Plasma proteome profiling has surged as a promising avenue for biomarker discovery, yet comprehensive platform comparisons remain scarce. Here, the authors evaluate eight proteomics platforms, revealing key differences and complementary strengths, providing crucial insights for researchers into coverage trade-offs and implicating biomarker discovery and clinical applications.

Nature Genetics - The field of blood proteomics faces an upsurge of data with the challenge of cross-study comparisons. This Perspective offers an in-depth analysis and proposes reference materials...

Metformin is one of the most used drugs worldwide. Given the increasing use of proteomics in trials, bioresources, and clinics, it is crucial to under…

Aims/hypothesis Type 1 diabetes manifests after irreversible beta cell damage, highlighting the crucial need for markers of the presymptomatic phase to enable early and effective interventions. Curren...

Nature Metabolism, Published online: 15 April 2025; doi:10.1038/s42255-025-01277-yA Nature Metabolism study shows that, under acute stress, fatty acids liberated by lipolysis of white fat cells cause release from local macrophages of the growth-differentiation factor GDF15, which, in turn, binds to the receptor GFRAL in the brain, evoking anxiety.