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Massive Photonics
@massivephotonics.bsky.social
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THE DNA-PAINT COMPANY. We offer comprehensive DNA-PAINT labeling kits & DNA-PAINT solutions such as services and collaborations. #SMLM #superresolution #DNAPAINT #microscopy
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massivephotonics.bsky.social
🚨New publication alert🚨
Authors introduce Dynamic Binder Exchange (DyBE), an approach that improves labeling efficiency in DNA-PAINT up to 15-fold.
onlinelibrary.wiley.com/doi/10.1002/...
Congratulations to all authors!!
Dynamic Binder Exchange Improves Protein Labeling Efficiency in DNA‐PAINT up to 15‐Fold
Dynamic Binder Exchange (DyBE) leverages transient binder–target interactions to enhance labeling efficiency by up to 15-fold in super-resolution microscopy. DyBE maps nanoscale receptor tyrosine kin...
onlinelibrary.wiley.com
February 5, 2026 at 1:15 PM
massivephotonics.bsky.social
🎉 𝗡𝗲𝘄 𝗽𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗮𝗹𝗲𝗿𝘁 🎉
Authors used 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 & 𝗣𝗲𝗽𝘁𝗶𝗱𝗲-𝗣𝗔𝗜𝗡𝗧 to investigate the 𝗻𝗮𝗻𝗼𝘀𝗰𝗮𝗹𝗲 𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗘-𝗰𝗮𝗱𝗵𝗲𝗿𝗶𝗻 𝗮𝗻𝗱 𝗙-𝗮𝗰𝘁𝗶𝗻 at adherens junctions in 𝗗𝗿𝗼𝘀𝗼𝗽𝗵𝗶𝗹𝗮 𝗲𝗺𝗯𝗿𝘆𝗼𝗻𝗶𝗰 𝘁𝗶𝘀𝘀𝘂𝗲. Congrats to all authors!

Our anti-GFP kit was used for E-cadherin imaging.

🔗 www.cell.com/biophysj/ful...
DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue
Cell junction remodeling is central to epithelial morphogenesis and tissue rheology, and depends on the interplay between adhesion molecules and the actomyosin cortex. E-cadherin constitutes the molec...
www.cell.com
January 21, 2026 at 9:49 AM
massivephotonics.bsky.social
The coolest Christmas party ever? 🏎️🎄We think so.
We swapped lab coats for helmets and raced around the track...turns out our need for speed doesn't stop with experiments.

🥇Jürgen, CEO
🥈Lucia, Scientist
🥉Jonas, Scientist
December 18, 2025 at 9:24 AM
massivephotonics.bsky.social
New preprint alert!
www.biorxiv.org/content/10.6...
Authors developed DNA-fluorophore labels inspired by DNA-PAINT & enhanced with LNA, enabling robust signal amplification for quantitative STED imaging with single-protein resolution. Congrats to all authors!
Our reagents were used for EGFR imaging.
Quantitative STED microscopy with DNA-fluorophore labels
Stimulated emission depletion (STED) microscopy enables super-resolution imaging of complex biological samples in 3D, in large volumes, and live. However, molecular quantification with STED has remain...
www.biorxiv.org
December 10, 2025 at 10:58 AM
massivephotonics.bsky.social
Who knew Christmas could be so pink? 💗🎄
Team outing to Munich's famous Pink Christmas Market = pink lights, fun vibes, and great company.
December 4, 2025 at 10:38 AM
massivephotonics.bsky.social
𝗧𝗮𝘂 𝗻𝗮𝗻𝗼-𝗮𝗴𝗴𝗿𝗲𝗴𝗮𝘁𝗲 𝘁𝗿𝗮𝗻𝘀𝗶𝘁𝗶𝗼𝗻𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿'𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 𝗿𝗲𝘃𝗲𝗮𝗹𝗲𝗱 𝗯𝘆 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧

Full study: doi.org/10.1002/advs...

Authors used our anti-mouse and anti-rabbit DNA-PAINT kits for tau visualization in brain tissue sections.

Congratulations to all authors!!

#DNAPAINT #SMLM #MassivePhotonics
Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease
Super-resolution microscopy identifies nano-sized tau aggregates (nano-aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age-Relate...
doi.org
November 25, 2025 at 10:42 AM
massivephotonics.bsky.social
🚀 𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝗠𝗔𝗦𝗦𝗜𝗩𝗘-𝗥𝗡𝗔-𝗙𝗜𝗦𝗛 𝗣𝗿𝗼𝗯𝗲𝘀 𝗮𝗻𝗱 𝗕𝘂𝗳𝗳𝗲𝗿 𝗞𝗶𝘁𝘀 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 of RNA targets 𝘂𝘀𝗶𝗻𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆.
🔗: www.massive-photonics.com/product-cate...

