Joao Pedro Magalhaes
@jpsenescence.bsky.social
Scientist decoding the aging genome, professor, geek, entrepreneur, speaker, writer, keen footballer.
An average person in an industrialized country lives better than the kings and ultra-rich did 100 years ago.
And an average person 100 years from now will live a better life than today's billionaires.
And an average person 100 years from now will live a better life than today's billionaires.
November 22, 2025 at 1:29 PM
An average person in an industrialized country lives better than the kings and ultra-rich did 100 years ago.
And an average person 100 years from now will live a better life than today's billionaires.
And an average person 100 years from now will live a better life than today's billionaires.
Reposted by Joao Pedro Magalhaes
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function
link.springer.com/article/10.1...
link.springer.com/article/10.1...
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function - Biogerontology
The mechanisms underlying skeletal muscle ageing, whilst poorly understood, are thought to involve dysregulated micro (mi)RNA expression. Using young and aged rat skeletal muscle tissue, we applied hi...
link.springer.com
November 20, 2025 at 11:43 PM
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Joao Pedro Magalhaes
circHERC1—A telomerase activator
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
circHERC1—A telomerase activator
circHERC1 activates TERT transcription to counteract aging.
www.science.org
November 17, 2025 at 9:51 PM
circHERC1—A telomerase activator
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Joao Pedro Magalhaes
Coevolution of cooperative lifestyles and reduced cancer prevalence in mammals
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Coevolution of cooperative lifestyles and reduced cancer prevalence in mammals
While cooperative mammals evolve reducing cancer prevalence, oncogenes can be maintained by selection in competitive species.
www.science.org
November 16, 2025 at 7:28 PM
Coevolution of cooperative lifestyles and reduced cancer prevalence in mammals
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Joao Pedro Magalhaes
Entropy and Human Aging
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Entropy and Human Aging
Entropy, a measure of disorder and randomness, is an essential feature of thermodynamics, chemistry, and information theory, but there has been little study of entropy in human aging. Entropy arises ...
onlinelibrary.wiley.com
November 15, 2025 at 2:28 PM
Entropy and Human Aging
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Joao Pedro Magalhaes
Open problems in ageing science: a roadmap for biogerontology
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Open problems in ageing science: a roadmap for biogerontology - GeroScience
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems ...
link.springer.com
November 14, 2025 at 8:01 PM
Open problems in ageing science: a roadmap for biogerontology
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Always a pleasure to visit @imbmainz.bsky.social and learn more about the exciting research on aging, epigenetics and evolution @unimainz.bsky.social
Thank you for the invitation and looking forward to fruitful collaborations 🙏
Thank you for the invitation and looking forward to fruitful collaborations 🙏
November 14, 2025 at 10:26 AM
Always a pleasure to visit @imbmainz.bsky.social and learn more about the exciting research on aging, epigenetics and evolution @unimainz.bsky.social
Thank you for the invitation and looking forward to fruitful collaborations 🙏
Thank you for the invitation and looking forward to fruitful collaborations 🙏
Great to see longevity being featured @natbiotech.nature.com but wouldn't statins also count as longevity drugs?
And if the best we can do is rebranding a weight-loss pill as longevity, then we need better science and less marketing.
Longevity needs rigor & innovation, not buzzwords.
And if the best we can do is rebranding a weight-loss pill as longevity, then we need better science and less marketing.
Longevity needs rigor & innovation, not buzzwords.
November 13, 2025 at 3:47 PM
Great to see longevity being featured @natbiotech.nature.com but wouldn't statins also count as longevity drugs?
And if the best we can do is rebranding a weight-loss pill as longevity, then we need better science and less marketing.
Longevity needs rigor & innovation, not buzzwords.
And if the best we can do is rebranding a weight-loss pill as longevity, then we need better science and less marketing.
Longevity needs rigor & innovation, not buzzwords.
Exciting opportunity @unibirmingham.bsky.social 🎓
We're recruiting 125th Anniversary Fellows and Chairs to help shape the future of discovery and innovation.
Any questions, please message me.
Deadline: 11 January 2026.
www.birmingham.ac.uk/jobs/125th-a...
We're recruiting 125th Anniversary Fellows and Chairs to help shape the future of discovery and innovation.
Any questions, please message me.
Deadline: 11 January 2026.
www.birmingham.ac.uk/jobs/125th-a...
125th Anniversary Fellows and Chairs - University of Birmingham
125th Anniversary Fellows and Chairs
www.birmingham.ac.uk
November 12, 2025 at 3:05 PM
Exciting opportunity @unibirmingham.bsky.social 🎓
We're recruiting 125th Anniversary Fellows and Chairs to help shape the future of discovery and innovation.
Any questions, please message me.
Deadline: 11 January 2026.
www.birmingham.ac.uk/jobs/125th-a...
We're recruiting 125th Anniversary Fellows and Chairs to help shape the future of discovery and innovation.
Any questions, please message me.
Deadline: 11 January 2026.
www.birmingham.ac.uk/jobs/125th-a...
