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jelenalab.bsky.social
JelenaBezbradicaLab
@jelenalab.bsky.social
230 followers 230 following 9 posts
Associate Professor at the University of Oxford. Innate sensing and signalling in macrophages. Inflammasomes. Signalling crosstalk in inflammation. https://www.kennedy.ox.ac.uk/research/research-groups/innate-immunity-and-inflammation
www.kennedy.ox.ac.uk
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jelenalab.bsky.social
JelenaBezbradicaLab @jelenalab.bsky.social · Mar 7
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
www.science.org
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Reposted by JelenaBezbradicaLab
lynndustin.bsky.social
Lynn B. Dustin @lynndustin.bsky.social · Jun 28
Congratulations to newly minted Dr. Esther L. Jones @estherlj.bsky.social on her successful DPhil viva! A great collaborative project between the L. Dustin and Jelena Bezbradica @jelenalab.bsky.social labs. Many thanks to examiners Irina Udalova @udalovalab.bsky.social and Menna Clatworthy.
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Reposted by JelenaBezbradicaLab
sunnyshinlab.bsky.social
Dr. Sunny Shin @sunnyshinlab.bsky.social · Jun 17
Excited to share that our paper examining how GM-CSF potentiates cytokine responses in human monocytes during bacterial infection is now online at the @asm.org journal Infection & Immunity! Congrats to @vvazquez.bsky.social, @mikelhaggadone.bsky.social, & co-authors! journals.asm.org/doi/full/10....
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Reposted by JelenaBezbradicaLab
sunnyshinlab.bsky.social
Dr. Sunny Shin @sunnyshinlab.bsky.social · Apr 2
Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
elifesciences.org
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jelenalab.bsky.social
JelenaBezbradicaLab @jelenalab.bsky.social · Mar 8
Elegant work by @jkagan1.bsky.social and team on identifying how innate immune receptor Caspase 11 recognises molecular patterns in LPS and self lipids.
jkagan1.bsky.social
Jonathan Kagan @jkagan1.bsky.social · Mar 8
What do Pablo Picasso and Charles Janeway have in common? Both were interested in patterns of life. Janeway was focused on pathogen associated molecular patterns (PAMPs) that are detected by our immune system. But what are these patterns he refers to?
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jelenalab.bsky.social
JelenaBezbradicaLab @jelenalab.bsky.social · Mar 8
Thanks Dave 😊
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Reposted by JelenaBezbradicaLab
lozanzi.bsky.social
Ivan Zanoni @lozanzi.bsky.social · Mar 7
#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity
ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.
www.science.org
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jelenalab.bsky.social
JelenaBezbradicaLab @jelenalab.bsky.social · Mar 7
Absolutely, it is one of its oldest described functions. Work by many groups is uncovering that TBK1 can licence antiviral responses while also putting the brakes on premature cell death. People and mice with loss of TBK1 suffer from uncontrolled cell death even in the absence of any infection.
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jelenalab.bsky.social
JelenaBezbradicaLab @jelenalab.bsky.social · Mar 7
Thank you so much ♥️
jelenalab.bsky.social
JelenaBezbradicaLab @jelenalab.bsky.social · Mar 7
Lovely work, lead by Fabi Fischer, in collaboration with @kaiwenchen-lab.bsky.social Dom De Nardo, Benjamin Demarco, Felicia Chan and Michelle Yeap. Thank you all for making this project and team work interactive and fun !
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jelenalab.bsky.social
JelenaBezbradicaLab @jelenalab.bsky.social · Mar 7
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
www.science.org
7 22 51
Reposted by JelenaBezbradicaLab
rebsamenlab.bsky.social
Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Jan 28
We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.

Registrations open March 1 - Attendance limited to 150 participants.

More info: wp.unil.ch/immunobiolog...

#ImmunoSky
Symposium immunobiology
wp.unil.ch
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Reposted by JelenaBezbradicaLab
ilesla.bsky.social
ilesla.bsky.social @ilesla.bsky.social · Jan 16
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.
How to Apply and Funding
iles.web.ox.ac.uk
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Reposted by JelenaBezbradicaLab
mdejong.bsky.social
Madelon de Jong @mdejong.bsky.social · Jan 5
Absolutely fantastic work by Vivian Lau and @gerardlab.bsky.social on IFNy-related tumour escape! Must-read for all tumour immunologists! 💯
gerardlab.bsky.social
Gerard Lab @gerardlab.bsky.social · Jan 4
Tumours escape the immune system by mutating to decrease their immunogenicity. In this study, now in
@natcomms.bsky.social, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape www.nature.com/articles/s41...
Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models - Nature Communications
Losing sensitivity to IFNγ may contribute to tumor immune escape, but containment of IFNγ-insensitive tumors is also reported. Here the authors show, by analyzing immune landscape differences between ...
www.nature.com
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jelenalab.bsky.social
JelenaBezbradicaLab @jelenalab.bsky.social · Jan 8
Ok, let's start here on @bsky.app by reposting this truly outstanding paper by @lozanzi.bsky.social and colleagues!
lozanzi.bsky.social
Ivan Zanoni @lozanzi.bsky.social · Dec 26
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
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jelenalab.bsky.social
JelenaBezbradicaLab @jelenalab.bsky.social · Jan 8
Congratulations 🎊!
jelenalab.bsky.social
JelenaBezbradicaLab @jelenalab.bsky.social · Nov 26
Congratulations, Dr. De Jong! We are so proud 👏
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