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Reposted by Nils Blüthgen

Edda Schulz @eddaschulz.bsky.social · 4d

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

www.nature.com

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Jeremy Berg @jeremymberg.bsky.social · 11d

When I was at NIH and shutdowns loomed, it was discovered that the administration was planning to shut down PubMed. The head of NCBI called the powers that be and pointed out that this would threaten patient safety

Who knows what will happen now

Just in case, remember Euruope-PMC
(europepmc.org )

a cartoon of donald trump with the words be prepared above him

ALT: a cartoon of donald trump with the words be prepared above him

media.tenor.com

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Nils Blüthgen @molsysbio.bsky.social · 6d

The Ärzteblatt asked me about the instability of Pubmed (Why my? Don't know...). Not sure if I agree with the colleagues that we should build up national resources, I rather think we should strengthen existing European ones (e.g. EuropePMC, ENA, EGA...)... www.aerzteblatt.de/archiv/wisse...

Wissenschaftliche Resilienz: Auf dem Weg aus der PubMed-Abhängigkeit – Deutsches Ärzteblatt

www.aerzteblatt.de

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CompCancer PhD programme @compcancer.bsky.social · 14d

Nicky McGranahan kicking off the last day showing the evolutionary history of metastasis. Amazing data and analysis.

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CompCancer PhD programme @compcancer.bsky.social · 14d

Very dynamic poster sessions at the late summer school on tumor heterogeneity and treatment followed by a rooftop party. Thank you @mdc-bimsb.bsky.social for hosting us!

Impression of the poster session at bimsb, showing the staircase

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CompCancer PhD programme @compcancer.bsky.social · 15d

Great talks from PhD students Tancredi Massimo Pentimalli, Adila Apsara: and Siddharth Annaldasula!

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CompCancer PhD programme @compcancer.bsky.social · 15d

Efrat Shema kicking off today’s program with a lecture on epigenetics and single cell methods.

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CompCancer PhD programme @compcancer.bsky.social · 16d

Final session for today: Sven Nelander discusses how patient specific models combined with advanced molecular biology and large scale computation allow for a better understanding of CNS cancers.

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CompCancer PhD programme @compcancer.bsky.social · 16d

We continue with Ido Amit who shows how single cell approaches allow to improve immune therapy and Anton Henssen introducing us to the world of extrachromosomal DNA and how this relates to tumor heterogeneity. Fascinating!

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CompCancer PhD programme @compcancer.bsky.social · 16d

First session: Uli Keilholz of the comprehensive cancer center on how complex data and models are now used in the clinics, and Heiko Enderling on modeling approaches. Both show excellent examples on how computation already now is impotent for clinical decisions, and how it will be in future.

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CompCancer PhD programme @compcancer.bsky.social · 16d

Kicking off today’s Late Summer School on tumor heterogeneity and treatment resistance with an amazing program. Great to see a huge turnout!

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Markus Landthaler @landthalerm.bsky.social · 28d

Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome

UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target transcripts within hours. Boehm et al. use conditional protein degradation and advanced transcriptomics to map t...

www.cell.com

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Nils Blüthgen @molsysbio.bsky.social · Sep 8

Join us for our first CompCancer seminar this fall on Thursday, 4pm with Chris Sander (Harvard): „Catch Cancer Early with the Help of AI Tools“. Maud Menten Room, House 18, Campus Nord HU

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humboldtuni.bsky.social @humboldtuni.bsky.social · Aug 26

Spatenstich für den Forschungsneubau Optobiologie an der #HumboldtUni. Gemeinsam mit der Charité und der @berlinualliance.bsky.social entsteht ein Zentrum für interdisziplinäre Spitzenforschung. Auf rund 3.800 m² entstehen Laborflächen für 110 Wissenschaftler*innen 👉 www.hu-berlin.de/de/pr/nachri...

Beim Spatenstich (v.l.n.r.): Dr. Ina Czyborra, Senatorin für Wissenschaft, Gesundheit und Pflege, Prof. Dr. Julia von Blumenthal, Präsidentin der Humboldt-Universität zu Berlin, Christian Gaebler, Senator für Stadtentwicklung, Bauen und Wohnen und Prof. Dr. Heyo K. Kroemer, Vorstandsvorsitzender Charité - Universitätsmedizin Berlin. Foto: Stefan Klenke

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Nils Blüthgen @molsysbio.bsky.social · Aug 19

Why do kids respond differently to a new virus than adults? Lev has the answer… it is differences in Stat signaling. Happy that we (mainly @astaburuaga-garcia.bsky.social ) could contribute a bit. Congratulations @sawitzkilab.bsky.social and @woodenrobo.bsky.social to this great paper!

