Proteins with noncanonical amino acids can serve as precision tools and therapeutics, but their creation is often inefficient. In a recent Nature publication, Iype et al. engineered bacteria to ferry designer amino acids as peptide cargos, overcoming a major uptake bottleneck and enabling robust, scalable incorporation under routine culture conditions.

Researchers from ETH Zurich have succeeded in introducing large quantities of unnatural amino acids into bacteria, enabling the creation of innovative and highly efficient designer proteins. These can...

Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...

Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...