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Sanne Massaar @massaarsanne.bsky.social · Jun 15

Great talk by @dpastoors.bsky.social , what a nice way to finish up #EHA2025 🤩 It's a wrap!

Dorien Pastoors @dpastoors.bsky.social · Jun 15

Thanks for the opportunity to present our work at the last day of #EHA2025 🤩 on MECOM as a repressor of CEBPA - also see our recent preprint: www.biorxiv.org/content/10.1... and I very much hope you can stay tuned for the final version soon-ish) #erasmusmcblood #hemesky

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Sanne Massaar @massaarsanne.bsky.social · Jun 13

This evening I'll be presenting our work on MBD4 knockout as a tool for modelling mutagenesis and clonal outgrowth at the poster session of #EHA2025. Come visit me at PF1115 if you're interested! #Hemesky 🩸🧪

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Reposted by Sanne Massaar

Dorien Pastoors @dpastoors.bsky.social · Jun 12

Spotted fellow #erasmusmcblood PhD candidate @shordijk.bsky.social at the #EHA wall of fame for her Mobility grant 🤩🤩 Congratulations !! @clotterdam.bsky.social

EHA wall of fame zoomed in to Sophie Hordijk

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Sanne Massaar @massaarsanne.bsky.social · Jun 8

Congratulations Dorien, amazing achievement!! And love the cover 🤩

Dorien Pastoors @dpastoors.bsky.social · Jun 8

SUPER excited to share that I got my PhD thesis - thanks to a special delivery from @massaarsanne.bsky.social to Milan!! On the 26th of June, I will defend my thesis at 15:30 CET. You can follow online at eur.cloud.panopto.eu/Panopto/Page... #hemesky

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Reposted by Sanne Massaar

Dorien Pastoors @dpastoors.bsky.social · Jun 8

SUPER excited to share that I got my PhD thesis - thanks to a special delivery from @massaarsanne.bsky.social to Milan!! On the 26th of June, I will defend my thesis at 15:30 CET. You can follow online at eur.cloud.panopto.eu/Panopto/Page... #hemesky

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Reposted by Sanne Massaar

Blood Journals' Portfolio @bloodjournals.hematology.org · Mar 25

🚨New Blood Advances issue out now featuring: Inside Blood Advances
VWF-ADAMTS13 imbalance bridges infections to stroke
Predicting risk in Hodgkin lymphoma for research and clinical practice
buff.ly/kKROS3q #thrombosisandhemostasis #lymphoidneoplasia

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Reposted by Sanne Massaar

Dorien Pastoors @dpastoors.bsky.social · Mar 21

Really enjoyed the meeting too and was very happy to be awarded the presentation prize 🤩!! Extra festive touch added by @bloodadvances.bsky.social which published @massaarsanne.bsky.social 's article on this project DURING her talk 👏 @oncodeinstitute.bsky.social #oncode #kwf #hemesky

Sanne Massaar @massaarsanne.bsky.social · Mar 21

Enjoyed last week's KWF Dutch Cancer Biology Meeting in the forests 🌳 of Lunteren where I got the opportunity to present on DNMT3A double mutant AML.
@dpastoors.bsky.social gave nice talk on p300&CBP regulating enhancer activity in AML which was awarded with the Best Presentation Award! 🤩🥳
#Hemesky

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Sanne Massaar @massaarsanne.bsky.social · Mar 21

Enjoyed last week's KWF Dutch Cancer Biology Meeting in the forests 🌳 of Lunteren where I got the opportunity to present on DNMT3A double mutant AML.
@dpastoors.bsky.social gave nice talk on p300&CBP regulating enhancer activity in AML which was awarded with the Best Presentation Award! 🤩🥳
#Hemesky

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Reposted by Sanne Massaar

Dorien Pastoors @dpastoors.bsky.social · Mar 21

Wooo - check the cover image of the current issue of Blood Advances by @massaarsanne.bsky.social & Emma Boertjes et al!!! Congratulations - methylation damage repair is impaired by double mutations in DNMT3A in AML

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Sanne Massaar @massaarsanne.bsky.social · Mar 17

The likely mechanism?

We show that whereas wildtype DNMT3A stimulates TDG-mediated methylation damage repair, mutated DNMT3A impairs this process.

Sanne Massaar @massaarsanne.bsky.social · Mar 17

Finally out! 🤩🎆

In this work we describe DNMT3A double mutant AML as an unique subtype with a poor prognosis and high levels of methylation damage.

