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Reposted by Luc Estebanez

Virginie van Wassenhove @virginievanw.bsky.social · 9d

Evenement à diffuser pour la fête de la science en @iledefrance.bsky.social @poncerlab.bsky.social
@bathellierlab.bsky.social @clairewyart.bsky.social

DIM C-BRAINS @c-brains.bsky.social · 9d

Fête de la Science 🧠

Lundi 6 octobre 17h-19h Hôtel de ville de Paris

Comprendre le cerveau et ses maladies : dialogue sur les enjeux éthiques, scientifiques et médicaux.

Avec @clairewyart.bsky.social , @bathellierlab.bsky.social ,...

Inscrivez-vous ici!
docs.google.com/forms/d/e/1F...

Comprendre le cerveau et ses maladies : dialogue sur les enjeux éthiques, scientifiques et médicaux - Formulaire d'inscription

Plongée au cœur des neurosciences : un débat inédit entre chercheurs et représentants de la société civile pour questionner l’avenir de la recherche. Dates de l’événement : 6 octobre 2025, de 17h à 19...

docs.google.com

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Luc Estebanez @lucestebanez.bsky.social · Sep 4

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➡️ Read our manuscript on the link below 🔽🔽🔽
➡️ Many thanks to our collaborators at L2S @centralesupelec.bsky.social , and to all members of the @touchmovelab.bsky.social‬ for their key input to this project.
➡️ Funding from Fondation 3DS and @agencerecherche.bsky.social

Cortical control of a forelimb prosthesis in mice

Robotic upper-limb prostheses aim to restore the autonomy of paralyzed patients and amputees. So far, advances in this field have relied on monkey pre-clinical and human clinical research. Here, we re...

www.biorxiv.org

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Luc Estebanez @lucestebanez.bsky.social · Sep 4

3/4 As learning progressed, the mice learned to coordinate the prosthesis movements across dimensions, and they managed to consolidate a dominant prosthesis trajectory that led to rewards.

Average dominant movement of the prosthesis leading to a rewarded lick. Left: along dimension 1 of the control space. Right: dimension 2. Light curves: individual movements during one session. Thick curve: average over the session.

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Luc Estebanez @lucestebanez.bsky.social · Sep 4

2/4 Our prosthesis can perform movements in a 3D space next to the body of the mice, that control it via a chronic invasive brain-machine interface. We show that the mice can drive it in a 2D subspace, while some mice managed to control it also in a 3D space.

Left: 2D control subspace. Each dimension is driven by the modulation of one of the neurons recorded in M1. Right: average learning curve, in terms of licks that provided water to the mouse.

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Luc Estebanez @lucestebanez.bsky.social · Sep 4

1/4 Today we introduce the first upper limb prosthesis for the mouse model, controlled by a brain-machine interface! We show that mice can control this prosthesis via a brain-machine interface to solve a rewarded task.

Left: the upper-limb prosthesis can collect water from a tank, and bring it close to the mouth. Right: skeleton of the prosthesis with 4 DOF. THis prosthesis relies on Bowden cables.

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Reposted by Luc Estebanez

Juan Gallego @juangallego.bsky.social · Aug 7

🚨 New preprint + thread 🧵
We've gone back to studying motoneuron control principles and their applications & here's paper #1:

A proof-of-concept study showing that people with tetraplegic spinal cord injury can control up to 2DoF from a single intramuscular implant

www.medrxiv.org/content/10.1...

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Reposted by Luc Estebanez

Micah G. Allen @micahgallen.com · Aug 1

Never thought I’d see the day when LinkedIn is the biggest driver of engagement in our papers, but we live in some strange times.

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Luc Estebanez @lucestebanez.bsky.social · Aug 1

6/6 This is all thanks to the incredibly talented and passionate Anton Dogadov, who carried this whole study!

Thanks for feedback on our first version of the paper from @gbouvier.bsky.social vier.bsky.social‬ at @neuropsi.bsky.social, Jean-François Léger @ibensens.bsky.social and many others!

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Luc Estebanez @lucestebanez.bsky.social · Aug 1

5/6 During cortical wave generation, the response to the movement was reshaped, and lost its relation to limb amplitude, likely being processed to match the task instead.

