Biological Psychiatry
@biologicalpsych.bsky.social
Official account for the Biological Psychiatry family of journals.
Publishing cutting-edge research in psychiatric neuroscience, cognitive neuroimaging, and global open science.
Publishing cutting-edge research in psychiatric neuroscience, cognitive neuroimaging, and global open science.
Reposted by Biological Psychiatry
🧠 We're hiring! 🧠 Are you passionate about neuroscience and education? Join our faculty at UNC Chapel Hill to inspire and teach the next generation of neuroscientists. Apply now: 🔗https://unc.peopleadmin.com/postings/308455
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
December 9, 2025 at 7:20 PM
🧠 We're hiring! 🧠 Are you passionate about neuroscience and education? Join our faculty at UNC Chapel Hill to inspire and teach the next generation of neuroscientists. Apply now: 🔗https://unc.peopleadmin.com/postings/308455
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
Reposted by Biological Psychiatry
📣We have 2 open faculty positions for senior researchers in Neuroscience at Queen's University!
healthsci.queensu.ca/administrati...
1. a new Director for our Centre for Neuroscience Studies
2. a non-human primate NeuroAI researcher
Please share widely and reach out for questions!
healthsci.queensu.ca/administrati...
1. a new Director for our Centre for Neuroscience Studies
2. a non-human primate NeuroAI researcher
Please share widely and reach out for questions!
Administrative Opportunities
healthsci.queensu.ca
December 9, 2025 at 6:55 PM
📣We have 2 open faculty positions for senior researchers in Neuroscience at Queen's University!
healthsci.queensu.ca/administrati...
1. a new Director for our Centre for Neuroscience Studies
2. a non-human primate NeuroAI researcher
Please share widely and reach out for questions!
healthsci.queensu.ca/administrati...
1. a new Director for our Centre for Neuroscience Studies
2. a non-human primate NeuroAI researcher
Please share widely and reach out for questions!
How can we leverage dynamic analytic approaches to describe brain activity patterns over time 🧠, infer causal mechanisms ➡️, decode latent dynamics 🕰️, and simulate complex neural processes 🤖? And how can these approaches provide insights into psychiatric illnesses 💡?
How to Probe Dynamics of Brain Function: A Narrative Review
The brain is the quintessential complex dynamic system. Static analytic approaches—such as time-averaged connectivity or correlations—remain widely used but cannot characterize dynamic processes that…
www.biologicalpsychiatryjournal.com
December 9, 2025 at 1:01 PM
How can we leverage dynamic analytic approaches to describe brain activity patterns over time 🧠, infer causal mechanisms ➡️, decode latent dynamics 🕰️, and simulate complex neural processes 🤖? And how can these approaches provide insights into psychiatric illnesses 💡?
What role does μ-opioid system 🧠 play in the atypical functional connectivity 🕸️ of the sensorimotor network in autism?
μ-Opioid Modulation of Sensorimotor Functional Connectivity in Autism: Insights from a Pharmacological Neuroimaging Investigation using Tianeptine
Reproducible patterns of atypical functional connectivity of sensorimotor and higher-order networks have been previously identified in the autistic brain. However, the neurosignalling pathways…
www.bpsgos.org
December 8, 2025 at 4:02 PM
What role does μ-opioid system 🧠 play in the atypical functional connectivity 🕸️ of the sensorimotor network in autism?
How does posterior cerebellar activation 🧠⚡ during executive functioning 💡 relate to general psychopathology 😔, and do these functional alterations ↔️ reflect inefficient information processing?
Cerebellar Functional Alterations during Executive Functioning are Associated with General Psychopathology in a Cross-Diagnostic Sample
Accumulating evidence points to the cerebellum’s role in executive functioning (EF) and transdiagnostic psychopathology. A general psychopathology ‘p-factor,’ capturing shared variation across mental…
www.biologicalpsychiatrycnni.org
December 8, 2025 at 1:02 PM
How does posterior cerebellar activation 🧠⚡ during executive functioning 💡 relate to general psychopathology 😔, and do these functional alterations ↔️ reflect inefficient information processing?
Can fMRI-based neurofunctional models 🧠💻 of empathic fear and subjective fear reveal distinct neural signatures ↔️ that can differentiate between anxiety and depression?
Neural patterns for empathic versus subjective fear in classifying between generalized anxiety disorder and major depressive disorder
Fear processing is multifaceted, involving dissociable neural and computational pathways that vary depending on its source and context. Yet, modality-specific fear processing, such as empathic versus…
www.biologicalpsychiatrycnni.org
December 7, 2025 at 4:01 PM
Can fMRI-based neurofunctional models 🧠💻 of empathic fear and subjective fear reveal distinct neural signatures ↔️ that can differentiate between anxiety and depression?
How do ketamine's 💊 actions on opioid and glutamatergic systems 🧠 explain its role as both a therapeutic agent ✨ and a substance with misuse potential ⚠️?
Bifunctional modulation of NMDA and opioid receptors in ketamine reinforcement and misuse: implications for substance use disorder treatment
Certain medications carry a risk by providing therapeutic benefits at the expense of misuse potential. Ketamine is being used with increasing prevalence for the treatment of depression and studies…
www.biologicalpsychiatryjournal.com
December 7, 2025 at 1:00 PM
How do ketamine's 💊 actions on opioid and glutamatergic systems 🧠 explain its role as both a therapeutic agent ✨ and a substance with misuse potential ⚠️?
Reposted by Biological Psychiatry
Excited to see this paper out in Biological Psychiatry! It highlights that emotional pain and fear represent distinct PTSD dimensions, leading us closer to identifying PTSD subtypes with dissociable biological underpinnings. Congrats on leading the charge on this cool study @zivbenzion.bsky.social
Dissecting Fear and Emotional Pain in PTSD: From Symptom Networks to Neural Signatures
Posttraumatic stress disorder (PTSD) is a heterogeneous condition with diverse symptom presentations and emotional experiences. While fear is traditio…
www.sciencedirect.com
December 2, 2025 at 4:03 PM
Excited to see this paper out in Biological Psychiatry! It highlights that emotional pain and fear represent distinct PTSD dimensions, leading us closer to identifying PTSD subtypes with dissociable biological underpinnings. Congrats on leading the charge on this cool study @zivbenzion.bsky.social
How do advanced EEG methods 〰️ identify the distinct brain mechanisms that underlie learning impairments 📚 across various psychopathologies 😔, especially in working memory and reinforcement learning 🔄?
Model-based EEG phenotyping uncovers distinct neurocomputational mechanisms underlying learning impairments across psychopathologies
Major depressive disorder (MDD), bipolar disorder (BP), and schizophrenia (SCZ) involve learning impairments with poorly understood mechanisms. Understanding both the similarities and differences in…
www.bpsgos.org
December 6, 2025 at 4:01 PM
How do advanced EEG methods 〰️ identify the distinct brain mechanisms that underlie learning impairments 📚 across various psychopathologies 😔, especially in working memory and reinforcement learning 🔄?
Reposted by Biological Psychiatry
The Two Faces of #PTSD: Fear vs. Emotional Pain. Our new research in Biological Psychiatry @biologicalpsych.bsky.social identifies distinct clinical & neural profiles.
AI says no one reads long papers, so we made an infographic!👇
Full Paper (for the insistents😉): doi.org/10.1016/j.bi...
AI says no one reads long papers, so we made an infographic!👇
Full Paper (for the insistents😉): doi.org/10.1016/j.bi...
December 6, 2025 at 11:35 AM
The Two Faces of #PTSD: Fear vs. Emotional Pain. Our new research in Biological Psychiatry @biologicalpsych.bsky.social identifies distinct clinical & neural profiles.
AI says no one reads long papers, so we made an infographic!👇
Full Paper (for the insistents😉): doi.org/10.1016/j.bi...
AI says no one reads long papers, so we made an infographic!👇
Full Paper (for the insistents😉): doi.org/10.1016/j.bi...
