Fabian Streit
@fstreit.bsky.social
psychologist|@zi_mannheim|psychiatric genetics|stress
depression pgc.unc.edu/for-researchers/working-groups/mdd
personality disorders https://zi-mannheim.de/pdgg
german national cohort nako.de/en/research/expert-groups/neurological-and-psychiatric-diseases
depression pgc.unc.edu/for-researchers/working-groups/mdd
personality disorders https://zi-mannheim.de/pdgg
german national cohort nako.de/en/research/expert-groups/neurological-and-psychiatric-diseases
Reposted by Fabian Streit
Examining the Contribution of Childhood Maltreatment to the Gender Gap in Depression: Insights from the German National Cohort (NAKO) https://www.medrxiv.org/content/10.64898/2026.02.02.26345366v1
February 3, 2026 at 11:10 PM
Examining the Contribution of Childhood Maltreatment to the Gender Gap in Depression: Insights from the German National Cohort (NAKO) https://www.medrxiv.org/content/10.64898/2026.02.02.26345366v1
Happy to share our newest preprint!
Depression is more common in females than in males, but it remains insufficiently understood why.
Using data from the German National Cohort (NAKO) @nako.de, we investigated whether childhood maltreatment may contribute to this gender gap.
doi.org/10.64898/202...
Depression is more common in females than in males, but it remains insufficiently understood why.
Using data from the German National Cohort (NAKO) @nako.de, we investigated whether childhood maltreatment may contribute to this gender gap.
doi.org/10.64898/202...
Examining the Contribution of Childhood Maltreatment to the Gender Gap in Depression: Insights from the German National Cohort (NAKO)
Background: Childhood maltreatment is a major risk factor for depression and may contribute to sex differences in depression prevalence. We examined sex-specific associations between childhood maltrea...
doi.org
February 4, 2026 at 10:28 AM
Happy to share our newest preprint!
Depression is more common in females than in males, but it remains insufficiently understood why.
Using data from the German National Cohort (NAKO) @nako.de, we investigated whether childhood maltreatment may contribute to this gender gap.
doi.org/10.64898/202...
Depression is more common in females than in males, but it remains insufficiently understood why.
Using data from the German National Cohort (NAKO) @nako.de, we investigated whether childhood maltreatment may contribute to this gender gap.
doi.org/10.64898/202...
Looking forward to it!
There's no other meeting like WCPG. Exciting news and important deadlines are on their way to you soon!
##WCPG26 #ISPG #PsychiatricGenetics #Glasgow #Scotland
##WCPG26 #ISPG #PsychiatricGenetics #Glasgow #Scotland
February 4, 2026 at 10:22 AM
Looking forward to it!
Reposted by Fabian Streit
New paper out:
Some people are systematically better at judging others’ intelligence.
Who are the best judges? People WHO are intelligent themselves, have good emotion-perception ability, and who are high in well-being.
www.sciencedirect.com/science/arti...
Some people are systematically better at judging others’ intelligence.
Who are the best judges? People WHO are intelligent themselves, have good emotion-perception ability, and who are high in well-being.
www.sciencedirect.com/science/arti...
The good judge of intelligence
Accurately judging others' intelligence is important, yet little is known about individual differences in this ability. In this study we investigated …
www.sciencedirect.com
January 16, 2026 at 3:35 PM
New paper out:
Some people are systematically better at judging others’ intelligence.
Who are the best judges? People WHO are intelligent themselves, have good emotion-perception ability, and who are high in well-being.
www.sciencedirect.com/science/arti...
Some people are systematically better at judging others’ intelligence.
Who are the best judges? People WHO are intelligent themselves, have good emotion-perception ability, and who are high in well-being.
www.sciencedirect.com/science/arti...
Happy to share this: we confirmed a significant link between smoking and depression using data from the @nako.de. Our analysis of over 170,000 participants shows that both current and former smokers face a higher lifetime risk of depression. #MentalHealth #ResearchNews #PublicHealth
January 27, 2026 at 2:38 PM
Happy to share this: we confirmed a significant link between smoking and depression using data from the @nako.de. Our analysis of over 170,000 participants shows that both current and former smokers face a higher lifetime risk of depression. #MentalHealth #ResearchNews #PublicHealth
Reposted by Fabian Streit
Analysis of over 170,000 adults indicates that current and former smokers experience depression more frequently than never-smokers, with risk decreasing the longer a person has quit smoking. doi.org/hbk2gw
Link between smoking and depression confirmed in study
A research group led by the Central Institute of Mental Health (CIMH) in Mannheim has confirmed for the first time within the German National Cohort (NAKO) an association between cigarette consumption and depression.
