Luc Estebanez
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lucestebanez.bsky.social
Luc Estebanez
@lucestebanez.bsky.social
250 followers 320 following 32 posts
Brain-machine interfaces, Neuroprostheses.
CNRS, Paris-Saclay Institute of Neuroscience @NeuroPSI.bsky.social
https://neuropsi.cnrs.fr/annuaire/luc-estebanez/

Member of team @TouchMoveLab.bsky.social
Posts Replies Media Videos
Reposted by Luc Estebanez
plosbiology.org
How to restore #motor function after #stroke? This study shows in mice that a combination of #RoboticRehabilitation & non-invasive gamma band #neuromodulation improves motor recovery by restoring movement-related oscillations & parvalbumin #interneuron dynamics @plosbiology.org 🧪 plos.io/4n7QJng
Enduring reduction of resting state functional connectivity (FC) of parvalbumin-positive interneurons (PV-INs) after stroke. Top left: Experimental timeline, with the cranial optical window implanted one week before the first imaging session. Imaging time point at −1 (PRE), 2, 5, 8, 14, 21, and 28 days after stroke. Top right: Left, representative image sequence of cortical PV-IN activity before stroke. The black dot indicates bregma. L: lateral; M: medial; R: rostral; C: caudal (Scale bar, 1 mm). Right, wide-field calcium imaging field-of-view aligned with the surface of the Allen Institute Mouse Brain atlas. The green area on the left hemisphere locates the damaged region. Yellow squares represent cortical areas defined in both left (L, contralesional) and right (R, ipsilesional) hemispheres. Red dot indicates bregma (Scale bar, 1 mm). Middle row: Pairwise Pearson’s correlation coefficients of cortical activity were visualized as averaged correlation matrices for each imaging time point after hemodynamic correction. Bottom row: Network diagrams of statistically significant FC alterations after 2, 5, 8, 14, 21, or 28 days from injury. Blue and red lines denote significant hyper-correlation and hypo-correlation compared to prestroke values, respectively.
October 16, 2025 at 7:59 AM
Reposted by Luc Estebanez
neuropsi.bsky.social
🤯 👁️ Did you know the primary visual cortex tracks head movements even in complete darkness?

Guy Bouvier and colleagues managed to decode multiple head movement variables in V1 without light in the room, and discovered two distinct brain sources delivering these signals!

Read more in PNAS 🔽🔽
www.pnas.org
October 11, 2025 at 8:25 AM
Reposted by Luc Estebanez
virginievanw.bsky.social
Evenement à diffuser pour la fête de la science en @iledefrance.bsky.social @poncerlab.bsky.social
@bathellierlab.bsky.social @clairewyart.bsky.social
September 29, 2025 at 1:43 PM
lucestebanez.bsky.social
1/4 Today we introduce the first upper limb prosthesis for the mouse model, controlled by a brain-machine interface! We show that mice can control this prosthesis via a brain-machine interface to solve a rewarded task.
Left: the upper-limb prosthesis can collect water from a tank, and bring it close to the mouth. Right: skeleton of the prosthesis with 4 DOF. THis prosthesis relies on Bowden cables.
September 4, 2025 at 9:29 AM
Reposted by Luc Estebanez
juangallego.bsky.social
🚨 New preprint + thread 🧵
We've gone back to studying motoneuron control principles and their applications & here's paper #1:

A proof-of-concept study showing that people with tetraplegic spinal cord injury can control up to 2DoF from a single intramuscular implant

www.medrxiv.org/content/10.1...
August 7, 2025 at 11:35 AM
Reposted by Luc Estebanez
micahgallen.com
Never thought I’d see the day when LinkedIn is the biggest driver of engagement in our papers, but we live in some strange times.
August 1, 2025 at 12:26 PM
lucestebanez.bsky.social
1/6 We have a new/updated preprint out, led by Anton Dogadov, demonstrating operant conditioning of large cortical waves over mouse S1 thanks to a mesoscale GCamp6 brain-machine interface!
www.biorxiv.org/content/10.1...
August 1, 2025 at 6:25 AM
Reposted by Luc Estebanez
alegrecortes.bsky.social
I'm excited to share my latest publication! 🚨
Global and local nature of cortical slow waves:
www.cell.com/iscience/ful...

