Leonard Frach
@leofrach.bsky.social
220 followers 270 following 23 posts
Postdoc in psychiatric genetics and clinical psychologist at University Hospital Bonn | PhD @ucl.ac.uk | Within-family analyses, statistical genetics, polygenic scores, behaviour genetics, epigenetics | he/him
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leofrach.bsky.social
Very exciting preprint by @axel-schmidt.bsky.social, @kuludwig.bsky.social and team!
Check out Kerstin's thread for overview
kuludwig.bsky.social
🔔Paper alert! Extremely excited to share a preprint from our lab! Spearheaded by @axel-schmidt.bsky.social, a super talented medical & computational geneticist, we studied latent Epstein-Barr virus (EBV) infection at population-scale.

Interested in how this works & what we found? Read along! 👇
leofrach.bsky.social
Looking for an *amazing* postdoc supervisor? 👀
Excellent opportunity with the one and only @jessiebaldwin.bsky.social
jessiebaldwin.bsky.social
I'm hiring! ✨ Looking for a Research Fellow to study environmental factors that mitigate intergenerational transmission of mental health.

3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science!

🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...
Research Fellow in Mental Health at UCL
Apply for the Research Fellow in Mental Health role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
www.jobs.ac.uk
Reposted by Leonard Frach
jessiebaldwin.bsky.social
I'm hiring! ✨ Looking for a Research Fellow to study environmental factors that mitigate intergenerational transmission of mental health.

3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science!

🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...
Research Fellow in Mental Health at UCL
Apply for the Research Fellow in Mental Health role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
www.jobs.ac.uk
Reposted by Leonard Frach
ajwright.bsky.social
New paper out at the Journal of Psychopathology and Clinical Science!

We examined unconditional & event-related changes in pathological vs normal-range personality using 4 metrics to compare their developmental links, how these vary with life events, and whether unique effects emerge across metrics
Reposted by Leonard Frach
tedmond.bsky.social
I'm looking for a PhD student to do some trailblazing at the frontier of personality genomics and lifespan gene-environment transactions (start Fall 2026)! If you want to work with me: psychology.msu.edu/graduatestud...
(PS @drmeltemyucel.bsky.social is taking a student too, in moral psych/dev!)
Reposted by Leonard Frach
msicorello.bsky.social
BIG PREPRINT🔬

In a newly founded consortium we show that we barely know anything about the neurobiology underlying emotion regulation capacity! (40 fmri samples, N=2175)

So, time-out for prefrontal cortex explanations!

And we also show why this might be the case 🧵

www.biorxiv.org/content/10.1...
The elusive neural signature of emotion regulation capabilities: evidence from a large-scale consortium
Cognitive reappraisal is a fundamental emotion regulation strategy for mental and physical well-being, but how its neural mechanisms relate to individual differences remains poorly understood. In a co...
www.biorxiv.org
Reposted by Leonard Frach
rjhfmstr.bsky.social
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...

Highlights below!
Reposted by Leonard Frach
margotvdweijer.bsky.social
New pre-print online: Imputing parental genotypes through Mendelian Imputation: Ethical and Legal Considerations
osf.io/preprints/ps...
OSF
osf.io
Reposted by Leonard Frach
leofrach.bsky.social
Very exciting preprint by @axel-schmidt.bsky.social, @kuludwig.bsky.social and team!
Check out Kerstin's thread for overview
kuludwig.bsky.social
🔔Paper alert! Extremely excited to share a preprint from our lab! Spearheaded by @axel-schmidt.bsky.social, a super talented medical & computational geneticist, we studied latent Epstein-Barr virus (EBV) infection at population-scale.

Interested in how this works & what we found? Read along! 👇
leofrach.bsky.social
Very exciting preprint by @axel-schmidt.bsky.social, @kuludwig.bsky.social and team!
Check out Kerstin's thread for overview
kuludwig.bsky.social
🔔Paper alert! Extremely excited to share a preprint from our lab! Spearheaded by @axel-schmidt.bsky.social, a super talented medical & computational geneticist, we studied latent Epstein-Barr virus (EBV) infection at population-scale.

Interested in how this works & what we found? Read along! 👇
Reposted by Leonard Frach
kuludwig.bsky.social
🔔Paper alert! Extremely excited to share a preprint from our lab! Spearheaded by @axel-schmidt.bsky.social, a super talented medical & computational geneticist, we studied latent Epstein-Barr virus (EBV) infection at population-scale.

Interested in how this works & what we found? Read along! 👇
Reposted by Leonard Frach
breunigsophie.bsky.social
Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...
Reposted by Leonard Frach
doctinak.bsky.social
PhD position in my group at @fau.de, as part of my @erc.europa.eu Consolidator project PAR2. German is not essential but an interest in social science genetics would be great! Sharing would be much appreciated ❤️

www.jobs.fau.de/jobs/phd-pos...
PHD Position at the Department of Developmental and Educational Psychology (m/f/d)
www.jobs.fau.de
Reposted by Leonard Frach
tabeasch.bsky.social
🚨New preprint is out!

How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
Design and model choices shape inference of age-varying genetic effects on complex traits
Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...
shorturl.at
Reposted by Leonard Frach
adriaan-vd-graaf.bsky.social
Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...
A network of metabolites and their potential causal relationships. Green edges are Detected by the statistical causal inference method MR-link-2
Reposted by Leonard Frach
sanders.senate.gov
While the world watches Israel's war with Iran, Netanyahu's extremist government continues to starve and massacre Palestinians in Gaza.

Today, Israeli forces again opened fire on people desperately trying to collect food aid, killing dozens. Over 56,000 have been killed so far.
Reposted by Leonard Frach
medrxivpreprint.bsky.social
Intergenerational Transmission of Parental Mental Health and Wellbeing Traits on Offspring Emotional and Behavioural Difficulties https://www.medrxiv.org/content/10.1101/2025.06.17.25329751v1
Reposted by Leonard Frach
neilmdavies.bsky.social
Looking for your next research position? We're recruiting two genetic epidemiologists to work on two projects at the Division of Psychiatry at UCL, part of the growing UCL Human Genomics group.
Reposted by Leonard Frach
chrisrayner.bsky.social
Thanks @eivindy.bsky.social! My first foray into the mysterious world of #SelectionBias. Very happy to receive feedback, and to discuss opportunities for improving/expanding this work!
eivindy.bsky.social
🧵 THREAD: Preprint from @chrisrayner.bsky.social reveals how to fix selection bias in the Norwegian #MoBa study using population-wide registry data! For the first time, we can quantify and adjust for selection bias in this major epidemiological resource.

Spread the good news!
osf.io/preprints/os...
OSF
osf.io
leofrach.bsky.social
Productive week @eivindy.bsky.social!
Glad to see this one out @chrisrayner.bsky.social, super useful!
Reposted by Leonard Frach
eivindy.bsky.social
🧵 THREAD: Preprint from @chrisrayner.bsky.social reveals how to fix selection bias in the Norwegian #MoBa study using population-wide registry data! For the first time, we can quantify and adjust for selection bias in this major epidemiological resource.

Spread the good news!
osf.io/preprints/os...
OSF
osf.io
leofrach.bsky.social
First Singapore for a conference followed by AUS!