Madelon de Jong
@mdejong.bsky.social
Postdoc at Uni of Oxford 🦴 | stroma-myeloid interactions and bone marrow inflammation 🔬 | she/her | https://www.kennedy.ox.ac.uk/team/madelon-de-jong
Pinned
Madelon de Jong
@mdejong.bsky.social
· Nov 15
My PhD on bone marrow inflammation in #myeloma has finally come to an end! Thesis written and distributed and I will be defending a week from now!
Very ready to go ahead full throttle on a new chapter in my career
Very ready to go ahead full throttle on a new chapter in my career
Terrific work from @jelenalab.bsky.social and Fabian Fischer on controlling cell death. Fantastic to see this out!
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
www.science.org
March 7, 2025 at 9:04 PM
Terrific work from @jelenalab.bsky.social and Fabian Fischer on controlling cell death. Fantastic to see this out!
I love me some Bernie Sanders
March 6, 2025 at 11:19 AM
I love me some Bernie Sanders
Super proud of my friend Sabrin @sabtahri.bsky.social, whose final (and terrific) PhD work came out today in #Blood (in collab with group of Niels vd Donk)
It demonstrates an association between BM CD16+ NK cells and response to dara!
#hemesky #hematology #myeloma
doi.org/10.1182/bloo...
It demonstrates an association between BM CD16+ NK cells and response to dara!
#hemesky #hematology #myeloma
doi.org/10.1182/bloo...
February 28, 2025 at 5:24 PM
Super proud of my friend Sabrin @sabtahri.bsky.social, whose final (and terrific) PhD work came out today in #Blood (in collab with group of Niels vd Donk)
It demonstrates an association between BM CD16+ NK cells and response to dara!
#hemesky #hematology #myeloma
doi.org/10.1182/bloo...
It demonstrates an association between BM CD16+ NK cells and response to dara!
#hemesky #hematology #myeloma
doi.org/10.1182/bloo...
And your annual reminder that one billion is a THOUSAND million. And most of these people have multiple billions (because investments are incremental). No one ever needs that kind of money. The homeless person on the street could do with some housing though.
February 25, 2025 at 9:08 AM
And your annual reminder that one billion is a THOUSAND million. And most of these people have multiple billions (because investments are incremental). No one ever needs that kind of money. The homeless person on the street could do with some housing though.
Reese Witherspoon became a billionaire and people are cheering and congratulating her on being a hugely talented business woman.
I feel people do not realise that money is a limited thing. Billionaires (skilled or not, it doesn’t matter) are hoarding the resource.
I feel people do not realise that money is a limited thing. Billionaires (skilled or not, it doesn’t matter) are hoarding the resource.
February 25, 2025 at 9:08 AM
Reese Witherspoon became a billionaire and people are cheering and congratulating her on being a hugely talented business woman.
I feel people do not realise that money is a limited thing. Billionaires (skilled or not, it doesn’t matter) are hoarding the resource.
I feel people do not realise that money is a limited thing. Billionaires (skilled or not, it doesn’t matter) are hoarding the resource.
What I find so brilliant about the haematopoiesis is that it takes place in a piece of tissue (bone) that already fulfils another role (holding up the meat sack).
Human design being space-efficient, ain’t it something
Human design being space-efficient, ain’t it something
February 17, 2025 at 9:17 PM
What I find so brilliant about the haematopoiesis is that it takes place in a piece of tissue (bone) that already fulfils another role (holding up the meat sack).
Human design being space-efficient, ain’t it something
Human design being space-efficient, ain’t it something
It’s one of the frustrating things about bsky still, posts don’t seem to get the engagement that they used to get on Twitter
January 29, 2025 at 7:40 PM
It’s one of the frustrating things about bsky still, posts don’t seem to get the engagement that they used to get on Twitter
When I said 2025 was gonna be my year 😭 Can I restart? I wasn’t ready
January 27, 2025 at 5:47 PM
When I said 2025 was gonna be my year 😭 Can I restart? I wasn’t ready
Just learned that US school libraries have banned Anne Frank’s diary, for the reason being she briefly discusses crushing on a girl.
Anne Frank’s diary! Banned!
Anne Frank’s diary! Banned!
January 22, 2025 at 9:09 AM
Just learned that US school libraries have banned Anne Frank’s diary, for the reason being she briefly discusses crushing on a girl.
Anne Frank’s diary! Banned!
Anne Frank’s diary! Banned!
This isn’t my data but I’m seeing something similar
January 17, 2025 at 3:39 PM
This isn’t my data but I’m seeing something similar
Hematologists! I need help!
What is the unmarked population? Lin-cKit+Sca1-CD16/32+CD34- in mouse bone marrow!
#hematology #hemesky
What is the unmarked population? Lin-cKit+Sca1-CD16/32+CD34- in mouse bone marrow!
