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Kira キラ

@lumpyplum.bsky.social

420 followers 840 following 800 posts

Civil litigator, art nerd, soccer lover, club demon. 🦋 lumpyplume.com (Goodreads/ Storygraph)(she) 🦦🦦 Carti +トンボ (Tommi)📍Philly

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Kira キラ @lumpyplum.bsky.social · Jan 16

2025 Nonfiction thoughts, collected:

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Kira キラ @lumpyplum.bsky.social · 13h

"tch la japonesa juega bien" yeah, I'll take that

Kira キラ @lumpyplum.bsky.social · 1d

My friend is throwing a shelf party when she gets her vitsœ shelving 😭 this brings me back to a design students' party listening to two moscot lemtosh broskis argue about serifs on fonts

Reposted by Kira キラ

Chasing Aphrodite @chasingaphrodite.bsky.social · 3d

The Pushkin job: unmasking the thieves behind an international rare books heist

As many as 170 rare and valuable editions of Russian classics were stolen from libraries across Europe. Were the thieves merely low-level opportunists, or were bigger forces at work?

www.theguardian.com/books/2025/o...

The Pushkin job: unmasking the thieves behind an international rare books heist

The long read: Between 2022 and 2023, as many as 170 rare and valuable editions of Russian classics were stolen from libraries across Europe. Were the thieves merely low-level opportunists, or were bi...

www.theguardian.com

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Kira キラ @lumpyplum.bsky.social · 2d

Honestly the universe was cooking when it broke my cell phone camera lens. "I'm sorry ma'am, I actually cannot scan the qr code"

Reposted by Kira キラ

William Shakespeare @shakespeare.lol · 2d

thou art damn’d to hell

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Reposted by Kira キラ

Chise @sailorrooscout.bsky.social · 2d

Researchers envision their vaccine being used as both a treatment and a preventive, and as an approach to treating multiple cancer types.
• www.umass.edu/news/article...

The study has been published in Cell Reports Medicine. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️

HIGHLIGHTS
•Lipid NPs carrying STING and TLR4 agonists promote synergistic type I interferons
• NPs drain efficiently to lymph nodes and increase polyfunctional T and B cells
• NPs improve tumor-free outcomes with memory against multiple aggressive tumor models
SUMMARY
We report on the utility of a "super-adjuvant" nanoparticle (NP) system as a modular, customizable platform for next-generation cancer vaccination. Using nanomaterials engineering technology, we aim to harness not only the effective adjuvanticity of whole-pathogen vaccines, but also the safety of subunit vaccines.
Our lipid-based NP platform co-encapsulates agonists of the stimulator of interferon genes (STING) and Toll-like receptor 4 (TLR4) pathways to promote synergistic production of type I interferons and other
proinflammatory cytokines in innate antigen-presenting dendritic cells and macrophages.
Compared to empty NPs and free agonists, dual-adjuvant NPs administered with antigenic peptides or tumor cell lysate promote increased antigen processing and presentation, drain efficiently to nearby lymph nodes, increase polyfunctional tumor-specific T and B cells, and improve tumor-free outcomes upon vaccination and subsequent challenge with multiple aggressive tumor cells.

Graphical Abstract

The vaccine combines two immune-stimulating molecules (adjuvants) in a tiny lipid nanoparticle that enhances both innate and adaptive immune responses. The innate immune system acts as the body’s first line of defense, responding quickly and non-specifically to invaders using cells that release inflammatory signals. The adaptive immune system takes longer to activate but provides a targeted, long-lasting response, training T-cells and B- cells to recognize and remember specific threats. Together, they form a coordinated defense: the innate system alerts and activates the adaptive system, which then delivers precise and durable immunity.

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Kira キラ @lumpyplum.bsky.social · 2d

Stream of consciousness architecture blog

bldgblog.com

BLDGBLOG

Architectural Conjecture | Urban Speculation | Landscape Futures

bldgblog.com

Kira キラ @lumpyplum.bsky.social · 2d

"I don't think it an act of will, but slowly and almost imperceptibly I managed to extend my sense of neutral, indefinite morning. I concentrated it, intensified that pale-gray awakening and with each morning I found it possible to carry that sensation with me further into the day."

Kira キラ @lumpyplum.bsky.social · 2d

For us it has always been about the days together, day after day, night after night, again and again."
...

