Kira Höffler
@kirahoeffler.bsky.social
PhD research fellow @ McLean Hospital 🇺🇸 & University of Bergen 🇳🇴 | epigenetics in psychiatry 🧠🧬 | she/her
Reposted by Kira Höffler
✨Hello folks!✨
We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦
"Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches"
🔗http://bit.ly/49syndi
Read our overview below!
🧵1/6
We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦
"Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches"
🔗http://bit.ly/49syndi
Read our overview below!
🧵1/6
November 1, 2025 at 5:20 PM
✨Hello folks!✨
We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦
"Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches"
🔗http://bit.ly/49syndi
Read our overview below!
🧵1/6
We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦
"Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches"
🔗http://bit.ly/49syndi
Read our overview below!
🧵1/6
New method for DNA methylation studies 🧬:
EpiAnceR+ improves ancestry adjustment without requiring genotyping data, while removing technical and biological noise. Easy to use in existing R pipelines.
link.springer.com/article/10.1...
EpiAnceR+ improves ancestry adjustment without requiring genotyping data, while removing technical and biological noise. Easy to use in existing R pipelines.
link.springer.com/article/10.1...
Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches - Epigenetics & Chromatin
Background Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs)...
link.springer.com
October 28, 2025 at 4:15 PM
New method for DNA methylation studies 🧬:
EpiAnceR+ improves ancestry adjustment without requiring genotyping data, while removing technical and biological noise. Easy to use in existing R pipelines.
link.springer.com/article/10.1...
EpiAnceR+ improves ancestry adjustment without requiring genotyping data, while removing technical and biological noise. Easy to use in existing R pipelines.
link.springer.com/article/10.1...
Curious whether response to psychotherapy in OCD can be predicted using clinical and DNA methylation data? Come see Poster 1️⃣ at #WCPG2025. I’ll be presenting our first machine learning findings!
October 22, 2025 at 5:00 PM
Curious whether response to psychotherapy in OCD can be predicted using clinical and DNA methylation data? Come see Poster 1️⃣ at #WCPG2025. I’ll be presenting our first machine learning findings!
Back at my favourite conference #WCPG2025 - this time in a slightly different setting (an all-inclusive beach hotel) #cancun #mexico @ispg.bsky.social
October 20, 2025 at 7:37 PM
Back at my favourite conference #WCPG2025 - this time in a slightly different setting (an all-inclusive beach hotel) #cancun #mexico @ispg.bsky.social
Reposted by Kira Höffler
The Biological Psychiatry family of journals is now officially on Bluesky!
Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.
Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.
September 25, 2025 at 9:36 AM
The Biological Psychiatry family of journals is now officially on Bluesky!
Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.
Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.
Inspiring AI Cures Conference at MIT with stunning views of beautiful Boston.
September 22, 2025 at 7:05 PM
Inspiring AI Cures Conference at MIT with stunning views of beautiful Boston.
I find it somewhat disappointing that medRxiv does not accommodate the use of the "ö" in my surname and instead only allows the internationalized spelling.
July 21, 2025 at 3:42 PM
I find it somewhat disappointing that medRxiv does not accommodate the use of the "ö" in my surname and instead only allows the internationalized spelling.
Reposted by Kira Höffler
Dieses Spiel werden die Beteiligten und Fans vorm Fernseher so schnell nicht vergessen. Drei Stunden komplett aufreibender Fußball. #FRAGER
July 19, 2025 at 10:03 PM
Dieses Spiel werden die Beteiligten und Fans vorm Fernseher so schnell nicht vergessen. Drei Stunden komplett aufreibender Fußball. #FRAGER
Reposted by Kira Höffler
After more than 7 years working on it, I’ve just submitted the manuscript for Discovering Statistics using R second edition. Tonnes more work on website/package and so on, but getting to this stage is monumental psychologically. It’s the book I feared I’d never finish.
July 4, 2025 at 6:50 PM
After more than 7 years working on it, I’ve just submitted the manuscript for Discovering Statistics using R second edition. Tonnes more work on website/package and so on, but getting to this stage is monumental psychologically. It’s the book I feared I’d never finish.
Reposted by Kira Höffler
Und ich dachte bislang immer, #CSD und #Regenbogenfahnen stünden für die demokratische Tradition der Kämpfe um Anerkennung jener Rechte, die letztlich das Grundgesetz allen verspricht: Freiheit und Gleichheit und Unantastbarkeit der Würde.