medicalxpress.com
January 22, 2026 at 5:39 PM
Analysis of over 170,000 adults indicates that current and former smokers experience depression more frequently than never-smokers, with risk decreasing the longer a person has quit smoking. doi.org/hbk2gw
Reposted by Fabian Streit
A very comprehensive review of the genetics of personlity led by @tedmond.bsky.social This is a great onramp for those who haven't checked into psychiatric genetics or bahviour genetics in a while. www.annualreviews.org/content/jour...
Personality Genomics
Recent research advances have precipitated the era of personality genomics: the study of how variation in human DNA sequence predicts individual differences in characteristic patterns of thinking, fee...
www.annualreviews.org
January 22, 2026 at 10:15 AM
A very comprehensive review of the genetics of personlity led by @tedmond.bsky.social This is a great onramp for those who haven't checked into psychiatric genetics or bahviour genetics in a while. www.annualreviews.org/content/jour...
Reposted by Fabian Streit
This is an interesting challenge, Its A LOT of data for psychology, but not for ML perse. I wonder whether there is juice to be squeezed out of other EMA data, which would only have partial feature overlap, loads of other EMA data lives here: openesmdata.org.
January 7, 2026 at 8:01 PM
This is an interesting challenge, Its A LOT of data for psychology, but not for ML perse. I wonder whether there is juice to be squeezed out of other EMA data, which would only have partial feature overlap, loads of other EMA data lives here: openesmdata.org.
Reposted by Fabian Streit
Want to make nice graphs with me, starting next year? I'm hiring for a position at the University of Witten/Herdecke.
uni-wh.softgarden.io/job/61280592...
uni-wh.softgarden.io/job/61280592...
December 3, 2025 at 12:48 PM
Want to make nice graphs with me, starting next year? I'm hiring for a position at the University of Witten/Herdecke.
uni-wh.softgarden.io/job/61280592...
uni-wh.softgarden.io/job/61280592...
Reposted by Fabian Streit
🚨New preprint from PGC SUI!! @pgcgenetics.bsky.social
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
Genome-wide association studies identify 77 loci for suicidality and provide novel biological insights
Suicidality is heritable and a leading cause of global morbidity and mortality, yet its biological etiology remains largely elusive. We conducted multi-ancestry genome-wide association study meta-anal...
www.medrxiv.org
October 27, 2025 at 4:20 PM
🚨New preprint from PGC SUI!! @pgcgenetics.bsky.social
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
Reposted by Fabian Streit
🧠 Why do some brains age faster than others?
🧬 Our new Nature Aging study of over 56,000 participants explores the genetics of the “brain age gap” — the difference between your brain’s biological and chronological age.
nature.com/articles/s43587-025-00962-7
Thread below 👇
🧬 Our new Nature Aging study of over 56,000 participants explores the genetics of the “brain age gap” — the difference between your brain’s biological and chronological age.
nature.com/articles/s43587-025-00962-7
Thread below 👇
Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health - Nature Aging
This genomic study of magnetic resonance imaging-based brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and physical health, and suggests high blood pressure and type 2 diabetes as causal factors of brain aging.
nature.com
October 7, 2025 at 9:38 AM
🧠 Why do some brains age faster than others?
🧬 Our new Nature Aging study of over 56,000 participants explores the genetics of the “brain age gap” — the difference between your brain’s biological and chronological age.
nature.com/articles/s43587-025-00962-7
Thread below 👇
🧬 Our new Nature Aging study of over 56,000 participants explores the genetics of the “brain age gap” — the difference between your brain’s biological and chronological age.
nature.com/articles/s43587-025-00962-7
Thread below 👇
Reposted by Fabian Streit
Breaking the Norm: Population-Scale Normative Modeling of Brain Structure in Depression and Anxiety https://www.medrxiv.org/content/10.1101/2025.09.26.25336528v1
September 28, 2025 at 5:12 PM
Breaking the Norm: Population-Scale Normative Modeling of Brain Structure in Depression and Anxiety https://www.medrxiv.org/content/10.1101/2025.09.26.25336528v1
Reposted by Fabian Streit
Breaking the Norm: Population-Scale Normative Modeling of Brain Structure in Depression and Anxiety | medRxiv www.medrxiv.org/content/10.1...
