Lab on a Chip
@labonachip.rsc.org
The leading miniaturization journal for engineers, chemists, biologists, bioengineers, biomedical scientists, physicists, materials scientists, and more
Published by @rsc.org 🌐 Website: rsc.li/labonachip
Published by @rsc.org 🌐 Website: rsc.li/labonachip
Available to read via #OpenAccess:
pubs.rsc.org/en/content/a...
Accelerated maturation of branched organoids confined in collagen droplets
Andreas R. Bausch et al
pubs.rsc.org/en/content/a...
Accelerated maturation of branched organoids confined in collagen droplets
Andreas R. Bausch et al
November 26, 2025 at 7:38 AM
Available to read via #OpenAccess:
pubs.rsc.org/en/content/a...
Accelerated maturation of branched organoids confined in collagen droplets
Andreas R. Bausch et al
pubs.rsc.org/en/content/a...
Accelerated maturation of branched organoids confined in collagen droplets
Andreas R. Bausch et al
On the inside back cover of issue 23 of Lab on a Chip:
Size-independent and automated single-colony-resolution microdroplet dispensing.
#OpenAccess from Arum Han et al @tamu.bsky.social
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Size-independent and automated single-colony-resolution microdroplet dispensing.
#OpenAccess from Arum Han et al @tamu.bsky.social
Read now:
pubs.rsc.org/en/content/a...
November 21, 2025 at 4:19 PM
On the inside back cover of issue 23 of Lab on a Chip:
Size-independent and automated single-colony-resolution microdroplet dispensing.
#OpenAccess from Arum Han et al @tamu.bsky.social
Read now:
pubs.rsc.org/en/content/a...
Size-independent and automated single-colony-resolution microdroplet dispensing.
#OpenAccess from Arum Han et al @tamu.bsky.social
Read now:
pubs.rsc.org/en/content/a...
On the back cover of issue 23 of Lab on a Chip:
Droplet-based cell viability assay for analysis of spheroid formation, proliferation and high-resolution IC50 profiling.
#OpenAccess from Mario Saupe et al.
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pubs.rsc.org/en/content/a...
Droplet-based cell viability assay for analysis of spheroid formation, proliferation and high-resolution IC50 profiling.
#OpenAccess from Mario Saupe et al.
Read now:
pubs.rsc.org/en/content/a...
November 21, 2025 at 10:04 AM
On the back cover of issue 23 of Lab on a Chip:
Droplet-based cell viability assay for analysis of spheroid formation, proliferation and high-resolution IC50 profiling.
#OpenAccess from Mario Saupe et al.
Read now:
pubs.rsc.org/en/content/a...
Droplet-based cell viability assay for analysis of spheroid formation, proliferation and high-resolution IC50 profiling.
#OpenAccess from Mario Saupe et al.
Read now:
pubs.rsc.org/en/content/a...
In the latest issue of Lab on a Chip:
Behaviorome profiling of anti-tumor and pro-tumor human neutrophil subtypes in a microphysiological system.
#OpenAccess from Caroline N. Jones et al.
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pubs.rsc.org/en/content/a...
Behaviorome profiling of anti-tumor and pro-tumor human neutrophil subtypes in a microphysiological system.
#OpenAccess from Caroline N. Jones et al.
Read now:
pubs.rsc.org/en/content/a...
Behaviorome profiling of anti-tumor and pro-tumor human neutrophil subtypes in a microphysiological system
Neutrophils exhibit a paradoxical role in cancer, either combating the tumor or facilitating its progression. Studies in mice have shown that polarizing neutrophils from a pro-tumor “N2” phenotype to ...
pubs.rsc.org
November 20, 2025 at 4:42 PM
In the latest issue of Lab on a Chip:
Behaviorome profiling of anti-tumor and pro-tumor human neutrophil subtypes in a microphysiological system.
#OpenAccess from Caroline N. Jones et al.
Read now:
pubs.rsc.org/en/content/a...
