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Marc Lensink

@marclensink.bsky.social

960 followers 820 following 290 posts

CNRS scientist computational molecular biology. Mostly talking about life, travel, science and board games, unless it's something else.

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Marc Lensink @marclensink.bsky.social · Nov 17

Lots of influx & new followers, so time for a short introduction. I put molecules together and make them wiggle, although I would like them not to. #structuralbiology #bioinformatics #capri #proteininteraction #evolution. May also post about my travels, board games, and various other topics.

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Jeffrey J. Gray @jeffreyjgray.bsky.social · 1d

Excited to share our new preprint “Unified Sampling and Ranking for Protein Docking with DFMDock” by PhD candidate Lee-Shin Chu and Post-Doc Sudeep Sarma! We designed a diffusion docking model that samples rigid-body conformations by predicting forces and ranks poses using predicted energies.

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Keith W. Dickinson @keithwdickinson.bsky.social · 1d

Today is a day when arts degrees are worthless, but the product of those degrees is so valuable it would kill an entire industry if they were made to pay for it.

The Verge @theverge.com · May 26

Nick Clegg says asking artists for use permission would ‘kill’ the AI industry

Paul McCartne, Elton John and others signed an open letter.

buff.ly

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Ewan Birney @ewanbirney.bsky.social · 1d

A reminder that the PhD program for EMBL is open for winter recruitment round. If you want to understand life at a molecular level and have a quantitative science (you don't have to have done biology - we love our mathematicians/physcists/chemists!) apply www.embl.org/about/info/e...

Application – EMBL International PhD Programme

www.embl.org

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François Ferron 🇪🇺 🔷️🔶️ @f2erron.fediscience.org.ap.brid.gy · 1d

The 4th edition of the Integrative Structural Biology Meeting (#BSI), co-organized with the Association Française de Cristallographie (#afc) and the Société Française de Biophysique (#SFB) will be held in Bordeaux 15th-19th of December 2025. Scientific […]

[Original post on fediscience.org]

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Daniel Pomarède @pomarede.bsky.social · 1d

#APOD Astronomy Picture of the Day

NGC 7380: The Wizard Nebula

Credit: Nevenka Blagovic Horvat & Miroslav Horvat

www.star.ucl.ac.uk/~apod/apod/a... 🧪🔭

Located only 8,000 light years away, the Wizard nebula, featured here, surrounds developing open star cluster NGC 7380. Visually, the interplay of stars, gas, and dust has created a shape that appears to some like a fictional medieval sorcerer. The active star-forming region spans 100 about light years, making it appear larger than the angular extent of the Moon. The Wizard Nebula can be located with a small telescope toward the constellation of the King of Aethiopia (Cepheus). Although the nebula may last only a few million years, some of the stars being formed may outlive our Sun.

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Marc Lensink @marclensink.bsky.social · 1d

Following for now. I will probably pass on it, but I'm excited by the idea.

Modiphius @modiphius.bsky.social · 2d

🔥Your personal Invitation to Hell.

The DOOM | Arena Board Game is releasing on Kickstarter soon! Follow today to get updates straight to your inbox.

buff.ly/v3MWDmQ

#DOOM #Boardgame #Miniatures

Marc Lensink @marclensink.bsky.social · 1d

Time to post a random food picture

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Volt Nederland @voltnederland.org · 1d

👇

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 1d

Am at the University of Copenhagen Frontier Research in Denmark meeting celebrating the @erc.europa.eu. Rector David Lassen highlights how his first meeting with the ERC was a grant rejection, and how it's important to tell early career scientists about the CV of failure in addition to successes 1/n

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Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 2d

📣Important update for #AlphaFold API users! New API fields launched on October 7th, 2025. We’ll maintain BOTH fields until June 25, 2026! Check the docs! 🔗
For more information, read the news item: www.ebi.ac.uk/pdbe/news/br...

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BioF:GREAT @biof-great.bsky.social · 2d

Using deuterium and neutron crystallography, the Imberty lab just cracked the atomic-level structure of the P. aeruginosa lectin, LecA, binding human sugars! 🧪

This structural insight is vital for designing new drugs. Great work, @anneimb.bsky.social team!

#DrugDesign #glycotime

Anne Imberty @anneimb.bsky.social · 2d

Neutrons are the best ... look at this histidine-galactose contact !! Our new neutron structure of lectin/gal is available as preprint in ChemRXiv chemrxiv.org/engage/chemr.... Thanks to @drmpblakeley.bsky.social @sebvidalchem.bsky.social and all colleagues for very fine collaboration

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Maxim Tsenkov @mitsenkov.bsky.social · 2d

The latest #AlphaFold DB update is out!

We synchronised with UniProt release 2025_03, predicted protein isoforms across all species, and provide MSAs used to generate each prediction.

Proud of the team at the PDBe for the hard work that went into this. Grateful to play my part in it!

EMBL-EBI @ebi.embl.org · 2d

We’re renewing our collaboration with Google DeepMind!

We'll keep developing the AlphaFold Database to support protein science worldwide 🎉

To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.

www.ebi.ac.uk/about/news/t...

