Nature Metabolism, Published online: 24 November 2025; doi:10.1038/s42255-025-01414-7We show that the size of the mitochondrial NAD+ pool in hepatocytes is regulated by SLC25A51 expression in vivo. We further find that selectively increasing mitochondrial NAD+ is sufficient to improve liver regeneration after partial hepatectomy, equivalent to the effect of systemic high-dose NAD+ precursor supplementation.

Quantifying metabolic activity in patient tumors could advance personalized cancer targeting. Meghdadi et al. develop a digital twin framework using machine learning to quantify metabolic fluxes in tissues from patients with glioma, identifying which patients may benefit from different targeted metabolic therapies like specialized diets or pharmacologic agents.

Nature Metabolism, Published online: 01 December 2025; doi:10.1038/s42255-025-01405-8Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.

The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...

Introduction Patients with intestinal failure caused by short bowel syndrome (SBS) are dependent on parenteral support (PS) for nutrition. Teduglutide, an analogue of glucagon-like peptide 2, has been...

In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.

FFAR4 is a lipid-sensing GPCR with pivotal roles in metabolic regulation and inflammation resolution. This review by Kong et al. integrates recent structural insights into FFAR4 activation, its expand...

Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.

Growing evidence from the microbiome field shows that harnessing gut microbes through diet can beneficially impact brain and behaviour. Which gut microbiome-targeted interventions have been studied as potential approaches for mental health?

Although incretin (GLP-1)-based drugs are highly successful for weight loss, there are some limitations to their use. A modified prolactin-releasing peptide, NN501, causes significant weight loss without apparent side effects and with slower weight gain after cessation, potentially proving suitable as an alternative therapy for the treatment of obesity.

This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.

Xu et al. reveal that unhealthy palmitic acid disrupts PPARα/δ and P53 interaction balance and impairs mutual transactivation, leading to decreased CD73 and increased TRAIL-R1/2, thereby facilitating ...

The gut microbiome can influence brain activity and complex behaviours. In this Review, Griffiths et al. discuss microbiome-associated effects on social behaviour in laboratory model organisms, free-living animals and humans, and consider potential mechanistic pathways.

In this Perspective, the functions of the recently identified post-translational-modification protein l-lactylation in the regulation of cellular metabolism and signalling are discussed, highlighting the potential of l-lactylation as a therapeutic target.

Developing genetic access to transcriptionally distinct enteric neurons in vivo enables the examination of morphological heterogeneity across cell types as well as cell-type-specific influences on GI ...

This Review summarizes our current knowledge about the genetic underpinnings of metabolic-dysfunction-associated steatotic liver disease and highlights its causal association with type 2 diabetes and insulin resistance.

Covid-19 has been linked to cardiovascular complications, but the long-term impacts, particularly for mild infections, are not well understood. Here, the authors investigate the long-term impacts of Covid-19 on cardiovascular disease using data on the whole population of Sweden aged 40-75 years.

Pilley et al. describe how metabolite levels change in 12 organs from male and female mice across five ages, spanning adolescence to old age. They reveal that organs show distinct age- and sex-specific changes in metabolism. They also develop metabolic clocks that predict putative metabolic drivers of aging, including hydroxyproline.

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