Lara Muffley
LightNews LightNews
banner
muffley.bsky.social
Lara Muffley
@muffley.bsky.social
410 followers 460 following 51 posts
Director of Program Operations (Variant Effects Portfolio) CMAP, CAVA and the Atlas of Variant Effects Alliance | she/her 🏳️‍🌈
https://fowlerlab.gs.washington.edu/people
https://brotmanbaty.org/research/atlas-of-variant-effects
Posts Replies Media Videos
Pinned
muffley.bsky.social
Lara Muffley @muffley.bsky.social · 21d
Looking for some heartwarming and interesting stories about early-career scientists making strides in genomics and precision medicine right here in Seattle? Check out the @brotmanbaty.bsky.social 's Promising Young Scientists Series! brotmanbaty.org/news/categor... @uwgenome.bsky.social
Reposted by Lara Muffley
amelierocks.bsky.social
So looking forward to this meeting!
muffley.bsky.social Lara Muffley @muffley.bsky.social · 16h
Also! We'd love your help in promoting this event in the #Australia #Australasia region! Topics and programming will be of interest to the #FunctionalGenomics #Genomics #Clinical #Research #Community ℹ️https://www.mss2026.org
November 25, 2025 at 7:29 PM
muffley.bsky.social
Also! We'd love your help in promoting this event in the #Australia #Australasia region! Topics and programming will be of interest to the #FunctionalGenomics #Genomics #Clinical #Research #Community ℹ️https://www.mss2026.org
November 25, 2025 at 7:17 PM
muffley.bsky.social
#VariantEffect26 will be in Melbourne Australia! 🐨
Note that there will be a computational modeling and a clinical variant interpretation workshop!!
Discounted tickets available for participants from LMICs.
More info and to register www.mss2026.org
varianteffect.bsky.social Atlas of Variant Effects Alliance @varianteffect.bsky.social · 1d
If you are planning to attend the Mutational Scanning Symposium (and companion workshops!) we recommend that you register as soon as possible to secure your spot!
ℹ️ www.mss2026.org
Keynotes! @mehurles.bsky.social @maitreya.bsky.social
#VariantEffect26 #Symposium #Workshop #RegisterNow
November 24, 2025 at 3:12 PM
Reposted by Lara Muffley
chaiannng.bsky.social
Thank you @amglazer.bsky.social for the exciting opportunity to collaborate! Since then, we've provided functional evidence supporting the VUS reclassification in children with abnormal sodium #ionchannel function at Sydney Children’s Hospital.
amglazer.bsky.social Andrew Glazer @amglazer.bsky.social · 5d
📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]
November 21, 2025 at 12:14 AM
Reposted by Lara Muffley
varianteffect.bsky.social
🧬 #SponsorshipOpportunity #VariantEffect26
For more info reach out directly to @muffley.bsky.social
or inquire here 📧 www.mss2026.org
We'd love to have your support!
November 18, 2025 at 12:47 PM
muffley.bsky.social
Join us for a special @varianteffect.bsky.social Fireside Chat on Jan 6th, 2026 (9-10am Pacific) w/ @maitreya.bsky.social (@uwgenome.bsky.social) & @mehurles.bsky.social (@sangerinstitute.bsky.social)

Visit www.varianteffect.org/event/firesi...
for more info and to add this event to your calendar
The image is a promotional graphic for a "Fireside Chat" event organized by the Variant Effects Seminar Series and the AVE Alliance. The background is light gray, and the text is in dark gray and green. At the top, there is a stylized image of a fireplace with flames. Below, bold text reads "Fireside Chat," with an invitation to join on January 6th, 2026, featuring Dr. Maitreya Dunham and Dr. Matthew Hurles discussing MAVEs in clinical space and model organism systems. The date and time are highlighted in dark and light green ovals: "01.06.26" and "9:00AM (Pacific)." To the right, the Atlas of Variant Effects logo is displayed featuring stylized DNA strands formed by interwoven lines. At the bottom, there are two photos: on the left is Dr. Maitreya Dunham, with the text "Maitreya Dunham, University of Washington," and on the right is Dr. Matthew Hurles, with the text "Matthew Hurles, Wellcome Sanger Institute."
November 10, 2025 at 2:30 PM
muffley.bsky.social
Looking for some heartwarming and interesting stories about early-career scientists making strides in genomics and precision medicine right here in Seattle? Check out the @brotmanbaty.bsky.social 's Promising Young Scientists Series! brotmanbaty.org/news/categor... @uwgenome.bsky.social
November 4, 2025 at 6:48 PM
muffley.bsky.social
🦕🦖🦕🦖🦕🦖 Conference dinner at Melbourne Museum ! Yes please.
varianteffect.bsky.social Atlas of Variant Effects Alliance @varianteffect.bsky.social · 21d
2026 Mutational Scanning Symposium & Workshop will be here before you know it! Register now to secure your spot and get a ticket 🎟️ for the conference dinner at Melbourne Museum! 🦕 tinyurl.com/MSS26Registr... #VariantEffect26 #Dinosaurs #RegisterNow
November 4, 2025 at 3:13 PM
Reposted by Lara Muffley
varianteffect.bsky.social
🗓️Abstract Deadline Extended
to December 1st, 2025!
#VariantEffect26
ℹ️https://www.mss2026.org
November 3, 2025 at 2:30 PM
Reposted by Lara Muffley
varianteffect.bsky.social
We have an incredible speaker line-up for next years Mutational Scanning Symposium 🤩. Register now and submit your abstract before the deadline next week!
ℹ️ www.mss2026.org
#VariantEffect26 #FOMO #Functional #Genomics #Symposium #Abstract #Deadline
October 31, 2025 at 2:11 PM
Reposted by Lara Muffley
varianteffect.bsky.social
brotmanbaty.org/news/q-and-a... @brotmanbaty.bsky.social Q&A with #VariantEffect26 co-organizer Rehan Villani.
October 17, 2025 at 6:10 PM
Reposted by Lara Muffley
christianlandry.bsky.social
Want to be our colleague? We have a faculty position in microbial systems biology looking for candidates. Please share. www.rh.ulaval.ca/emplois-disp...
Tenure-Track Faculty Position in Omics Data Analysis in the Field of Microbial Systems Biology | Ressources humaines | Université Laval
www.rh.ulaval.ca
October 9, 2025 at 9:00 AM
Reposted by Lara Muffley
varianteffect.bsky.social
Variant Effects Seminar Series
October and November lineup! Join us!
ℹ️https://www.varianteffect.org/seminar-series/
October 3, 2025 at 1:50 PM
Reposted by Lara Muffley
sangerinstitute.bsky.social
This role, based at Sanger, will lead on the communications for the Atlas of Variant Effects Alliance - an initiative that is mapping the effects of all the possible variants of human genes 🧬

