TAGHIVscience
@taghivscience.bsky.social
Treatment Action Group's Basic Science, Vaccines & Cure Project, by Richard Jefferys. 🏳️⚧️
Primary Treatment Action Group account: https://bsky.app/profile/treatmentactiongroup.org
TAG website: https://www.treatmentactiongroup.org/
Primary Treatment Action Group account: https://bsky.app/profile/treatmentactiongroup.org
TAG website: https://www.treatmentactiongroup.org/
HIV-1 transcription dominates over host gene activity at the #HIV integration site journals.asm.org/doi/10.1128/... (open access)
HIV-1 transcription dominates over host gene activity at the HIV-1 integration site | mBio
HIV-1 persists as an integrated provirus in infected cells. Antiretroviral therapy
(ART) does not inhibit HIV-1 promoter activity. Therefore, despite effective ART,
HIV-1 promoter continues to drive H...
journals.asm.org
November 25, 2025 at 5:59 PM
HIV-1 transcription dominates over host gene activity at the #HIV integration site journals.asm.org/doi/10.1128/... (open access)
Reposted by TAGHIVscience
A TCR-mimic bispecific antibody reduces HIV-1 provirus and delays viral rebound in HLA-matched humanized mice @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 7, 2025 at 3:17 PM
A TCR-mimic bispecific antibody reduces HIV-1 provirus and delays viral rebound in HLA-matched humanized mice @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by TAGHIVscience
Enhanced HIV-1 Control After Antibody Therapy is Associated with Autologous Antibodies and Reservoir Clearance in the RIO trial https://www.medrxiv.org/content/10.1101/2025.11.03.25339415v1
November 6, 2025 at 4:42 PM
Enhanced HIV-1 Control After Antibody Therapy is Associated with Autologous Antibodies and Reservoir Clearance in the RIO trial https://www.medrxiv.org/content/10.1101/2025.11.03.25339415v1
The human cost of US foreign aid cuts: implications for #HIV service delivery, research and innovation in South Africa www.tandfonline.com/doi/full/10.... (open access)
The human cost of US foreign aid cuts: implications for HIV service delivery, research and innovation in South Africa
In early 2025, the abrupt suspension of U.S. foreign aid to South Africa – including funding from United States President’s Emergency Plan for AIDS Relief (PEPFAR), the United States Agency for Int...
www.tandfonline.com
November 25, 2025 at 4:57 PM
The human cost of US foreign aid cuts: implications for #HIV service delivery, research and innovation in South Africa www.tandfonline.com/doi/full/10.... (open access)
Development of In Vitro Assay for Viral Escape from Broadly Neutralizing Antibodies www.sciencedirect.com/science/arti... (open access) #HIV
Development of In Vitro Assay for Viral Escape from Broadly Neutralizing Antibodies
In vitro models to study HIV-1 escape from broadly neutralizing antibodies (bNAbs) are highly important for designing in vivo bNAb combination therapy…
www.sciencedirect.com
November 25, 2025 at 4:54 PM
Development of In Vitro Assay for Viral Escape from Broadly Neutralizing Antibodies www.sciencedirect.com/science/arti... (open access) #HIV
Identification of inducible #HIV reservoirs in tonsillar, intestinal and cervical tissue models of HIV latency www.nature.com/articles/s41... (open access) @natcomms.nature.com
Identification of inducible HIV reservoirs in tonsillar, intestinal and cervical tissue models of HIV latency - Nature Communications
HIV’s persistence in diverse tissue reservoirs poses a challenge to cure efforts, necessitating targeted approaches. Here, the authors develop human tissue models of HIV latency and find that inducibl...
www.nature.com
November 25, 2025 at 4:53 PM
Identification of inducible #HIV reservoirs in tonsillar, intestinal and cervical tissue models of HIV latency www.nature.com/articles/s41... (open access) @natcomms.nature.com
Reposted by TAGHIVscience
World AIDS Day is on Dec. 1.
Since 2004, global deaths have been in decline due to greater access to diagnostics, treatment & prevention.
This hard-won progress is now at risk due to major cuts to global public health.
We can't afford to go backward.
Since 2004, global deaths have been in decline due to greater access to diagnostics, treatment & prevention.
This hard-won progress is now at risk due to major cuts to global public health.
We can't afford to go backward.
November 25, 2025 at 2:32 PM
World AIDS Day is on Dec. 1.
Since 2004, global deaths have been in decline due to greater access to diagnostics, treatment & prevention.
This hard-won progress is now at risk due to major cuts to global public health.
We can't afford to go backward.
Since 2004, global deaths have been in decline due to greater access to diagnostics, treatment & prevention.
This hard-won progress is now at risk due to major cuts to global public health.
We can't afford to go backward.
Reposted by TAGHIVscience
In 2025, sudden US funding cuts & reductions from key donors shocked the global AIDS response.
This #WorldAIDSDay2025, UNAIDS Global's new report shows how these disruptions unfolded - and the resilience of communities protecting progress.
🔗 https://www.unaids.org/en/2025-world-aids-day
This #WorldAIDSDay2025, UNAIDS Global's new report shows how these disruptions unfolded - and the resilience of communities protecting progress.