🖥️🧬 #AlphaFold
@pdbeurope.bsky.social

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Captain it’s Wednesday @wednesday.bsky.social · 1d

Captain it's Wednesday

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Marc Lensink @marclensink.bsky.social · 2d

Walking along the waterline..

At sunset, a lone fisherman sitting on the quay, only contour visible. At the horizon, a big ship has anchored for the night.

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Jake Yeston @jakeyeston.bsky.social · 2d

Quantum mechanics of a macroscopic variable, published by today’s laureates in @science.org in 1988. In addition to the science, it’s remarkably lucid writing

www.science.org/doi/10.1126/...

🧪

ARE MACROSCOPIC DEGREES OF FREEDOM GOVERNED BY quantum mechanics? Our everyday experience tells us that a classical description appears to be entirely adequate. The trajectory of the center of mass of a billiard ball is predicted wonderfully well by classical mechanics. Even the Brownian motion
of a tiny speck of dust in a drop of water is a purely classical phenomenon. Until recently, quantum mechanics manifested itself at the macroscopic level only through such collective phenomena as
superconductivity, flux quantization, or the Josephson effect. However, these "macroscopic" effects actually arise from the coherent superposition of a large number of microscopic variables each
governed by quantum mechanics. Thus, for example, the current through a Josephson tunnel junction and the phase difference across it are normally treated as classical variables.

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Ezgi Karaca @ezgikaraca.bsky.social · 3d

And the legacy continues! 😊

@amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social #EMBOIntegMod25 ! 🍀🧿

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Marc Lensink @marclensink.bsky.social · 3d

Jaja

Marc Lensink @marclensink.bsky.social · 3d

Okay people, it was nice knowing you...

Weather forecast for Izmir, Turkey for the coming three days: a combined precipitation of 57.2 mm of rain

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ianVisits @ianvisits.co.uk · 6d

In memoriam...

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Nereide @drnereide.bsky.social · 8d

🧵
Question: "If chimps are so much like us, why are they endangered while humans dominate the globe?"

Goodall: "Well, in some ways we're not successful at all. We're destroying our home. That's not a bit successful."

— #JaneGoodall, 3 Apr. 1934 - 1 Oct. 2025

#ForeverInspiring #LegacyOfHope 🧪

The photo features Jane Goodall and infant chimpanzee Flint reach out to touch each other's hands. Flint was the first infant born at Gombe (Tanzania) after Jane arrived. With him, she had a great opportunity to study chimp development.

Photo source: https://education.nationalgeographic.org/resource/jane-goodall/

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Marc Lensink @marclensink.bsky.social · 7d

I totally loved Jessica Jones and Daredevil. Luke Cage started off meh, but was okay in the end. I never saw much appeal in The Punisher so sort of put off watching that, but recently I got around to it. I'm only about halfway the first season, but actually quite enjoying it!

Reposted by Marc Lensink

Giulio Tesei @giuliotesei.bsky.social · 7d

I'm hiring for a PhD position at Malmö University, Sweden!

The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.

More details and application form: tinyurl.com/4zm92365

Please feel free to share!

@vetenskapsradet.bsky.social | @mau.se

Snapshot of a condensate near a lipid membrane with Swedish Research Council and Malmö University logos.

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Instruct-ERIC @instruct-eric.bsky.social · 7d

Join us in Brussels for the 7th Instruct Biennial Structural Biology Conference!

#IBSBC2026 showcases the latest in integrative structural biology from leading scientists across the world. This year's conference will take place 27-29 May - register below!

instruct-eric.org/ibsbc2026

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 7d

Integrative modelling of biomolecular dynamics

Time-dependent and -resolved experiments combined with computation provide a view on molecular dynamics beyond that available from static, ensemble-averaged experiments

Review w @dariagusew.bsky.social & Carl G Henning Hansen
doi.org/10.48550/arX...

$Figure 1 from the review. Caption: Comparison of a schematic example showing static, time-dependent, and time-resolved experiments illustrated by a protein folding process. (a) A static experiment measuring the observable O$_{\text{exp}}$ is shown, which can be modelled as a distribution of simulated values, O$_{\text{calc}}$, representing a conformational ensemble of folded and unfolded states. (b) Shows a time-dependent experiment, where the equilibrium dynamics of reversible folding gives rise to measured transition times $\tau_1$ and $\tau_2$. These can be modelled as equilibrium dynamics, illustrated by a free energy (FE) surface along a chosen degree of freedom (D.O.F.) (c) A time-resolved experiment probes a non-equilibrium process, where the system begins at $t_{0}$ in the folded state. During the observation time $t$ the protein unfolds until $t_{\text{max}}$. At each time point, a distinct ensemble average, O$_{\text{exp}}$, can be observed, reflecting the proteins changing structure. This evolution can be modelled as distributions of O$_{\text{calc}}$ at each time point. These are shown together with a FE surface.$

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Arne Elofsson @bioinfo.se · 7d

Elaborate machinery for inserting proteins into the outer membrane of bacteria www.nature.com/articles/d41...

Elaborate machinery for inserting proteins into the outer membrane of bacteria

Bacteria in the gut use an unusual molecular apparatus to insert complex proteins into their outer membrane.

www.nature.com

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