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JMCC Plus
@jmccplus.bsky.social
710 followers 3 following 37 posts
The open access journal of the ISHR

The journal aims to publish fundamental and translational research that advances knowledge of the mechanisms responsible for both normal and diseased cardiovascular function
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jmccplus.bsky.social
🧪 Just out: a new #review of Rac1-driven signalling in cardiomyocytes — covering #hypertrophy, #arrhythmia and #redox stress.

A must-read for anyone in cardiac research! 💙

#Cardiology #HeartResearch #SignalTransduction #CardioSky

www.sciencedirect.com/science/arti...
Cardiomyocyte Rac1 signaling in hypertrophy, arrhythmia, and cardiac stress adaptation
Cardiovascular disease remains the leading cause of mortality globally and is often marked by pathologic cardiac remodeling including hypertrophy and …
www.sciencedirect.com
November 26, 2025 at 12:25 PM
jmccplus.bsky.social
On your way to #AHA or just looking for some weekend reading?

Check out the latest paper from Warren et al who uncovered region-specific metabolic and signalling changes in the endocardium vs epicardium in a mini-pig model of #HCM 🫀🫀

sciencedirect.com/science/arti...

#CardioSky #AnimalModel
Signaling pathway alterations in hearts of a porcine model harboring a β-myosin heavy chain (MYH7-R403Q) gene variant
The disease-causing myosin variant (MYH7-403Q) is linked to hypertrophic cardiomyopathy (HCM). We carried out a research study of signaling pathways i…
sciencedirect.com
November 7, 2025 at 3:46 PM
jmccplus.bsky.social
New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology

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#CardioSky
YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs
The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeo…
sciencedirect.com
November 3, 2025 at 12:47 PM
jmccplus.bsky.social
We often treat #diabetes and #heart #disease separately — but they’re connected🫀.

A recent study from Srinivas, Alluri et al. shows that removing CHOP in β-cells protects against both metabolic dysfunction and cardiac fibrosis in T2D mice.

sciencedirect.com/science/arti...

#CardioSky #NewPaper
Deletion of CHOP in beta cell protects mice from cardiovascular complications in type 2 diabetes: evidence from a pre-clinical mouse model
Cardiovascular complications are the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D), which is recognized as a major i…
sciencedirect.com
October 30, 2025 at 1:52 PM
jmccplus.bsky.social
🫀 New in JMCC Plus!

Age, sex & vessel region shape vasomotor function in the descending thoracic #aorta — with #endothelial integrity & relaxation declining with age.

Want to know more- check out Saemann et al.:

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#CardioSky @jmccardiology.bsky.social
Age, sex, and vessel region affect the vasomotor function and gene expression signature of the aorta in mice
Vascular aging is associated with endothelial dysfunction, changes in vascular elasticity or stiffness, and the prevalence of cardiovascular diseases.…
sciencedirect.com
October 27, 2025 at 7:21 PM
jmccplus.bsky.social
New work from Nicole S. York and the group of Leigh Anne Swayne at the University of Victoria charts how #H9c2 heart cells change shape, signal, & express genes during differentiation—revealing both their promise & limits as #cardiomyocyte models.

#CardioSky

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Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation
Cell culture models enable advancement in our understanding of heart development and heart disease. The H9c2 rat ventricular cardiomyoblast cell line …
sciencedirect.com
October 23, 2025 at 2:18 PM
jmccplus.bsky.social
Ever wondered how #Calcium channels cluster in #iPSC derived #Cardiomyocytes?

New work just published from Schwenzer et al. should put your mind at rest as they investigated just that!

Check out the latest paper for more information

www.sciencedirect.com/science/arti...

#CardioSky
Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy
The clustering of L-type calcium channels for functional regulation of intracellular calcium signaling remains poorly understood. Here we applied supe…
sciencedirect.com
October 17, 2025 at 10:09 AM
jmccplus.bsky.social
Looking for some weekend reading? 📜

New work from from the University of Ottawa Heart Institute, show how metabolic substrates regulate effects of Wnt/β-catenin signaling in #cardiomyocytes, specifically affecting regulation of #Connexin43

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Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner
Both Nav1.5 and Cx43 are critical for the fast electrical impulse conduction in the myocardium and their reductions create the arrhythmogenic substrat…
sciencedirect.com
October 3, 2025 at 12:35 PM
jmccplus.bsky.social
New work out in the from @ox.ac.uk looks into developing sex-specific human ventricular #electromechanical multiscale models. Given the importance of #biologicalsex in #CardiovascularHealth this could be a very important tool!

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#CardioSky
Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation
Women are under-represented in cardiovascular research, leading to poorer outcomes. Investigating sex-differences in electromechanical function is ess…
sciencedirect.com
September 8, 2025 at 2:51 PM
jmccplus.bsky.social
🧬 New pig models of neonatal #HCM show severe cardiac #hypertrophy and perinatal lethality from MYBPC3 and MYH7 mutations.
Pigs were highly sensitive to sarcomeric gene disruption, developing severe HCM, suggesting they may not be ideal genetic models.
🔗 www.sciencedirect.com/science/arti...
August 12, 2025 at 10:01 AM
jmccplus.bsky.social
12-week-old #ob/ob mice show mild DCM with no major structural changes in #MAMs.
Proteins linked to lipid metabolism and stress response were increased in MAMs, while hypoxic stress triggered more cardiomyocyte death.

www.sciencedirect.com/science/arti...
August 8, 2025 at 10:01 AM
jmccplus.bsky.social
New paper out in our September issue from
Bass-Stringer and colleagues @bakerresearchau.bsky.social
looking at PI3K.

