Krista Freeman
@kfreeman.bsky.social
Big phan of physics & phages | cryo-EM, phage engineering, a little immunology | e-bike enthusiast
CWRU Physics Assistant Professor
Cleveland kid.
CWRU Physics Assistant Professor
Cleveland kid.
Pinned
Krista Freeman
@kfreeman.bsky.social
· Apr 16
Structure and infection dynamics of mycobacteriophage Bxb1
Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages…
www.sciencedirect.com
Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Well, I just was denied the COVID vaccine in Cleveland, Ohio. I can’t begin to express the rage I feel at being barred from protecting my vulnerable loved ones. My “senators” just got voicemails - I will keep calling until access to these safe and effective vaccines is restored. My body, my choice.
September 5, 2025 at 12:34 PM
Well, I just was denied the COVID vaccine in Cleveland, Ohio. I can’t begin to express the rage I feel at being barred from protecting my vulnerable loved ones. My “senators” just got voicemails - I will keep calling until access to these safe and effective vaccines is restored. My body, my choice.
Reposted by Krista Freeman
Join me in donating to ABRCMS. For many of us early in our careers (and for many of us now), this is THE conference. Let’s make sure future generations get the same experience.
I was told if each poster judge donated $25, their goal would be quickly met, but I think we can do better! 🙏🏾💪🏾
I was told if each poster judge donated $25, their goal would be quickly met, but I think we can do better! 🙏🏾💪🏾
Calling all @apsphysiology.bsky.social members: let’s help raise some money to support ABRCMS student presentation awards! Goal is $1200/discipline to support 12 awards by Sept 30th! 🧪 abrcms.org/donate/stude...
ABRCMS Fundraising - Student Presentation Awards - ABRCMS
Judges – Help Us Raise Funds for Student Presentation Awards Thank you for your service as a judge at ABRCMS. Your dedication has helped shape the future of countless student scientists, and we’re dee...
abrcms.org
August 21, 2025 at 2:48 AM
Join me in donating to ABRCMS. For many of us early in our careers (and for many of us now), this is THE conference. Let’s make sure future generations get the same experience.
I was told if each poster judge donated $25, their goal would be quickly met, but I think we can do better! 🙏🏾💪🏾
I was told if each poster judge donated $25, their goal would be quickly met, but I think we can do better! 🙏🏾💪🏾
Reposted by Krista Freeman
Together with leading science organizations, ASM filed an amicus brief calling for immediate restoration of NIH grants supporting early-career scientists. Read the press release: asm.org/press-releas...
Four Leading Science Organizations File Amicus Brief Supporting Funding Restoration
ASM joined leading life science organizations in an amicus brief filed in support of a suit calling for immediate funding restoration.
asm.org
May 2, 2025 at 8:41 PM
Together with leading science organizations, ASM filed an amicus brief calling for immediate restoration of NIH grants supporting early-career scientists. Read the press release: asm.org/press-releas...
Reposted by Krista Freeman
Now online! Structure and infection dynamics of mycobacteriophage Bxb1
Structure and infection dynamics of mycobacteriophage Bxb1
Cryo-EM and cryo-ET reveal the structural details and conformational dynamics of mycobacteriophage Bxb1 as it infects its Mycobacterium smegmatis host.