Behaviorome profiling of anti-tumor and pro-tumor human neutrophil subtypes in a microphysiological system.
#OpenAccess from Caroline N. Jones et al.
Read now:
pubs.rsc.org/en/content/a...
In the latest issue of Lab on a Chip:
Endothelial-smooth muscle microgauges for modeling pulmonary arterial vasoregulation.
#OpenAccess from William J. Polacheck et al.
Read now: pubs.rsc.org/en/content/a...
Endothelial-smooth muscle microgauges for modeling pulmonary arterial vasoregulation.
#OpenAccess from William J. Polacheck et al.
Read now: pubs.rsc.org/en/content/a...
Endothelial-smooth muscle microgauges for modeling pulmonary arterial vasoregulation
Pulmonary arterial hypertension (PAH) is a devastating disease for which there is no cure. The pathogenesis of PAH involves endothelial dysfunction and dysregulation of vascular tone, resulting in pro...
pubs.rsc.org
November 20, 2025 at 1:17 PM
In the latest issue of Lab on a Chip:
Endothelial-smooth muscle microgauges for modeling pulmonary arterial vasoregulation.
#OpenAccess from William J. Polacheck et al.
Read now: pubs.rsc.org/en/content/a...
Endothelial-smooth muscle microgauges for modeling pulmonary arterial vasoregulation.
#OpenAccess from William J. Polacheck et al.
Read now: pubs.rsc.org/en/content/a...
On the inside front cover of issue 23 of Lab on a Chip:
Present and future of smart functional materials as actuators in microfluidic devices.
Lourdes Basabe-Desmonts, Fernando Benito-Lopez et al.
pubs.rsc.org/en/content/a...
Present and future of smart functional materials as actuators in microfluidic devices.
Lourdes Basabe-Desmonts, Fernando Benito-Lopez et al.
pubs.rsc.org/en/content/a...
November 20, 2025 at 10:37 AM
On the inside front cover of issue 23 of Lab on a Chip:
Present and future of smart functional materials as actuators in microfluidic devices.
Lourdes Basabe-Desmonts, Fernando Benito-Lopez et al.
pubs.rsc.org/en/content/a...
Present and future of smart functional materials as actuators in microfluidic devices.
Lourdes Basabe-Desmonts, Fernando Benito-Lopez et al.
pubs.rsc.org/en/content/a...
Reposted by Lab on a Chip
Sol–gel coating-derived liquid marbles as highly efficient micro-photobioreactors for cyanobacterial cultivation pubs.rsc.org/en/content/a...
Sol–gel coating-derived liquid marbles as highly efficient micro-photobioreactors for cyanobacterial cultivation
Monolayer nanoparticle-covered liquid marbles (mNPc LMs), fabricated using a sol–gel SiO2 coating as the particle source, were developed as micro-photobioreactors (PBRs) for high-efficiency cyanobacte...
pubs.rsc.org
November 19, 2025 at 8:58 AM
Sol–gel coating-derived liquid marbles as highly efficient micro-photobioreactors for cyanobacterial cultivation pubs.rsc.org/en/content/a...
On the front cover of issue 23 of Lab on a Chip:
Mechanical actuation on surface (MAOS) microfluidics: compression for preparation in next-generation sequencing.
Mais J. Jebrail et al.
pubs.rsc.org/en/content/a...
Mechanical actuation on surface (MAOS) microfluidics: compression for preparation in next-generation sequencing.
Mais J. Jebrail et al.
pubs.rsc.org/en/content/a...
November 19, 2025 at 9:14 AM
On the front cover of issue 23 of Lab on a Chip:
Mechanical actuation on surface (MAOS) microfluidics: compression for preparation in next-generation sequencing.
Mais J. Jebrail et al.
pubs.rsc.org/en/content/a...
Mechanical actuation on surface (MAOS) microfluidics: compression for preparation in next-generation sequencing.
Mais J. Jebrail et al.
pubs.rsc.org/en/content/a...