New study showing that aging rewires muscle microRNAs, but calorie restriction reverses many of these changes!
In rats, 35% of age-related miRNAs returned to youthful levels under CR, including pathways related to metabolism, autophagy & inflammation.
link.springer.com/article/10.1...
In rats, 35% of age-related miRNAs returned to youthful levels under CR, including pathways related to metabolism, autophagy & inflammation.
link.springer.com/article/10.1...
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function - Biogerontology
The mechanisms underlying skeletal muscle ageing, whilst poorly understood, are thought to involve dysregulated micro (mi)RNA expression. Using young and aged rat skeletal muscle tissue, we applied hi...
link.springer.com
November 11, 2025 at 7:14 PM
New study showing that aging rewires muscle microRNAs, but calorie restriction reverses many of these changes!
In rats, 35% of age-related miRNAs returned to youthful levels under CR, including pathways related to metabolism, autophagy & inflammation.
link.springer.com/article/10.1...
In rats, 35% of age-related miRNAs returned to youthful levels under CR, including pathways related to metabolism, autophagy & inflammation.
link.springer.com/article/10.1...
I'm delighted to share our curated list of 100 open problems in ageing science.
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
Open problems in ageing science: a roadmap for biogerontology - GeroScience
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems ...
link.springer.com
November 9, 2025 at 11:46 PM
I'm delighted to share our curated list of 100 open problems in ageing science.
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
Reposted by Joao Pedro Magalhaes
FOXM1 enhances DNA repair in aged cells to maintain the peripheral heterochromatin barrier to senescence enhancers
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
FOXM1 enhances DNA repair in aged cells to maintain the peripheral heterochromatin barrier to senescence enhancers
DNA damage is a key driver of aging, contributing to epigenetic erosion, senescence, and chronic inflammation. However, genoprotective strategies to counteract aging remain intangible. Here we show th...
www.biorxiv.org
November 7, 2025 at 4:16 PM
FOXM1 enhances DNA repair in aged cells to maintain the peripheral heterochromatin barrier to senescence enhancers
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share my new piece @clarkesworldmagazine.com 🚀
I discuss the future of human longevity and its depiction in science fiction. And how the eventual medical control of aging and lifespan will reshape both society and storytelling.
clarkesworldmagazine.com/de_magalhaes...
I discuss the future of human longevity and its depiction in science fiction. And how the eventual medical control of aging and lifespan will reshape both society and storytelling.
clarkesworldmagazine.com/de_magalhaes...
What is the Retirement Age of a Jedi? by João Pedro de Magalhães
Clarkesworld Science Fiction and Fantasy Magazine and Podcast.
clarkesworldmagazine.com
November 3, 2025 at 7:42 PM
Excited to share my new piece @clarkesworldmagazine.com 🚀
I discuss the future of human longevity and its depiction in science fiction. And how the eventual medical control of aging and lifespan will reshape both society and storytelling.
clarkesworldmagazine.com/de_magalhaes...
I discuss the future of human longevity and its depiction in science fiction. And how the eventual medical control of aging and lifespan will reshape both society and storytelling.
clarkesworldmagazine.com/de_magalhaes...
Reposted by Joao Pedro Magalhaes
Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues | The EMBO Journal
imageimageCyclin-dependent kinase inhibitors p16Ink4a and p21Cip1 are commonly used markers of cellular senescence, however their heterogeneity in
vivo remains unclear. This comparative data analysis ...
www.embopress.org
November 2, 2025 at 9:39 PM
Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Joao Pedro Magalhaes
A full life cycle biological clock based on routine clinical data and its impact in health and diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A full life cycle biological clock based on routine clinical data and its impact in health and diseases - Nature Medicine
The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.
www.nature.com
November 1, 2025 at 3:09 PM
A full life cycle biological clock based on routine clinical data and its impact in health and diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New (and provocative) piece with David Gems 🚨
Extending healthspan rather than lifespan should not be the goal of aging research.
Rather, our goal is to understand and intervene in aging to improve late-life health and save of lives: i.e. life-extension.
www.preprints.org/manuscript/2...
Extending healthspan rather than lifespan should not be the goal of aging research.
Rather, our goal is to understand and intervene in aging to improve late-life health and save of lives: i.e. life-extension.
www.preprints.org/manuscript/2...
www.preprints.org
October 31, 2025 at 6:29 PM
New (and provocative) piece with David Gems 🚨
Extending healthspan rather than lifespan should not be the goal of aging research.
Rather, our goal is to understand and intervene in aging to improve late-life health and save of lives: i.e. life-extension.
www.preprints.org/manuscript/2...
Extending healthspan rather than lifespan should not be the goal of aging research.
Rather, our goal is to understand and intervene in aging to improve late-life health and save of lives: i.e. life-extension.
www.preprints.org/manuscript/2...
