Author | Lightnews

🧪Intellectuals,
Selection for the prestigious National Academy of Sciences (India) Membership is a joy!
Yours truly, Ph.D, MNASc 😀
Grateful to everyone who have stood by me rock solid in this scenic and transformative journey. Heartfelt Thank you to The National Academy of Sciences, India...

Seema @molbioinfo.bsky.social · Jul 24

Happy to share our latest paper using machine-learning-QSAR on ChEMBL dataset. We identified and designed novel inhibitors for Acid Ceramidase inhibition in Glioblastoma using SHAP-based mechanistic interpretations. Thankful to proactive Reviewers and Editors.
rdcu.be/exD3a

An innovative machine learning-based QSAR approach for prediction and structural analysis of novel/repurposed acid ceramidase (ASAH1) inhibitors for glioblastoma therapy

rdcu.be

Seema @molbioinfo.bsky.social · Jan 3

Interesting, so sharing here:
x.com/nlarusstone/...

x.com

Reposted by Seema

Shah Selbe @shahselbe.bsky.social · Dec 9

It is always mind boggling at how massive @agu.org is every year. This is just one session of the poster room, which changes over twice daily for the duration of the conference. #AGU24

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Seema @molbioinfo.bsky.social · Nov 28

And here I was wondering RNA Capping at the first mention of the word 'cap'...caps impart efficient translation and stability to mRNA... 🤔

Arjun Raj @arjunraj.bsky.social · Nov 27

I strongly disagree with the idea of caps. Caps are always brought up because "mega-labs are bad!!" Regardless of whether they are good or bad, mega-labs are rarely affected by caps. Instead, it is middle-class labs that are shifted towards subsistence. That is bad for the scientific ecosystem, IMO.

Rob Patro @robp.bsky.social · Nov 27

Dear @pnas.org ,

I strongly disagree. I believe that in the current funding environment, caps to individual labs and PIs are and would be absolutely crucial for sustaining scientific innovation. Would you consider a counter opinion piece? Who’d be interested in writing one with me?

Reposted by Seema

Armand Sarlangue @armandsarlangue.bsky.social · Nov 26

The great Matterhorn in all its glory… A classic shot from the Swiss alps, but the light was too good to not click this one.

#bluesky #photography #mountains #nature #landscape #landscapephotography #naturephotography

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Seema @molbioinfo.bsky.social · Nov 26

E.g.?

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Seema @molbioinfo.bsky.social · Nov 23

RNA-mediated DNA damage repair:
www.nature.com/articles/s41...
#RNAbiology
#RNAsky

RNA-mediated double-strand break repair by end-joining mechanisms - Nature Communications

Double-strand breaks (DSBs) in DNA are challenging to repair. Here, the authors show that transcript RNAs impact the DSB repair outcomes in human and yeast cells by promoting NHEJ or MMEJ in a sequenc...

www.nature.com

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Seema @molbioinfo.bsky.social · Nov 22

#RNABiology
#RNAsky
#tRNA

freecell @ifreecell.bsky.social · Nov 21

Zhu et al. discovered that tRNAs also play an important role in regulating mRNA degradation during translation. Data revealed that specific tRNAs that decode arginine codons directly recruit the CCR4-NOT complex to translating ribosomes, thereby promoting mRNA turnover.

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Seema @molbioinfo.bsky.social · Nov 21

RNA aficianados,
Just attended my first seminar series at RNA Collaborative - The RNA Institute, SUNY University at Albany yesterday. It is awesome science and a great way to stay updated in everything RNA. Registration is free:
www.rnasociety.org/rna-collabor...
#rnabiology
#rnasky
🧪

RNA Collaborative Seminar Series

www.rnasociety.org

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Seema @molbioinfo.bsky.social · Nov 21

Any answers? Looks like this is a ResearchGate question. 😀
#rnabiology
#rnasky
#moleculardynamics

Reposted by Seema

John Prensner @johnprensner.bsky.social · Nov 16

Here is a paper where I would just like to say "Thank you" to the authors.

I thoroughly enjoyed this.

I hope you do too.

#GENESky
#RNAsky
#CANsky
#genomics
#bioinformatics
🧪
🧬💻
🔎 microproteins

www.cell.com/cell-reports...

RNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancer

Li et al. thoroughly analyzed RNA splicing junctions in 34,775 samples and identified 29,051 tumor-specific transcripts that may serve as cancer driver genes, neoantigens, and circulating biomarkers.

www.cell.com

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Seema @molbioinfo.bsky.social · Nov 20

Is 108 kb Air the longest lncRNA?
Any new champion in this category?🤔
#rnabiology
#rnasky
🧪

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Seema @molbioinfo.bsky.social · Nov 20

#rnabiology

STCmicrobeblog @stcmicrobeblog.bsky.social · Nov 20

...to resurrect an old blog post from 2015:

Your Operating System on a Thumbdrive – A Snippet

At the heart of every cell's 'operating system' you find the ribosomes, these ingenious nano‑machines that translate messenger RNA (mRNA) into all kinds of...

schaechter.asmblog.org/schaechter/2...

Seema @molbioinfo.bsky.social · Nov 20

Molecular dynamics aficionados! Which is the most accurate RNA force-field currently?
#rnabiology
#computationalbiology
#rnasky
🧪

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Seema @molbioinfo.bsky.social · Nov 19

Yes, what you really want to do is key when you have lot of time till the day you think of retirement....juggle it with playing it safe. Do the balancing act.

Seema @molbioinfo.bsky.social · Nov 18

#rnasky

Seema @molbioinfo.bsky.social · Nov 18

Deers and LncRNAs...
www.nature.com/nsmb/volumes...

#rna
#rnabiology

www.nature.com

Seema @molbioinfo.bsky.social · Nov 18

Deers and LncRNAs...
www.nature.com/nsmb/volumes...

#rna
#rnabiology

www.nature.com