𝗨𝘀𝗶𝗻𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗳𝗼𝗿 𝗥𝗡𝗔 𝗶𝗺𝗮𝗴𝗶𝗻𝗴, 𝘆𝗼𝘂 𝗰𝗮𝗻:
▪️ 𝗦𝘁𝘂𝗱𝘆 𝗥𝗡𝗔 𝗢𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 - reveal nanoscale org. of individual species in dense environ.
▪️𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝘁𝗵𝗲 𝘁𝗿𝗮𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗼𝗺𝗲 - study how RNA expression & organization changes
▪️ 𝗜𝗻𝘃𝗲𝘀𝘁𝗶𝗴𝗮𝘁𝗲 𝘃𝗶𝗿uses - map genome organization & biogenesis with molecular precision

𝗪𝗵𝘆 𝘃𝗶𝘀𝘂𝗮𝗹𝗶𝘇𝗲 𝗥𝗡𝗔 𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗮𝘁 𝘁𝗵𝗲 𝗻𝗮𝗻𝗼𝘀𝗰𝗮𝗹𝗲?
RNA molecules can form complex networks inside cells vital to gene regulation & disease mechanisms (lncRNAs, P-bodies, viruses).Visualizing organization helps reveal how these (mal)function.Traditional RNA profiling is limited by RNA species density.

𝗢𝘂𝗿 𝗥𝗡𝗔 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝘀:
▪️𝗖𝘂𝘀𝘁𝗼𝗺 𝗥𝗡𝗔 𝗙𝗜𝗦𝗛 𝗽𝗿𝗼𝗯𝗲𝘀 - for nanoscale imaging of user-defined RNAs
▪️𝗥𝗡𝗔-𝗙𝗜𝗦𝗛 𝗕𝘂𝗳𝗳𝗲𝗿 𝗞𝗶𝘁 - for no guesswork, high-quality sample prep
▪️𝗣𝗿𝗲-𝗱𝗲𝘀𝗶𝗴𝗻𝗲𝗱 𝗥𝗡𝗔-𝗙𝗜𝗦𝗛 𝗽𝗿𝗼𝗯𝗲𝘀 - for perfect positive controls

🔗 𝗨𝗻𝗹𝗼𝗰𝗸 𝗻𝗮𝗻𝗼𝘀𝗰𝗮𝗹𝗲 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀: www.massive-photonics.com/product-cate...

Authors 𝗺𝗮𝗽𝗽𝗲𝗱 𝘁𝗵𝗲 𝗻𝗮𝗻𝗼𝘀𝗰𝗮𝗹𝗲 𝟯𝗗 𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝘁𝗵𝗲 𝗽𝗿𝗲𝘀𝘆𝗻𝗮𝗽𝘁𝗶𝗰 𝗮𝗰𝘁𝗶𝘃𝗲 𝘇𝗼𝗻𝗲 and revealed that the C-terminus of the scaffolding protein bassoon is oriented toward the synaptic cleft, while its N-terminus extends toward synaptic vesicles.

Fantastic work by Florelle Domart, Evelyn Garlick, Isabelle Jansen, Maria Augusta Lima, & Thomas Dresbach!

We’re thrilled to report 𝗮𝘂𝘁𝗵𝗼𝗿𝘀 𝘂𝘀𝗲𝗱 𝗼𝘂𝗿 𝗮𝗻𝘁𝗶-𝗿𝗮𝗯𝗯𝗶𝘁, 𝗮𝗻𝘁𝗶-𝗺𝗼𝘂𝘀𝗲, 𝗮𝗻𝘁𝗶-𝗚𝗙𝗣, 𝗮𝗻𝗱 𝗮𝗻𝘁𝗶-𝗔𝗟𝗙𝗔 𝘁𝗮𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗸𝗶𝘁𝘀 𝗳𝗼𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴!

Why our DNA-PAINT Halo Kits?
✔️ Ultra-precise labeling with small single-domain antibodies (~15 kDa)
✔️ Full compatibility with the Halo system - no interference with Halo-ligand binding
✔️ Unmatched resolution with DNA-PAINT (10–20 nm)
✔️ Seamless integration into existing super-resolution workflows

⭐ Anti-Halo single-domain antibodies licensed from @nanotag.bsky.social, where they’re available unmodified and fluorophore-coupled.

🧬 Curious about starting DNA-PAINT super-resolution microscopy? Reach out: [email protected]

💡 𝗣𝗿𝗼 𝗧𝗶𝗽: For maximum resolution use imager dye 𝗖𝘆𝟯𝗕.

Speed or resolution: which will drive your next discovery?

𝗦𝘁𝗮𝗻𝗱𝗮𝗿𝗱 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲𝘀 (in DNA-PAINT Kits)
🔹 Resolution: ~20 nm
🔹 Imaging time: 30–60 min/target
🔹 Exposure: 150–250 ms
👉 Compatible with 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧

𝗙𝗔𝗦𝗧-𝗟𝗕 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲𝘀 (option in FAST Kits)
🔹 Resolution: ~10 nm
🔹 Imaging time: 10–30 min/target
🔹 Exposure: 100–150 ms
👉 Best for 𝗵𝗶𝗴𝗵𝗲𝘀𝘁 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻
👉 Compatible with 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧

𝗙𝗔𝗦𝗧 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲𝘀 (option in FAST Kits)
🔹 Resolution: ~15 nm
🔹 Imaging time: 5–15 min/target
🔹 Exposure: 30–75 ms
👉 Best for 𝗳𝗮𝘀𝘁𝗲𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴

💡 𝗣𝗿𝗼 𝗧𝗶𝗽: For maximum resolution use imager dye 𝗖𝘆𝟯𝗕.

Speed or resolution: which will drive your next discovery?

✨ 𝗦𝘁𝗮𝗻𝗱𝗮𝗿𝗱 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲𝘀 (in DNA-PAINT Kits)
🔹 Resolution: ~20 nm
🔹 Imaging time: 30–60 min/target
🔹 Exposure: 150–250 ms
👉 Compatible with 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