Joseph Marcus
@josephmarcusid.medsky.social
Infectious Diseases MD, preschool parent, lifelong learner, opinions are my own
Interests: Getting trainees excited about ID/Research, ECMO infections, STIs, and Transfusion-Transmitted Infections
https://scholar.usuhs.edu/en/persons/joseph-marcus
Interests: Getting trainees excited about ID/Research, ECMO infections, STIs, and Transfusion-Transmitted Infections
https://scholar.usuhs.edu/en/persons/joseph-marcus
Are there any stewards on #IDSky that have experience working to improving local antimicrobial prescribing in non-CF bronchiectasis exacerbations?
Are there hospitals were ID is very involved in antibiotic selection and duration?
Are there hospitals were ID is very involved in antibiotic selection and duration?
November 24, 2025 at 12:12 AM
Are there any stewards on #IDSky that have experience working to improving local antimicrobial prescribing in non-CF bronchiectasis exacerbations?
Are there hospitals were ID is very involved in antibiotic selection and duration?
Are there hospitals were ID is very involved in antibiotic selection and duration?
Two Transplant ECMO #IDSky papers this week:
1) 🇺🇸 Pre-🫁 transplant ECMO associated with ⬆️ BSI post-transplant
link.springer.com/article/10.1...
2) 🇨🇭Post ❤️ transplant ECMO associated with ⬆️ 1 yr infections including bacterial and fungal
journals.lww.com/transplantat...
1) 🇺🇸 Pre-🫁 transplant ECMO associated with ⬆️ BSI post-transplant
link.springer.com/article/10.1...
2) 🇨🇭Post ❤️ transplant ECMO associated with ⬆️ 1 yr infections including bacterial and fungal
journals.lww.com/transplantat...
Impact of pre-transplant veno-venous extracorporeal membrane oxygenation on post-lung transplant infections - Journal of Artificial Organs
Bridging critically ill patients to lung transplantation with veno-venous extracorporeal membrane oxygenation (VV-ECMO) may increase infection risk, yet its impact on post-transplant outcomes remains ...
link.springer.com
November 22, 2025 at 11:02 PM
Two Transplant ECMO #IDSky papers this week:
1) 🇺🇸 Pre-🫁 transplant ECMO associated with ⬆️ BSI post-transplant
link.springer.com/article/10.1...
2) 🇨🇭Post ❤️ transplant ECMO associated with ⬆️ 1 yr infections including bacterial and fungal
journals.lww.com/transplantat...
1) 🇺🇸 Pre-🫁 transplant ECMO associated with ⬆️ BSI post-transplant
link.springer.com/article/10.1...
2) 🇨🇭Post ❤️ transplant ECMO associated with ⬆️ 1 yr infections including bacterial and fungal
journals.lww.com/transplantat...
A great @cidjournal.bsky.social case series that led to lots of discussion with the fellows today- 4 🇬🇧 pts with HBV reactivation after change off of a TAF-based HIV regimen
Pt1/4: +HBcAB, -HBVsAg, -HBVsAB
Pt2/3: +HBcAB, -HBVsAg,+HBVsAB
#IDSky
academic.oup.com/cid/advance-...
Pt1/4: +HBcAB, -HBVsAg, -HBVsAB
Pt2/3: +HBcAB, -HBVsAg,+HBVsAB
#IDSky
academic.oup.com/cid/advance-...
Hepatitis B reactivation following switch away from tenofovir-containing anti-retroviral therapy in people living with HIV: A case series and lessons for practice
Abstract. The potential for hepatitis B reactivation must be considered when switching people with HIV and prior hepatitis B exposure away from tenofovir-c
academic.oup.com
November 22, 2025 at 12:44 AM
A great @cidjournal.bsky.social case series that led to lots of discussion with the fellows today- 4 🇬🇧 pts with HBV reactivation after change off of a TAF-based HIV regimen
Pt1/4: +HBcAB, -HBVsAg, -HBVsAB
Pt2/3: +HBcAB, -HBVsAg,+HBVsAB
#IDSky
academic.oup.com/cid/advance-...