Reposted by Joao Pedro Magalhaes
Evidence for improved DNA repair in long-lived bowhead whale
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
October 30, 2025 at 11:13 PM
Evidence for improved DNA repair in long-lived bowhead whale
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joao Pedro Magalhaes
Living healthily to 120: Implications for entrepreneurship
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Living healthily to 120: Implications for entrepreneurship
Research on how to slow, halt, and reverse aging processes is making progress. Pharmaceutical, big-tech, and venture capital companies and their owner…
www.sciencedirect.com
October 28, 2025 at 11:00 PM
Living healthily to 120: Implications for entrepreneurship
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Talking genetics, aging, and the brain at beautiful Coimbra, Portugal.
Neurodegenerative diseases like Alzheimer’s remain devastating and without treatment. How can we harness advances in longevity drugs and cellular rejuvenation to develop new therapies?
Neurodegenerative diseases like Alzheimer’s remain devastating and without treatment. How can we harness advances in longevity drugs and cellular rejuvenation to develop new therapies?
October 25, 2025 at 12:27 PM
Talking genetics, aging, and the brain at beautiful Coimbra, Portugal.
Neurodegenerative diseases like Alzheimer’s remain devastating and without treatment. How can we harness advances in longevity drugs and cellular rejuvenation to develop new therapies?
Neurodegenerative diseases like Alzheimer’s remain devastating and without treatment. How can we harness advances in longevity drugs and cellular rejuvenation to develop new therapies?
Reposted by Joao Pedro Magalhaes
Circadian system and aging: where both times interact
www.frontiersin.org/journals/agi...
www.frontiersin.org/journals/agi...
Frontiers | Circadian system and aging: where both times interact
Time shapes life both through its steady progression, as seen in aging, and through its eternal return, reflected in biological rhythms. These two temporal f...
www.frontiersin.org
October 24, 2025 at 2:24 PM
Circadian system and aging: where both times interact
www.frontiersin.org/journals/agi...
www.frontiersin.org/journals/agi...
Reposted by Joao Pedro Magalhaes
Organ-Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Organ‐Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming
Transient in vivo expression of Yamanaka factors (OSKM) enhances regenerative competence and rejuvenation across multiple tissues. We highlight mechanistic links between injury-induced dedifferentiat...
onlinelibrary.wiley.com
October 21, 2025 at 1:04 PM
Organ-Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
PhD studentship available in our lab to study ageing, longevity and cellular rejuvenation using computational methods and machine learning/AI.
Applications are open to UK and international students.
Deadline: 27 November 2025.
www.findaphd.com/phds/project...
Applications are open to UK and international students.
Deadline: 27 November 2025.
www.findaphd.com/phds/project...
Developing and applying computational methods to study ageing and cellular rejuvenation at University of Birmingham on FindAPhD.com
PhD Project - Developing and applying computational methods to study ageing and cellular rejuvenation at University of Birmingham, listed on FindAPhD.com
www.findaphd.com
October 19, 2025 at 7:00 PM
PhD studentship available in our lab to study ageing, longevity and cellular rejuvenation using computational methods and machine learning/AI.
Applications are open to UK and international students.
Deadline: 27 November 2025.
www.findaphd.com/phds/project...
Applications are open to UK and international students.
Deadline: 27 November 2025.
www.findaphd.com/phds/project...
Reposted by Joao Pedro Magalhaes
Aging as a Loss of Goal-Directedness: An Evolutionary Simulation and Analysis Unifying Regeneration with Anatomical Rejuvenation
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Aging as a Loss of Goal‐Directedness: An Evolutionary Simulation and Analysis Unifying Regeneration with Anatomical Rejuvenation
The paper proposes that the root cause of aging is the loss of anatomical goal-directedness after development. Using evolutionary neural cellular automata simulations, the authors show that after the....
advanced.onlinelibrary.wiley.com
October 16, 2025 at 10:36 PM
Aging as a Loss of Goal-Directedness: An Evolutionary Simulation and Analysis Unifying Regeneration with Anatomical Rejuvenation
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Joao Pedro Magalhaes
Six Drivers of Aging Identified Among Genes Differentially Expressed With Age
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Six Drivers of Aging Identified Among Genes Differentially Expressed With Age
A meta-analysis of 25 transcriptomic datasets from mammalian tissues revealed 45 genes consistently upregulated or downregulated with age. Orthologs of these genes were functionally evaluated using C...
onlinelibrary.wiley.com
October 14, 2025 at 5:28 PM
Six Drivers of Aging Identified Among Genes Differentially Expressed With Age
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Joao Pedro Magalhaes
Human Cell Aging Transcriptome Atlas (HCATA): a single-cell atlas of age-associated transcriptomic alterations across human tissues
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Human Cell Aging Transcriptome Atlas (HCATA): a single-cell atlas of age-associated transcriptomic alterations across human tissues - Communications Biology
The Human Cell Aging Transcriptome Atlas contains single cell RNA-sequencing data from 3,475 human samples and interactive tools to explore age-related alterations in gene expression and go term enrichment in a diverse set of tissues and cell types.
www.nature.com
October 11, 2025 at 11:34 PM
Human Cell Aging Transcriptome Atlas (HCATA): a single-cell atlas of age-associated transcriptomic alterations across human tissues
www.nature.com/articles/s42...
www.nature.com/articles/s42...