🔗 https://www.unaids.org/en/2025-world-aids-day
November 25, 2025 at 2:05 PM
In 2025, sudden US funding cuts & reductions from key donors shocked the global AIDS response.
This #WorldAIDSDay2025, UNAIDS Global's new report shows how these disruptions unfolded - and the resilience of communities protecting progress.
🔗 https://www.unaids.org/en/2025-world-aids-day
This #WorldAIDSDay2025, UNAIDS Global's new report shows how these disruptions unfolded - and the resilience of communities protecting progress.
🔗 https://www.unaids.org/en/2025-world-aids-day
Reposted by TAGHIVscience
This is a story about how America’s world-leading cancer and dementia research system was destroyed by frauds and naifs who broke the law.
There must be consequences.
There must be consequences.
Some incredible details in this piece
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
November 22, 2025 at 10:12 PM
This is a story about how America’s world-leading cancer and dementia research system was destroyed by frauds and naifs who broke the law.
There must be consequences.
There must be consequences.
Reposted by TAGHIVscience
Read our full statement: www.doctorswithoutborders.ca/canadas-cuts...
Canada's cuts to The Global Fund will fuel reversal of progress on HIV, TB, and Malaria | Doctors Without Borders / Médecins Sans Frontières (MSF ...
Canada's reduced pledge to The Global Fund reflects recent aid cuts, a shift from its previous leading role in fighting AIDS, TB, and malaria.
www.doctorswithoutborders.ca
November 24, 2025 at 6:36 PM
Read our full statement: www.doctorswithoutborders.ca/canadas-cuts...
RFK Jr isn't the only person trying to manufacture evidence to confirm their erroneous biases and bigotry.
Streeting is admitting that the Pathways “trial” already has a predetermined outcome. Stuffing it with SEGM placeholders is evidence of this.
The only way we are going to end state-mandated torture of trans kids is to get Labour out of government completely.
The only way we are going to end state-mandated torture of trans kids is to get Labour out of government completely.
November 24, 2025 at 6:21 PM
RFK Jr isn't the only person trying to manufacture evidence to confirm their erroneous biases and bigotry.
Reposted by TAGHIVscience
The CDC is lying to you about vaccines and autism. The CDC webpage about vaccines and autism now misrepresents the science and lies to the public about vaccines and autism. It’s just part of RFK Jr.'s ongoing war on vaccines. sciencebasedmedicine.org/the-cdc-is-l...
The CDC is lying to you about vaccines and autism
The CDC webpage about vaccines and autism now misrepresents the science and lies to the public about vaccines and autism. It's just part of HHS Secretary Robert F. Kennedy Jr.'s continuing war on vacc
sciencebasedmedicine.org
November 24, 2025 at 1:57 PM
The CDC is lying to you about vaccines and autism. The CDC webpage about vaccines and autism now misrepresents the science and lies to the public about vaccines and autism. It’s just part of RFK Jr.'s ongoing war on vaccines. sciencebasedmedicine.org/the-cdc-is-l...
Reposted by TAGHIVscience
Some incredible details in this piece
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
November 22, 2025 at 8:15 PM
Some incredible details in this piece
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
Reposted by TAGHIVscience
"Guys, seriously, get your own lawyer if you need it. Elon’s great, but you need to watch your own back.”
What happened to DOGE after Musk left.
www.politico.com/news/magazin...
What happened to DOGE after Musk left.
www.politico.com/news/magazin...
Inside the DOGE Succession Drama Elon Musk Left Behind
What really happened when he logged out of Washington.
www.politico.com
November 22, 2025 at 8:12 PM
"Guys, seriously, get your own lawyer if you need it. Elon’s great, but you need to watch your own back.”
What happened to DOGE after Musk left.
www.politico.com/news/magazin...
What happened to DOGE after Musk left.
www.politico.com/news/magazin...
Reposted by TAGHIVscience
ACT-UP London Mass Die-In, Vigil and reading of names.
World AIDS Day 1/12/25
8.00am sharp
Trafalgar Square
#actuplondon #actup #worldaidsday
World AIDS Day 1/12/25
8.00am sharp
Trafalgar Square
#actuplondon #actup #worldaidsday
November 24, 2025 at 3:56 PM
ACT-UP London Mass Die-In, Vigil and reading of names.
World AIDS Day 1/12/25
8.00am sharp
Trafalgar Square
#actuplondon #actup #worldaidsday
World AIDS Day 1/12/25
8.00am sharp
Trafalgar Square
#actuplondon #actup #worldaidsday
Among the many things Carl Dieffenbach was working on: the re-competition and renewal of #HIV clinical research networks: ACTG, HPTN, HVTN, IMPAACT.
As someone who has worked in HIV for 35+ years, I can tell you Carl is a consummate scientific leader. We’ve been lucky to have him at head of DAIDS. The only thing that wins here is the virus.
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
November 24, 2025 at 4:31 PM
Among the many things Carl Dieffenbach was working on: the re-competition and renewal of #HIV clinical research networks: ACTG, HPTN, HVTN, IMPAACT.
