Martin Schwalm
@martinschwalm.bsky.social
42 followers
29 following
6 posts
A biochemist with an interest in science, music and the restoration of classic cars.
Founder of tracerDB.org
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Reposted by Martin Schwalm
Reposted by Martin Schwalm
Reposted by Martin Schwalm
Geordi Frere
@geordifrere.bsky.social
· Jan 4
Functional Characterization of Pathway Inhibitors for the Ubiquitin-Proteasome System (UPS) as Tool Compounds for CRBN and VHL-Mediated Targeted Protein Degradation
Small molecule degraders such as PROteolysis TArgeting Chimeras (PROTACs) and molecular glues are new modalities for drug development and important tools for target validation. When appropriately opti...
dx.doi.org
Martin Schwalm
@martinschwalm.bsky.social
· Dec 18
Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example
The human kinome has tremendous medical potential. In the past decade, mixed-lineage protein kinase 3 (MLK3) has emerged as an interesting and druggable target in oncogenic signaling. The important ro...
pubs.acs.org
Reposted by Martin Schwalm
Ingo Hartung
@hartungingo.bsky.social
· Nov 25
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
Reposted by Martin Schwalm
