Liam McGuffin
@liammcguffin.bsky.social
Professor of Bioinformatics at the University of Reading, developer of methods for protein structure and function prediction.
https://www.reading.ac.uk/bioinf/
https://www.reading.ac.uk/bioinf/
Pinned
Liam McGuffin
@liammcguffin.bsky.social
· Dec 12
Our MultiFOLD2 server is also now freely available to all. It's the top-ranked server on the hardest domain targets in #CASP16 by GDT_TS. With integrated stoichiometry prediction it outperforms AF3 on common multimer subsets in CAMEO. www.reading.ac.uk/bioinf/Multi...
Reposted by Liam McGuffin
Our paper on the performance of ModFOLDdock2 at #CASP16 onlinelibrary.wiley.com/doi/10.1002/...
Highlights of Model Quality Assessment in CASP16
Model quality assessment (MQA) remains a critical component of structural bioinformatics for both structure predictors and experimentalists seeking to use predictions for downstream applications. In ...
onlinelibrary.wiley.com
September 5, 2025 at 8:41 AM
Our paper on the performance of ModFOLDdock2 at #CASP16 onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Liam McGuffin
We used IntFOLD, and MultiFOLD to model interactions between Cx62 and calpain-1: "Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62" | Haematologica haematologica.org/article/view...
Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62
| Haematologica
haematologica.org
August 5, 2025 at 8:41 AM
We used IntFOLD, and MultiFOLD to model interactions between Cx62 and calpain-1: "Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62" | Haematologica haematologica.org/article/view...
Reposted by Liam McGuffin
Our new paper has been published: Prediction and quality assessment of protein quaternary structure models using the MultiFOLD2 and ModFOLDdock2 servers url: academic.oup.com/nar/article/...
Prediction and quality assessment of protein quaternary structure models using the MultiFOLD2 and ModFOLDdock2 servers
Abstract. Understanding the structures of protein complexes is pivotal for breakthroughs in health, agriculture, bioengineering, and beyond. MultiFOLD2 and
academic.oup.com
July 9, 2025 at 8:37 AM
Our new paper has been published: Prediction and quality assessment of protein quaternary structure models using the MultiFOLD2 and ModFOLDdock2 servers url: academic.oup.com/nar/article/...
Reposted by Liam McGuffin
Our new paper is out: Prediction and quality assessment of protein quaternary structure models using the MultiFOLD2 and ModFOLDdock2 servers
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Prediction and quality assessment of protein quaternary structure models using the MultiFOLD2 and ModFOLDdock2 servers
Abstract. Understanding the structures of protein complexes is pivotal for breakthroughs in health, agriculture, bioengineering, and beyond. MultiFOLD2 and
academic.oup.com
April 28, 2025 at 8:54 AM
Our new paper is out: Prediction and quality assessment of protein quaternary structure models using the MultiFOLD2 and ModFOLDdock2 servers
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Reposted by Liam McGuffin
Pleased to share that our latest study has been published in Hematologica!
@rdgplateletlabs.bsky.social
pubmed.ncbi.nlm.nih.gov/40045892/
@rdgplateletlabs.bsky.social
pubmed.ncbi.nlm.nih.gov/40045892/
Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62 - PubMed
Connexin (Cx) gap junction proteins are expressed by a multitude of cells and function as plasma membrane hemichannels or dock to form intercellular communication tunnels. Whilst Cx43 has garnered con...
pubmed.ncbi.nlm.nih.gov
March 7, 2025 at 4:09 PM
Pleased to share that our latest study has been published in Hematologica!
@rdgplateletlabs.bsky.social
pubmed.ncbi.nlm.nih.gov/40045892/
@rdgplateletlabs.bsky.social
pubmed.ncbi.nlm.nih.gov/40045892/
Reposted by Liam McGuffin
Excited to share our latest preprint evaluating AlphaFold3, Boltz-1, Chai-1 and Protenix for predicting protein-ligand interactions, featuring our newly introduced benchmark dataset 🌹Runs N’ Poses🌹!
www.biorxiv.org/content/10.1...
🧵👇 (1/n)
www.biorxiv.org/content/10.1...
🧵👇 (1/n)
Have protein-ligand co-folding methods moved beyond memorisation?
Deep learning has driven major breakthroughs in protein structure prediction, however the next critical advance is accurately predicting how proteins interact with other molecules, especially small mo...
www.biorxiv.org
February 8, 2025 at 10:02 AM
Excited to share our latest preprint evaluating AlphaFold3, Boltz-1, Chai-1 and Protenix for predicting protein-ligand interactions, featuring our newly introduced benchmark dataset 🌹Runs N’ Poses🌹!
www.biorxiv.org/content/10.1...
🧵👇 (1/n)
www.biorxiv.org/content/10.1...
🧵👇 (1/n)
Reposted by Liam McGuffin
CASP16 group picture - in Punta Cana
December 20, 2024 at 3:17 PM
CASP16 group picture - in Punta Cana
Our MultiFOLD2 server is also now freely available to all. It's the top-ranked server on the hardest domain targets in #CASP16 by GDT_TS. With integrated stoichiometry prediction it outperforms AF3 on common multimer subsets in CAMEO. www.reading.ac.uk/bioinf/Multi...
December 12, 2024 at 4:55 PM
Our MultiFOLD2 server is also now freely available to all. It's the top-ranked server on the hardest domain targets in #CASP16 by GDT_TS. With integrated stoichiometry prediction it outperforms AF3 on common multimer subsets in CAMEO. www.reading.ac.uk/bioinf/Multi...
The ModFOLDdock2 server is now online and freely available to all. The ModFOLDdock2 variants ranked within the top few groups at #CASP16 in QMODE1/2 metrics. ModFOLDdock2 is the best method for predicting the interface accuracy of modelled protein complexes.
www.reading.ac.uk/bioinf/ModFO...
www.reading.ac.uk/bioinf/ModFO...
December 11, 2024 at 4:01 PM
The ModFOLDdock2 server is now online and freely available to all. The ModFOLDdock2 variants ranked within the top few groups at #CASP16 in QMODE1/2 metrics. ModFOLDdock2 is the best method for predicting the interface accuracy of modelled protein complexes.
www.reading.ac.uk/bioinf/ModFO...
www.reading.ac.uk/bioinf/ModFO...
ModFOLDdock2 is the top ranked method for predicting the interface accuracy of modelled protein complexes #CASP16. The server is available here: www.reading.ac.uk/bioinf/ModFO...
December 3, 2024 at 3:37 PM
ModFOLDdock2 is the top ranked method for predicting the interface accuracy of modelled protein complexes #CASP16. The server is available here: www.reading.ac.uk/bioinf/ModFO...
My group members, Shaima and @recep44.bsky.social, presented their posters on MultiFOLD2 for multimer modelling and FunFOLD5 for predicting protein-ligand interactions at #CASP16. Lots of interest and positive feedback!
December 3, 2024 at 1:47 PM
My group members, Shaima and @recep44.bsky.social, presented their posters on MultiFOLD2 for multimer modelling and FunFOLD5 for predicting protein-ligand interactions at #CASP16. Lots of interest and positive feedback!
Yesterday at #CASP16 I presented our new ModFOLDdock2 servers for the quality assessment of multimer models. It's great to see progress in the field but there are still many challenges ahead!
December 3, 2024 at 1:43 PM
Yesterday at #CASP16 I presented our new ModFOLDdock2 servers for the quality assessment of multimer models. It's great to see progress in the field but there are still many challenges ahead!