How is functional brain activity 🧠 correlated 🔗 with intermittent rhythmic delta/theta EEG activity 〰️, and how does this correlation vary across healthy individuals and transdiagnostic psychiatric groups?
Functional brain activity associated with intermittent rhythmic delta/theta activity: A transdiagnostic EEG-fMRI resting state study
Intermittent rhythmic delta/theta electroencephalographic (EEG) activity (IRDA/IRTA) has been implicated in the pathophysiology of neuropsychiatric illnesses. Therefore, a combined EEG and functional…
www.bpsgos.org
December 6, 2025 at 1:01 PM
How is functional brain activity 🧠 correlated 🔗 with intermittent rhythmic delta/theta EEG activity 〰️, and how does this correlation vary across healthy individuals and transdiagnostic psychiatric groups?
What white matter 🧠🕸️ microstructure alterations ↔️ are found in social anxiety disorder 😬 and how do these vary by age 👶👩🧓 and sex ♀️♂️?
White matter microstructure alterations in social anxiety disorder – a mega-analysis across 12 cohorts in the ENIGMA-Anxiety Working Group
Studies investigating social anxiety disorder (SAD) have reported inconsistent alterations in white matter (WM) microstructure. The ENIGMA-Anxiety Working Group investigated differences in…
www.biologicalpsychiatrycnni.org
December 5, 2025 at 4:02 PM
What white matter 🧠🕸️ microstructure alterations ↔️ are found in social anxiety disorder 😬 and how do these vary by age 👶👩🧓 and sex ♀️♂️?
How does the relationship between synaptic density 🔗 and cortical microstructure 🧠 differ in healthy subjects, schizophrenia spectrum disorder patients, and their unaffected siblings?
Relationship between synaptic density and cortical (micro)structure in healthy subjects, patients with schizophrenia spectrum disorder and unaffected siblings: a multimodal [11C]UCB-J PET and MRI study
The structure and tissue composition of the cortex may be sensitive to loss of synapses. However, the relation between measurements of synaptic density, cortical thickness and microstructure remains…
www.biologicalpsychiatrycnni.org
December 5, 2025 at 1:01 PM
How does the relationship between synaptic density 🔗 and cortical microstructure 🧠 differ in healthy subjects, schizophrenia spectrum disorder patients, and their unaffected siblings?
How effective is accelerated repeated TMS 🧠⚡ across symptom domains of neuropsychiatric disorders 😔, and how do sex ♂️♀️ and dose 🎚️ influence its outcomes?
Domain-Specific Efficacy of Accelerated Repetitive Transcranial Magnetic Stimulation in Neuropsychiatric Disorders: A Systematic Review and Meta-Analysis
Accelerated repetitive transcranial magnetic stimulation (arTMS; ≥2 sessions/day) delivers high neuromodulatory doses over compressed timelines. It is increasingly used to target circuit-level…
www.biologicalpsychiatryjournal.com
December 4, 2025 at 4:01 PM
How effective is accelerated repeated TMS 🧠⚡ across symptom domains of neuropsychiatric disorders 😔, and how do sex ♂️♀️ and dose 🎚️ influence its outcomes?
Are fear 😱 and emotional pain 💔 characterized by shared or unique symptom networks 🕸️ and neural signatures 🧠 in PTSD?
Dissecting Fear and Emotional Pain in PTSD: From Symptom Networks to Neural Signatures
Posttraumatic stress disorder (PTSD) is a heterogeneous condition with diverse symptom presentations and emotional experiences. While fear is traditionally viewed as central, growing evidence…
www.biologicalpsychiatryjournal.com
December 4, 2025 at 1:02 PM
Are fear 😱 and emotional pain 💔 characterized by shared or unique symptom networks 🕸️ and neural signatures 🧠 in PTSD?
How do parabrachial nucleus 🧠 neurons relay threat ⚠️ information to ventral tegmental area dopamine neurons to influence long-term aversive memory 🤔 ?
