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Daniel Mordes

@mordeslab.bsky.social

22 followers 39 following 4 posts

Neuropathologist and Investigator at the Institute for Neurodegenerative Diseases and Weill Institute for Neurosciences at UCSF; aspiring coffee connoisseur

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Daniel Mordes @mordeslab.bsky.social · 5d

Excited to share our study on the function of the protein kinase TBK1, which is linked to ALS and dementia, in the regulation of selective autophagy and lysosomes. #neurodegeneration #ALS
Thank you to all collaborators and to the NIH iNDI.
www.sciencedirect.com/science/arti...

Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks

Loss-of-function variants in TBK1, encoding a protein kinase, are strongly associated with familial amyotrophic lateral sclerosis (ALS) and frontotemp…

www.sciencedirect.com

Daniel Mordes @mordeslab.bsky.social · Jun 5

Great review article on autophagy in the brain.

Autophagy, aging, and age-related neurodegeneration: Neuron www.cell.com/neuron/fullt...

Autophagy, aging, and age-related neurodegeneration

This review discusses the links between the autophagy pathway, aging, and age-associated neurodegeneration in Alzheimer’s, Parkinson’s, motor neuron, and Huntington’s diseases. The authors highlight t...

www.cell.com

Reposted by Daniel Mordes

Beth Stevens @bethstevenslab.bsky.social · Apr 28

Excited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko
See below for details and preprint

Mike Dolan @dolanmjg.bsky.social · Apr 28

How does the brain repair myelin after injury?

We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...

Details below 👇

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration

Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...

www.biorxiv.org

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Reposted by Daniel Mordes

Science Magazine @science.org · Apr 28

"As I catch my breath, it starts to dawn on me that I’ve completed my first race. And suddenly, my future career as physician-scientist finally begins to seem attainable, too."

This week's #ScienceWorkingLife: scim.ag/4jTnvY3

An illustration of a woman rowing across the globe. Hedline is: How I regained my confidence as a scientist through rowing.

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Daniel Mordes @mordeslab.bsky.social · Mar 27

Grateful to the incredible mentorship of Kevin Eggan and the support of HSCRB and all Eggan lab members when starting this project. Congrats to Karen and Julie on this study. #ALS

Daniel Mordes @mordeslab.bsky.social · Mar 27

Excited to share our study on familial ALS and frontotemporal dementia (FTD), showing that a C9ORF72-ALS/FTD dipeptide protein perturbs phosphorylation of RNA binding proteins. SRSF7 sustains levels of STMN2 in induced neurons.
actaneurocomms.biomedcentral.com/articles/10....

C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7 - Acta Neuropathologica Communications

A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and combined ALS/FTD. The repeat is transcribed in ...

actaneurocomms.biomedcentral.com

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