Available to read now via #OpenAccess.
pubs.rsc.org/en/content/a...
Benchmarking microfluidic and immunomagnetic platforms for isolating circulating tumor cells in pancreatic cancer
Ian Papautsky, Gina Votta-Velis et al
pubs.rsc.org/en/content/a...
Benchmarking microfluidic and immunomagnetic platforms for isolating circulating tumor cells in pancreatic cancer
Ian Papautsky, Gina Votta-Velis et al
A microfluidic device has demonstrated high efficiency in isolating circulating tumor cells from blood samples, offering potential for earlier detection and improved monitoring of pancreatic cancer. doi.org/g9989x
Microfluidic device captures pancreatic cancer's 'seeds of metastasis'
Pinned between the stomach and spine, the pancreas supervises both digestion and blood sugar in the body. It's also the site of an aggressive cancer called pancreatic ductal adenocarcinoma, or PDAC.
medicalxpress.com
November 14, 2025 at 8:42 AM
Available to read now via #OpenAccess.
pubs.rsc.org/en/content/a...
Benchmarking microfluidic and immunomagnetic platforms for isolating circulating tumor cells in pancreatic cancer
Ian Papautsky, Gina Votta-Velis et al
pubs.rsc.org/en/content/a...
Benchmarking microfluidic and immunomagnetic platforms for isolating circulating tumor cells in pancreatic cancer
Ian Papautsky, Gina Votta-Velis et al
Reposted by Lab on a Chip
A new U of T #DentalFacultyPub! Microengineered diabetic wound-on-a-chip model for emulating chronic wound dynamics
Microengineered diabetic wound-on-a-chip model for emulating chronic wound dynamics - PubMed
Diabetic wounds, which affect 19-34% of individuals with diabetes mellitus, remain a serious complication due to their chronic, non-healing nature and high risk of limb amputation. Traditional 2D…
pubmed.ncbi.nlm.nih.gov
November 10, 2025 at 6:30 PM
A new U of T #DentalFacultyPub! Microengineered diabetic wound-on-a-chip model for emulating chronic wound dynamics
On the inside back cover of issue 22 of Lab on a Chip:
Trapping nanoscale particles via quasi-Scholte mode in acoustofluidics.
#OpenAccess from Feiyan Cai, Jianjian Wang, Yongqing Fu et al.
Read now: pubs.rsc.org/en/content/a...
Trapping nanoscale particles via quasi-Scholte mode in acoustofluidics.
#OpenAccess from Feiyan Cai, Jianjian Wang, Yongqing Fu et al.
Read now: pubs.rsc.org/en/content/a...
November 6, 2025 at 1:22 PM
On the inside back cover of issue 22 of Lab on a Chip:
Trapping nanoscale particles via quasi-Scholte mode in acoustofluidics.
#OpenAccess from Feiyan Cai, Jianjian Wang, Yongqing Fu et al.
Read now: pubs.rsc.org/en/content/a...
Trapping nanoscale particles via quasi-Scholte mode in acoustofluidics.
#OpenAccess from Feiyan Cai, Jianjian Wang, Yongqing Fu et al.
Read now: pubs.rsc.org/en/content/a...
On the back cover of issue 22 of Lab on a Chip:
Modular RCA-CRISPR/Cas12a amplification on a multi-volume SlipChip for ultrafast, single-copy quantification of circRNA and miRNA in ovarian cancer.
Jun Yang, Zaian Deng et al.
pubs.rsc.org/en/content/a...
Modular RCA-CRISPR/Cas12a amplification on a multi-volume SlipChip for ultrafast, single-copy quantification of circRNA and miRNA in ovarian cancer.
Jun Yang, Zaian Deng et al.
pubs.rsc.org/en/content/a...
November 6, 2025 at 1:08 PM
On the back cover of issue 22 of Lab on a Chip:
Modular RCA-CRISPR/Cas12a amplification on a multi-volume SlipChip for ultrafast, single-copy quantification of circRNA and miRNA in ovarian cancer.