Reposted by TAGHIVscience
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
Hearing news that Carl Dieffenbach, the Director of the Division of AIDS at #NIH (NIAID), has been removed from his position because he was "not aligned with HHS/OMB."
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
November 24, 2025 at 5:49 AM
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
Reposted by TAGHIVscience
A lot of the transformational advances in HIV science — Truvada PrEP, Treatment as prevention (HPTN 052), U=U, lenacapavir PrEP etc. happened under Carl's watch. A kind and generous person to boot. Huge loss.
As @gregggonsalves.bsky.social said, here is the main winner in the forced departure of Carl Dieffenbach.
November 24, 2025 at 3:08 PM
A lot of the transformational advances in HIV science — Truvada PrEP, Treatment as prevention (HPTN 052), U=U, lenacapavir PrEP etc. happened under Carl's watch. A kind and generous person to boot. Huge loss.
Reposted by TAGHIVscience
this guy constantly manages to do shit like this and displace it in the media and discourse with something that goes with a laugh track somehow
bsky.app/profile/newy...
bsky.app/profile/newy...
One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc
The Shutdown of U.S.A.I.D. Has Already Killed Hundreds of Thousands
The short documentary “Rovina’s Choice” tells the story of what goes when aid goes.
newyorkermag.visitlink.me
November 21, 2025 at 9:40 PM
this guy constantly manages to do shit like this and displace it in the media and discourse with something that goes with a laugh track somehow
bsky.app/profile/newy...
bsky.app/profile/newy...
Reposted by TAGHIVscience
Earlier this week, a new page titled “Vaccines and Autism” appeared on the CDC website. The agency's employees are not happy about it.
“The best way I can put it is it feels like we’re on a hijacked airplane.”
“The best way I can put it is it feels like we’re on a hijacked airplane.”
“Embarrassing” and “horrifying”: CDC workers describe the new vaccines and autism page
"The best way I can put it is it feels like we're on a hijacked airplane."
www.motherjones.com
November 21, 2025 at 5:36 PM
Earlier this week, a new page titled “Vaccines and Autism” appeared on the CDC website. The agency's employees are not happy about it.
“The best way I can put it is it feels like we’re on a hijacked airplane.”
“The best way I can put it is it feels like we’re on a hijacked airplane.”
Reposted by TAGHIVscience
BREAKING: Federal judge rejects DOJ's effort to subpoena the names and medical records of children who have received gender-affirming medical care from the Children's Hospital of Philadelphia. storage.courtlistener.com/recap/gov.us...
November 21, 2025 at 10:26 PM
BREAKING: Federal judge rejects DOJ's effort to subpoena the names and medical records of children who have received gender-affirming medical care from the Children's Hospital of Philadelphia. storage.courtlistener.com/recap/gov.us...
Reposted by TAGHIVscience
Gmail users!!
They've turned on AI scraping by default now...Here's how to turn it off.
Pass it on!!
www.malwarebytes.com/blog/news/20...
They've turned on AI scraping by default now...Here's how to turn it off.
Pass it on!!
www.malwarebytes.com/blog/news/20...
Gmail can read your emails and attachments to train its AI, unless you opt out
A new Gmail update may allow Google to use your private messages and attachments for AI training. Here's how to turn it off.
www.malwarebytes.com
November 21, 2025 at 9:11 AM
Gmail users!!
They've turned on AI scraping by default now...Here's how to turn it off.
Pass it on!!
www.malwarebytes.com/blog/news/20...
They've turned on AI scraping by default now...Here's how to turn it off.
Pass it on!!
www.malwarebytes.com/blog/news/20...
Reposted by TAGHIVscience
No single person, especially someone with zero expertise, should be able to just change the CDC website on a whim. The fact that federal health and science pages are no longer trustable is a catastrophe for public health and democracy.
Kennedy Says He Told C.D.C. to Change Website’s Language on Autism and Vaccines
www.nytimes.com
November 21, 2025 at 8:05 PM
No single person, especially someone with zero expertise, should be able to just change the CDC website on a whim. The fact that federal health and science pages are no longer trustable is a catastrophe for public health and democracy.
Reposted by TAGHIVscience
The man has to go. www.thenation.com/article/soci...
RFK Jr., American Psycho
He needs to go. Now.
www.thenation.com
November 21, 2025 at 11:31 AM
The man has to go. www.thenation.com/article/soci...
Reposted by TAGHIVscience
The frontline CDC staff first asked to change the vaccines-autism website to promote a false link between the two wouldn't do so, @lenasun.bsky.social discovered wapo.st/3X9Mr43
CDC in turmoil after agency backpedals on rejecting vaccines-autism link
Sen. Bill Cassidy (R-Louisiana), who voted to confirm Health Secretary Robert F. Kennedy Jr. after he pledged not to remove language stating vaccines do not cause autism from the CDC website, condemne...
wapo.st
November 21, 2025 at 3:36 PM
The frontline CDC staff first asked to change the vaccines-autism website to promote a false link between the two wouldn't do so, @lenasun.bsky.social discovered wapo.st/3X9Mr43