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Luc Estebanez @lucestebanez.bsky.social · Aug 1

4/6 Importantly, limb movements were likely required to trigger rewardable waves, but were only successful when the cortex was in the specific, suppressed state.

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Luc Estebanez @lucestebanez.bsky.social · Aug 1

3/6 We have now gone much further, and show that learning this task triggers a reshaping of the cortical dynamics, including a strong suppression of activity before rewardable wave.

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Luc Estebanez @lucestebanez.bsky.social · Aug 1

2/6 One year ago, we showed that mice can learn to guide mesoscale cortical of the somatosensory cortex from a start to a target area to obtain rewards.

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Luc Estebanez @lucestebanez.bsky.social · Aug 1

1/6 We have a new/updated preprint out, led by Anton Dogadov, demonstrating operant conditioning of large cortical waves over mouse S1 thanks to a mesoscale GCamp6 brain-machine interface!
www.biorxiv.org/content/10.1...

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Reposted by Luc Estebanez

Javier Alegre-Cortés @alegrecortes.bsky.social · Jul 29

I'm excited to share my latest publication! 🚨
Global and local nature of cortical slow waves:
www.cell.com/iscience/ful...

In brief, we explored in silico how cortical slow waves are shaped by both external inputs and intrinsic properties of neuronal populations.

Global and local nature of cortical slow waves

Explaining the macroscopic activity of a neuronal population from its microscopic properties poses a great challenge, not just because of the many local agents that play a role, but due to the impact ...

www.cell.com

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Reposted by Luc Estebanez

Tanuj Gulati @tanujgulati.bsky.social · Jul 21

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Excited to share our new paper in @cp-cellreports.bsky.social , led by grad student @rohitrangwani.bsky.social ! 🧠🤖
We show that robust #BrainMachineInterface (#BMI) control is possible using #cerebellar activity- even in a #stroke-affected brain.
#Neuroscience
www.cell.com/cell-reports...

Redirecting

doi.org

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Reposted by Luc Estebanez

Science Magazine @science.org · Jul 22

Octopuses fall for the “rubber arm” illusion, just like us.

Learn more: scim.ag/40xyT4y

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Reposted by Luc Estebanez

Michael Lin, MD PhD @michaelzlin.bsky.social · Jul 17

Two voltage imaging studies in two days using ASAP fluorescent indicators.

First, visualizing electrical brain waves with ASAP3, in Cell. Free link below. Though recorded by EEG for 100 years, how brain waves arise from different neuron types has been unclear.

authors.elsevier.com/sd/article/S...

ScienceDirect.com | Science, health and medical journals, full text articles and books.

authors.elsevier.com

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Reposted by Luc Estebanez

Julien Bouvier @jul-bouvier.bsky.social · Jul 16

Don't miss this upcoming informal gathering on the theme of SEARCHING FOR PRINCIPLES IN MOTOR CONTROL on Sept 23-24, 25 in Sorbonne University. It will enable you to present your work to the French motor community. Registration is free! motorconference.sciencesconf.org

Searching for Principles in Motor Control - Sciencesconf.org

motorconference.sciencesconf.org

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Reposted by Luc Estebanez

Brice Bathellier @bathellierlab.bsky.social · Jul 13

If you have missed it, wonderful workshop in Montpellier on most recent optical imaging techniques for neurosciences. One week left to register lnkd.in/etEmGyMm
Visit workshop 284
Free registration, accomodation possible on site.

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Reposted by Luc Estebanez

Science Magazine @science.org · Jul 7

Scientists have developed OpenExo, an open source exoskeleton framework that could make wearable robotics more accessible and accelerate the development of new devices.

Read more in #ScienceRobotics: scim.ag/4koYIKY

OpenExo: An open-source modular exoskeleton to augment human function

We present an open-source, open-hardware exoskeleton to aid in accelerating the growth of robotic exoskeleton research.

scim.ag

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Reposted by Luc Estebanez

CNRS Biologie @cnrsbiologie.bsky.social · Jul 5

Les souris ont-elles aussi une représentation cognitive de leur corps ?

