Lightnews — Scholar-powered news

Olaya Rendueles

@olayarendueles.bsky.social

1.8K followers 630 following 170 posts

Microbial evolution & ecology, focus on surface structures (capsules) and HGT (#plasmids #phages), mostly in #Klebsiella #MicroSky From Asturias 🇪🇸 living in 🇫🇷 @cnrs.bsky.social

Posts Media Videos Starter Packs

Pinned

Olaya Rendueles @olayarendueles.bsky.social · Sep 9

Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social

This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky

Julie Le Bris @julielebris.bsky.social · Sep 5

Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇

Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio

The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...

journals.asm.org

10 18

Reposted by Olaya Rendueles

Cascales Lab @cascaleslab.bsky.social · 1d

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...

Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)

emploi.cnrs.fr

35 24

Olaya Rendueles @olayarendueles.bsky.social · 4d

Nouveau gouvernement : Sébastien Lecornu remet sa démission, Emmanuel Macron l’accepte via @le_Parisien

leparisien.fr/politique/no...

Nouveau gouvernement : Sébastien Lecornu remet sa démission, Emmanuel Macron l’accepte

Le Premier ministre Sébastien Lecornu a remis ce lundi matin sa démission au président de la République, qui l’a acceptée.

leparisien.fr

Olaya Rendueles @olayarendueles.bsky.social · 8d

Congrats!!! Lovely pic!

Reposted by Olaya Rendueles

Jeunes microbiologistes de la SFM @jm-sfm.bsky.social · 16d

Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠

1 6 10

Reposted by Olaya Rendueles

International Microbiology Literacy Initiative - IMiLI @imili-micro.bsky.social · 17d

Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org

1 12 11

Olaya Rendueles @olayarendueles.bsky.social · 18d

Jorge Peña @jorgeapenas.bsky.social · 18d

📢 Apply to our (2-year) research fellowships at @iast.fr

Join a multidisciplinary, interdisciplinary, transdisciplinary, and indisciplinary group of scholars in Toulouse, walkable/cyclable pink city of chocolatines in the South of France.

Deadline: November 15, 2025.

www.iast.fr/research-fel...

Research Fellowships

Each year, IAST invites applications for post-doctoral Research Fellowships, which offer candidates an opportunity to devote themselves full-time to their research at the start of their careers. Fello...

www.iast.fr

Olaya Rendueles @olayarendueles.bsky.social · 18d

Acquisition of different rmp alleles can lead to hypervirulence in vivo, but effects are difficult to predict as there is a strong strain-dependency.
@klebclub.bsky.social

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 19d

The acquisition of rmpADC can increase virulence of classical Klebsiella pneumoniae in the absence of other hypervirulence-associated genes https://www.biorxiv.org/content/10.1101/2025.09.20.677538v1

Olaya Rendueles @olayarendueles.bsky.social · 19d

@klebclub.bsky.social

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 19d

𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢 𝘱𝘯𝘦𝘶𝘮𝘰𝘯𝘪𝘢𝘦 is a Gram-negative, non-motile, straight rod-shaped bacterium that can divide rapidly, with some strains having a median doubling time of < 30 min, forming biofilms that interfere with both antibiotic and immune clearance

Olaya Rendueles @olayarendueles.bsky.social · 21d

This promises to be a great read!
“the pathogenicity island was horizontally transferred from Yersinia pestis to E. coli and other Enterobacterales approximatively 4,800 years ago” ⏩️ it then spread to Klebsiella and positively selected over the last 100 yrs ago

bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 21d

Evidence for Neolithic acquisition of the high pathogenic island by Escherichia coli followed by recent selection https://www.biorxiv.org/content/10.1101/2025.09.17.676721v1

5 13

Reposted by Olaya Rendueles

Don Vinh @donvinh.bsky.social · 22d

4 41 240

Reposted by Olaya Rendueles

Didier Mazel @amazeld.bsky.social · 21d

I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...

Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria | PNAS

Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to d...

www.pnas.org

2 7 31

Reposted by Olaya Rendueles

Zamin Iqbal @zaminiqbal.bsky.social · 23d

Super paper from the mighty Mia Winkler, @genomarit.bsky.social and Iren Lohr.
"We have previously shown that there were relatively few strain-sharing events across ecological niches...plasmid-sharing is considerably more common across niches than strain-sharing. "
www.biorxiv.org/content/10.1...

