment
Abstract. The main limitations of cancer treatment with high doses of recombinant interleukin 2 (IL-2) are high toxicity and the undesired expansion of reg
ow.ly
December 17, 2025 at 6:05 PM
Researchers evaluated SB834Fc, an IL-2 mutated variant, for its anti-tumor properties. Their results support SB834Fc as a candidate to develop a new IL-2 based cancer #immunotherapy with less toxicity than other IL-2 treatments. Read more online: ow.ly/7Axz50XIyeG.
#InternationalVeterinaryMedicineDay recognizes the essential role of Vets in global health. Animal models, both traditional and nontraditional, are crucial for studying the complex immunology of diseases that jump species barriers. 📖 Zoonotic Diseases collection: academic.oup.com/jimmunol/pag....
Immunology of Zoonotic Diseases and Relevant Animal Models
Crystal Loving guest edits a collection of reviews featuring research on diseases that lie at the interface of human and animal health.
academic.oup.com
December 9, 2025 at 5:14 PM
#InternationalVeterinaryMedicineDay recognizes the essential role of Vets in global health. Animal models, both traditional and nontraditional, are crucial for studying the complex immunology of diseases that jump species barriers. 📖 Zoonotic Diseases collection: academic.oup.com/jimmunol/pag....
Reposted by The Journal of Immunology
Happy #InternationalVeterinaryMedicineDay! See how diverse species are advancing research in our special collection in The Journal of Immunology, "Beyond the Mouse: Nontraditional Animal Models." Discover more: https://ow.ly/i5Vk50XGp5K.
December 9, 2025 at 5:01 PM
Happy #InternationalVeterinaryMedicineDay! See how diverse species are advancing research in our special collection in The Journal of Immunology, "Beyond the Mouse: Nontraditional Animal Models." Discover more: https://ow.ly/i5Vk50XGp5K.
Data suggest that transcription factor specificity protein 1 (SP1) aggravates allergic rhinitis through the upregulation of forkhead box C1 (FOXC1), which reverses the protective effect of SP1 silencing on epithelial barrier damage. Read more online: ow.ly/cKOO50XFVik.
Associated transcription factors of allergic rhinitis: SP1 aggravates nasal epithelial barrier damage
Abstract. Allergic rhinitis (AR) is a respiratory airway disorder characterized by inflammation and barrier dysfunction. The transcription factor specifici
ow.ly
December 9, 2025 at 4:03 PM
Data suggest that transcription factor specificity protein 1 (SP1) aggravates allergic rhinitis through the upregulation of forkhead box C1 (FOXC1), which reverses the protective effect of SP1 silencing on epithelial barrier damage. Read more online: ow.ly/cKOO50XFVik.
Researchers found that MEF2D blocks T-cell–mediated antitumor immunity by regulating the expression of CD70 and activating the CD70-CD27 signaling axis. Manipulating this pathway may improve the efficacy of liver cancer immunotherapy. Learn more: ow.ly/nh8n50XFUxU.
MEF2D regulates T-cell function via CD70-CD27 signaling and promotes immune evasion in hepatocellular carcinoma
Abstract. Hepatocellular carcinoma (HCC) stands as one of the most prevalent and fatal malignancies globally, posing a persistent challenge in its treatmen
ow.ly
December 8, 2025 at 7:37 PM
Researchers found that MEF2D blocks T-cell–mediated antitumor immunity by regulating the expression of CD70 and activating the CD70-CD27 signaling axis. Manipulating this pathway may improve the efficacy of liver cancer immunotherapy. Learn more: ow.ly/nh8n50XFUxU.
📥 Submit your abstracts for IMMUNOLOGY2026™ by Dec 16 and ensure that your original abstract is published in The Journal of Immunology as a supplement: immunology2026.aai.org/abstracts/
📖 Explore last year's IMMUNOLOGY2025™ abstracts now: academic.oup.com/jimmunol/iss...
📖 Explore last year's IMMUNOLOGY2025™ abstracts now: academic.oup.com/jimmunol/iss...
🔬 The second abstract period for #IMMUNOLOGY2026™ is now OPEN!
Submit your research December 2–16 and share your findings with the top minds in #immunology. Join us in Boston, MA, April 15–19, 2026.
🔗 immunology2026.aai.org/abstracts
#AAI2026
Submit your research December 2–16 and share your findings with the top minds in #immunology. Join us in Boston, MA, April 15–19, 2026.
🔗 immunology2026.aai.org/abstracts
#AAI2026
December 5, 2025 at 7:14 PM
📥 Submit your abstracts for IMMUNOLOGY2026™ by Dec 16 and ensure that your original abstract is published in The Journal of Immunology as a supplement: immunology2026.aai.org/abstracts/
📖 Explore last year's IMMUNOLOGY2025™ abstracts now: academic.oup.com/jimmunol/iss...
📖 Explore last year's IMMUNOLOGY2025™ abstracts now: academic.oup.com/jimmunol/iss...
This November #TopRead from Wei Luo and Shlomchik Lab demonstrated that PTEN deficiency selectively expanded germinal center B cells in Peyer’s patches but had no impact on those induced by immunization, revealing an unknown role for PTEN. Read more: ow.ly/Ia9k50XAbiP.
December 3, 2025 at 2:55 PM
This November #TopRead from Wei Luo and Shlomchik Lab demonstrated that PTEN deficiency selectively expanded germinal center B cells in Peyer’s patches but had no impact on those induced by immunization, revealing an unknown role for PTEN. Read more: ow.ly/Ia9k50XAbiP.