🤝 @cnrs-paris-saclay.bsky.social @univparissaclay.bsky.social @lucestebanez.bsky.social @touchmovelab.bsky.social @neuropsi.bsky.social

👉 Lire l'article dans @plosbiology.org
buff.ly/2JK2msI

Les souris ont aussi une représentation cognitive riche de leur corps

L’illusion de la « main en caoutchouc » montre que la manipulation astucieuse de perceptions visuelles et tactiles peut nous convaincre en quel

buff.ly

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Reposted by Luc Estebanez

Dominika Radziun @nikaradziun.bsky.social · Jul 4

How does the brain integrate artificial body extensions? Using a custom-built finger-extending exoskeleton, we show that wearable augmentations are quickly integrated into body representation, with proprioceptive space adapting to the device’s structure and function.

www.biorxiv.org/content/10.1...

Dynamics of sensorimotor plasticity during exoskeletal finger augmentation

How does the brain integrate artificial body extensions into its somatosensory representation? While prior work has shown that tool use alters body representation, little is known about how artificial...

www.biorxiv.org

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Reposted by Luc Estebanez

Paris-Saclay Institute of Neuroscience @neuropsi.bsky.social · Jul 2

🎉 L'interdisciplinarité est à l'oeuvre dans notre institut.

🤝 Nos liens forts avec la communauté des ingénieurs du L2S @centralesupelec.bsky.social nous valent le label PRIME de @cnrs.fr !

Le projet Neurocontrol : où les neurosciences rencontrent l’automatique – MITI

Retrouver l'interview des porteurs du projet Neurocontrol, fruit d’une collaboration entre neuroscientifiques et automaticiens

miti.cnrs.fr

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Reposted by Luc Estebanez

Paris-Saclay Institute of Neuroscience @neuropsi.bsky.social · Jun 28

🔬🐁 We have a new position open!

➡️ Our "Chaire Professeur Junior" position focuses on multi-omics during brain development. This research-heavy position follows a tenure-track scheme, leading to a full professor position.

🗓️ Application deadline: 22/08/2025

www.universite-paris-saclay.fr

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Reposted by Luc Estebanez

Paris-Saclay Institute of Neuroscience @neuropsi.bsky.social · Jun 25

C'est notre grande tristesse d'annoncer le décès de Heather McLean, Maitresse de Conférence en neuroscience à @univparissaclay.bsky.social, chercheuse à @neuropsi.bsky.social.

Notre chère collègue et amie, Heather McLean, nous a quittés le 16 juin 2025, après s’être battue comme une lionne, avec beaucoup de courage et de détermination, contre le cancer. Canadienne de naissance, elle est arrivée en France en 1992 pour effectuer un postdoctorat dans le laboratoire de Jean Champagnat à Gif-sur-Yvette, où elle a étudié les réseaux de neurones impliqués dans les rythmes respiratoires. Après un second postdoctorat dans l’équipe de Yehezkel Ben-Ari en 1998, elle a été recrutée comme maître de conférences dans notre université. Elle y a enseigné la physiologie et les neurosciences avec passion, dynamisme et bonne humeur. Elle s’est également beaucoup investie dans la formation des professeurs des écoles en étant tout d’abord responsable d’un parcours dédié au sein de la Licence Sciences de la Vie, puis responsable de la Licence Sciences, Enseignement, Médiation. Heather McLean a contribué en première ligne à l'internationalisation des formations de l’Université Paris-Saclay, en tant que coordinatrice Erasmus+ pour le service des relations internationales, ainsi qu’en tant que directrice adjointe déléguée aux relations internationales de la graduate school Life Sciences and Health.

Parallèlement, Heather a mené des recherches sur les récepteurs métabotropiques au glutamate et à l’adénosine dans le cortex cérébelleux, dans l’équipe d’Hervé Daniel. En 2020, elle a rejoint l’équipe de Valérie Doyère où elle a développé une thématique centrée sur l’étude des effets de la manipulation des circuits neuronaux sur l’apparition d'états anxieux et de peurs à l’adolescence. Son HDR, intitulée From Synapses to Cognition, reflète bien son parcours : un véritable voyage au cœur du cerveau et au sein de NeuroPSI.

Heather McLean était très appréciée de ses collègues et des étudiant·e·s envers qui elle se montrait toujours à l’écoute et bienveillante. Sa bonne humeur, son esprit collaboratif et sa curiosité nous manqueront à toutes et à tous, énormément.

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