#SMLM #DNAPAINT #RNAImaging #RNAFISH #Microscopy #MassivePhotonics
November 18, 2025 at 1:03 PM
massivephotonics.bsky.social
New pre-print alert! “𝟯𝗗 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗰𝗼𝗺𝗯𝗶𝗻𝗲𝗱 𝘄𝗶𝘁𝗵 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗿𝗲𝘀𝗼𝗹𝘃𝗲𝘀 𝘁𝗵𝗲 𝗮𝗿𝗿𝗮𝗻𝗴𝗲𝗺𝗲𝗻𝘁 𝗼𝗳 𝗕𝗮𝘀𝘀𝗼𝗼𝗻 𝗮𝘁 𝗮𝗰𝘁𝗶𝘃𝗲 𝘇𝗼𝗻𝗲𝘀” Congrats to all authors!!

www.biorxiv.org/content/10.1...

#MINFLUX #DNAPAINT #MassivePhotonics #Microscopy #Bassoon
3D MINFLUX combined with DNA-PAINT resolves the arrangement of Bassoon at active zones
Neurotransmitter release and membrane retrieval at active zones require precise spatial and temporal coordination relying on an intricate molecular machinery. However, the exact nano-structural organi...
www.biorxiv.org
October 16, 2025 at 7:43 AM
Reposted by Massive Photonics
abbelight.bsky.social
Join us & Massive Photonics on 23 Oct 2025 (4–5 PM CET) for a webinar with Prof. Ralf Jungmann, KOL on DNA-PAINT!

Discover how single-molecule #SpatialOmics is reshaping #BioImaging.

🎁 Win a Smart DNA-PAINT Kit!

Register now: us06web.zoom.us/webinar/regi...

#DNAPAINT #Microscopy #SMLM
October 8, 2025 at 1:35 PM
massivephotonics.bsky.social
Don’t forget to come by our booth at #SeeingIsBelieving2025!! We can't wait to chat 🧬 🔬

📍Booth No. 6

#DNAPAINT #SMLM #Superresolution #Microscopy
October 9, 2025 at 7:28 AM
massivephotonics.bsky.social
🧬 𝗡𝗲𝘄 𝗣𝗿𝗼𝗱𝘂𝗰𝘁 𝗟𝗮𝘂𝗻𝗰𝗵! 🧬The highly-requested 𝗮𝗻𝘁𝗶-𝗛𝗮𝗹𝗼 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗸𝗶𝘁 is finally here!
Reveal nanoscale organization of Halo-tagged proteins with our plug-and-play DNA-PAINT kit.

🔗Learn More: www.massive-photonics.com/product-cate...
September 24, 2025 at 7:30 AM
massivephotonics.bsky.social
🔬 𝗪𝗵𝗶𝗰𝗵 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲 𝗶𝘀 𝗿𝗶𝗴𝗵𝘁 𝗳𝗼𝗿 𝘆𝗼𝘂?
Our #DNAPAINT Labeling Kits let you choose the balance of 𝘀𝗽𝗲𝗲𝗱 𝗮𝗻𝗱 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 that fits your research.

⭐DNA-PAINT kits: www.massive-photonics.com/product-cate...
⭐FAST DNA-PAINT kits: www.massive-photonics.com/product-cate...
September 18, 2025 at 12:40 PM
massivephotonics.bsky.social
🚀 New Product Launch! 🚀
Ready to push your imaging to 𝘀𝘂𝗯-𝗻𝗮𝗻𝗼𝗺𝗲𝘁𝗲𝗿 𝘀𝗽𝗮𝘁𝗶𝗮𝗹 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻? Introducing our newest 𝗥𝗘𝗦𝗜 𝗞𝗶𝘁 𝗳𝗼𝗿 𝗔𝗟𝗙𝗔-𝘁𝗮𝗴𝗴𝗲𝗱 𝗽𝗿𝗼𝘁𝗲𝗶𝗻𝘀!
🔗 www.massive-photonics.com/product-cate...