In brief, we explored in silico how cortical slow waves are shaped by both external inputs and intrinsic properties of neuronal populations.
Global and local nature of cortical slow waves
Explaining the macroscopic activity of a neuronal population from its microscopic properties poses a great challenge, not just because of the many local agents that play a role, but due to the impact ...
www.cell.com
July 29, 2025 at 10:13 AM
Reposted by Luc Estebanez
tanujgulati.bsky.social
(1/8)
Excited to share our new paper in @cp-cellreports.bsky.social , led by grad student @rohitrangwani.bsky.social ! 🧠🤖
We show that robust #BrainMachineInterface (#BMI) control is possible using #cerebellar activity- even in a #stroke-affected brain.
#Neuroscience
www.cell.com/cell-reports...
Redirecting
doi.org
July 21, 2025 at 6:58 PM
Reposted by Luc Estebanez
science.org
Octopuses fall for the “rubber arm” illusion, just like us.

Learn more: scim.ag/40xyT4y
July 22, 2025 at 7:56 PM
Reposted by Luc Estebanez
michaelzlin.bsky.social
Two voltage imaging studies in two days using ASAP fluorescent indicators.

First, visualizing electrical brain waves with ASAP3, in Cell. Free link below. Though recorded by EEG for 100 years, how brain waves arise from different neuron types has been unclear.

authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
July 17, 2025 at 7:39 PM
Reposted by Luc Estebanez
jul-bouvier.bsky.social
Don't miss this upcoming informal gathering on the theme of SEARCHING FOR PRINCIPLES IN MOTOR CONTROL on Sept 23-24, 25 in Sorbonne University. It will enable you to present your work to the French motor community. Registration is free! motorconference.sciencesconf.org
Searching for Principles in Motor Control - Sciencesconf.org
motorconference.sciencesconf.org
July 16, 2025 at 2:15 PM
Reposted by Luc Estebanez
bathellierlab.bsky.social
If you have missed it, wonderful workshop in Montpellier on most recent optical imaging techniques for neurosciences. One week left to register lnkd.in/etEmGyMm
Visit workshop 284
Free registration, accomodation possible on site.
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
July 13, 2025 at 9:05 AM
Reposted by Luc Estebanez
science.org
Scientists have developed OpenExo, an open source exoskeleton framework that could make wearable robotics more accessible and accelerate the development of new devices.

Read more in #ScienceRobotics: scim.ag/4koYIKY
OpenExo: An open-source modular exoskeleton to augment human function
We present an open-source, open-hardware exoskeleton to aid in accelerating the growth of robotic exoskeleton research.
scim.ag
July 7, 2025 at 7:15 PM
Reposted by Luc Estebanez
cnrsbiologie.bsky.social
Les souris ont-elles aussi une représentation cognitive de leur corps ?

🤝 @cnrs-paris-saclay.bsky.social @univparissaclay.bsky.social @lucestebanez.bsky.social @touchmovelab.bsky.social @neuropsi.bsky.social

👉 Lire l'article dans @plosbiology.org
buff.ly/2JK2msI
Les souris ont aussi une représentation cognitive riche de leur corps
L’illusion de la « main en caoutchouc » montre que la manipulation astucieuse de perceptions visuelles et tactiles peut nous convaincre en quel
buff.ly
July 5, 2025 at 5:00 AM
Reposted by Luc Estebanez
nikaradziun.bsky.social
How does the brain integrate artificial body extensions? Using a custom-built finger-extending exoskeleton, we show that wearable augmentations are quickly integrated into body representation, with proprioceptive space adapting to the device’s structure and function.

www.biorxiv.org/content/10.1...
Dynamics of sensorimotor plasticity during exoskeletal finger augmentation
How does the brain integrate artificial body extensions into its somatosensory representation? While prior work has shown that tool use alters body representation, little is known about how artificial...
www.biorxiv.org
July 4, 2025 at 5:44 AM
Reposted by Luc Estebanez
neuropsi.bsky.social
🎉 L'interdisciplinarité est à l'oeuvre dans notre institut.