Lev Petrov @woodenrobo.bsky.social · Aug 19

Excited to see my magnum opus published! Here, we explore how age correlates with changes in STAT signaling and modulates the immune response towards inflammation. See for youself!
Also, it's been a long time since pre-print, so here's the reworked explainer thread!
www.cell.com/cell-reports...

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

Petrov et al. identify an age-dependent shift in interferon signaling during SARS-CoV-2 infection, with older individuals favoring a STAT3-driven inflammatory response. This mechanistic insight helps ...

www.cell.com

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Nils Blüthgen @molsysbio.bsky.social · Aug 19

Very moving obituary by Stas Svartsman for Benny Shilo. I met Benny a few years ago at the WiKo in Berlin and enjoyed our very inspiring conversations about signaling dynamics and patterning. Glad that I met him.

www.cell.com/developmenta...

Ben-Zion Shilo (1951–2025)

Ben-Zion Shilo, a distinguished Israeli geneticist (Figure 1), passed away this April at the age of 73 at his home in Rehovot. Benny, as he was known to his friends and colleagues around the world, ma...

www.cell.com

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Sawitzki Lab @sawitzkilab.bsky.social · Aug 19

Lev Petrov @woodenrobo.bsky.social · Aug 19

Excited to see my magnum opus published! Here, we explore how age correlates with changes in STAT signaling and modulates the immune response towards inflammation. See for youself!
Also, it's been a long time since pre-print, so here's the reworked explainer thread!
www.cell.com/cell-reports...

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

Petrov et al. identify an age-dependent shift in interferon signaling during SARS-CoV-2 infection, with older individuals favoring a STAT3-driven inflammatory response. This mechanistic insight helps ...

www.cell.com

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Reposted by Nils Blüthgen

Sawitzki Lab @sawitzkilab.bsky.social · Aug 19

Excited to share our new study on how age-related changes in STAT signaling impact antiviral responses and hyperinflammation in COVID-19!

🧵 Explainer thread by the first author Lev Petrov linked below ⬇️

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

Petrov et al. identify an age-dependent shift in interferon signaling during SARS-CoV-2 infection, with older individuals favoring a STAT3-driven inflammatory response. This mechanistic insight helps ...

www.cell.com

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Leif Erik Sander 🇪🇺🇺🇦 @sanderlab.bsky.social · Aug 7

Wollen Sie mit einer komplizierten Infektion von Infektionsspezialisten behandelt werden oder soll das einfach irgendwer nebenbei "mitmachen"? Die Politik meint: Letzteres muss reichen in Deutschland. Anders ist die Abschaffung der LG Infektiologie nicht zu verstehen. #KHAG @spdfraktion.de #CDUCSU

Leif Erik Sander 🇪🇺🇺🇦 @sanderlab.bsky.social · Aug 7

Der aktuelle Entwurf der Bundesregierung zum Krankenhausanpassungsgesetz (KHAG) enthält gravierende Rückschritte, allen voran die Streichung der Leistungsgruppe Infektiologie. Mit dieser Fehlentscheidung schwächt das BMG die Effizienz + Qualität der Versorgung & konterkariert die Ziele der Reform. 🧵

Screenshot aus dem Referentenentwurf: "Zu Leistungsgruppe Nummer 3" Die Leistungsgruppe Infektiologie wird gestrichen.

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Nils Blüthgen @molsysbio.bsky.social · Aug 1

Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025

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Nils Blüthgen @molsysbio.bsky.social · Aug 1

Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025

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Nils Blüthgen @molsysbio.bsky.social · Jul 25

Maybe they recently contacted a different {{Last Name))? Maybe they should consider using Latin alphabet in the subject line?

Picture of an email, starting with Greek letters, followed by Desr Dr. {{Ladt Name}}

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Nils Blüthgen @molsysbio.bsky.social · Jul 22

Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust www.science.org/doi/10.1126/...

Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer

A cell-sorting approach reveals distinct modes of cancer resistance to active-state RAS inhibitors.

www.science.org

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Nils Blüthgen @molsysbio.bsky.social · Jul 22

Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust www.science.org/doi/10.1126/...

Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer

A cell-sorting approach reveals distinct modes of cancer resistance to active-state RAS inhibitors.

www.science.org

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Nils Blüthgen @molsysbio.bsky.social · Jul 17

This is very cool. Congratulations! @olivierpertz.bsky.social

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