#SMLM #RESI #DNAPAINT #Microscopy #nuclearpore
DNA-PAINT and RESI imaging of ALFA-tagged nuclear pore protein Nup96 using the RESI anti-ALFA kit. For RESI imaging, four Exchange-PAINT rounds were performed using a mixture of anti-ALFA single-domain antibodies carrying docking strands F1, F2, F3, and F4 (10,000 frames per round,100 ms integration time, ~ 80 min total imaging time). Image post-processing was carried out using the open-source DNA-PAINT analysis software Picasso's RESI module. For classic DNA-PAINT, all four imager strands were added to the sample simultaneously. DNA-PAINT and RESI imaging of ALFA-tagged nuclear pore protein Nup96 using the RESI anti-ALFA kit. For RESI imaging, four Exchange-PAINT rounds were performed using a mixture of anti-ALFA single-domain antibodies carrying docking strands F1, F2, F3, and F4 (10,000 frames per round,100 ms integration time, ~ 80 min total imaging time). Image post-processing was carried out using the open-source DNA-PAINT analysis software Picasso's RESI module. For classic DNA-PAINT, all four imager strands were added to the sample simultaneously.
September 11, 2025 at 8:52 AM
massivephotonics.bsky.social
🚀 New to DNA-PAINT? We make getting started simple.

Check out our 𝗽𝗹𝘂𝗴-𝗮𝗻𝗱-𝗽𝗹𝗮𝘆 #DNAPAINT 𝗹𝗮𝗯𝗲𝗹𝗶𝗻𝗴 𝗮𝗻𝗱 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗸𝗶𝘁𝘀:
✅ Seamless integration into immunostaining workflows
✅ Wide range of kits designed for various targets
✅ Includes all labeling & imaging reagents needed

🔗 massive-photonics.com
September 4, 2025 at 7:47 AM
massivephotonics.bsky.social
📢 Don’t forget to stop by our booth at #SMLMS2025!

We’re excited to share how our #DNAPAINT solutions and labeling kits can help you unlock nanoscale insights 🔬🧬

📍WP Building Foyer, near the windows
August 28, 2025 at 9:53 AM
massivephotonics.bsky.social
📢 We're heading to Single Molecule Localization Microscopy Symposium 2025 in Bonn!

📍 Stop by our booth in the foyer of the WP building to say hello and discuss how our DNA-PAINT kits and solutions enable multiplexed nanoscale imaging.

#SMLM #SMLMS2025 #DNAPAINT
August 25, 2025 at 12:17 PM
massivephotonics.bsky.social
I𝗺𝗺𝘂𝗻𝗼𝗹𝗮𝗯𝗲𝗹𝗶𝗻𝗴 𝘆𝗼𝘂𝗿 𝘀𝗮𝗺𝗽𝗹𝗲𝘀 𝘂𝘀𝗶𝗻𝗴 𝗽𝗿𝗶𝗺𝗮𝗿𝘆 𝗮𝗻𝘁𝗶𝗯𝗼𝗱𝗶𝗲𝘀? Take your imaging to nanoscale resolution with our 𝗽𝗹𝘂𝗴-𝗮𝗻𝗱-𝗽𝗹𝗮𝘆 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝘀𝗲𝗰𝗼𝗻𝗱𝗮𝗿𝘆 𝗯𝗶𝗻𝗱𝗲𝗿 𝗸𝗶𝘁𝘀.

🔗 www.massive-photonics.com/product-cate...

#DNAPAINT #SuperResolution #SMLM #Microscopy
DNA-PAINT samples/images generated using our secondary binder kits: 🔹 Paxillin & Vimentin – Massive-sdAB-FAST 2-Plex Kit 🔹 Tom20 & HSP60 – Massive-AB 2-Plex Kit 🔹 Tom20 – Massive-sdAB 1-Plex Kit 🔹 Tubulin –= Massive-sdAB-FAST 1-Plex Kit AB = antibody | sdAB = single-domain antibody
August 7, 2025 at 7:51 AM
massivephotonics.bsky.social
𝗠𝗲𝘀𝘀𝗮𝗴𝗲 𝘂𝘀 𝗱𝗶𝗿𝗲𝗰𝘁𝗹𝘆—𝘄𝗲’𝗿𝗲 𝗵𝗲𝗿𝗲 𝘁𝗼 𝗵𝗲𝗹𝗽.
We’ve added a new WhatsApp chat feature to our website! 🚀 Need help navigating or have product questions?
👉 www.massive-photonics.com
DNA-PAINT Labeling Kits for Super-Resolution Imaging
Massive-Photonics offers ready-to-use labelling kits for DNA-PAINT based super-resolution imaging.
www.massive-photonics.com
August 6, 2025 at 8:54 AM
massivephotonics.bsky.social
🚨 New Publication Alert 🚨
Researchers achieved ångström resolution imaging of cell-surface glycans of the glycocalyx using RESI microscopy, a DNA-PAINT based technology, and metabolic labeling.

