ALT: the sun shines through the trees in the foreground

Some studies containing instructions in white text or small font — visible only to machines — will be withdrawn from preprint servers.

ALT: a man wearing headphones is sweating while sitting in an airplane .

Oncogene aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research. Oncogene propagates ...

Home page for the paper ‘The Strain on Scientific Publishing’ by Mark A Hanson, Dan Brockington, Paolo Crosetto and Pablo Gomez Barreiro

Nature Protocols - This protocol describes simple, small-scale laboratory production of mRNA for research and preclinical use. This includes sequence design, DNA template production, mRNA synthesis...

ALT: a woman in a black jacket is giving the middle finger while standing in the water .

Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.

Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...

Analysis flags hundreds of studies that seem to follow a template, reporting correlations between complex health conditions and single variables based on publicly available data sets.

The function of the proteasome besides degrading protein remains enigmatic. Goldberg et al. demonstrate that proteasomes can process proteins into antimicrobial peptides (AMPs) to ward off bacterial infection, revealing a new function of proteasomes in innate immunity.

Company finds candidates that bind to tricky proteins that deliver chemical messages in and out of cells

Dysregulation of the dopamine-ACOD1 axis correlates with sepsis severity.

Xu et al. conduct a single-arm, phase 2 study evaluating the efficacy and safety of nivolumab plus induction chemotherapy and radiotherapy in patients with nasopharyngeal carcinoma. This combination therapy sparing concurrent cisplatin improves failure-free survival compared with a historical benchmark, and has low toxicity and favorable patient-reported tolerability and quality-of-life.

The UK DRI at Cambridge is recruiting a Research Associate to investigate how E3 ubiquitin ligases drive degradation of protein aggregates in neurodegeneration

Mutations in RAS enzymes commonly drive cancer. Targeting an overlooked protein complex that works with RAS offers a fresh avenue to cancer therapy.

Total cell cycle duration is a key hallmark of cancer initiation, and determines whether defects in apoptosis, senescence, immune surveillance, angiogenesis, DNA repair, polarity and proliferation lead to cancer development.

ALT: han solo from star wars is pointing at the camera with his finger .