A One Health study of Klebsiella pneumoniae species complex plasmids shows a highly diverse and ecologically adaptable plasmidome

Plasmids play a pivotal role in the horizontal gene transfer of antimicrobial resistance (AMR) and virulence determinants among bacteria. Members of the Klebsiella pneumoniae species complex (KpSC) ca...

www.biorxiv.org

11 22

Reposted by Olaya Rendueles

Lucy Weinert @lucyweinert.bsky.social · 25d

www.findaphd.com/phds/project...

Investigating pathogenicity in zoonotic Streptococcus suis at University of Cambridge on FindAPhD.com

PhD Project - Investigating pathogenicity in zoonotic Streptococcus suis at University of Cambridge, listed on FindAPhD.com

www.findaphd.com

15 6

Reposted by Olaya Rendueles

ASM @asm.org · Jul 16

Using experimental evolution in host-mimicking media, researchers show that inflammation-like environments limit the loss of quorum sensing—a common adaptation during chronic infections—in Pseudomonas aeruginosa. Learn more in #mSystems: asm.social/2vd

Population densities and frequencies of protease-deficient mutants over time. Differences in environmental factors associated with inflammation varied the population density (A) and the frequency of evolved protease-deficient mutants, PDMs (B), over time. Box plot tracks the average and overall distribution of population density at each detected time point within each selective environment. Each line shows the tracked population density or PDM frequency along the daily passage in a single population, grouped by selective environments (Casein SCFM or casamino acids, labeled CAA SCFM, and with or without supplemented 2 mM hydrogen peroxide, OS±).

1 14 23

Olaya Rendueles @olayarendueles.bsky.social · 28d

What an incredible week for @julielebris.bsky.social with one published ms in @asm.org #mBio on #capsule phenotypic heterogeneity & a preprint on the modular evolution of a highly exchangeable locus ⏩️capsule 😅
All her hard work is paying off!
#ProudPI
#microsky @klebclub.bsky.social
Check her 🧵👇🏻

Julie Le Bris @julielebris.bsky.social · Sep 10

How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇

Serotype swapping in Klebsiella spp. by plug-and-play

Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...

www.biorxiv.org

1 9

Reposted by Olaya Rendueles

José R Penadés @jrpenades.bsky.social · Sep 9

Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...

Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization

Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...

www.cell.com

50 99

Olaya Rendueles @olayarendueles.bsky.social · Sep 9

Julie Le Bris @julielebris.bsky.social · Sep 5

Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇

Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio

journals.asm.org

10 18

Olaya Rendueles @olayarendueles.bsky.social · Sep 8

This year, extra special, because after 25 yrs, Real Oviedo is finally where it belongs, in the first division of Spanish football league!

Olaya Rendueles @olayarendueles.bsky.social · Sep 8

Asturian@s, Feliz Dia!
Today is always special for me, the festivities to celebrate my region -and it’s patron saint, Covadonga.
I always feel a little pinch in my heart, when I am not there to celebrate, this, yet again, rainy day 😅
#DiaDeAsturias #DiaDeCovadonga #AsturiasParaisoNatural

1 8

Reposted by Olaya Rendueles

Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Sep 6

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters

Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.

www.science.org

7 47 98

Olaya Rendueles @olayarendueles.bsky.social · Sep 5

Excellent Anne & co! Congratulations 🎈 will read!

Olaya Rendueles @olayarendueles.bsky.social · Sep 5

Excellent! Well done François!

Reposted by Olaya Rendueles

bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · Sep 5

Group size dependent selection for cooperation versus freeloading in collective chemical defence https://www.biorxiv.org/content/10.1101/2025.09.03.672859v1

2 1

Reposted by Olaya Rendueles

Benoit Pons @benoitjpons.bsky.social · Sep 4

How do bacteria choose what type of defences to use against phages? We explored that question in the last paper I worked on as a postdoc at the Uni of Exeter @uniofexeteresi.bsky.social with Stineke van Houte, Stefano Pagliara and Edze Westra (not on Bluesky)
doi.org/10.1098/rstb...

Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection | Philosophical Transactions of the Royal Society B: Biological Sciences

Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance....

doi.org

1 16 25

Reposted by Olaya Rendueles

Benoit Pons @benoitjpons.bsky.social · Sep 4

However, we noticed some heterogeneity in the population, with some CRISPR-immune bacteria stalling and suffering from elongation, particularly at high phage doses, which is consistent with this second hypothesis

Cumulative probability of division curves. Surface-based resistant bacteria are not affected by the presence of phage and the median time between two division is the same for all treatments. CRISPR-resistant bacteria median division time is slightly increased at low phage dose and significantly increased at high phage dose

Microfluidics image displaying bacteria of several different sizes. The one on the right hand side is elongated (8 times longer than a bacteria that just completed division)

1 1 2