Neural mechanisms underlying flexible learning and decision-making are not fully understood. Using single-cell calcium imaging, authors here found that neurons in orbitofrontal and secondary motor cortex exhibit complementary roles in reward learning, with neurons in the former exerting a sustained role in conditions of uncertainty.

Background: In 2023, the World Health Organization declared that there is no safe amount of alcohol consumption. It is becoming increasingly clear that even at lower doses, ethanol exposure impacts bo...

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