dlvr.it
April 15, 2025 at 6:51 PM
Now online! Structure and infection dynamics of mycobacteriophage Bxb1
Reposted by Krista Freeman
Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Structure and infection dynamics of mycobacteriophage Bxb1
Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages…
www.sciencedirect.com
April 17, 2025 at 2:40 PM
Reposted by Krista Freeman
Some eye-catching #TeamTomo work here. Congrats to @kfreeman.bsky.social and all the authors! 🧪🧶🧬🔬
Krista Freeman et al 𝘊𝘌𝘓𝘓
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
April 18, 2025 at 7:55 PM
Some eye-catching #TeamTomo work here. Congrats to @kfreeman.bsky.social and all the authors! 🧪🧶🧬🔬
Reposted by Krista Freeman
Krista Freeman et al 𝘊𝘌𝘓𝘓
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
April 18, 2025 at 10:33 AM
Krista Freeman et al 𝘊𝘌𝘓𝘓
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
Reposted by Krista Freeman
Host invasion by a mycobacteriophage—visualized in action! 🦠✨
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria
Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Structure and infection dynamics of mycobacteriophage Bxb1
Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages…
www.sciencedirect.com
April 17, 2025 at 12:58 AM
Host invasion by a mycobacteriophage—visualized in action! 🦠✨
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria
Reposted by Krista Freeman
Do you love phages? Other viruses? Cool science done by cool people? Check out this paper by my former bay mate @kfreeman.bsky.social and colleagues that sheds light on the cool molecular machines that are phage tails.
Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Structure and infection dynamics of mycobacteriophage Bxb1
Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages…
www.sciencedirect.com
April 16, 2025 at 8:45 PM
Do you love phages? Other viruses? Cool science done by cool people? Check out this paper by my former bay mate @kfreeman.bsky.social and colleagues that sheds light on the cool molecular machines that are phage tails.
Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Structure and infection dynamics of mycobacteriophage Bxb1
Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages…
www.sciencedirect.com
April 16, 2025 at 12:50 PM
Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Krista Freeman
Excited about progress we are making to build a system for preclinical interrogation of #phages for #Tb
#TBSKY
virologyj.biomedcentral.com/articles/10....
#TBSKY
virologyj.biomedcentral.com/articles/10....
Evaluation of host immune responses to Mycobacteriophage Fionnbharth by route of delivery - Virology Journal
For much of the last decade, tuberculosis (TB) was the leading cause of mortality due to an infectious pathogen (Mycobacterium tuberculosis, M.tb). Approximately 1.3 million deaths in 2023 worldwide w...
virologyj.biomedcentral.com
January 21, 2025 at 4:42 PM
Excited about progress we are making to build a system for preclinical interrogation of #phages for #Tb
#TBSKY
virologyj.biomedcentral.com/articles/10....
#TBSKY
virologyj.biomedcentral.com/articles/10....
Reposted by Krista Freeman
Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection.
DOI: 10.1038/s41467-024-54666-4
https://pubmed.ncbi.nlm.nih.gov/39609405/
DOI: 10.1038/s41467-024-54666-4
https://pubmed.ncbi.nlm.nih.gov/39609405/
Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection - PubMed
Nontuberculous mycobacterium (NTM) infections are challenging to manage and are frequently non-responsive to aggressive but poorly-tolerated antibiotic therapies. Immunosuppressed lung transplant patients are susceptible to NTM infections and poor patient outcomes are common. Bacteriophages present …
pubmed.ncbi.nlm.nih.gov
December 5, 2024 at 1:37 PM
Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection.
DOI: 10.1038/s41467-024-54666-4
https://pubmed.ncbi.nlm.nih.gov/39609405/
DOI: 10.1038/s41467-024-54666-4
https://pubmed.ncbi.nlm.nih.gov/39609405/
Reposted by Krista Freeman
Come join us at CWRU Physics! We're hiring in Condensed Matter Experiment at assistant professor level. 🧪⚛️
case.edu/academic-car...
case.edu/academic-car...
Assistant Professor (tenure-track) in Experimental Condensed Matter Physics - Department of Physics | Academic Careers | Case Western Reserve University
The Department of Physics at Case Western Reserve University invites applications for a tenure-track faculty position at the rank of Assistant Profes...
case.edu
November 19, 2024 at 8:43 PM
Come join us at CWRU Physics! We're hiring in Condensed Matter Experiment at assistant professor level. 🧪⚛️
case.edu/academic-car...
case.edu/academic-car...
Thanks for making this starter pack, Joscelyn! Awesome to see so many MOSAIC scholars assembling here in the bluer skies. So happy to connect!
