Lightnews — Scholar-powered news

Reposted by Mike Krashes

Kate Wassum @katewassum.bsky.social · Feb 19

🚨📃New Wassum Lab Paper📃🚨

Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇

www.nature.com/articles/s41...

Free full text: rdcu.be/eaxEv

A dual-pathway architecture for stress to disrupt agency and promote habit - Nature

Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...

www.nature.com

27 87 250

Reposted by Mike Krashes

Henning Fenselau @henningfenselau.bsky.social · Feb 14

www.science.org/doi/10.1126/... very excited to share our latest work, out now in Science. Congratulations to Marielle who led our studies! And, all other authors - this was a wonderful collaborative effort

Thalamic opioids from POMC satiety neurons switch on sugar appetite

High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...

www.science.org

2 13 39

Mike Krashes @mikekrashes.bsky.social · Jan 14

I’m always looking for a side hustle

1

Mike Krashes @mikekrashes.bsky.social · Jan 13

Counter business you say. Is that something I can do remotely?

1

Mike Krashes @mikekrashes.bsky.social · Jan 13

Is this worth it? It being me leaving my house

1

Reposted by Mike Krashes

Annegret Falkner @neurrriot.bsky.social · Jan 2

New year new work from the lab! We explore whether aggression experience and observation lead to similar changes in future aggression strategy. (They do!) We perform 2-color imaging across the whole social behavior network across time and track changes www.biorxiv.org/content/10.1...

Aggression experience and observation promote shared behavioral and neural changes

The ability to observe the social behavior of others and use observed information to bias future action is a fundamental building block of social cognition. A foundational question is whether social o...

www.biorxiv.org

2 27 49

Reposted by Mike Krashes

Nature Neuroscience @natneuro.nature.com · Dec 18

We're so excited to join the party over here! Follow this account to learn more about the latest papers published in Nature Neuroscience!

18 75

Reposted by Mike Krashes

Keri Martinowich @martinowk.bsky.social · Dec 17

Reposting new preprint investigating sex-differentially expressed (DE) genes in human ventromedial hypothalamus and arcuate 🧠. Data identifies extensive sex DE, which is linked to genetic risk for sex-biased disorders including autism, depression, and schizophrenia

www.biorxiv.org/content/10.1...

Figure 1 of paper showing study overview and identification of VMH and ARC spatial domains in human brain

5 23 67

Mike Krashes @mikekrashes.bsky.social · Dec 16

Secret Level, PAC-Man episode 6

1 1

Reposted by Mike Krashes

Jan Siemens @jansiemens.bsky.social · Dec 10

My inaugural post on Bluesky - quite fittingly, I'm thrilled to share our first study on heat acclimation, which identifies a neuronal mechanism that drives heat tolerance in mice. (www.nature.com/articles/s41... )
Here is the gist 🧵 (1/n):

Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance - Nature Neuroscience

Ambroziak, Nencini, Pohle and colleagues identify a slowly emerging plasticity mechanism in a discrete set of hypothalamic preoptic neurons that is triggered by long-term heat exposure and that drives...

www.nature.com

2 14 42

Mike Krashes @mikekrashes.bsky.social · Dec 7

I thought this was a friendly space where I can feel safe with my opinions. That’s a TwitterX response Tom

1 2

Mike Krashes @mikekrashes.bsky.social · Dec 6

Don’t hate until you try it

1

Reposted by Mike Krashes

Randy J Seeley @seeleyrj.bsky.social · Dec 4

Latest from our group in collaboration with Lotte Bjerre Knudsen and other Novo scientists. They developed a GLP-1/Leptin co-agonist that we put through its paces in a number of mouse models to prove that both parts of the molecule matter. More options on the table!
www.science.org/doi/10.1126/...

Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist

Orthogonal murine models demonstrate the bioactivity and neuronal targets of a GLP-1/leptin coagonist in relation to food intake and body weight.

www.science.org

2 14 31

Reposted by Mike Krashes

danasmall.bsky.social @danasmall.bsky.social · Dec 4

@mikekrashes.bsky.social on GLP-1.

Current Biology @currentbiology.bsky.social · Dec 3

Everyone is talking about #Ozempic #Wegovy which are agonists of the GLP-1 receptor. For more about this receptor and its physiological role, see the quickguide by Michael Krashes in our latest issue

www.cell.com/current-biol...