Pt1/4: +HBcAB, -HBVsAg, -HBVsAB
Pt2/3: +HBcAB, -HBVsAg,+HBVsAB
#IDSky
academic.oup.com/cid/advance-...
New #IDSky paper describing antimicrobial dosing in ECMO by @haifalyster.bsky.social:
🔑 Critical illness contributes to more PK variability than ECMO
🔑 Lipopophilic, protein-bound
drugs sequestered by circuit
🔑 Use extended infusions for beta-lactams
www.sciencedirect.com/science/arti...
🔑 Critical illness contributes to more PK variability than ECMO
🔑 Lipopophilic, protein-bound
drugs sequestered by circuit
🔑 Use extended infusions for beta-lactams
www.sciencedirect.com/science/arti...
Antimicrobial Pharmacokinetics and Stewardship in Critically Ill Adult Patients Receiving ECMO: Challenges, Evidence, and Future Directions
Infection is a common indication and complication for extracorporeal membrane oxygenation (ECMO), and adult ECMO recipients face increased nosocomial …
www.sciencedirect.com
November 19, 2025 at 2:16 AM
New #IDSky paper describing antimicrobial dosing in ECMO by @haifalyster.bsky.social:
🔑 Critical illness contributes to more PK variability than ECMO
🔑 Lipopophilic, protein-bound
drugs sequestered by circuit
🔑 Use extended infusions for beta-lactams
www.sciencedirect.com/science/arti...
🔑 Critical illness contributes to more PK variability than ECMO
🔑 Lipopophilic, protein-bound
drugs sequestered by circuit
🔑 Use extended infusions for beta-lactams
www.sciencedirect.com/science/arti...
I just had my first day as the Associate Director of my hospital’s Infectious Disease Fellowship!
I’m excited to spend more time with the fellows!
#IDSky
I’m excited to spend more time with the fellows!
#IDSky
November 18, 2025 at 1:06 AM
I just had my first day as the Associate Director of my hospital’s Infectious Disease Fellowship!
I’m excited to spend more time with the fellows!
#IDSky
I’m excited to spend more time with the fellows!
#IDSky
Fascinating article on the history of syphilis:
“English people called it the
“Spanish disease”… the Spanish called it mal inglés.
The Dutch called it “Spanish smallpox”
The Russians blamed the Poles, and the Turks referred to it as the “Christian disease””
#IDSky
academic.oup.com/jid/advance-...
“English people called it the
“Spanish disease”… the Spanish called it mal inglés.
The Dutch called it “Spanish smallpox”
The Russians blamed the Poles, and the Turks referred to it as the “Christian disease””
#IDSky
academic.oup.com/jid/advance-...
Syphilis Transmission: Contagion of Bodies and Words
Syphilis, infection caused by Treponema pallidum, occurred in Naples and in Europe in the late 15th century impacting on people’s lives. Here, we explored
academic.oup.com
November 16, 2025 at 3:56 AM
Fascinating article on the history of syphilis:
“English people called it the
“Spanish disease”… the Spanish called it mal inglés.
The Dutch called it “Spanish smallpox”
The Russians blamed the Poles, and the Turks referred to it as the “Christian disease””
#IDSky
academic.oup.com/jid/advance-...
“English people called it the
“Spanish disease”… the Spanish called it mal inglés.
The Dutch called it “Spanish smallpox”
The Russians blamed the Poles, and the Turks referred to it as the “Christian disease””
#IDSky
academic.oup.com/jid/advance-...
European Guidelines: ✅ Repeat BCx in asymptomatic pts at end of therapy for IE
🇺🇸 Guidelines: ❌
Single center 🇨🇭 study of ~600 pts with IE shows limited utility
I have not heard of this practice. Do any US hospitals get routine BCx at end of IE therapy?
doi.org/10.1093/cid/...
#IDSky
🇺🇸 Guidelines: ❌
Single center 🇨🇭 study of ~600 pts with IE shows limited utility
I have not heard of this practice. Do any US hospitals get routine BCx at end of IE therapy?
doi.org/10.1093/cid/...