June 23, 2025 at 1:18 PM
Und ich dachte bislang immer, #CSD und #Regenbogenfahnen stünden für die demokratische Tradition der Kämpfe um Anerkennung jener Rechte, die letztlich das Grundgesetz allen verspricht: Freiheit und Gleichheit und Unantastbarkeit der Würde.
I got to meet Jacinda Ardern, my favourite politician and former Prime Minister of New Zealand, today. Just for that, moving to Boston was worth it. 😊
June 1, 2025 at 10:14 PM
I got to meet Jacinda Ardern, my favourite politician and former Prime Minister of New Zealand, today. Just for that, moving to Boston was worth it. 😊
Reposted by Kira Höffler
Women make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40% #womeninSTEM
We want to change it, through targeted editorial policies & outreach. But change will take everyone!
🧪
www.nature.com/articles/d41...
We want to change it, through targeted editorial policies & outreach. But change will take everyone!
🧪
www.nature.com/articles/d41...
Gender equality in research publishing is a responsibility for everyone
A concerted effort is needed to support women in their choice of journal when submitting their manuscript.
www.nature.com
May 31, 2025 at 4:31 AM
Women make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40% #womeninSTEM
We want to change it, through targeted editorial policies & outreach. But change will take everyone!
🧪
www.nature.com/articles/d41...
We want to change it, through targeted editorial policies & outreach. But change will take everyone!
🧪
www.nature.com/articles/d41...
Reposted by Kira Höffler
Another breakthrough made possible by federal funding The result “is a triumph for the American peoples’ investment in biomedical research”
Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...
Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...
Baby Is Healed With World’s First Personalized Gene-Editing Treatment
www.nytimes.com
May 15, 2025 at 9:47 PM
Another breakthrough made possible by federal funding The result “is a triumph for the American peoples’ investment in biomedical research”
Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...
Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...
Reposted by Kira Höffler
Check out our new OCD GWAS (53,660 cases and 2,044,417 controls) in @natgenet.nature.com 🧬🧠
Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.
Open access: www.nature.com/articles/s41...
Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.
Open access: www.nature.com/articles/s41...
May 13, 2025 at 1:25 PM
Check out our new OCD GWAS (53,660 cases and 2,044,417 controls) in @natgenet.nature.com 🧬🧠
Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.
Open access: www.nature.com/articles/s41...
Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.
Open access: www.nature.com/articles/s41...
Reposted by Kira Höffler
Margot Friedländer. So eine große Persönlichkeit. Bin traurig.
May 9, 2025 at 7:03 PM
Margot Friedländer. So eine große Persönlichkeit. Bin traurig.
Reposted by Kira Höffler
Big news for health data research and population diversity: The Mexico City Prospective Study data are now available securely to approved researchers worldwide. www.ndph.ox.ac.uk/news/latin-a...
Cohort description: www.ctsu.ox.ac.uk/research/pro...
Cohort description: www.ctsu.ox.ac.uk/research/pro...
Latin-American genetic data available securely to approved researchers worldwide/Datos genéticos latinoamericanos disponibles para investigadores de todo el mundo
www.ndph.ox.ac.uk
May 2, 2025 at 9:05 AM
Big news for health data research and population diversity: The Mexico City Prospective Study data are now available securely to approved researchers worldwide. www.ndph.ox.ac.uk/news/latin-a...
Cohort description: www.ctsu.ox.ac.uk/research/pro...
Cohort description: www.ctsu.ox.ac.uk/research/pro...
Reposted by Kira Höffler
Bioconductor 3.21 released with 72 new software packages, for a total of 2341 software packages, 432 experiment data packages, 928 annotation packages, 30 workflows and 5 books bioconductor.org/news/bioc_3_... 🧬🖥️🧪 #Rstats
Bioconductor - Bioconductor 3.21 Released
The Bioconductor project aims to develop and share open source software for precise and repeatable analysis of biological data. We foster an inclusive and collaborative community of developers and…
bioconductor.org
April 16, 2025 at 6:30 PM
Bioconductor 3.21 released with 72 new software packages, for a total of 2341 software packages, 432 experiment data packages, 928 annotation packages, 30 workflows and 5 books bioconductor.org/news/bioc_3_... 🧬🖥️🧪 #Rstats
Reposted by Kira Höffler
Do adult blood-trained epigenetic measures generalize to child saliva? What does this mean for psychiatric epigenetics? Come find out and talk to me at poster S193 - now with new cross-tissue epigenome-wide results! #SOBP2025
April 26, 2025 at 2:30 PM
Do adult blood-trained epigenetic measures generalize to child saliva? What does this mean for psychiatric epigenetics? Come find out and talk to me at poster S193 - now with new cross-tissue epigenome-wide results! #SOBP2025
