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Reposted by Marco Fumasoni

Anshul Kundaje @anshulkundaje.bsky.social · 24d

I'm curious if other mid career PIs have considered completely abandoning the trad publication model. We've been making gradual moves towards that end goal. But it's been difficult to completely jump ship for one main reason for me at least. 1/

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Reposted by Marco Fumasoni

Alexandra Dallaire @alexdallaire.bsky.social · Sep 3

I’m super happy to present the first discoveries of the RIKEN-Cambridge Joint Crop Symbiosis Research Team, based in Japan 🇯🇵

doi.org/10.1101/2025...

A thread 👇

Reductive evolution of the DNA replication machinery in endosymbiotic fungi

The molecular machinery for replicating and repairing DNA accurately is critically important for life and highly conserved across the Tree of Life. Here we show that two major lineages of fungi, Glome...

doi.org

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Marco Fumasoni @marcofumasoni.bsky.social · 28d

Great findings indeed, I have so many questions 🤩! I’m intrigued that TLS loss precedes the loss of Polδ. While the latter could be host control, the former shouldn’t. Like @morielab.bsky.social, I wonder how far can Polδ go alone, and what does the plant supply for efficient genome duplication!

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liti_nice @litinice.bsky.social · Jul 3

how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)

Melania D'Angiolo @melaniadangiolo.bsky.social · Jul 3

Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response.

www.biorxiv.org/content/10.1...

The adaptive molecular landscape of reprogrammed telomeric sequences

Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequen...

www.biorxiv.org

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Reposted by Marco Fumasoni

Molecular Systems Biology @molsystbiol.org · Jul 3

@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....

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Gilles FISCHER @gillesfischer.bsky.social · Jun 9

📢 New paper out in Mol Syst Biol!
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....

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Reposted by Marco Fumasoni

Melania D'Angiolo @melaniadangiolo.bsky.social · Jul 3

Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response.

www.biorxiv.org/content/10.1...

The adaptive molecular landscape of reprogrammed telomeric sequences

Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequen...

www.biorxiv.org

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Marco Fumasoni @marcofumasoni.bsky.social · Jul 3

Looking forward to reading this!!

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Centre de Regulació Genòmica (CRG) @crg.eu · Jul 1

Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute.
www.crg.eu/en/news/moni...

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Monica Bettencourt-Dias @monicabettencourt.bsky.social · Jul 1

Happy to be the next (and 1st female) @crg.eu director. The CRG always stood out to me, for its excellence in understanding life's principles, with implications for health and biodiversity, & its collaborative, open and innovative way of doing science. Thrilled to join its amazing community in 2026!

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Marco Fumasoni @marcofumasoni.bsky.social · Jul 2

They are so lucky to have you!!

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Marco Fumasoni @marcofumasoni.bsky.social · Jun 27

Thank you Sebastian! 😊

Marco Fumasoni @marcofumasoni.bsky.social · Jun 27

Grazie Gianni! Spero ci si vede presto che ti racconto del resto!

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Marco Fumasoni @marcofumasoni.bsky.social · Jun 26

Big shout-out to @reviewcommons.org for finding four thorough, constructive reviewers, and to @molsystbiol.org & @embopress.org for a smooth journal transition and editorial process!

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Marco Fumasoni @marcofumasoni.bsky.social · Jun 26

Here is the link to the full and open-access article: www.embopress.org/doi/full/10....

Compensatory evolution to DNA replication stress is robust to nutrient availability | Molecular Systems Biology

imageimageGlucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain consistent and broadly beneficial, recapitulating fitness gains across d...

www.embopress.org

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Marco Fumasoni @marcofumasoni.bsky.social · Jun 26

The work of brilliant PhD student @mariananatalin6.bsky.social is now out in @molsystbiol.org! We asked how nutrients shape compensatory evolution to DNA replication stress. We find changes in physiology and adaptation rates, yet core genetic adaptation remains robust! See her thread for details!👇

Mariana Natalino @mariananatalin6.bsky.social · Jun 26

Excited to share the first paper of my PhD with @marcofumasoni.bsky.social ‬, now published in @molsystbiol.org 🥳! We explored how nutrient levels influence adaptation to perturbed DNA replication. Here’s what we learned 🧵👇 www.embopress.org/doi/full/10....

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Kenichi Tsuda @kenichitsuda.bsky.social · May 16

This is wild. Chromosome distributions into different nuclei!

Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi
www.science.org/doi/10.1126/...

Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi

Nuclei define eukaryotes, enabling macromolecular compartmentalization and cellular regulation. Each nucleus is believed to contain one or more haploid sets of chromosomes (1N). However, we discovered...

www.science.org

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Reposted by Marco Fumasoni

IRB Barcelona @irbbarcelona.org · May 13

🔬 Just like species evolve to survive, tumours adapt to resist treatment.

A new computational tool reveals how cancers rewire driver genes to beat chemotherapy.

Published in @natcomms.nature.com
Read the news ➡️ bit.ly/43tyKko

#CancerResearch #Genomics #ComputationalBiology #DrugResistance
⬇️

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Marco Trizzino @marcotrizzino.bsky.social · May 7

And just like that, overnight our lab loses two 5-year R01s (both of which just started) because of the new NIH rules about foreign co-PIs. This is so painful.

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Marco Fumasoni @marcofumasoni.bsky.social · Apr 28

We are working on making it available soon as a tool (RepliFlow). In the meantime, if you are interested in applying it to your dataset (any organism welcome), feel free to get in touch. Feedback on the preprint is also very welcome!

Marco Fumasoni @marcofumasoni.bsky.social · Apr 28

To illustrate the modular nature of our framework, we propose a minimal model of DNA replication that does not account for the spatial configuration of DNA, and still accurately infers microscopic properties such as origin firing rates and replication fork speeds.

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Marco Fumasoni @marcofumasoni.bsky.social · Apr 28

We show that from population-wide DNA content alone (without any labeled nucleotides) it is possible to uncover not just cell cycle phase durations but also how DNA replication unfolds inside cells (alpha in the picture below)

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Marco Fumasoni @marcofumasoni.bsky.social · Apr 28

🗞️New preprint out! Together with Adolfo Alsina and Pablo Sartori (both not on here), we combined experiments and theory to extract detailed information on DNA replication dynamics from simple DNA content flow cytometry data.
www.biorxiv.org/content/10.1...

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Reposted by Marco Fumasoni

jobRxiv @jobrxiv.org · Oct 19

Postdoctoral fellow position in the Genome Maintenance and Evolution lab @ jobrxiv.org/job/inst... #ScienceJobs #AcademicSky

Postdoctoral fellow position in the Genome Maintenance and Evolution lab @

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

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Marco Fumasoni @marcofumasoni.bsky.social · Oct 10

🎺Please RT! We have a funded #Postdocposition in our lab at @IGCiencia in Portugal 🇵🇹🇪🇺! Come and join us in exploring the wonders and evolution of genome maintenance processes, and engage with the extended #LifeScience community in #Lisbon! Details here: fumalab.github.io/join

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