Jun Yang, Zaian Deng et al.
pubs.rsc.org/en/content/a...
Modular RCA-CRISPR/Cas12a amplification on a multi-volume SlipChip for ultrafast, single-copy quantification of circRNA and miRNA in ovarian cancer.
Jun Yang, Zaian Deng et al.
pubs.rsc.org/en/content/a...
On the inside front cover of issue 22 of Lab on a Chip:
High-throughput impedance monitoring in 3D tumor cultures: a multiplex, microfluidic-free platform for drug screening.
#OpenAccess from Gianni Ciofani, Attilio Marino, Kamil Ziaja et al
@iitalk.bsky.social pubs.rsc.org/en/content/a...
High-throughput impedance monitoring in 3D tumor cultures: a multiplex, microfluidic-free platform for drug screening.
#OpenAccess from Gianni Ciofani, Attilio Marino, Kamil Ziaja et al
@iitalk.bsky.social pubs.rsc.org/en/content/a...
November 5, 2025 at 2:42 PM
On the inside front cover of issue 22 of Lab on a Chip:
High-throughput impedance monitoring in 3D tumor cultures: a multiplex, microfluidic-free platform for drug screening.
#OpenAccess from Gianni Ciofani, Attilio Marino, Kamil Ziaja et al
@iitalk.bsky.social pubs.rsc.org/en/content/a...
High-throughput impedance monitoring in 3D tumor cultures: a multiplex, microfluidic-free platform for drug screening.
#OpenAccess from Gianni Ciofani, Attilio Marino, Kamil Ziaja et al
@iitalk.bsky.social pubs.rsc.org/en/content/a...
On the front cover of issue 22 of Lab on a Chip:
A review of microfluidic approaches for carbon capture and storage research.
#OpenAccess from Myeongsub Kim et al.
pubs.rsc.org/en/content/a... #!divAbstract
A review of microfluidic approaches for carbon capture and storage research.
#OpenAccess from Myeongsub Kim et al.
pubs.rsc.org/en/content/a... #!divAbstract
November 5, 2025 at 10:06 AM
On the front cover of issue 22 of Lab on a Chip:
A review of microfluidic approaches for carbon capture and storage research.
#OpenAccess from Myeongsub Kim et al.
pubs.rsc.org/en/content/a... #!divAbstract
A review of microfluidic approaches for carbon capture and storage research.
#OpenAccess from Myeongsub Kim et al.
pubs.rsc.org/en/content/a... #!divAbstract
Reposted by Lab on a Chip
microfabricated stamps, fresh off the printer :)
October 26, 2025 at 4:24 PM
microfabricated stamps, fresh off the printer :)
Reposted by Lab on a Chip
Reposted by Lab on a Chip
The @darpa.mil funded study also demonstrated that human organ chips are a more clinically relevant model for preclinical testing of crRNA therapeutics’ efficacy and safety.
In @labonachip.rsc.org:
pubs.rsc.org/en/content/a...
In @labonachip.rsc.org:
pubs.rsc.org/en/content/a...
Preclinical assessment of pan-influenza A virus CRISPR RNA therapeutics in a human lung alveolus chip
CRISPR technology offers an entirely new approach to therapeutic development because it can target specific nucleotide sequences with high specificity, however, preclinical animal models are not usefu...
pubs.rsc.org
October 29, 2025 at 11:41 PM
The @darpa.mil funded study also demonstrated that human organ chips are a more clinically relevant model for preclinical testing of crRNA therapeutics’ efficacy and safety.
In @labonachip.rsc.org:
pubs.rsc.org/en/content/a...
In @labonachip.rsc.org:
pubs.rsc.org/en/content/a...