👇
ashpublications.org/bloodadvance...

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Sanne Massaar @massaarsanne.bsky.social · Jan 6

Check it out!! New insights from our department on the role of MECOM and CEBPA in AML
👇👇👇

Dorien Pastoors @dpastoors.bsky.social · Jan 6

Excited to share our preprint on #HemeSky: "MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia"! @delwelruud.bsky.social and co-authors! www.biorxiv.org/content/10.1... [1/15]

MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia

Enhancer translocations, due to 3q26 rearrangements, drive out-of-context MECOM expression in an aggressive subtype of acute myeloid leukemia (AML). Direct depletion of MECOM using an endogenous auxin...

www.biorxiv.org

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Sanne Massaar @massaarsanne.bsky.social · Dec 21

Thank you Madelon! 😄

Sanne Massaar @massaarsanne.bsky.social · Dec 21

Thanks Dorien! ☺️

Reposted by Sanne Massaar

Dorien Pastoors @dpastoors.bsky.social · Dec 20

Congratulations!! Fundamental insights into how mutations in DNMT3A can impair DNA damage repair 👀⬇️ 😎

Sanne Massaar @massaarsanne.bsky.social · Dec 20

Although still in 'First Edition' style, I am happy to finally share our latest article on DNMT3A double mutant AML. Hope to be able to share the way-easier-to-read print version of the paper soon! (1/2) #hemesky ashpublications.org/bloodadvance...

Double mutant DNMT3A AML: a unique subtype experiencing increased DNA damage and poor prognosis

Key Points. 1. Wildtype DNMT3A enhances TDG-mediated repair, whereas mutant DNMT3A impairs this process.2. Double mutant DNMT3A AML exhibits increased DNA

ashpublications.org

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Sanne Massaar @massaarsanne.bsky.social · Dec 20

In this work we show that double mutant DNMT3A AML, a subgroup comprising approximately 4% of the complete AML population, is linked to increased methylation-linked DNA damage, diverging driver mutation landscape and unfavorable overall survival. (2/2)

Sanne Massaar @massaarsanne.bsky.social · Dec 20

Although still in 'First Edition' style, I am happy to finally share our latest article on DNMT3A double mutant AML. Hope to be able to share the way-easier-to-read print version of the paper soon! (1/2) #hemesky ashpublications.org/bloodadvance...

Double mutant DNMT3A AML: a unique subtype experiencing increased DNA damage and poor prognosis

Key Points. 1. Wildtype DNMT3A enhances TDG-mediated repair, whereas mutant DNMT3A impairs this process.2. Double mutant DNMT3A AML exhibits increased DNA

ashpublications.org

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Sanne Massaar @massaarsanne.bsky.social · Dec 9

Great, looks cool!

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Sanne Massaar @massaarsanne.bsky.social · Dec 9

Hahah, thanks for trying, I did not notice! I'll try to stop by tonight, do you know the number of the poster?

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Sanne Massaar @massaarsanne.bsky.social · Dec 9

Hahaha we can definitely work with that!

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Reposted by Sanne Massaar

Tim Triche, Jr.🔰 @timtriche.bsky.social · Dec 8

METHods section was *right there*

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Reposted by Sanne Massaar

Dorien Pastoors @dpastoors.bsky.social · Dec 8

check out Mechanisms of deMethylation by Massaar et al!!! (@tvantienhoven.bsky.social i need you for better puns but the poster session is tonight)

Sanne Massaar @massaarsanne.bsky.social · Dec 8

Interested in how DNMT3A mutations affect the DNA demethylation pathways in AML? Come find me at poster 2718 tonight! #hemesky #ASH24

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Sanne Massaar @massaarsanne.bsky.social · Dec 8

Interested in how DNMT3A mutations affect the DNA demethylation pathways in AML? Come find me at poster 2718 tonight! #hemesky #ASH24

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Reposted by Sanne Massaar

Dorien Pastoors @dpastoors.bsky.social · Dec 6

Woohoo!! latest bluesky addition from rotterdam is fellow Delwel lab PhD student @jengelberts.bsky.social 🥳 and now we FINALLY have enough people for our own starter pack go.bsky.app/N8zjL6y 😁 #HemeSky

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Sanne Massaar @massaarsanne.bsky.social · Dec 2

Definitely! I would love to be added @alessandrodonada.bsky.social 🧪🩸

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