#IDSky
November 14, 2025 at 3:55 AM
European Guidelines: ✅ Repeat BCx in asymptomatic pts at end of therapy for IE
🇺🇸 Guidelines: ❌
Single center 🇨🇭 study of ~600 pts with IE shows limited utility
I have not heard of this practice. Do any US hospitals get routine BCx at end of IE therapy?
doi.org/10.1093/cid/...
#IDSky
🇺🇸 Guidelines: ❌
Single center 🇨🇭 study of ~600 pts with IE shows limited utility
I have not heard of this practice. Do any US hospitals get routine BCx at end of IE therapy?
doi.org/10.1093/cid/...
#IDSky
Egypt 🇪🇬 became the 27th country to eliminate Trachoma representing decades of public health investment.
Trachoma still found in 30 countries
#IDSky
www.who.int/news/item/12...
Trachoma still found in 30 countries
#IDSky
www.who.int/news/item/12...
November 12, 2025 at 11:58 PM
Egypt 🇪🇬 became the 27th country to eliminate Trachoma representing decades of public health investment.
Trachoma still found in 30 countries
#IDSky
www.who.int/news/item/12...
Trachoma still found in 30 countries
#IDSky
www.who.int/news/item/12...
More evidence to be aggressive with Linezolid dosing in ECMO.
#IDSky
link.springer.com/article/10.1...
#IDSky
link.springer.com/article/10.1...
Underexposure of linezolid in critically ill patients with extracorporeal membrane oxygenation (ECMO): results from a monocentric study including blood samples from 52 patients - Infection
Purpose Linezolid serum concentrations in critically ill patients show high variability. In this retrospective study, we analysed the linezolid plasma through levels (Cmin) in patients on intensive ca...
link.springer.com
November 10, 2025 at 2:29 AM
More evidence to be aggressive with Linezolid dosing in ECMO.
#IDSky
link.springer.com/article/10.1...
#IDSky
link.springer.com/article/10.1...
Reposted by Joseph Marcus
Hey ID Fellows, what are your favorite ID consults? Asked that question during a recent visit to the ID division at Johns Hopkins, and here's what their fellows said. #IDSky
blogs.jwatch.org/hiv-id-obser...
blogs.jwatch.org/hiv-id-obser...
Favorite ID Fellow Consults: Johns Hopkins Edition
Just back from a visit to the Infectious Diseases Division at Johns Hopkins, thanks to the kind invitation of current ID chief Dr. Amita Gupta and her predecessor, Dr. David Thomas. On a personal note...
blogs.jwatch.org
November 7, 2025 at 9:55 PM
Hey ID Fellows, what are your favorite ID consults? Asked that question during a recent visit to the ID division at Johns Hopkins, and here's what their fellows said. #IDSky
blogs.jwatch.org/hiv-id-obser...
blogs.jwatch.org/hiv-id-obser...
New CID State of the Art Review released today on antibiotic allergy delabeling:
academic.oup.com/cid/article/...
#IDSky
academic.oup.com/cid/article/...
#IDSky
State-of-the-Art Review: Antibiotic Allergy—A Multidisciplinary Approach to Delabeling
Antibiotic allergy poses a major threat to the appropriate use of antimicrobials. Current evidence provides a clear pathway for point-of-care assessment, d
academic.oup.com
November 7, 2025 at 2:58 AM
New CID State of the Art Review released today on antibiotic allergy delabeling:
academic.oup.com/cid/article/...
#IDSky
academic.oup.com/cid/article/...
#IDSky
The updated SOFA-2 scores was released today!
It updates original SOFA score with more contemporary practices.
#IDSky
jamanetwork.com/journals/jam...
It updates original SOFA score with more contemporary practices.
#IDSky
jamanetwork.com/journals/jam...
October 30, 2025 at 12:46 AM
The updated SOFA-2 scores was released today!
It updates original SOFA score with more contemporary practices.
#IDSky
jamanetwork.com/journals/jam...
It updates original SOFA score with more contemporary practices.
#IDSky
jamanetwork.com/journals/jam...
Reposted by Joseph Marcus
One year of outpatient clindamycin prescriptions at a military healthcare system demonstrated that less than half of patients had a beta-lactam allergy and that the top 2% of prescribers accounted for 18% of prescriptions. doi.org/10.1017/ash....
Evaluation of outpatient clindamycin prescriptions across a large military healthcare network | Antimicrobial Stewardship & Healthcare Epidemiology | Cambridge Core
Evaluation of outpatient clindamycin prescriptions across a large military healthcare network - Volume 5 Issue 1
doi.org
October 29, 2025 at 1:38 PM
One year of outpatient clindamycin prescriptions at a military healthcare system demonstrated that less than half of patients had a beta-lactam allergy and that the top 2% of prescribers accounted for 18% of prescriptions. doi.org/10.1017/ash....
There are many factors that influence this decision:
Trainee’s:
✅career goals
✅previous research experience
✅upcoming clinical responsibilities
Mentor’s:
✅ability to take another project or connect to a different mentor
Both:
✅Previous conversations and expectations
Trainee’s:
✅career goals
✅previous research experience
✅upcoming clinical responsibilities
Mentor’s:
✅ability to take another project or connect to a different mentor
Both:
✅Previous conversations and expectations
#IDResearchChallenges 🥼🧫🧬👨🔬👩🔬
Your trainee who crushed their poster session at #IDWeek2025, really wants another project so that they can go to #IDWeek2026
Do you:
A) Find a new project ASAP
B) Wait for 📝 draft
C) Wait for 📝 submission
D) Other
#IDSky
Your trainee who crushed their poster session at #IDWeek2025, really wants another project so that they can go to #IDWeek2026
Do you:
A) Find a new project ASAP
B) Wait for 📝 draft
C) Wait for 📝 submission
D) Other
#IDSky
October 29, 2025 at 1:06 AM
There are many factors that influence this decision:
Trainee’s:
✅career goals
✅previous research experience
✅upcoming clinical responsibilities
Mentor’s:
✅ability to take another project or connect to a different mentor
Both:
✅Previous conversations and expectations
Trainee’s:
✅career goals
✅previous research experience
✅upcoming clinical responsibilities
Mentor’s:
✅ability to take another project or connect to a different mentor
Both:
✅Previous conversations and expectations
In an outpatient setting with ⬆️ rates of clindamycin resistance, who is prescribing clindamycin?
⬆️ 2% of prescribers = 20% of scripts (check out Pareto graph in figure 1)
❌ scripts from ER +Primary Care
❌Indications w/ beta-lactam allergy- 🦷 infection
❌ w/o: SSTI
doi.org/10.1017/ash....
#IDSky
⬆️ 2% of prescribers = 20% of scripts (check out Pareto graph in figure 1)
❌ scripts from ER +Primary Care
❌Indications w/ beta-lactam allergy- 🦷 infection
❌ w/o: SSTI
doi.org/10.1017/ash....
#IDSky
Evaluation of outpatient clindamycin prescriptions across a large military healthcare network | Antimicrobial Stewardship & Healthcare Epidemiology | Cambridge Core
Evaluation of outpatient clindamycin prescriptions across a large military healthcare network - Volume 5 Issue 1
doi.org
October 27, 2025 at 9:52 PM
In an outpatient setting with ⬆️ rates of clindamycin resistance, who is prescribing clindamycin?
⬆️ 2% of prescribers = 20% of scripts (check out Pareto graph in figure 1)
❌ scripts from ER +Primary Care
❌Indications w/ beta-lactam allergy- 🦷 infection
❌ w/o: SSTI
doi.org/10.1017/ash....
#IDSky
⬆️ 2% of prescribers = 20% of scripts (check out Pareto graph in figure 1)
❌ scripts from ER +Primary Care
❌Indications w/ beta-lactam allergy- 🦷 infection
❌ w/o: SSTI
doi.org/10.1017/ash....
