MJ Koh Group
@mjkoh87.bsky.social
70 followers
96 following
5 posts
Research Group in the Department of Chemistry at the National University of Singapore (NUS). Transforming chemical & carbohydrate synthesis through base metal catalysis, radical cross-coupling & molecular editing.
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Reposted by MJ Koh Group
Nature Synthesis
@natsynth.nature.com
· Sep 4
Iron-catalysed radical difunctionalization of alkenes - Nature Synthesis
Three-component, iron-based catalytic transformations offer a promising and sustainable approach to building complex molecules in a single step. This Review highlights advances and ongoing challenges ...
www.nature.com
Reposted by MJ Koh Group
MJ Koh Group
@mjkoh87.bsky.social
· Apr 7
Site‐Selective Carbonylation of Azetidines via Copper‐Catalyzed Difluorocarbene Insertion
γ-Lactams are privileged five-membered pharmaco-phores in numerous bioactive compounds, but access to these motifs typically rely on cycloaddition/substitution chemistry involving activated substrate...
onlinelibrary.wiley.com
MJ Koh Group
@mjkoh87.bsky.social
· Feb 22
Catalytic difluorocarbene insertion enables access to fluorinated oxetane isosteres - Nature Chemistry
Catalytic methods to introduce fluorine into the backbone of small-ring heterocycles are challenging due to the problems of strain-induced ring cleavage and defluorination. Now, a copper catalyst medi...
www.nature.com