The latest issue of The JI is now online! Read cutting edge research, brief reviews, and more.
🔗 ow.ly/RMa250XA7Ce
#ReadTheJI #Immunology
🔗 ow.ly/RMa250XA7Ce
#ReadTheJI #Immunology
Volume 214 Issue 11 | The Journal of Immunology | Oxford Academic
The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.
ow.ly
December 1, 2025 at 4:20 PM
The latest issue of The JI is now online! Read cutting edge research, brief reviews, and more.
🔗 ow.ly/RMa250XA7Ce
#ReadTheJI #Immunology
🔗 ow.ly/RMa250XA7Ce
#ReadTheJI #Immunology
This #CuttingEdge article reports that neutralizing FLT3L may effectively treat Sjögren’s and other FLT3L-associated autoimmune diseases. Read all about in The JI: ow.ly/u3lj50XyhWR.
November 26, 2025 at 5:27 PM
This #CuttingEdge article reports that neutralizing FLT3L may effectively treat Sjögren’s and other FLT3L-associated autoimmune diseases. Read all about in The JI: ow.ly/u3lj50XyhWR.
Data suggest that S. mansoni may have evolved to manipulate TRPV1+ neuron activation as a countermeasure to limit IL-17-mediated inflammation, facilitating systemic dissemination and chronic parasitism. Read more: ow.ly/3zz250XxJKa .
November 25, 2025 at 7:21 PM
Data suggest that S. mansoni may have evolved to manipulate TRPV1+ neuron activation as a countermeasure to limit IL-17-mediated inflammation, facilitating systemic dissemination and chronic parasitism. Read more: ow.ly/3zz250XxJKa .
New data reveals the complex relationship between bone marrow antibody secreting repertoires, mucosal humoral immune responses, and B cell receptor antigen specificity during #influenza infection. Read more in this #TopRead article: ow.ly/3INy50Xt1vV.
Clonally expanded IgG, but not IgA, antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections
The Editors have selected this article as a highlight of the issue.
ow.ly
November 21, 2025 at 7:53 PM
New data reveals the complex relationship between bone marrow antibody secreting repertoires, mucosal humoral immune responses, and B cell receptor antigen specificity during #influenza infection. Read more in this #TopRead article: ow.ly/3INy50Xt1vV.
In this #CuttingEdge article, researchers describe the pivotal role of uterine NK cells in pregnancy, offering novel insights into their lineage specification and revealing Eomesodermin as crucial to their establishment. Learn more: ow.ly/jA6550XsYGs
Eomesodermin defines uterine NK cells crucial for pregnancy success in mice
Abstract. Uterine natural killer cells have been thought to be critical for reproductive success, and their developmental origins remain unclear. Here, we
ow.ly
November 17, 2025 at 4:44 PM
In this #CuttingEdge article, researchers describe the pivotal role of uterine NK cells in pregnancy, offering novel insights into their lineage specification and revealing Eomesodermin as crucial to their establishment. Learn more: ow.ly/jA6550XsYGs
The JI and @immunohorizons.bsky.social are looking for a biostatistics editor! This is a unique opportunity to contribute to the advancement of immunological research by ensuring the statistical rigor and methodological soundness of published work. Learn more: ow.ly/qYic50Xmu4V.
November 7, 2025 at 3:05 PM
The JI and @immunohorizons.bsky.social are looking for a biostatistics editor! This is a unique opportunity to contribute to the advancement of immunological research by ensuring the statistical rigor and methodological soundness of published work. Learn more: ow.ly/qYic50Xmu4V.
Learn how canine cancer models are evaluating new immunotherapies for osteosarcoma, glioma, non-Hodgkin lymphoma, melanoma, uroepithelial cancer, and head and neck cancers in humans in The JI’s special collection on non-traditional animal models: ow.ly/6FRH50XmtjP.
Role of companion dogs in cancer immunotherapy development
Abstract. Rodent models for evaluating new cancer immunotherapies often fail to fully recapitulate the complexity of immune interactions that occur in canc
ow.ly
November 6, 2025 at 7:00 PM
Learn how canine cancer models are evaluating new immunotherapies for osteosarcoma, glioma, non-Hodgkin lymphoma, melanoma, uroepithelial cancer, and head and neck cancers in humans in The JI’s special collection on non-traditional animal models: ow.ly/6FRH50XmtjP.
Woodchucks are naturally affected by Woodchuck Hepatitis Virus, with disease progression very similar to hepatitis B in people. This review in the special collection on nontraditional animal models discusses the huge impact of this animal model.
🔗 ow.ly/EQ3r50Xmt9l.
🔗 ow.ly/EQ3r50Xmt9l.
Immunological aspects of naturally occurring model of hepatitis B virus (HBV) infection, hepatitis B, and HBV-associated hepatocellular carcinoma in the American woodchuck Marmota monax
Abstract. Infection of eastern North American woodchucks (Marmota monax) with woodchuck hepatitis virus (WHV) represents the most valuable immunopathogenic
ow.ly
November 5, 2025 at 5:30 PM
Woodchucks are naturally affected by Woodchuck Hepatitis Virus, with disease progression very similar to hepatitis B in people. This review in the special collection on nontraditional animal models discusses the huge impact of this animal model.
🔗 ow.ly/EQ3r50Xmt9l.
🔗 ow.ly/EQ3r50Xmt9l.