September 29, 2025 at 12:08 AM
Breaking the Norm: Population-Scale Normative Modeling of Brain Structure in Depression and Anxiety | medRxiv www.medrxiv.org/content/10.1...
Reposted by Fabian Streit
The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits
A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits https://www.medrxiv.org/content/10.1101/2025.07.11.25331310v1
July 16, 2025 at 2:47 PM
The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits
Reposted by Fabian Streit
Got prov. approval for 2 major grants in Neuro-AI & Dynamical Systems Reconstruction, on learning & inference in non-stationary environments, out-of-domain generalization, and DS foundation models. To all AI/math/DS enthusiasts: Expect job announcements (PhD/PostDoc) soon! Feel free to get in touch.
July 13, 2025 at 6:23 AM
Got prov. approval for 2 major grants in Neuro-AI & Dynamical Systems Reconstruction, on learning & inference in non-stationary environments, out-of-domain generalization, and DS foundation models. To all AI/math/DS enthusiasts: Expect job announcements (PhD/PostDoc) soon! Feel free to get in touch.
Reposted by Fabian Streit
I’m excited to share our genetic study on panic disorder in the FinnGen sample. We found a genomewide significant hit within the SORCS3 gene and showed that SORCS3 serum protein levels were 40% higher in panic disorder patients compared to controls medrxiv.org/cgi/content/...
Genome-wide Association Study Identifies SORCS3 as a Novel Susceptibility Locus for Panic Disorder in the FinnGen Study
Panic disorder is an anxiety disorder with poorly understood etiology. Although twin studies suggest modest heritability (∼40%), few genetic variants have been associated with it. We carried out a gen...
medrxiv.org
July 10, 2025 at 12:44 PM
I’m excited to share our genetic study on panic disorder in the FinnGen sample. We found a genomewide significant hit within the SORCS3 gene and showed that SORCS3 serum protein levels were 40% higher in panic disorder patients compared to controls medrxiv.org/cgi/content/...
Reposted by Fabian Streit
#ctglab is hiring! We have #vacancies! 2 PhD & 2 postdoc positions, in #statistical #genetics and/or #bioinformatics - if you like GWAS, method development and linking with biology - check these out 👇
werkenbij.vu.nl/vacatures/tw...
werkenbij.vu.nl/vacatures/po...
werkenbij.vu.nl/vacatures/po...
werkenbij.vu.nl/vacatures/tw...
werkenbij.vu.nl/vacatures/po...
werkenbij.vu.nl/vacatures/po...
May 24, 2025 at 3:02 PM
#ctglab is hiring! We have #vacancies! 2 PhD & 2 postdoc positions, in #statistical #genetics and/or #bioinformatics - if you like GWAS, method development and linking with biology - check these out 👇
werkenbij.vu.nl/vacatures/tw...
werkenbij.vu.nl/vacatures/po...
werkenbij.vu.nl/vacatures/po...
werkenbij.vu.nl/vacatures/tw...
werkenbij.vu.nl/vacatures/po...
werkenbij.vu.nl/vacatures/po...
Great to see this paper finally online, and happy we could contribute (a bit) to it! It's a big progress in regard to variant discovery (especially for the other 4 Big 5) but Ted and team also ran a wide range of super interesting follow-up analyses, that showcase the potential of the results. 🥳🧬
Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
May 20, 2025 at 1:21 PM
Great to see this paper finally online, and happy we could contribute (a bit) to it! It's a big progress in regard to variant discovery (especially for the other 4 Big 5) but Ted and team also ran a wide range of super interesting follow-up analyses, that showcase the potential of the results. 🥳🧬
Reposted by Fabian Streit
We are currently looking for new collaborators with genotyping and autism data in order to increase our sample size for our next large-scale genome-wide meta-analyses of autism. Want to contribute? Contact us! 📩
pgc.unc.edu/for-research...
pgc.unc.edu/for-research...
Autism Working Group – PGC
pgc.unc.edu
May 14, 2025 at 12:49 PM
We are currently looking for new collaborators with genotyping and autism data in order to increase our sample size for our next large-scale genome-wide meta-analyses of autism. Want to contribute? Contact us! 📩
pgc.unc.edu/for-research...
pgc.unc.edu/for-research...
