Des chercheurs de l'UCLouvain, en collaboration avec des experts de huit pays européens, ont fait une avancée majeure dans l'étude de notre microbiote intestinal. Ils ont découvert Dysosmobacter welbionis, une bactérie capable de transformer un nutriment végétal courant, le myo-inositol, en butyrate, une molécule cruciale pour le métabolisme et la santé intestinale. L'importance de cette découverte réside dans le potentiel de cette bactérie à améliorer notre compréhension du lien entre alimentation et santé, notamment pour les personnes qui tolèrent mal les fibres fermentescibles. Cette avancée pourrait ouvrir des pistes prometteuses pour traiter ou prévenir des affections liées à une déficience en butyrate.

Uno studio internazionale, a cui ha partecipato anche l’Italia, ha identificato un batterio intestinale che potrebbe aiutare a prevenire malattie metaboliche come diabete, obesità e fegato grasso. La…

Des chercheurs de l’UCLouvain et de huit pays européens ont identifié une bactérie intestinale humaine capable de transformer un nutriment végétal en une molécule essentielle au bon fonctionnement de…

Studio internazionale con partecipazione italiana rileva il ruolo protettivo del batterio per il fegato e il metabolismo Potrebbe essere un batterio intestinale l’inaspettato alleato nella prevenzione e nella gestione delle malattie metaboliche. A rivelarlo è uno studio internazionale pubblicato sulla rivista Gut, che ha visto la partecipazione di ricercatori italiani del Cnr-Ispaam di Portici, dell’Università […]

Dietary restriction promotes the expansion of effector T cells via ketone bodies, which enhances anti-tumour immunity and synergizes with immunotherapy in mice.

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.

In this Review, Galli and colleagues discuss the mechanisms and associated biomarkers of traditional and emerging factors responsible for the residual risk of recurrent adverse cardiovascular events i...

Proof-of-concept of a humanised gut-brain axis ex vivo model with physiological coupling of intestinal and blood-brain barrier for mechanistical assessment of butyrate- or fiber-rich diets on the sero...

Qiao et al. identify gut microbes and amino acid-metabolizing genes that influence tumor burden. A Bacteroides asparaginase, bo-ansB, modulates host tumor responses to dietary asparagine (Asn) by depl...

Nature Metabolism, Published online: 08 January 2026; doi:10.1038/s42255-025-01425-4Elevated adipocyte-derived AFABP in obesity disrupts iron homeostasis in intestinal stem cells (ISCs), which impairs PPARα signalling and blocks ISC differentiation after injury.

Exposure to twelve widely used preservative food additives are associated with a higher incidence of type 2 diabetes in the French NutriNet-Santé cohort of 108,723 adults, supporting recommendations to favour fresh and minimally processed foods

Yabut and Drucker discuss clinical and preclinical evidence about the potential roles of GLP-1 medicines on cancer incidence, development and therapy and speculate about their mechanism on cancer cell...

By studying metabolism across day and night in human participants, Marjot et al. show that MASLD is a nighttime disease driven by poor insulin action and low insulin levels. These daily patterns persist after weight loss, suggesting that nighttime metabolic dysfunction is a key driver of liver fat accumulation.

How cancer cells subvert immunity to colonize the lymph node remains unclear. Terasaki et al. uncover that lymph node metastasis may be driven by an immune-to-cancer mitochondria transfer axis that impairs immune function and augments cancer immune evasion programs through type I interferon signaling.

Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.

The glucagon-like peptide-2 receptor (GLP-2R) is recognized as a potential target for the treatment of obesity and type 2 diabetes (T2D). Yet, the impact and mechanism of GLP-2R activation on these me...

This multicenter study demonstrates use of dried and capillary blood as a minimally invasive, scalable approach for Alzheimer’s biomarker testing in research, with potential as a widely scalable population-based research approach, especially in resource-limited settings.

Nature Metabolism, Published online: 02 January 2026; doi:10.1038/s42255-025-01407-6The authors use Perturb-seq analysis in human pancreatic islet beta cells, as well as in vivo and in vitro analyses, to identify potential therapeutic targets for type 2 diabetes, including ZZEF1, which regulates insulin synthesis and cellular stress in islet β cells.

An international group of scientists led by Professor Marc-Emmanuel Dumas at Imperial College London & CNRS, along with Prof. Patrice Cani (Imperial & University of Louvain, UCLouvain), Dr. Dominique Gauguier (Imperial & INSERM, Paris) and Prof. Peter Liu (University of Ottawa Heart Institute), has identified an unexpected natural compound that helps counter insulin resistance and type 2 diabetes. The compound, trimethylamine (TMA), is a metabolite created by gut microbes from dietary choline. According to a study in Nature Metabolism, TMA can interrupt a key immune pathway and contribute to healthier blood sugar levels.

Nature Metabolism, Published online: 08 January 2026; doi:10.1038/s42255-025-01426-3When the brain detects ongoing fuel depletion, sympathetic nervous system outflow to white adipose tissue induces lipolysis to mobilize fuel. Yet there exists a subset of ‘stable adipocytes’ that resist lipolysis via this mechanism. The discovery of a novel lipolysis mechanism reshapes our understanding of how body energy requirements are met in times of need.