Daniel Mordes
@mordeslab.bsky.social
Neuropathologist and Investigator at the Institute for Neurodegenerative Diseases and Weill Institute for Neurosciences at UCSF; aspiring coffee connoisseur
Excited to share our study on the function of the protein kinase TBK1, which is linked to ALS and dementia, in the regulation of selective autophagy and lysosomes. #neurodegeneration #ALS
Thank you to all collaborators and to the NIH iNDI.
www.sciencedirect.com/science/arti...
Thank you to all collaborators and to the NIH iNDI.
www.sciencedirect.com/science/arti...
Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks
Loss-of-function variants in TBK1, encoding a protein kinase, are strongly associated with familial amyotrophic lateral sclerosis (ALS) and frontotemp…
www.sciencedirect.com
October 30, 2025 at 4:41 AM
Excited to share our study on the function of the protein kinase TBK1, which is linked to ALS and dementia, in the regulation of selective autophagy and lysosomes. #neurodegeneration #ALS
Thank you to all collaborators and to the NIH iNDI.
www.sciencedirect.com/science/arti...
Thank you to all collaborators and to the NIH iNDI.
www.sciencedirect.com/science/arti...
Great review article on autophagy in the brain.
Autophagy, aging, and age-related neurodegeneration: Neuron www.cell.com/neuron/fullt...
Autophagy, aging, and age-related neurodegeneration: Neuron www.cell.com/neuron/fullt...
Autophagy, aging, and age-related neurodegeneration
This review discusses the links between the autophagy pathway, aging, and age-associated
neurodegeneration in Alzheimer’s, Parkinson’s, motor neuron, and Huntington’s diseases.
The authors highlight t...
www.cell.com
June 5, 2025 at 9:57 PM
Great review article on autophagy in the brain.
Autophagy, aging, and age-related neurodegeneration: Neuron www.cell.com/neuron/fullt...
Autophagy, aging, and age-related neurodegeneration: Neuron www.cell.com/neuron/fullt...
Reposted by Daniel Mordes
Excited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko
See below for details and preprint
See below for details and preprint
How does the brain repair myelin after injury?
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration
Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...
www.biorxiv.org
April 28, 2025 at 11:48 AM
Excited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko
See below for details and preprint
See below for details and preprint
Reposted by Daniel Mordes
"As I catch my breath, it starts to dawn on me that I’ve completed my first race. And suddenly, my future career as physician-scientist finally begins to seem attainable, too."
This week's #ScienceWorkingLife: scim.ag/4jTnvY3
This week's #ScienceWorkingLife: scim.ag/4jTnvY3
April 28, 2025 at 3:07 PM
"As I catch my breath, it starts to dawn on me that I’ve completed my first race. And suddenly, my future career as physician-scientist finally begins to seem attainable, too."
This week's #ScienceWorkingLife: scim.ag/4jTnvY3
This week's #ScienceWorkingLife: scim.ag/4jTnvY3
Excited to share our study on familial ALS and frontotemporal dementia (FTD), showing that a C9ORF72-ALS/FTD dipeptide protein perturbs phosphorylation of RNA binding proteins. SRSF7 sustains levels of STMN2 in induced neurons.
actaneurocomms.biomedcentral.com/articles/10....
actaneurocomms.biomedcentral.com/articles/10....
C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7 - Acta Neuropathologica Communications
A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and combined ALS/FTD. The repeat is transcribed in ...
actaneurocomms.biomedcentral.com
March 27, 2025 at 5:57 PM
Excited to share our study on familial ALS and frontotemporal dementia (FTD), showing that a C9ORF72-ALS/FTD dipeptide protein perturbs phosphorylation of RNA binding proteins. SRSF7 sustains levels of STMN2 in induced neurons.
actaneurocomms.biomedcentral.com/articles/10....
actaneurocomms.biomedcentral.com/articles/10....