Reposted by Lab on a Chip
To explore the use of CRISPR-Cas13 for developing influenza therapeutics, @wyssinstitute.bsky.social & @harvardmed.bsky.social scientists used a human lung chip infected with influenza A virus to evaluate the on-target and off-target effects of antiviral crRNA therapeutics. 🧪
![A quote in black text reads: “[C]rRNA and gene target interactions are so specific and sensitive that the efficacy of antiviral crRNA therapeutics targeting human IAVs or human gene sequences cannot be assessed in animal models. ... Second, off-target effects and potential toxicities of crRNAs cannot be analyzed in animal models because humans and animals share different genomes, anatomy, immune systems, and physiology.” Below the quote is the citation in a yellow rectangle: Man et al. (2025) DOI: 10.1039/D5LC00156K. The design of the graphic includes an orange background with a yellow quotation mark to the top left, and part of a dark orange oval and a lighter orange oval with see-through lines running through it, perpendicular to one another, at the top right and bottom left.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:in2pnzujy66a7qnesoxha6ar/bafkreifarfdpdw3i3ur7ydtlcpmj74xxbrsebul34f5hs2dimdzparzjly@jpeg)
October 29, 2025 at 11:41 PM
To explore the use of CRISPR-Cas13 for developing influenza therapeutics, @wyssinstitute.bsky.social & @harvardmed.bsky.social scientists used a human lung chip infected with influenza A virus to evaluate the on-target and off-target effects of antiviral crRNA therapeutics. 🧪
On the inside back cover of issue 21 of Lab on a Chip:
Kappa(κ)Chip: a modular microfluidic device for analyte screening using parallelized assays and a multiple shear rate approach.
#OpenAccess from Jose A. Wippold et al.
Read now: pubs.rsc.org/en/content/a...
Kappa(κ)Chip: a modular microfluidic device for analyte screening using parallelized assays and a multiple shear rate approach.
#OpenAccess from Jose A. Wippold et al.
Read now: pubs.rsc.org/en/content/a...
October 27, 2025 at 3:08 PM
On the inside back cover of issue 21 of Lab on a Chip:
Kappa(κ)Chip: a modular microfluidic device for analyte screening using parallelized assays and a multiple shear rate approach.
#OpenAccess from Jose A. Wippold et al.
Read now: pubs.rsc.org/en/content/a...
Kappa(κ)Chip: a modular microfluidic device for analyte screening using parallelized assays and a multiple shear rate approach.
#OpenAccess from Jose A. Wippold et al.
Read now: pubs.rsc.org/en/content/a...
Engineering a diagnostic platform based on a spatially resolved electrochemiluminescence immunoassay for low-plex biomarker detection at point-of-care: mild traumatic brain injury and cardiac applications.
#OpenAccess from Marc E. Pfeifer et al.
Read now: pubs.rsc.org/en/content/a...
#OpenAccess from Marc E. Pfeifer et al.
Read now: pubs.rsc.org/en/content/a...
October 27, 2025 at 1:21 PM
Engineering a diagnostic platform based on a spatially resolved electrochemiluminescence immunoassay for low-plex biomarker detection at point-of-care: mild traumatic brain injury and cardiac applications.
#OpenAccess from Marc E. Pfeifer et al.
Read now: pubs.rsc.org/en/content/a...
#OpenAccess from Marc E. Pfeifer et al.
Read now: pubs.rsc.org/en/content/a...
On the inside front cover of issue 21 of Lab on a Chip:
In situ electrochemical measurement of alkaline phosphatase activity in engineered gut models using a porous membrane electrode device.
Kosuke Ino, Yoshinobu Utagawa et al.
pubs.rsc.org/en/content/a...
In situ electrochemical measurement of alkaline phosphatase activity in engineered gut models using a porous membrane electrode device.
Kosuke Ino, Yoshinobu Utagawa et al.
pubs.rsc.org/en/content/a...
October 27, 2025 at 9:43 AM
On the inside front cover of issue 21 of Lab on a Chip:
In situ electrochemical measurement of alkaline phosphatase activity in engineered gut models using a porous membrane electrode device.
Kosuke Ino, Yoshinobu Utagawa et al.
pubs.rsc.org/en/content/a...