🤝 Nos liens forts avec la communauté des ingénieurs du L2S @centralesupelec.bsky.social nous valent le label PRIME de @cnrs.fr !
Le projet Neurocontrol : où les neurosciences rencontrent l’automatique – MITI
Retrouver l'interview des porteurs du projet Neurocontrol, fruit d’une collaboration entre neuroscientifiques et automaticiens
miti.cnrs.fr
July 2, 2025 at 10:41 AM
Reposted by Luc Estebanez
neuropsi.bsky.social
🔬🐁 We have a new position open!

➡️ Our "Chaire Professeur Junior" position focuses on multi-omics during brain development. This research-heavy position follows a tenure-track scheme, leading to a full professor position.

🗓️ Application deadline: 22/08/2025
www.universite-paris-saclay.fr
June 28, 2025 at 3:18 PM
Reposted by Luc Estebanez
neuropsi.bsky.social
C'est notre grande tristesse d'annoncer le décès de Heather McLean, Maitresse de Conférence en neuroscience à @univparissaclay.bsky.social, chercheuse à @neuropsi.bsky.social.
Notre chère collègue et amie, Heather McLean, nous a quittés le 16 juin 2025, après s’être battue comme une lionne, avec beaucoup de courage et de détermination, contre le cancer. Canadienne de naissance, elle est arrivée en France en 1992 pour effectuer un postdoctorat dans le laboratoire de Jean Champagnat à Gif-sur-Yvette, où elle a étudié les réseaux de neurones impliqués dans les rythmes respiratoires. Après un second postdoctorat dans l’équipe de Yehezkel Ben-Ari en 1998, elle a été recrutée comme maître de conférences dans notre université. Elle y a enseigné la physiologie et les neurosciences avec passion, dynamisme et bonne humeur. Elle s’est également beaucoup investie dans la formation des professeurs des écoles en étant tout d’abord responsable d’un parcours dédié au sein de la Licence Sciences de la Vie, puis responsable de la Licence Sciences, Enseignement, Médiation. Heather McLean a contribué en première ligne à l'internationalisation des formations de l’Université Paris-Saclay, en tant que coordinatrice Erasmus+ pour le service des relations internationales, ainsi qu’en tant que directrice adjointe déléguée aux relations internationales de la graduate school Life Sciences and Health.   Parallèlement, Heather a mené des recherches sur les récepteurs métabotropiques au glutamate et à l’adénosine dans le cortex cérébelleux, dans l’équipe d’Hervé Daniel. En 2020, elle a rejoint l’équipe de Valérie Doyère où elle a développé une thématique centrée sur l’étude des effets de la manipulation des circuits neuronaux sur l’apparition d'états anxieux et de peurs à l’adolescence. Son HDR, intitulée From Synapses to Cognition, reflète bien son parcours : un véritable voyage au cœur du cerveau et au sein de NeuroPSI.   Heather McLean était très appréciée de ses collègues et des étudiant·e·s envers qui elle se montrait toujours à l’écoute et bienveillante. Sa bonne humeur, son esprit collaboratif et sa curiosité nous manqueront à toutes et à tous, énormément.
June 25, 2025 at 7:50 PM
Reposted by Luc Estebanez
pierrelemerre.bsky.social
I am extremely grateful and beyond happy to share that I have been awarded an @inserm.fr #ATIP-Avenir fellowship to start my own lab to study neuronal circuits for auditory categorization! Thanks to everyone who made this possible.
June 26, 2025 at 1:20 PM
Reposted by Luc Estebanez
zeronoiselab.bsky.social
Now out in @natcomms.nature.com‬: Mice and monkeys spontaneously shift through comparable cognitive states - and it's written all over their faces! (1/7)
www.nature.com/articles/s41...
Inferring internal states across mice and monkeys using facial features - Nature Communications
Here, the authors created a virtual reality task for monkeys and mice to explore if internal states like attention are similar across species. Their facial expressions during the task were similar, su...
www.nature.com
June 10, 2025 at 11:21 AM
Reposted by Luc Estebanez
bathellierlab.bsky.social
Two postdoc positions in the lab within the ERC Synergy project "Chronology" in collaboration with S. Ostojic, M. Jazayeri and V. van Wassenhove @virginievanw.bsky.social . Two focuses: sound sequences representations across the brain & novel all-optical technology. Contact: [email protected]
June 15, 2025 at 8:20 AM
Reposted by Luc Estebanez
pierrebat.cpesr.fr
Du poids indéniable de l'école dans la production des inégalités genrées face aux mathématiques