Kira キラ @lumpyplum.bsky.social · 2d

"We are not one of those couples that has to have time apart, to miss and rediscover one another to go away and be reunited in a collision of love. Distance, leave-taking and reunions are not what bind us to one another.

Kira キラ @lumpyplum.bsky.social · Apr 14

On the Calculation of Volume I, a novel by Solvej Balle, translated by Barbara Haveland. Cover quote: "Absolutely, absolutely incredible." - Karl Ove Knausgård

"We try to avoid long phone calls when we're apart. Not only because otherwise we would only end up having long, detailed dialogues on the condition of the books, publication years, the illustrations and the pricing but also because such conversations seem to increase the distance between us. The minute we deviate from simple, practical matters, the conversation lapses imperceptibly into a kind of audio link, a muted love mumble. Our communication, initially meaningful and coherent, turns into a series of fitful exchanges containing neither sentences nor information: little words and sounds meant-I suppose-to keep the line between us open, but which, instead, make all too clear how far apart we are. So we have learned to split the work between us, stick to practical matters, and only speak to one another when necessary."

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Kira キラ @lumpyplum.bsky.social · 3d

A soundscape gothic rock day
youtu.be/vL57NTZAIxc?...

Souretsu -Funeral-

YouTube video by Sheena Ringo - Topic

youtu.be

Kira キラ @lumpyplum.bsky.social · 3d

tight leather jacket, baggy jeans and metal framed sunnies like a eurotrash raver going for a pack of smokes

Kira キラ @lumpyplum.bsky.social · 4d

You're in Philly??

Reposted by Kira キラ

Chris 🎃 DevPods.gg gamedev community @chrisdeleon.bsky.social · 6d

cool context about the frog from a quote post, including 🧵reply under it I'm not at all an expert in this domain to be able to verify this, but on a quick check these seem to fit what's said in the post 🐸

especially may be of interest for people confused since different frogs mean other things here

ti zhang @zerochilltea.bsky.social · 6d

so the frog is 卖娃青蛙。https://m.thepaper.cn/newsDetail_forward_23101624 it was designed by a mom with the last name Tong in Nanjing, inspired by the toad in en.wikipedia.org/wiki/Calabas.... it is a mascot of 躺平culture (lay-flat, against capitalism)

Chris 🎃 DevPods.gg gamedev community @chrisdeleon.bsky.social · 6d

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Kira キラ @lumpyplum.bsky.social · 6d

Texting phillies fans congrats like they just gave birth

Kira キラ @lumpyplum.bsky.social · 6d

Screams of red October rattled through the land

Kira キラ @lumpyplum.bsky.social · 6d

Mums will just be silently going through their year then fall hits and they're like 'here the fuck I am!!!'

Reposted by Kira キラ

Clayton Ashley @claytonashley.bsky.social · 7d

tumblr post by barackinaroundthechristmastree which reads:
please. stop praying for my grandpa!!!! you are making him too strong. he broke out of the hosptial and the cops cant get him. he's too powerful

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Kira キラ @lumpyplum.bsky.social · 6d

Can't get over this surreal first date with a person wondering why I would ask about soccer when the sport could lead to injury.

Kira キラ @lumpyplum.bsky.social · 7d

Took me a second to decode the green sperm on the paper

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Kira キラ @lumpyplum.bsky.social · 7d

Just stumbled on an old diary entry "maybe I shouldn't have eaten beef stew from the Indonesian corner store with gambling machines"

Kira キラ @lumpyplum.bsky.social · 7d

Just saw the artist afaq share darfuridp.org and wanted to bookmark the organization

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Kira キラ @lumpyplum.bsky.social · 8d

Philly things

Axios @axios.com · 8d

"We are not saying the word '6 7' anymore," one teacher posted herself saying to her class on TikTok. "If you do, you have to write a 67 word essay about what the word means... after five times if you still do it, your essay is going to bop up to 670 words."

The 6-7 TikTok trend among tweens and teens is leading to classroom bans

The term "6-7" originates from a song called "Doot Doot" by the rapper Skrilla.

www.axios.com

Kira キラ @lumpyplum.bsky.social · 8d

I shall emerge from this winter with the most obscure and niche deep interests

Kira キラ @lumpyplum.bsky.social · 8d

Working on a new sanbaso dance and found this similar maiko version.

youtu.be/n96DPz90Qec?...

花童　～民謡三番叟～

YouTube video by 柴田範房

youtu.be