🔗 www.nature.com/articles/s41...

#DNAPAINT #SuperResolution #RESI #Glycobiology #SMLM
Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology
By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...
www.nature.com
July 28, 2025 at 1:58 PM
massivephotonics.bsky.social
🔬 𝗕𝗲𝗵𝗶𝗻𝗱 𝘁𝗵𝗲 𝗕𝗶𝗻𝗱𝗲𝗿𝘀: 𝗠𝗲𝗲𝘁 𝗝ü𝗿𝗴𝗲𝗻 𝗦𝗰𝗵𝗺𝗶𝗲𝗱🔬
Today, we’re spotlighting Dr. Jürgen Schmied, CEO and co-founder of Massive Photonics, whose leadership is central to our goal of enabling scientists solve critical research questions using DNA-PAINT technologies.

#SMLM #DNAPAINT #Microscopy #DNAorigami
July 23, 2025 at 7:23 AM
massivephotonics.bsky.social
Our scientists have stamina!!! 💪🏃‍♀️A big congrats to our team for crushing the B2Run here in Munich! 🎉

#gemeinsamaktiv #stark
July 18, 2025 at 9:23 AM
massivephotonics.bsky.social
🚨 𝗡𝗲𝘄 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗞𝗶𝘁 𝗗𝗿𝗼𝗽! 🚨
Ready to image 𝗛𝘂𝗺𝗮𝗻 𝗜𝗴𝗚𝘀 at the nanoscale?
🔗Click here: bit.ly/3GOvpUu
Compatible with all our DNA-PAINT kits for seamless multiplexing.

#DNAPAINT #SMLM #Microscopy #MassivePhotonics
July 17, 2025 at 8:13 AM
massivephotonics.bsky.social
🚀𝗔𝗹𝗿𝗲𝗮𝗱𝘆 𝘄𝗼𝗿𝗸𝗶𝗻𝗴 𝘄𝗶𝘁𝗵 𝗽𝗿𝗼𝘁𝗲𝗶𝗻-𝘁𝗮𝗴𝗴𝗲𝗱 𝗰𝗲𝗹𝗹 𝗹𝗶𝗻𝗲𝘀? Take your imaging to the nanoscale with our 𝗽𝗹𝘂𝗴-𝗮𝗻𝗱-𝗽𝗹𝗮𝘆 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗸𝗶𝘁𝘀 - designed to fit seamlessly into your existing immunostaining workflows.

www.massive-photonics.com/product-cate...

#DNAPAINT #SuperResolution #FluorescentProteins #SMLM
Images created using our DNA-PAINT Kits for GFP, ALFA, mEOS, and RFP protein tag labeling. GFP - Nup96, ALFA - vimentin, mEOS - Tom20, RFP - EGFR. Credit for the beautiful ALFA-tag image goes to the Christophe Leterrier lab.
July 16, 2025 at 7:31 AM
massivephotonics.bsky.social
🔬 𝗕𝗲𝗵𝗶𝗻𝗱 𝘁𝗵𝗲 𝗕𝗶𝗻𝗱𝗲𝗿𝘀: 𝗠𝗲𝗲𝘁 𝗞𝗶𝗺𝗯𝗲𝗿𝗹𝘆 🔬

Ever wonder what actually goes on at Massive Photonics before you get your hands on one of our ready-to-use DNA-PAINT kits?

#MassivePhotonics #SuperResolution #SMLM #CellImaging #DNAPAINT
July 10, 2025 at 10:02 AM
massivephotonics.bsky.social
🚨 New Product Alert 🚨
Introducing a 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗞𝗶𝘁 𝗳𝗼𝗿 𝗥𝗙𝗣-𝘁𝗮𝗴𝗴𝗲𝗱 𝗣𝗿𝗼𝘁𝗲𝗶𝗻𝘀!

𝗟𝗲𝗮𝗿𝗻 𝗺𝗼𝗿𝗲: www.massive-photonics.com/product-cate...

#SMLM #DNAPAINT #Microscopy #RFP #CellImaging #MassivePhotonics
July 8, 2025 at 8:04 AM