I started a list of MOSAIC scholars to help find and support each other. I'm sure I've missed many people, lmk if you want to be added!
go.bsky.app/9Ui711k
go.bsky.app/9Ui711k
November 17, 2024 at 3:38 PM
Thanks for making this starter pack, Joscelyn! Awesome to see so many MOSAIC scholars assembling here in the bluer skies. So happy to connect!
LOVING the NIH BioArt effort! BUT… where are the phages?? Hoping to see some in the official release! Anyone know if there’s a mechanism to request additions?
#PhageSky
#PhageSky
October 30, 2024 at 10:45 PM
LOVING the NIH BioArt effort! BUT… where are the phages?? Hoping to see some in the official release! Anyone know if there’s a mechanism to request additions?
#PhageSky
#PhageSky
I’m pleased to share that I’ll be joining Case Western Reserve University as an Assistant Professor of Physics, starting July 2025! Looking forward to returning to my Physics roots while continuing to investigate the wonderful world of phages. :)
July 29, 2024 at 1:57 PM
I’m pleased to share that I’ll be joining Case Western Reserve University as an Assistant Professor of Physics, starting July 2025! Looking forward to returning to my Physics roots while continuing to investigate the wonderful world of phages. :)
Big congrats to Graham Hatfull on being elected a member of the National Academy of Sciences! I couldn’t ask for a better mentor. So glad to have had the opportunity to learn from him the last 7 (!) years!!
May 1, 2024 at 3:08 AM
Big congrats to Graham Hatfull on being elected a member of the National Academy of Sciences! I couldn’t ask for a better mentor. So glad to have had the opportunity to learn from him the last 7 (!) years!!
Home from my first ever ABRCMS and feeling, in a word, uplifted! I hope to come back year after year to cultivate friendships, learn from mentors, and connect with the amazing next generation of diverse scientists.
Huge thanks to the ASM MOSAIC program for the warm welcome :)
Huge thanks to the ASM MOSAIC program for the warm welcome :)
November 19, 2023 at 10:46 PM
Home from my first ever ABRCMS and feeling, in a word, uplifted! I hope to come back year after year to cultivate friendships, learn from mentors, and connect with the amazing next generation of diverse scientists.
Huge thanks to the ASM MOSAIC program for the warm welcome :)
Huge thanks to the ASM MOSAIC program for the warm welcome :)
Reposted by Krista Freeman
PhamClust: a phage genome clustering tool using proteomic equivalence
@mSystemsJ Methods and Protocols from Graham Hatfull
journals.asm.org/doi/10.1128/...
@mSystemsJ Methods and Protocols from Graham Hatfull
journals.asm.org/doi/10.1128/...
October 4, 2023 at 1:54 PM
PhamClust: a phage genome clustering tool using proteomic equivalence
@mSystemsJ Methods and Protocols from Graham Hatfull
journals.asm.org/doi/10.1128/...
@mSystemsJ Methods and Protocols from Graham Hatfull
journals.asm.org/doi/10.1128/...
Just test driving this new platform… apparently if I add a test tube my post will go to the ScienceSky feed? 🧪
And I suppose threads can be done with a string of comments on a post?
So far so good… the waters do seem calmer here.
And I suppose threads can be done with a string of comments on a post?
So far so good… the waters do seem calmer here.
September 11, 2023 at 1:40 PM
Just test driving this new platform… apparently if I add a test tube my post will go to the ScienceSky feed? 🧪
And I suppose threads can be done with a string of comments on a post?
So far so good… the waters do seem calmer here.
And I suppose threads can be done with a string of comments on a post?
So far so good… the waters do seem calmer here.
Hi, my name is Krista… a recent transplant from Science Twitter. I’m a postdoc studying bacteriophages - viruses that infect bacteria. When I’m not reconstructing cool phage structures or working on my faculty applications, I love traveling and exploring the great outdoors.
September 10, 2023 at 8:27 PM
Hi, my name is Krista… a recent transplant from Science Twitter. I’m a postdoc studying bacteriophages - viruses that infect bacteria. When I’m not reconstructing cool phage structures or working on my faculty applications, I love traveling and exploring the great outdoors.