Reposted by Fabian Streit
🚨 I just released the alpha-version of my AI in Genomics textbook! It covers (so far!) sequence language models & deep learning for DNA/RNA/proteins. Check it out: biobook.michel.science
Sequence Language Models & Deep Learning in Genomics
biobook.michel.science
May 12, 2025 at 12:25 PM
🚨 I just released the alpha-version of my AI in Genomics textbook! It covers (so far!) sequence language models & deep learning for DNA/RNA/proteins. Check it out: biobook.michel.science
Reposted by Fabian Streit
So depressing...
Well the NIH has cancelled the Women's Health Initiative, the largest study of women in history
It has been running continuously since 1991 and has provided massive key knowledge about diseases in women
Unreal
www.science.org/content/arti...
It has been running continuously since 1991 and has provided massive key knowledge about diseases in women
Unreal
www.science.org/content/arti...
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
www.science.org
April 23, 2025 at 5:44 PM
So depressing...
Reposted by Fabian Streit
🎉Hello and welcome to the PGC Africa Working Group takeover 🎉
For the next 2 weeks, we will share with you exciting updates from @pgc-africa.bsky.social brought to you by @jaredgm.bsky.social and Ofure Ubah
1/4
For the next 2 weeks, we will share with you exciting updates from @pgc-africa.bsky.social brought to you by @jaredgm.bsky.social and Ofure Ubah
1/4
April 15, 2025 at 9:09 AM
🎉Hello and welcome to the PGC Africa Working Group takeover 🎉
For the next 2 weeks, we will share with you exciting updates from @pgc-africa.bsky.social brought to you by @jaredgm.bsky.social and Ofure Ubah
1/4
For the next 2 weeks, we will share with you exciting updates from @pgc-africa.bsky.social brought to you by @jaredgm.bsky.social and Ofure Ubah
1/4
Reposted by Fabian Streit
Postdoc closing soon - two more days to apply for our statistical genetics role in antidepressant response at @kingsioppn.bsky.social
📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
April 8, 2025 at 5:40 AM
Postdoc closing soon - two more days to apply for our statistical genetics role in antidepressant response at @kingsioppn.bsky.social
Reposted by Fabian Streit
Our new study in Molecular Psychiatry, in 1528 children and their parents (@ntrbiopsy.bsky.social) shows that indirect genetic effects—where parental genetics shape offspring traits via environmental influences (genetic nurture)—impact DNA methylation of children. doi.org/10.1038/s413... (1/5)
Intergenerational transmission of complex traits and the offspring methylome - Molecular Psychiatry
Molecular Psychiatry - Intergenerational transmission of complex traits and the offspring methylome
doi.org
April 6, 2025 at 2:07 PM
Our new study in Molecular Psychiatry, in 1528 children and their parents (@ntrbiopsy.bsky.social) shows that indirect genetic effects—where parental genetics shape offspring traits via environmental influences (genetic nurture)—impact DNA methylation of children. doi.org/10.1038/s413... (1/5)
Reposted by Fabian Streit
🎉 Great news from @ebbsociety.bsky.social
👏 Congrats to our Chair, @francescacirulli.bsky.social, for receiving the Diversity Award in recognition of her dedication to fostering diversity and inclusion in research!
📅Join us in celebrating this achievement at the ALBA session at #EBBS2025
👏 Congrats to our Chair, @francescacirulli.bsky.social, for receiving the Diversity Award in recognition of her dedication to fostering diversity and inclusion in research!
📅Join us in celebrating this achievement at the ALBA session at #EBBS2025
🌟We are proud to announce
🌍Diversity Award: Congratulations to Francesca Cirulli, Research Director at Istituto Superiore di Sanità (Italy), for her dedication to promoting diversity and inclusion in research
🙌 Join us in applauding her achievement
@francescacirulli.bsky.social
🌍Diversity Award: Congratulations to Francesca Cirulli, Research Director at Istituto Superiore di Sanità (Italy), for her dedication to promoting diversity and inclusion in research
🙌 Join us in applauding her achievement
@francescacirulli.bsky.social
April 2, 2025 at 3:47 PM
🎉 Great news from @ebbsociety.bsky.social
👏 Congrats to our Chair, @francescacirulli.bsky.social, for receiving the Diversity Award in recognition of her dedication to fostering diversity and inclusion in research!
📅Join us in celebrating this achievement at the ALBA session at #EBBS2025
👏 Congrats to our Chair, @francescacirulli.bsky.social, for receiving the Diversity Award in recognition of her dedication to fostering diversity and inclusion in research!
📅Join us in celebrating this achievement at the ALBA session at #EBBS2025