Lightnews — Scholar-powered news

Reposted by Marc de Manuel

Natanael Spisak @natanaels.bsky.social · Sep 3

Very happy to share our work on signature SBS5. See Molly's thread for a short summary

Molly Przeworski @mollyprz.bsky.social · Sep 2

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

www.biorxiv.org

1 7 32

Reposted by Marc de Manuel

Molly Przeworski @mollyprz.bsky.social · Sep 2

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

www.biorxiv.org

4 46 110

Reposted by Marc de Manuel

Manuel Irimia @mirimiam.bsky.social · Jul 23

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

www.upf.edu

1 65 48

Reposted by Marc de Manuel

Jonathan Pritchard @jkpritch.bsky.social · Jun 1

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.

Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

3 110 83

Marc de Manuel @marcdemanuel.bsky.social · Apr 29

Truly honored to be appointed an Ambassador for the ERC. Looking forward to keep advocating for the importance of frontier science in Spain, Europe, and beyond.

European Research Council (ERC) @erc.europa.eu · Apr 29

🚀 We are proud to launch the new "Ambassadors for the ERC" initiative, together with @ercgrantees.bsky.social !

We aim to empower researchers across Europe to advocate for frontier research. Find out more 👉 bit.ly/44bQzp7

🌟 Excited to see what can be achieved!

#Amb4ERC

1 9

Reposted by Marc de Manuel

European Research Council (ERC) @erc.europa.eu · Apr 29

🚀 We are proud to launch the new "Ambassadors for the ERC" initiative, together with @ercgrantees.bsky.social !

We aim to empower researchers across Europe to advocate for frontier research. Find out more 👉 bit.ly/44bQzp7

🌟 Excited to see what can be achieved!

#Amb4ERC

1 18 52

Reposted by Marc de Manuel

Molly Przeworski @mollyprz.bsky.social · Apr 24

Posting on behalf of Shamil Sunyaev: Eimear(Vice Chair) and I (Chair) are organizing the 2025 Gordon Research Conference (GRC) on Human Genetics and Genomics, which will be held on July 6-11, 2025 in beautiful University of Southern Maine, Portland, Maine.

2025 Human Genetics and Genomics Conference GRC

The 2025 Gordon Research Conference on Human Genetics and Genomics will be held in Portland, Maine. Apply today to reserve your spot.

www.grc.org

3 35 50

Reposted by Marc de Manuel

Institut de Biologia Evolutiva (IBE) @ibe-barcelona.bsky.social · Apr 23

🔊 We're Hiring! 🔊
The #IBE seeks a Post-award Research Project Manager - European Projects. 🌍

📄 Full-time | 🕒 2-year renewable contract
📆 Apply by: 4th May

Explore all our #JobOffers & #JoinOurTeam 👉 https://www.ibe.upf-csic.es/work-with-us/job-offers

6 6

Reposted by Marc de Manuel

Sri Kosuri @srikosuri.bsky.social · Feb 8

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

83 860 1K

Reposted by Marc de Manuel

Molly Przeworski @mollyprz.bsky.social · Feb 2

“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and @gcbias.bsky.social: www.biorxiv.org/content/10.1...

The distribution of highly deleterious variants across human ancestry groups

A major focus of human genetics is to map severe disease mutations. Increasingly that goal is understood as requiring huge numbers of people to be sequenced from every broadly-defined genetic ancestry...

www.biorxiv.org

1 70 130

Marc de Manuel @marcdemanuel.bsky.social · Jan 4

Last days to apply!

Marc de Manuel @marcdemanuel.bsky.social · Nov 25

📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.

PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB

RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs

3 2

Reposted by Marc de Manuel

Marc de Manuel @marcdemanuel.bsky.social · Nov 25

📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.

PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB

RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs

44 45

Reposted by Marc de Manuel

Molly Przeworski @mollyprz.bsky.social · Dec 5

Most of the talks from our Oct meeting are now online, with a few more to come: www.precisionmedicine.columbia.edu/videos

39 84

Marc de Manuel @marcdemanuel.bsky.social · Nov 25

📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.

PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB

RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs

44 45

Reposted by Marc de Manuel

Vall d’Hebron Institute of Oncology @vhio.bsky.social · Nov 21

📢 Are you interested in doing a PhD in Life Sciences #VHIO?

🎓 PhD call open: 8-10 fully funded scholarships for international Life Sciences & Medical students 🧬 🩺

Apply now 👉 linke.to/PHDFellowshi...

🗓 Deadline for applications: 29th November 2024

PhD Fellowships - VHIO

linke.to

6 11

Reposted by Marc de Manuel

Jonathan Pritchard @jkpritch.bsky.social · Nov 22

In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox:
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?

8 73 160

Reposted by Marc de Manuel

Anna Obenauf @obenaufa.bsky.social · Nov 20

Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025

2 100 100

Reposted by Marc de Manuel

Yoav Gilad @ygilad.bsky.social · Nov 19

Accepting postdoc applications to work on a broad range of topics including gene regulatory variation, response eQTL mapping, complex traits, comparative genomics in primates, and predictive models.

8 10

Reposted by Marc de Manuel

Kit Yates @kityates.bsky.social · Nov 14

Here's a starter pack of people on here who I've found and who I know are excellent Science Communicators.
Give them a follow:
go.bsky.app/4SAvt2B

62 180 450

Reposted by Marc de Manuel

Stephen Turner @stephenturner.us · Nov 15

A thread with some new starter packs in genomics and bioinformatics 🧵 1/13...

8 55 120

Reposted by Marc de Manuel

Mark Hibbins, Great Lakes Swashbuckler @rejectresubmit.bsky.social · Oct 2

I'm recruiting students / postdocs to join my new lab at the University of Rochester for Fall 2025 onwards! If you're interested in phylogenetic comparative methods, genome evolution, and/or computational biology, please get in touch! More info:

mhibbins.github.io

Hibbins Lab

mhibbins.github.io

1 58 49

Marc de Manuel @marcdemanuel.bsky.social · Nov 13

Bioinformatics folks working on HPCs—anyone got a go-to alternative to vscode? It’s become mysteriously slow and unresponsive on our system lately

1

Reposted by Marc de Manuel

Iñaki Ruiz-Trillo @multicellgenome.bsky.social · Nov 13

The new program of Evolutionary Medical Genomics, lead by @mirimiam.bsky.social, and shared between our Institute, CRG & UPF will hold its 1st symposium next week. Our work on unicellular relatives of animals and tumorigenesis will be represented by Yosuke.
Link: evomedgenomics.com/events/inaug...

1 7 11

Reposted by Marc de Manuel

Love Dalén @lovedalen.bsky.social · Nov 13

🧬🐭🐴🐻Job Alert🐻🐴🐭🧬

We are hiring 3 postdoctoral researchers in DeepTime Palaeogenomics!

All positions are for 2 years (extension possible), & are fully funded both in terms of employment and project costs.

Deadline: 2 Dec 2024

Please RT!

Apply:
www.su.se/english/abou...

1 72 73

Reposted by Marc de Manuel

Kirk Lohmueller @klohmueller.bsky.social · Nov 12

Hi all! I'm excited to announce a tenure track faculty position in conservation genomics in EEB at UCLA! We're looking for candidates who use genomic tools to study evolutionary processes related to conservation. Note, the actual application deadline is Nov 29. recruit.apo.ucla.edu/JPF09875

Conservation Genomics Faculty Position

University of California, Los Angeles is hiring. Apply now!

recruit.apo.ucla.edu

99 86