In situ electrochemical measurement of alkaline phosphatase activity in engineered gut models using a porous membrane electrode device.
Kosuke Ino, Yoshinobu Utagawa et al.
pubs.rsc.org/en/content/a...
Reposted by Lab on a Chip
Full article:
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Multiplexed detection of respiratory viral pathogens by isothermal amplification on an autonomously loaded chip at the point-of-care
Recent viral outbreaks have shown the need for reliable diagnostic platforms to rapidly detect various viral and bacterial pathogens at the point-of-care. Over the last decade, isothermal nucleic acid...
pubs.rsc.org
October 23, 2025 at 2:21 PM
Full article:
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
In our latest issue:
Myo-MOVES: a custom electrical stimulation system for functional studies of 3D bioengineered muscle
#OpenAccess from Juan M. Fernández-Costa, Javier Ramón-Azcón et al
@juanmafercos.bsky.social @ainoatejedera.bsky.social @ibecbarcelona.eu.
Read now: pubs.rsc.org/en/content/a...
Myo-MOVES: a custom electrical stimulation system for functional studies of 3D bioengineered muscle
#OpenAccess from Juan M. Fernández-Costa, Javier Ramón-Azcón et al
@juanmafercos.bsky.social @ainoatejedera.bsky.social @ibecbarcelona.eu.
Read now: pubs.rsc.org/en/content/a...
Myo-MOVES: a custom electrical stimulation system for functional studies of 3D bioengineered muscle
Electrical pulse stimulation (EPS) is used to replicate motor neuron activation in muscle tissues, enabling in vitro studies of muscle contraction. However, both custom-built and commercial existing E...
pubs.rsc.org
October 22, 2025 at 11:26 AM
In our latest issue:
Myo-MOVES: a custom electrical stimulation system for functional studies of 3D bioengineered muscle
#OpenAccess from Juan M. Fernández-Costa, Javier Ramón-Azcón et al
@juanmafercos.bsky.social @ainoatejedera.bsky.social @ibecbarcelona.eu.
Read now: pubs.rsc.org/en/content/a...
Myo-MOVES: a custom electrical stimulation system for functional studies of 3D bioengineered muscle
#OpenAccess from Juan M. Fernández-Costa, Javier Ramón-Azcón et al
@juanmafercos.bsky.social @ainoatejedera.bsky.social @ibecbarcelona.eu.
Read now: pubs.rsc.org/en/content/a...
On the front cover of issue 21 of Lab on a Chip:
Dynamic sub-wavelength microparticle patterning via phase-modulated pulsing coherent surface acoustic wave tweezers.
Yancheng Wang et al.
pubs.rsc.org/en/content/a...
Dynamic sub-wavelength microparticle patterning via phase-modulated pulsing coherent surface acoustic wave tweezers.
Yancheng Wang et al.
pubs.rsc.org/en/content/a...
October 22, 2025 at 9:45 AM
On the front cover of issue 21 of Lab on a Chip:
Dynamic sub-wavelength microparticle patterning via phase-modulated pulsing coherent surface acoustic wave tweezers.
Yancheng Wang et al.
pubs.rsc.org/en/content/a...
Dynamic sub-wavelength microparticle patterning via phase-modulated pulsing coherent surface acoustic wave tweezers.
Yancheng Wang et al.
pubs.rsc.org/en/content/a...
Reposted by Lab on a Chip
A luminescence-based point-of-care #HIV viral load test for antiretroviral therapy monitoring pubs.rsc.org/en/content/a... (subscription req for full text)
A luminescence-based point-of-care HIV viral load test for antiretroviral therapy monitoring
Effective monitoring of HIV treatment remains constrained by limited access to affordable, sensitive, and user-friendly viral load diagnostics, particularly in resource-limited settings. To address th...
pubs.rsc.org
October 21, 2025 at 12:50 PM
A luminescence-based point-of-care #HIV viral load test for antiretroviral therapy monitoring pubs.rsc.org/en/content/a... (subscription req for full text)