#IDSky
@kenkoonwong.bsky.social with another deep look at the SoMe ## of #IDWeek2025:
1) ID is divided between #IDSky and #IDTwitter
2) More posts+ engagement on 🦋than X
3) Certain accounts such as @boghuma.bsky.social @sairabt.bsky.social @jonathanrydermd.bsky.social are essential follows for IDWeek
1) ID is divided between #IDSky and #IDTwitter
2) More posts+ engagement on 🦋than X
3) Certain accounts such as @boghuma.bsky.social @sairabt.bsky.social @jonathanrydermd.bsky.social are essential follows for IDWeek
#IDWeek2025 had the lowest post count since 2022 (1,272 posts). While top posters shifted to Bluesky, X remained on par—the key difference was engagement rates favoring Bluesky. Grateful to learn so much from our SoMe community! 📊💙🙏
#idsky
#idsky
#IDWeek2025 Posts/Tweets Analysis | Everyday Is A School Day
IDWeek2025 had the lowest post count since 2022 (1,272 posts). While top posters shifted to Bluesky, X remained on par—the key difference was engagement rates favoring Bluesky. Grateful to learn so mu...
www.kenkoonwong.com
October 27, 2025 at 1:45 AM
@kenkoonwong.bsky.social with another deep look at the SoMe ## of #IDWeek2025:
1) ID is divided between #IDSky and #IDTwitter
2) More posts+ engagement on 🦋than X
3) Certain accounts such as @boghuma.bsky.social @sairabt.bsky.social @jonathanrydermd.bsky.social are essential follows for IDWeek
1) ID is divided between #IDSky and #IDTwitter
2) More posts+ engagement on 🦋than X
3) Certain accounts such as @boghuma.bsky.social @sairabt.bsky.social @jonathanrydermd.bsky.social are essential follows for IDWeek
#IDResearchChallenges 🥼🧫🧬👨🔬👩🔬
Your trainee who crushed their poster session at #IDWeek2025, really wants another project so that they can go to #IDWeek2026
Do you:
A) Find a new project ASAP
B) Wait for 📝 draft
C) Wait for 📝 submission
D) Other
#IDSky
Your trainee who crushed their poster session at #IDWeek2025, really wants another project so that they can go to #IDWeek2026
Do you:
A) Find a new project ASAP
B) Wait for 📝 draft
C) Wait for 📝 submission
D) Other
#IDSky
October 26, 2025 at 9:34 PM
#IDResearchChallenges 🥼🧫🧬👨🔬👩🔬
Your trainee who crushed their poster session at #IDWeek2025, really wants another project so that they can go to #IDWeek2026
Do you:
A) Find a new project ASAP
B) Wait for 📝 draft
C) Wait for 📝 submission
D) Other
#IDSky
Your trainee who crushed their poster session at #IDWeek2025, really wants another project so that they can go to #IDWeek2026
Do you:
A) Find a new project ASAP
B) Wait for 📝 draft
C) Wait for 📝 submission
D) Other
#IDSky
Reports of Serph filter as treatment for ECMO released in single center 🇭🇷 case series showed ~53% clearance in 24 hours and reduction in several inflammatory markers
#IDSky
www.frontiersin.org/journals/med...
#IDSky
www.frontiersin.org/journals/med...
Frontiers | Seraph® filter effectiveness in the treatment of circuit-related infections in ECMO patients—a single-center report
IntroductionNosocomial infections in patients undergoing extracorporeal membrane oxygenation (ECMO) are common and associated with poorer outcomes. This stud...
www.frontiersin.org
October 26, 2025 at 2:35 AM
Reports of Serph filter as treatment for ECMO released in single center 🇭🇷 case series showed ~53% clearance in 24 hours and reduction in several inflammatory markers
#IDSky
www.frontiersin.org/journals/med...
#IDSky
www.frontiersin.org/journals/med...
#IDWeek2025 was such a wonderful experience!
What were the favorite sessions of #IDSky (for me to catch up on after the meeting)?
What were the favorite sessions of #IDSky (for me to catch up on after the meeting)?
October 23, 2025 at 3:19 PM
#IDWeek2025 was such a wonderful experience!
What were the favorite sessions of #IDSky (for me to catch up on after the meeting)?
What were the favorite sessions of #IDSky (for me to catch up on after the meeting)?
