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Madelon de Jong

@mdejong.bsky.social

2.6K followers 790 following 64 posts

Postdoc at Uni of Oxford 🦴 | stroma-myeloid interactions and bone marrow inflammation 🔬 | she/her | https://www.kennedy.ox.ac.uk/team/madelon-de-jong

www.kennedy.ox.ac.uk

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Madelon de Jong @mdejong.bsky.social · Nov 15

My PhD on bone marrow inflammation in #myeloma has finally come to an end! Thesis written and distributed and I will be defending a week from now!

Very ready to go ahead full throttle on a new chapter in my career

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Madelon de Jong @mdejong.bsky.social · Mar 7

Terrific work from @jelenalab.bsky.social and Fabian Fischer on controlling cell death. Fantastic to see this out!

JelenaBezbradicaLab @jelenalab.bsky.social · Mar 7

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways

TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

www.science.org

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Madelon de Jong @mdejong.bsky.social · Mar 6

I love me some Bernie Sanders

Madelon de Jong @mdejong.bsky.social · Mar 3

He is evil

Madelon de Jong @mdejong.bsky.social · Feb 28

Super proud of my friend Sabrin @sabtahri.bsky.social, whose final (and terrific) PhD work came out today in #Blood (in collab with group of Niels vd Donk)

It demonstrates an association between BM CD16+ NK cells and response to dara!

#hemesky #hematology #myeloma

doi.org/10.1182/bloo...

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Madelon de Jong @mdejong.bsky.social · Feb 25

And your annual reminder that one billion is a THOUSAND million. And most of these people have multiple billions (because investments are incremental). No one ever needs that kind of money. The homeless person on the street could do with some housing though.

Madelon de Jong @mdejong.bsky.social · Feb 25

Reese Witherspoon became a billionaire and people are cheering and congratulating her on being a hugely talented business woman.

I feel people do not realise that money is a limited thing. Billionaires (skilled or not, it doesn’t matter) are hoarding the resource.

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Madelon de Jong @mdejong.bsky.social · Feb 17

What I find so brilliant about the haematopoiesis is that it takes place in a piece of tissue (bone) that already fulfils another role (holding up the meat sack).

Human design being space-efficient, ain’t it something

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Madelon de Jong @mdejong.bsky.social · Feb 6

Disgusting

Madelon de Jong @mdejong.bsky.social · Feb 2

What the hell???

Madelon de Jong @mdejong.bsky.social · Jan 29

It’s one of the frustrating things about bsky still, posts don’t seem to get the engagement that they used to get on Twitter

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Madelon de Jong @mdejong.bsky.social · Jan 27

When I said 2025 was gonna be my year 😭 Can I restart? I wasn’t ready

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Madelon de Jong @mdejong.bsky.social · Jan 22

Just learned that US school libraries have banned Anne Frank’s diary, for the reason being she briefly discusses crushing on a girl.

Anne Frank’s diary! Banned!

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Madelon de Jong @mdejong.bsky.social · Jan 17

This isn’t my data but I’m seeing something similar

Madelon de Jong @mdejong.bsky.social · Jan 17

Hematologists! I need help!

What is the unmarked population? Lin-cKit+Sca1-CD16/32+CD34- in mouse bone marrow!

#hematology #hemesky

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Madelon de Jong @mdejong.bsky.social · Jan 14

Getting a bit tired of the inflation of importance of the physician-scientist. And I say that as someone who went to med school once upon a time.

Acting like they’re the most important being in research sells basic biologists, far stronger in bench lab skills, way short.

Madelon de Jong @mdejong.bsky.social · Jan 13

I’m jealous!! Enjoy the warmth!

Madelon de Jong @mdejong.bsky.social · Jan 7

Landed my 2nd ever grant, hurray! 🥳

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Madelon de Jong @mdejong.bsky.social · Jan 5

Eurostar really getting on my last nerve and it’s only Jan 5th

Madelon de Jong @mdejong.bsky.social · Jan 5

Absolutely fantastic work by Vivian Lau and @gerardlab.bsky.social on IFNy-related tumour escape! Must-read for all tumour immunologists! 💯

Gerard Lab @gerardlab.bsky.social · Jan 4

Tumours escape the immune system by mutating to decrease their immunogenicity. In this study, now in
@natcomms.bsky.social, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape www.nature.com/articles/s41...

Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models - Nature Communications

Losing sensitivity to IFNγ may contribute to tumor immune escape, but containment of IFNγ-insensitive tumors is also reported. Here the authors show, by analyzing immune landscape differences between ...

www.nature.com

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Reposted by Madelon de Jong

Ivan Zanoni @lozanzi.bsky.social · Dec 26

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

www.cell.com

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Reposted by Madelon de Jong

Dr Jon Goldin @drjongoldin.bsky.social · Dec 24

For anyone who may need these over Xmas…just in case

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Reposted by Madelon de Jong

Sanne Massaar @massaarsanne.bsky.social · Dec 20

Although still in 'First Edition' style, I am happy to finally share our latest article on DNMT3A double mutant AML. Hope to be able to share the way-easier-to-read print version of the paper soon! (1/2) #hemesky ashpublications.org/bloodadvance...

Double mutant DNMT3A AML: a unique subtype experiencing increased DNA damage and poor prognosis

Key Points. 1. Wildtype DNMT3A enhances TDG-mediated repair, whereas mutant DNMT3A impairs this process.2. Double mutant DNMT3A AML exhibits increased DNA

ashpublications.org

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Madelon de Jong @mdejong.bsky.social · Dec 20

Woop woop!!! Congrats Sanne 👌🏼

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Madelon de Jong @mdejong.bsky.social · Dec 16

Now in press, excellent paper by @zkellermayer.bsky.social where he shows that in the myeloma 5TGM1 model activation of NK cells, ILC1 and CD8+ T cells is lost upon disease progression! 👀

Awesome work, happy to have contributed #mmsm

onlinelibrary.wiley.com/doi/full/10....

Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma

Malignant plasma cells in multiple myeloma patients reside in the bone marrow and continuously interact with local immune cells. Progression and therapy response are influenced by this immune environ...

onlinelibrary.wiley.com

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Madelon de Jong @mdejong.bsky.social · Dec 13

Things to love about living in Oxford: