Author | Lightnews

Leonard Van Gelder @leonardvangelder.bsky.social · Sep 18

Most tools use averages, or normal values, that really represent nothing about the individual using them. Not too mention they might be measuring the least important things. Companies aren’t invested enough in changing their algorithms or tools

Leonard Van Gelder @leonardvangelder.bsky.social · Apr 15

New form of stats introduced in psychology world:

www.sciencedirect.com/science/arti...

Evolving an idionomic approach to processes of change: Towards a unified personalized science of human improvement

The wide variety of “third wave” cognitive behavioral therapy (CBT) methods (e.g., Acceptance and Commitment Therapy or “ACT”, Compassion Focused Ther…

www.sciencedirect.com

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Leonard Van Gelder @leonardvangelder.bsky.social · Apr 15

Agreed. Perhaps possibility of new idionomic approaches may help bridge the individual to group and group to individual friction. So much ground work to be laid to see. We’re doing our part 👷‍♂️👨‍💻

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Leonard Van Gelder @leonardvangelder.bsky.social · Apr 15

100% - broad reaches of a principle long known in physics but not getting enough attention elsewhere

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Leonard Van Gelder @leonardvangelder.bsky.social · Apr 13

Embracing the #nonergodicity of biology is the future of health.

#complexityscience #medicine

www.newyorker.com/magazine/202...

Medical Benchmarks and the Myth of the Universal Patient

From growth charts to anemia thresholds, clinical standards assume a single human prototype. Why are we still using one-size-fits-all health metrics?

www.newyorker.com

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Leonard Van Gelder @leonardvangelder.bsky.social · Apr 9

#physicaltherapy #rehabilitation #occupationaltherapy
contextualhealth.org/biggest-thre...

Bot Verification

contextualhealth.org

Leonard Van Gelder @leonardvangelder.bsky.social · Apr 6

File under #nonergodicity

Journal of Biomechanics @jbiomech.bsky.social · Apr 6

😃 A new article published in J Biomech by Crisco et al found that reporting thumb motion as CMC joint motion involves significant errors without a discernable pattern, making true CMC motion prediction impossible from thumb motion measurements.

👀https://buff.ly/p2Uh1PI
#BiomechSky

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Reposted by Leonard Van Gelder

Arne Elofsson @bioinfo.se · Apr 2

Millimetre-scale bioresorbable optoelectronic systems for electrotherapy www.nature.com/articles/s41...

Millimetre-scale bioresorbable optoelectronic systems for electrotherapy - Nature

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses ...

www.nature.com

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Reposted by Leonard Van Gelder

Asaf (Klaf) Weisman @asafklaf.bsky.social · Apr 3

First phase 3 trial for the novel non-opioid drug Suzetrigine. It’s not placebo controlled and aimed to test the safety profile of the drug. I am not sure wheter this could be considered “well-tolerated” and “generally safe”

#physio
#painscience
#neuroskyence
🧪🛟

www.tandfonline.com/doi/full/10....

Suzetrigine, a Non-Opioid NaV1.8 Inhibitor With Broad Applicability for Moderate-to-Severe Acute Pain: A Phase 3 Single-Arm Study for Surgical or Non-Surgical Acute Pain

Many patients experience inadequate pain control due to limited options that are both efficacious and safe for treating moderate-to-severe acute pain; therefore, opioids are still frequently prescr...

www.tandfonline.com

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Leonard Van Gelder @leonardvangelder.bsky.social · Apr 2

🚨 The paper is out! 🚨

If you work with movement, read this!
Human performance isn’t about optimizing parts. Rather, it is a continuous process of adaptation to ever-shifting constraints, both internal & external.

#movement #movementscience #sportscience #physio #physicaltherapy

shorturl.at/i59kC

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Leonard Van Gelder @leonardvangelder.bsky.social · Mar 31

Tendon tissue changes from loading may not matter much. Loading might help for other reasons—or just via movement variability reducing nociception. In the end, all pain ties back to changes in the nociceptive apparatus
#painscience #physicaltherapy #sportskyence
pubmed.ncbi.nlm.nih.gov/35850720/

Tendon pain - what are the mechanisms behind it? - PubMed

Potential mechanism-based pharmacological treatment approaches could be developed by blocking promotors of nerve ingrowth, such as NGF, and promoting inhibitors of nerve ingrowth, like semaphorins, as...

pubmed.ncbi.nlm.nih.gov

Leonard Van Gelder @leonardvangelder.bsky.social · Mar 31

“We instead observed substantial interindividual variability..”
#nonergodicity #humanhealth #medicine #painscience

Royal Society Publishing @royalsocietypublishing.org · Mar 31

Awakening not associated with an increased rate of cortisol secretion: royalsocietypublishing.org/doi/10.1098/... #ProcB #neuroscience

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Leonard Van Gelder @leonardvangelder.bsky.social · Mar 31

Movement science has a problem: the myth of optimality. Sneak peek from Madhur Mangalam’s describing 60+ conflicting “optimal” states during the act of hiking. More coming soon. #physio #physicaltherapy #movementscience #sportsmedicine #complexityscience #sportscience

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Leonard Van Gelder @leonardvangelder.bsky.social · Mar 30

Absolutely love this image. We have to think bigger than the #brain.
#neuroscience #painscience #medicine

Jonathan A. Michaels @jonathanamichaels.bsky.social · Mar 30

“Relevant computations happen in here too”

Maimon on the limitations of pure connectivity data in the fly

Reposted by Leonard Van Gelder

mj @malthusjohn.bsky.social · Mar 23

Since meaning (including Identity) derives from context, we have to take more than one viewpoint into consideration.

Even grammatically, we have to assign units to uncountable concepts, pointing to this paradox. Did those units exist before we created them?

What about the other direction? >

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Leonard Van Gelder @leonardvangelder.bsky.social · Mar 27

How did we ditch basic biology for the illusion of #regenerativemedicine. #Regeneration doesn’t exist at a single level of biology, or even a few—and we can’t yet target the scope of #multilevelselection to make it real.
#medicine #painscience #complexityscience
www.sciencedirect.com/science/arti...

Platelet-Rich Plasma Injections are Inferior to Corticosteroid Injections for Short-Term Pain Relief: A Prospective, Double-Blinded, Randomized Controlled Trial

We aimed to evaluate and compare the clinical benefits of platelet-rich plasma (PRP) injections compared to corticosteroid (CS) injections in patients…

www.sciencedirect.com

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Leonard Van Gelder @leonardvangelder.bsky.social · Mar 26

#multilevelselection in #pain - So much more for us to learn in the periphery and spinal cord!

Ewan St. John Smith @psalmotoxin.bsky.social · Mar 24

An exciting one for #PainResearch 👇

Patrik Ernfors @patrikernfors.bsky.social · Mar 24

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.

www.nature.com/articles/s41...

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Reposted by Leonard Van Gelder

PessoaBrain @pessoabrain.bsky.social · Mar 25

𝗖𝗮𝗻 𝘄𝗲 𝗽𝗿𝗲𝗱𝗶𝗰𝘁 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻?
Some aspects are well predicted, others are extremely difficult.
doi.org/10.1038/s415...

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Leonard Van Gelder @leonardvangelder.bsky.social · Mar 24

Not sure who all needs to hear this today but #complexityscience provides a little hope.

Jay 🦋 @jay.bsky.team · Mar 23

"When a complex system is far from equilibrium, small islands of coherence in a sea of chaos have the capacity to shift the entire system to a higher order."

Iya Prigogine, Noble prize-winning chemist

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Leonard Van Gelder @leonardvangelder.bsky.social · Mar 24

#physicaltherapy
#physiotherapy
#complexityscience
#neuroscience
#painscience

Leonard Van Gelder @leonardvangelder.bsky.social · Mar 24

While historically, the RCT has had its place for scientific analysis, it has caused more problems than good in many contexts involving humans. Dynamic Grouping may better fit the non-ergodic nature of human problems.
www.researchgate.net/publication/...

#medicine #science #research

(PDF) AI-driven dynamic grouping for adaptive clinical trials: Rethinking randomization in precision medicine

PDF | Integrating artificial intelligence into biomedical human subjects research is transforming traditional experimental paradigms. This review... | Find, read and cite all the research you need on ...

www.researchgate.net

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Leonard Van Gelder @leonardvangelder.bsky.social · Mar 2

#multilevelselection

Monica Carson @brainimmunity.bsky.social · Mar 1

Lifelong #health is not just about our genes-it’s about additive & synergistic consequences of life choices, life #exposures with #genetics
Interesting #aging study quantifying contributions to disease patterns & mortality #medsky #academicresearch #neuroskyence #immunosky #neuroinflammation

Dr. Anusha Seneviratne @anushans.bsky.social · Mar 1

🧪 This study highlights why we should not focus so much on genetic factors or drug targets. The #exposome (environmental exposures) has greater impact on disease patterns and premature mortality than genetic factors. www.nature.com/articles/s41... #planetaryhealth #academicsky #medsky #idsky

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Leonard Van Gelder @leonardvangelder.bsky.social · Jan 30

It is amazing to me how people still try & create these artificial constructs of an isolated movement system and outdated biomechanical concepts.
“Your body isn’t just moving -it’s networking” Madhur
#neuroscience #physio #movement

www.researchgate.net/publication/...

(PDF) Mechanical and cognitive postural instability drive shifts in whole-body coordination network

PDF | Conventional human movement science often considers body parts and processes separately as belonging to complementary but distinct domains (motor... | Find, read and cite all the research you ne...

www.researchgate.net

Leonard Van Gelder @leonardvangelder.bsky.social · Jan 26

“Without that noise aspect, the model would fail,” Lynn said. “It wouldn’t produce anything that worked, which was surprising to us. It turns out you actually need to balance the Hebbian snowball effect with the randomness to get everything to look like real brains.”
#complexityscience #neuroscience

Middle-Aged Bear @middleagedbear.bsky.social · Jan 26

biologicalsciences.uchicago.edu/news/simple-...

Interesting work linking network topology concepts to neuroscience!

Surprisingly simple model explains how brain cells organize and connect

Scientists from UChicago, Harvard, and Yale propose a self-organizing model of connectivity that applies across a wide range of organisms and potentially other types of networks as well.

biologicalsciences.uchicago.edu

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Reposted by Leonard Van Gelder

Carlos Alberto Alonso @alonsostudio.bsky.social · Jan 26

Emergent properties reveal how the brain transforms countless neural sparks into unified thoughts and emotions.

The same process drives creativity, where diverse ideas combine into something greater than the sum of their parts.

#neuroscience #creativity

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