Reposted by Joseph Marcus
Due to the USG Shutdown, I wasn’t able to attend or present @idweek.bsky.social. I was supposed to give the talk on top viral studies that will impact your practice. Here are the papers I was going to highlight:
See next posts
See next posts
October 22, 2025 at 1:36 PM
Due to the USG Shutdown, I wasn’t able to attend or present @idweek.bsky.social. I was supposed to give the talk on top viral studies that will impact your practice. Here are the papers I was going to highlight:
See next posts
See next posts
Check out my mentee’s poster (1841). IM PGY2 Dr. Hill presents on factors associated with false positive HBVsAg in military service members
#IDWeek2025
#IDWeek2025
October 22, 2025 at 4:48 PM
Check out my mentee’s poster (1841). IM PGY2 Dr. Hill presents on factors associated with false positive HBVsAg in military service members
#IDWeek2025
#IDWeek2025
MIC Speaker #2 Dr. Bryson (VCU): Can I Trust this Susceptibility Testing Result?
Acceptable variation in testing regardless of method used.
Certain drug/bug combos have higher variability (ex. Cefidercol w/ significant variation by media brand and method)
#IDWeek2025
Acceptable variation in testing regardless of method used.
Certain drug/bug combos have higher variability (ex. Cefidercol w/ significant variation by media brand and method)
#IDWeek2025
October 22, 2025 at 3:11 PM
MIC Speaker #2 Dr. Bryson (VCU): Can I Trust this Susceptibility Testing Result?
Acceptable variation in testing regardless of method used.
Certain drug/bug combos have higher variability (ex. Cefidercol w/ significant variation by media brand and method)
#IDWeek2025
Acceptable variation in testing regardless of method used.
Certain drug/bug combos have higher variability (ex. Cefidercol w/ significant variation by media brand and method)
#IDWeek2025
The Many Facets of Clinical Breakpoints begins with “What Makes a Good Breakpoint?” by Dr. Lewis (OHSU):
Breakpoints-a mix of science and art based on:
1) MIC distribution, mechanisms of resistance (the original way breakpoints were determined)
2) PK-PD
3) Clinical data
#IDWeek2025
Breakpoints-a mix of science and art based on:
1) MIC distribution, mechanisms of resistance (the original way breakpoints were determined)
2) PK-PD
3) Clinical data
#IDWeek2025
October 22, 2025 at 2:35 PM
The Many Facets of Clinical Breakpoints begins with “What Makes a Good Breakpoint?” by Dr. Lewis (OHSU):
Breakpoints-a mix of science and art based on:
1) MIC distribution, mechanisms of resistance (the original way breakpoints were determined)
2) PK-PD
3) Clinical data
#IDWeek2025
Breakpoints-a mix of science and art based on:
1) MIC distribution, mechanisms of resistance (the original way breakpoints were determined)
2) PK-PD
3) Clinical data
#IDWeek2025
Dr. Kontoyiannis on his career at #IDWeek2025-
1) Early career- identifying clinical characteristics of mucor (rediscovered “reverse halo” sign)
2) Epi-increasing prevalence w/ rise of Vori in early 2000s
3) Late 2000s- better outcomes with early Ampho
4) Development of a treatment algorithm
1) Early career- identifying clinical characteristics of mucor (rediscovered “reverse halo” sign)
2) Epi-increasing prevalence w/ rise of Vori in early 2000s
3) Late 2000s- better outcomes with early Ampho
4) Development of a treatment algorithm
October 22, 2025 at 2:06 PM
Dr. Kontoyiannis on his career at #IDWeek2025-
1) Early career- identifying clinical characteristics of mucor (rediscovered “reverse halo” sign)
2) Epi-increasing prevalence w/ rise of Vori in early 2000s
3) Late 2000s- better outcomes with early Ampho
4) Development of a treatment algorithm
1) Early career- identifying clinical characteristics of mucor (rediscovered “reverse halo” sign)
2) Epi-increasing prevalence w/ rise of Vori in early 2000s
3) Late 2000s- better outcomes with early Ampho
4) Development of a treatment algorithm
Has anyone on #IDSky been able to fill out CME forms for lectures at #IDWeek2025?
October 22, 2025 at 11:04 AM
Has anyone on #IDSky been able to fill out CME forms for lectures at #IDWeek2025?