Ventral Tegmental Area dopamine neurons regulated by Parabrachial Nucleus mediate long-term aversive memory
Ventral Tegmental Area (VTA) dopamine neurons are intermixed with glutamate and GABA neurons, which had been implicated in aversion. While it is unclear the neuronal circuitry involved in regulation…
www.biologicalpsychiatryjournal.com
December 3, 2025 at 4:00 PM
How do parabrachial nucleus 🧠 neurons relay threat ⚠️ information to ventral tegmental area dopamine neurons to influence long-term aversive memory 🤔 ?
Paper mills 🏭, citation cartels 🤝, coercive citation practices ⛓️, fake reviewers 🎭, and AI-generated papers 🤖 challenge scientific integrity.
Learn more about what we're doing in our journals to address this.
Learn more about what we're doing in our journals to address this.
Biological Psychiatry: Addressing new challenges to scientific integrity including paper mills, citation cartels, coercive citation practices, fake reviewers, and AI-generated papers
Preserving the scientific integrity of papers published in the family of Biological Psychiatry journals has never been more important and more challenging. Real papers from real authors based on real…
www.biologicalpsychiatryjournal.com
December 3, 2025 at 1:50 PM
Paper mills 🏭, citation cartels 🤝, coercive citation practices ⛓️, fake reviewers 🎭, and AI-generated papers 🤖 challenge scientific integrity.
Learn more about what we're doing in our journals to address this.
Learn more about what we're doing in our journals to address this.
📣 Our latest Special Issue is now out! 📣
Exploring Sleep Alterations in Severe Mental Disorders: Converging Evidence From Basic, Translational, and Clinical Research was edited by Armando D’Agostino, Anna Castelnovo, Giulio Tononi, and Fabio Ferrarelli.
💤 🧠 🧬
Learn more about what's in the issue ⬇️
Exploring Sleep Alterations in Severe Mental Disorders: Converging Evidence From Basic, Translational, and Clinical Research was edited by Armando D’Agostino, Anna Castelnovo, Giulio Tononi, and Fabio Ferrarelli.
💤 🧠 🧬
Learn more about what's in the issue ⬇️
Current Issue Table of Contents: Biological Psychiatry
buff.ly
December 1, 2025 at 11:30 AM
📣 Our latest Special Issue is now out! 📣
Exploring Sleep Alterations in Severe Mental Disorders: Converging Evidence From Basic, Translational, and Clinical Research was edited by Armando D’Agostino, Anna Castelnovo, Giulio Tononi, and Fabio Ferrarelli.
💤 🧠 🧬
Learn more about what's in the issue ⬇️
Exploring Sleep Alterations in Severe Mental Disorders: Converging Evidence From Basic, Translational, and Clinical Research was edited by Armando D’Agostino, Anna Castelnovo, Giulio Tononi, and Fabio Ferrarelli.
💤 🧠 🧬
Learn more about what's in the issue ⬇️
How are advanced PET imaging biomarkers 🔬 enhancing our ability to study neuroimmune dynamics 🧠🛡️ in psychiatric illness 😔 to refine diagnostics 🩺 and discover new therapies ✨?
Find out here 👇
Find out here 👇
Imaging Neuroimmune Dysfunction: From TSPO to Emerging PET Targets
Dysregulation of the neuroimmune system is increasingly recognized as a key contributor to psychiatric illness, yet its complexity and the limitations of current methodologies have hindered a clear…
www.biologicalpsychiatryjournal.com
November 28, 2025 at 1:01 PM
How are advanced PET imaging biomarkers 🔬 enhancing our ability to study neuroimmune dynamics 🧠🛡️ in psychiatric illness 😔 to refine diagnostics 🩺 and discover new therapies ✨?
Find out here 👇
Find out here 👇
What role do the pituitary adenylate cyclase activating polypeptide 🧬 connections play in the pathway from the bed nucleus of the stria terminalis to the dorsal medial habenula 🧠➡️🧠 to mediate depression-like behaviors 😔 after chronic stress?