Glucagon-like peptide-1 receptor

Michael Krashes discusses glucagon-like peptide-1 receptors, their physiological role in glucose metabolism and the mode of action of their agonists that are used to treat obesity and were later shown...

www.cell.com

1 2 5

Reposted by Mike Krashes

Alex Chesler @alexchesler.bsky.social · Dec 4

NIH’s own @mikekrashes.bsky.social telling it like it is.

Current Biology @currentbiology.bsky.social · Dec 3

Everyone is talking about #Ozempic #Wegovy which are agonists of the GLP-1 receptor. For more about this receptor and its physiological role, see the quickguide by Michael Krashes in our latest issue

www.cell.com/current-biol...

Glucagon-like peptide-1 receptor

Michael Krashes discusses glucagon-like peptide-1 receptors, their physiological role in glucose metabolism and the mode of action of their agonists that are used to treat obesity and were later shown...

www.cell.com

3 7

Reposted by Mike Krashes

Current Biology @currentbiology.bsky.social · Dec 3

Everyone is talking about #Ozempic #Wegovy which are agonists of the GLP-1 receptor. For more about this receptor and its physiological role, see the quickguide by Michael Krashes in our latest issue

www.cell.com/current-biol...

Glucagon-like peptide-1 receptor

Michael Krashes discusses glucagon-like peptide-1 receptors, their physiological role in glucose metabolism and the mode of action of their agonists that are used to treat obesity and were later shown...

www.cell.com

2 18 60

Reposted by Mike Krashes

Deniz Atasoy @denizatasoy.bsky.social · Dec 3

Parallel gut-to-brain pathways orchestrate feeding behaviors

www.nature.com/articles/s41...

Parallel gut-to-brain pathways orchestrate feeding behaviors - Nature Neuroscience

This study identifies parallel gut–brain pathways that fine-tune feeding. Distinct brainstem neurons and visceral afferents either sense esophageal stretch to regulate eating speed or detect gut nutri...

www.nature.com

3 16

Mike Krashes @mikekrashes.bsky.social · Dec 3

New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5

Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety

Nature Metabolism - Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.

rdcu.be

2 15 40

Mike Krashes @mikekrashes.bsky.social · Dec 2

A little late for Thanksgiving but if you have friends and family members curious about anti-obesity medications, this is very easy to digest piece (nailed that pun....still got it) authors.elsevier.com/a/1kCED3QW8S...

authors.elsevier.com

1 6 21

Mike Krashes @mikekrashes.bsky.social · Nov 27

These two papers really shaped our understanding of how calories are encoded in the hypothalamus: pubmed.ncbi.nlm.nih.gov/29024666/

pubmed.ncbi.nlm.nih.gov/29212021/

Dynamics of Gut-Brain Communication Underlying Hunger - PubMed

Communication between the gut and brain is critical for homeostasis, but how this communication is represented in the dynamics of feeding circuits is unknown. Here we describe nutritional regulation o...

pubmed.ncbi.nlm.nih.gov

8

Reposted by Mike Krashes

SSIBsociety @ssibsociety.bsky.social · Nov 27

We've joined the blue skies.

Follow along to those interested in all things ingestive behavior.

Also, be sure to check out SSIB2025 👉 www.ssib.org/2025/

Neuroskyence: 🧠🟦 or 🧠📈
Interoception: 🧠🫀 or 🧠🫁
Neuropsychiatry: 🧠🩺

4 15

Reposted by Mike Krashes

Linda Rinaman @neurorinaman.bsky.social · Nov 27

Stress, GLP1, hypothalamus, NTS, what more could you want? Collaboration across the pond led by the amazing Dr. Marie Holt @MKBHolt www.sciencedirect.com/science/arti...

Modulation of stress-related behaviour by preproglucagon neurons and hypothalamic projections to the nucleus of the solitary tract

Stress-induced behaviours are driven by complex neural circuits and some neuronal populations concurrently modulate diverse behavioural and physiologi…

www.sciencedirect.com

1 10 41

Mike Krashes @mikekrashes.bsky.social · Nov 26

I will be the first to buy

2

Mike Krashes @mikekrashes.bsky.social · Nov 23

Is this not truthsocial

1 5