"Rapid emergence of a maths gender gap in first grade"
par P. Martinot et al.

Une étude sur 3 million d'enfants en France (!!!) qui va faire du bruit

#LaRAC @nature.com
www.nature.com/articles/s41...
Preventing gender disparities in mathematics is a worldwide preoccupation1,2. In infancy and early childhood, boys and girls exhibit similar core knowledge of number and space3,4,5,6,7,8. Gender disparities in maths are, therefore, thought to primarily reflect an internalization of the sociocultural stereotype that ‘girls are bad at maths’. However, where, when and how widely this stereotype becomes entrenched remains uncertain. Here, we report the results of a 4-year longitudinal assessment of language and mathematical performance of all French first and second graders (2,653,082 children). Boys and girls exhibited very similar maths scores upon school entry, but a gender gap in favour of boys became highly significant after 4 months of schooling and reached an effect size of about 0.20 after 1 year. These findings were repeated each year and varied only slightly across family, class or school type and socio-economic level. Although schooling correlated with age, exploiting the near-orthogonal variations indicated that the gender gap increased with schooling rather than with age. These findings point to the first year of school as the time and place where a maths gender gap emerges in favour of boys, thus helping focus the search for solutions and interventions. Ecart de genre en maths à T1 (début CP), T2 (janvier CP) et T3 (début CE1) en fonction de l'âge des enfants en mois lors de la passation du test, pour les quatre années de cohorte (d de Cohen). Étant donné que l'entrée à l'école est strictement déterminée par la date de naissance, les enfants du même âge peuvent différer dans leur durée de scolarisation (couleurs et lignes de régression). Quel que soit l'âge auquel ils ont passé le test, les enfants présentaient un écart minime ou nul entre les sexes en mathématiques à T1, mais l'effet s'est accentué après 4 mois (T2) et 12 mois (T3) de scolarisation.
June 12, 2025 at 2:34 PM
lucestebanez.bsky.social
🐀💪More coverage of our latest mouse limb embodiment work @plosbiology.org in @newsweek.com !
Scientists trick mice with human experiment with 'unparalleled' value
"This opens up many opportunities."
www.newsweek.com
June 11, 2025 at 4:44 PM
Reposted by Luc Estebanez
plosbiology.org
The "rubber hand illusion" in mice... @lucestebanez.bsky.social &co use automated videography to show that mice display quantifiable behavioral markers of the embodiment of an #ArtificialLimb, opening the door to future research into human #BodyOwnership disorders @plosbiology.org 🧪 plos.io/4jHsESn
The rubber-hand illusion was translated to the mouse model. Just like in humans, embodiment in mice can be achieved by brushing the real forelimb of the mouse and the artificial limb (yellow) in synchrony to generate matching visual and touch percepts. This study suggests that as the mouse looks at the artificial limb, it perceives it as its own limb, and feels threatened if the artificial limb is threatened. Image credit: Luc Estebanez.
June 10, 2025 at 8:08 AM