Learn more here 👇
Learn more here 👇
BNST PACAP signaling in the dorsal medial habenula mediates depression- related behavioral responses after chronic stress
Hallmark behaviors associated with depression-related disorders include reduction in reward responsivity and increased despair. However, the neurocircuits and mechanisms underlying reward responding…
www.biologicalpsychiatryjournal.com
November 27, 2025 at 4:02 PM
What role do the pituitary adenylate cyclase activating polypeptide 🧬 connections play in the pathway from the bed nucleus of the stria terminalis to the dorsal medial habenula 🧠➡️🧠 to mediate depression-like behaviors 😔 after chronic stress?
Learn more here 👇
Learn more here 👇
What have clinical trials 🧪 revealed about optimizing 📈 the use of immunomodulatory drugs 💊 for psychiatric disorders 🧠?
Find out here 👇
Find out here 👇
Lessons from clinical trials of immunomodulatory drugs in psychiatric disorders
Immune dysregulation has been implicated in the pathophysiology of psychiatric disorders, with peripheral inflammatory markers correlating with symptom severity, treatment refractoriness, and neural…
www.biologicalpsychiatryjournal.com
November 27, 2025 at 1:02 PM
What have clinical trials 🧪 revealed about optimizing 📈 the use of immunomodulatory drugs 💊 for psychiatric disorders 🧠?
Find out here 👇
Find out here 👇
Can studying white matter network 🕸️ disruption in Multiple Sclerosis advance our understanding of depression's 😔 pathophysiology?
Learn more here ⬇️
Learn more here ⬇️
Depression as a disease of white matter network disruption: Learning from Multiple Sclerosis
Depression is a common and debilitating psychiatric disorder that is associated with substantial morbidity and mortality. For nearly 40 years, scientists have attempted to localize depression in the…
www.biologicalpsychiatryjournal.com
November 26, 2025 at 4:03 PM
Can studying white matter network 🕸️ disruption in Multiple Sclerosis advance our understanding of depression's 😔 pathophysiology?
Learn more here ⬇️
Learn more here ⬇️
How are methamphetamine-induced 💊 changes ↔️ in functional brain connectivity patterns 🧠🔗 linked to attention 🎯 and arousal ⚡?
Find out here ⬇️
Find out here ⬇️
Methamphetamine modulates functional connectivity signatures of sustained attention and arousal
Between-subjects studies suggest that psychostimulants can shift whole-brain functional connectivity toward patterns linked to heightened sustained attention. In this study, we examined how a single…
www.biologicalpsychiatrycnni.org
November 26, 2025 at 1:01 PM
How are methamphetamine-induced 💊 changes ↔️ in functional brain connectivity patterns 🧠🔗 linked to attention 🎯 and arousal ⚡?
Find out here ⬇️
Find out here ⬇️
How do altered brain network 🧠 co-activation 🤝 patterns relate to clinical symptoms 🏥 in major depressive disorder 😞 ?
Find out here 👇
Find out here 👇
Synergistic Co-Activation Probabilities of Large-Scale Resting State Networks in Major Depressive Disorder
Major depressive disorder (MDD) involves subtle, distributed alterations across multiple large-scale resting-state brain networks (RSNs), highlighting the need for integrative approaches to uncover…
www.biologicalpsychiatrycnni.org
November 25, 2025 at 4:01 PM
How do altered brain network 🧠 co-activation 🤝 patterns relate to clinical symptoms 🏥 in major depressive disorder 😞 ?
Find out here 👇
Find out here 👇
How do mood and psychotic disorders differentially affect effort-cost decision-making 💪💰 and how is that related to subjective value representation ⭐?
Learn more here 👇
Learn more here 👇
Understanding Effort-Cost Decision-Making Mechanisms in Mood and Psychotic Disorders: A Computational Modeling Approach Across Physical and Cognitive Effort Paradigms
Effort-cost decision-making (ECDM) is a core component of motivational deficits across diagnostic boundaries, yet mechanisms underlying ECDM deficits are not yet fully understood. Importantly,…
www.biologicalpsychiatrycnni.org
November 25, 2025 at 1:00 PM
How do mood and psychotic disorders differentially affect effort-cost decision-making 💪💰 and how is that related to subjective value representation ⭐?
Learn more here 👇
Learn more here 👇