#hematology #hemesky
January 17, 2025 at 3:29 PM
Hematologists! I need help!
What is the unmarked population? Lin-cKit+Sca1-CD16/32+CD34- in mouse bone marrow!
#hematology #hemesky
What is the unmarked population? Lin-cKit+Sca1-CD16/32+CD34- in mouse bone marrow!
#hematology #hemesky
Getting a bit tired of the inflation of importance of the physician-scientist. And I say that as someone who went to med school once upon a time.
Acting like they’re the most important being in research sells basic biologists, far stronger in bench lab skills, way short.
Acting like they’re the most important being in research sells basic biologists, far stronger in bench lab skills, way short.
January 14, 2025 at 7:43 AM
Getting a bit tired of the inflation of importance of the physician-scientist. And I say that as someone who went to med school once upon a time.
Acting like they’re the most important being in research sells basic biologists, far stronger in bench lab skills, way short.
Acting like they’re the most important being in research sells basic biologists, far stronger in bench lab skills, way short.
I’m jealous!! Enjoy the warmth!
January 13, 2025 at 9:19 AM
I’m jealous!! Enjoy the warmth!
Landed my 2nd ever grant, hurray! 🥳
January 7, 2025 at 4:43 PM
Landed my 2nd ever grant, hurray! 🥳
Eurostar really getting on my last nerve and it’s only Jan 5th
January 5, 2025 at 3:59 PM
Eurostar really getting on my last nerve and it’s only Jan 5th
Absolutely fantastic work by Vivian Lau and @gerardlab.bsky.social on IFNy-related tumour escape! Must-read for all tumour immunologists! 💯
Tumours escape the immune system by mutating to decrease their immunogenicity. In this study, now in
@natcomms.bsky.social, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape www.nature.com/articles/s41...
@natcomms.bsky.social, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape www.nature.com/articles/s41...
Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models - Nature Communications
Losing sensitivity to IFNγ may contribute to tumor immune escape, but containment of IFNγ-insensitive tumors is also reported. Here the authors show, by analyzing immune landscape differences between ...
www.nature.com
January 5, 2025 at 1:22 PM
Absolutely fantastic work by Vivian Lau and @gerardlab.bsky.social on IFNy-related tumour escape! Must-read for all tumour immunologists! 💯
Reposted by Madelon de Jong
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
December 26, 2024 at 5:24 PM
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Reposted by Madelon de Jong
For anyone who may need these over Xmas…just in case
December 24, 2024 at 9:36 PM
For anyone who may need these over Xmas…just in case
Reposted by Madelon de Jong
Although still in 'First Edition' style, I am happy to finally share our latest article on DNMT3A double mutant AML. Hope to be able to share the way-easier-to-read print version of the paper soon! (1/2) #hemesky ashpublications.org/bloodadvance...
Double mutant DNMT3A AML: a unique subtype experiencing increased DNA damage and poor prognosis
Key Points. 1. Wildtype DNMT3A enhances TDG-mediated repair, whereas mutant DNMT3A impairs this process.2. Double mutant DNMT3A AML exhibits increased DNA
ashpublications.org
December 20, 2024 at 4:34 PM
Although still in 'First Edition' style, I am happy to finally share our latest article on DNMT3A double mutant AML. Hope to be able to share the way-easier-to-read print version of the paper soon! (1/2) #hemesky ashpublications.org/bloodadvance...
Woop woop!!! Congrats Sanne 👌🏼
December 20, 2024 at 5:20 PM
Woop woop!!! Congrats Sanne 👌🏼
Now in press, excellent paper by @zkellermayer.bsky.social where he shows that in the myeloma 5TGM1 model activation of NK cells, ILC1 and CD8+ T cells is lost upon disease progression! 👀
Awesome work, happy to have contributed #mmsm
onlinelibrary.wiley.com/doi/full/10....
Awesome work, happy to have contributed #mmsm
onlinelibrary.wiley.com/doi/full/10....
Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma
Malignant plasma cells in multiple myeloma patients reside in the bone marrow and continuously interact with local immune cells. Progression and therapy response are influenced by this immune environ...
onlinelibrary.wiley.com
December 16, 2024 at 3:05 PM
Now in press, excellent paper by @zkellermayer.bsky.social where he shows that in the myeloma 5TGM1 model activation of NK cells, ILC1 and CD8+ T cells is lost upon disease progression! 👀
Awesome work, happy to have contributed #mmsm
onlinelibrary.wiley.com/doi/full/10....
Awesome work, happy to have contributed #mmsm
onlinelibrary.wiley.com/doi/full/10....
Things to love about living in Oxford:
December 13, 2024 at 8:58 PM
Things to love about living in Oxford: