Julie Le Bris
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julielebris.bsky.social
Julie Le Bris
@julielebris.bsky.social
1.2K followers 660 following 28 posts
PhD student interested in microbial evolution and ecology🧬 @Institut Pasteur
#Klebsiella #MicroSky
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julielebris.bsky.social
Julie Le Bris @julielebris.bsky.social · Sep 5
Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
journals.asm.org
Reposted by Julie Le Bris
imili-micro.bsky.social
Everything you need to explain AMR to family and friends-12:

@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social
@klebclub.bsky.social ‪
@olayarendueles.bsky.social‬

the ESKAPE Rogues

www.imili-eah.com/prod-api/pro...
November 20, 2025 at 8:32 AM
Reposted by Julie Le Bris
femsjournals.bsky.social
New insights into #Hpylori’s virulence machinery 🕵️🧪 Josenhans lab & coll. unravel new interactions between CagT4SS surface proteins and outer membrane proteins HopQ & HopZ—key for host interaction and #proinflammatory signaling. 🦠
@lmumuenchen.bsky.social

👉 buff.ly/toApn0c
November 17, 2025 at 1:01 PM
Reposted by Julie Le Bris
femsjournals.bsky.social
🦠 Small changes, big defense! Jordan Vacheron & coll. show specific SNPs in #Pseudomonas protegens CHA0 (algC & ykcC) remodel LPS to block #phage ΦGP100—while growth, competitiveness & root colonization stay intact, in lab conditions. 🧬 @unil.bsky.social
👉 buff.ly/MFOH2er
November 6, 2025 at 8:01 AM
Reposted by Julie Le Bris
femsjournals.bsky.social
What can an “orphan” #Cas4 do? 🧫 In #archaea M. mazei, Solo-Cas4 cleaves dsDNA in a metal-dependent manner and is upregulated in stationary phase—hinting at roles in stress or DNA metabolism.
Biochemical characterization by Schmitz lab @uni-kiel.de
👉 buff.ly/kpz0yZ1
November 3, 2025 at 8:01 AM
Reposted by Julie Le Bris
femsjournals.bsky.social
#C.albicans invades tissues as hyphae but spreads as yeast, How?
@jlspragu.bsky.social & coll. show yeast can reach the bloodstream by hitchhiking with invasive hyphae or by switching forms. 🧫 More clues for understanding systemic infections !
👉 buff.ly/0vklJeb
November 2, 2025 at 10:00 AM
Reposted by Julie Le Bris
femsjournals.bsky.social
🔍 From rods to stars, bacteria craft their shapes using bPBPs & GTases. Garcia-del Portillo lab’s global analysis reveals unexpected diversity & flexibility in these morphogenetic complexes. 🦠 @cnb-csic.bsky.social
👉 Read more : buff.ly/D0pMhMr
October 27, 2025 at 2:05 PM
Reposted by Julie Le Bris
femsjournals.bsky.social
De-DUFing the DUFs 🧩 @franznarberhaus.bsky.social lab uncovers how small DUF1127 proteins regulate #phosphate uptake by binding the sensor kinase PhoR. Their conserved role from Agrobacterium to E. coli highlights how even small DUFs can shape bacterial physiology 🦠
buff.ly/jJd9Eho
October 21, 2025 at 7:02 AM
Reposted by Julie Le Bris
femsjournals.bsky.social
New insights from #CRISPR-Cas systems! 🧬 @cyanolab.bsky.social reveals that in the #cyanobacteria Synechocystis, RNase J works with RNase E to mature CRISPR3 RNAs—key for RNA-based immune defense. RNase J can also team up with PNPase in a degradosome-like complex.
buff.ly/CrxiQPy
October 17, 2025 at 8:02 AM
Reposted by Julie Le Bris
femsjournals.bsky.social
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
October 14, 2025 at 9:02 AM
Reposted by Julie Le Bris
dbikard.bsky.social
Entretien pour Brut sur la vie Miroir, l'ingénierie génétique et l'éthique de ces recherches: www.brut.media/fr/videos/sc...
Manipulations génétiques, virus créés par l’IA, bactéries miroirs : quelles limites à la recherche scientifique ?
Elles pourraient aider à lutter contre les cancers… mais aussi détruire toute trace de vie sur Terre ! Ce sont les bactéries miroirs. En avez-vous déjà entendu parler ? Et la vie miroir, ça vous dit q...
www.brut.media
October 11, 2025 at 1:30 PM
Reposted by Julie Le Bris
femsjournals.bsky.social
A new subgroup of #CRISPR-associated transposons, V-K_V2, has been discovered in Nostocales #cyanobacteria by @cyanolab.bsky.social & colleagues 🧬. Its unique features suggest genetic mobility and V2 tracrRNAs are now included in the updated CRISPRtracrRNA tool.
buff.ly/gioIfEB
October 8, 2025 at 11:03 AM
Reposted by Julie Le Bris
femsjournals.bsky.social
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use.
buff.ly/JST7ZR1
October 4, 2025 at 10:01 AM
Reposted by Julie Le Bris
femsjournals.bsky.social
Phages are promising against antibiotic-resistant bacteria—but resistance can emerge. 🦠 New work from @baerboletta.bsky.social lab shows E. coli can resist phages in the lab, but in the gut that resistance comes at a cost: context is crucial for #PhageTherapy success.
buff.ly/NLOjnE2
September 27, 2025 at 8:00 AM
Reposted by Julie Le Bris
jm-sfm.bsky.social
Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠
September 24, 2025 at 2:31 PM
Reposted by Julie Le Bris
enningalab.bsky.social
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫

Thread coming soon!
biorxiv-microbiol.bsky.social bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Sep 18
Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1
September 18, 2025 at 4:58 PM
Reposted by Julie Le Bris
femsjournals.bsky.social
New tool alert! 🚀 MCAAT uses de Bruijn graphs to detect #CRISPR arrays in #metagenomes, capturing data lost in assemblies. A step forward in uncovering the hidden diversity of CRISPR-Cas systems. By Talibli & Voß
buff.ly/QMX9yIe
September 18, 2025 at 8:01 AM
Reposted by Julie Le Bris
femsjournals.bsky.social
Archaea thrive in harsh niches that challenge DNA integrity. 🧬 In H. volcanii, Sailer et al. revealed Cas1 & Hel308a as new Microhomology-Mediated End Joining (MMEJ) players, expanding the toolkit for archaeal genomes repair.
buff.ly/lnyY7JF
September 15, 2025 at 12:30 PM
Reposted by Julie Le Bris
benoitjpons.bsky.social
How do bacteria choose what type of defences to use against phages? We explored that question in the last paper I worked on as a postdoc at the Uni of Exeter @uniofexeteresi.bsky.social with Stineke van Houte, Stefano Pagliara and Edze Westra (not on Bluesky)
doi.org/10.1098/rstb...
Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection | Philosophical Transactions of the Royal Society B: Biological Sciences
Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance....
doi.org
September 4, 2025 at 4:02 PM
julielebris.bsky.social
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
Serotype swapping in Klebsiella spp. by plug-and-play
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
www.biorxiv.org
September 10, 2025 at 8:17 AM
Reposted by Julie Le Bris
olayarendueles.bsky.social
Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social

This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
September 9, 2025 at 5:11 AM
julielebris.bsky.social
Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
journals.asm.org
September 5, 2025 at 1:49 PM
Reposted by Julie Le Bris
femsjournals.bsky.social
#CRISPR is more than Cas9 ✂️ 🧬 @BeiselLab reveals a short tracrRNA from S. pyogenes is toxic in L. paracasei, even without Cas9, underscoring challenges of using CRISPR-Cas9 in non-native hosts.
#microsky
buff.ly/qWjkxdK
August 27, 2025 at 12:02 PM
Reposted by Julie Le Bris
annechevallereau.bsky.social
#phagesky

I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?

Repost appreciated :)
August 19, 2025 at 8:11 AM
Reposted by Julie Le Bris
olayarendueles.bsky.social
Looking forward to #ESEB2025 Day 1!
In this meeting, the team has two talks:
I’ll present coevolutionary dynamics between bacteria & their prophages in S43 Tuesday PM & @julielebris.bsky.social will speak on Thursday AM, S34, on phenotypic heterogeneity of capsule expression.
August 18, 2025 at 5:38 AM
Reposted by Julie Le Bris
femsjournals.bsky.social
🔬 We’re past the midpoint of the year; perfect time to look back at what’s been discovered so far. From how Salmonella slows its escape from immune cells to the microbes thriving in oil reservoirs, these are the most-read #microLife papers of 2025 so far: buff.ly/TfhOvEc
August 13, 2025 at 12:01 PM