Exploring a new #genetherapy to improve heart function in mice and sheep.

sciencedirect.com/science/arti...

#CardioSky
Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart
Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only availab…
sciencedirect.com
August 7, 2025 at 5:19 PM
jmccplus.bsky.social
Calling all #immunofluorescence scientists! Teng et al. showed glyoxal enhances IF signal and co-localisation while reducing staining artifacts, making it a superior alternative to PFA in murine cardiac tissue research.

www.sciencedirect.com/science/arti...
August 6, 2025 at 10:01 AM
jmccplus.bsky.social
📈 Circulating adropin is linked to higher risk of #AKI in patients with acutely decompensated #heartfailure (#ADHF) after decongestive therapy.
It outperformed conventional biomarkers like urinary ACR and NT-proBNP.
#CardioRenal #Biomarkers

www.sciencedirect.com/science/arti...
July 31, 2025 at 10:01 AM
jmccplus.bsky.social
Kazantzi et al show that #MEK–ERK1/2 and #PKC pathways independently and synergistically modulate ETB receptor upregulation under flow cessation. These signalling axes may be promising targets for #cerebrovascular disease.

Read more here! www.sciencedirect.com/science/arti...
July 29, 2025 at 9:40 AM
jmccplus.bsky.social
New work just out from Fowler et al, invesigated the role of subthreshold #DADs on arrhythmia generation in #CPVT!

Congrats to the Authors!

sciencedirect.com/science/arti...

#CardioSky
Disruption of ventricular activation by subthreshold delayed afterdepolarizations in RyR2-R420Q catecholaminergic polymorphic ventricular tachycardia
Catecholaminergic polymorphic ventricular tachycardia (CPVT) carries increased risk of ventricular arrhythmias due to altered Ca2+ regulation associat…
sciencedirect.com
June 29, 2025 at 5:14 PM
jmccplus.bsky.social
NIH-funded and need to publish in an open-access journal? JMCC Plus is fully OA and we're offering a 50% APC discount until 30 Sept 2025! Submit your work and join our growing community of cardiovascular researchers. #OpenAccess #Cardiac #Research

www.sciencedirect.com/journal/jour...
June 26, 2025 at 10:02 AM
jmccplus.bsky.social
New in JMCC Plus: This study presents a multidimensional analysis to investigate culture-induced alterations in living #myocardial slices, demonstrating structural integrity despite changes to slices’ functional and #molecular profiles

Read more here! www.sciencedirect.com/science/arti...
June 23, 2025 at 10:02 AM
jmccplus.bsky.social
Exciting news! Clarivate has released the inaugural #ImpactFactor for 2024, and JMCC Plus, just 3 years since its launch, has earned a spot in Q2! A huge thank you to our authors, reviewers, and readers for helping us reach this milestone. #AcademicPublishing #JMCCPlus
June 20, 2025 at 2:47 PM
jmccplus.bsky.social
Heart failure alters organelle dynamics. Latchman et al. reveal striking shifts in failing cardiomyocytes- more rounded #mitochondria, disrupted SR-mitochondria juxtaposition and altered lipid droplet size across #heart #failure types .
www.sciencedirect.com/science/arti...
‪@upenn.edu @temple.edu‬
June 16, 2025 at 11:32 AM
jmccplus.bsky.social
New #CardioBreakthrough: Gemfibrozil—beyond lipid-lowering—blocks caspase‑11‑driven pyroptosis in mouse hearts, reducing infarct size during ischemia/reperfusion. A promising repurposed therapy post-#AMI! Congratulations to all authors.

Want to know more?
www.sciencedirect.com
June 11, 2025 at 11:41 AM
jmccplus.bsky.social
Looking for some weekend reading?

We recently published some work from Chambers et al. looking at the effect of an #SGLT2i on #mitochondrial function from non-diabetic mice with #Cardiomyopathy

Accompanied by a very nice editorial!

sciencedirect.com/science/arti...
SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice
Mitochondrial dysfunction with decreased ATP production and increased release of reactive oxygen species (ROS) is a hallmark of the failing heart. Alt…
sciencedirect.com
May 30, 2025 at 12:14 PM
jmccplus.bsky.social
Are you looking for a new model of arrhythmia?
Maybe performance horses are the answer!
Great work just out from Avison et al!

www.sciencedirect.com/science/arti...
Performance horses as a model for exercise-associated cardiac arrhythmias and sudden cardiac death
This paper reviews the myocardial substrate of horses relative to that of humans and discusses the utility of performance horses as a model of exercis…
www.sciencedirect.com
May 19, 2025 at 12:58 PM
jmccplus.bsky.social
The JMCC and JMCC Plus Reception is in full swing at #ISHR World Congress 2025! A great opportunity to bring our editorial team and reviewers together, while hearing from JMCC #EiC Rong Tian and JMCC Plus #EiC @davorpavlovic.bsky.social
May 12, 2025 at 10:22 AM
jmccplus.bsky.social
The 25th World Congress of #ISHR 2025 in Nara, Japan, has officially begun with over 1000 members attending! A fantastic start to the conference, welcomed by traditional Japanese music, before hearing from this years' ISHR awardees.
@ishr-aus.bsky.social
May 12, 2025 at 12:57 AM