This is a part-time role, closing on 14th Oct.
More info ⤵️
sanger.wd103.myworkdayjobs.com/WellcomeSang...
October 2, 2025 at 10:25 AM
Reposted by Lara Muffley
ee-reh-neh.bsky.social
I'm stoked to be organising next year's MSS right here in beautiful Melbourne! We know Australia is very far away, and we're working hard to make sure we can support as many ECRs to attend as possible, so please do register and apply for a travel award!
varianteffect.bsky.social Atlas of Variant Effects Alliance @varianteffect.bsky.social · Sep 26
📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org

#FunctionalGenomics #Symposium #Australia #CallForAbstracts
October 2, 2025 at 1:47 AM
muffley.bsky.social
@varianteffect.bsky.social @sangerinstitute.bsky.social #JobOpening This person would work closely with me. Reach out if you are interested in learning more!
varianteffect.bsky.social Atlas of Variant Effects Alliance @varianteffect.bsky.social · Oct 1
We are #Hiring!
Communications role for our Global Alliance! 🌍🧬
Please share this post with your network, or apply if you are interested!
📍 Location: Hinxton, England
🕒 Part-time role
ℹ️ sanger.wd103.myworkdayjobs.com/en-US/Wellco...

#ScienceJobs #Communications #Genomics
#PartTimeRole #UKJobs
October 1, 2025 at 1:54 PM
Reposted by Lara Muffley
varianteffect.bsky.social
We are hiring! Communications role for our Global Alliance! sanger.wd103.myworkdayjobs.com/en-US/Wellco... #job #hiring #Communications Hinxton, Cambridgeshire UK
Scientific Communications Manager -Part Time
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
September 30, 2025 at 7:57 PM
muffley.bsky.social
Submit your abstract for the upcoming Mutational Scanning Symposium (deadline is Nov 2nd, 2025!)
General info: www.mss2026.org
Abstract submission form: docs.google.com/forms/d/e/1F...
varianteffect.bsky.social Atlas of Variant Effects Alliance @varianteffect.bsky.social · Sep 26
📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org

#FunctionalGenomics #Symposium #Australia #CallForAbstracts
September 26, 2025 at 1:55 PM
Reposted by Lara Muffley
varianteffect.bsky.social
Next up! Two applications of MAVE!
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (‪@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.
September 3, 2025 at 5:40 PM
Reposted by Lara Muffley
varianteffect.bsky.social
This is one not to miss!
We look forward to seeing you all in Melbourne. #VariantEffect26
⏰Abstract deadline is Nov 2nd 2025.
uwgenome.bsky.social UW Genome Sciences @uwgenome.bsky.social · Sep 18
Registration is now open for the Mutational Scanning Symposium!!
25-27 March 2026
Melbourne, Australia
Matt Hurles (Wellcome Sanger) and Maitreya Dunham (University of Washington)
Deadline for abstract submissions: 2 November 2025.
www.mss2026.org
MSS26
Mutational Scanning Symposium 2026, 25-27 March, Melbourne
www.mss2026.org
September 18, 2025 at 9:35 PM
Reposted by Lara Muffley
scifri.bsky.social
Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.
A Trailblazing Geneticist Reflects On Her Life And Work
Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.
buff.ly
September 19, 2025 at 6:12 PM
Reposted by Lara Muffley
varianteffect.bsky.social
Registration is now open for the Mutational Scanning Symposium!! This is one not to miss. Invited speakers include @mehurles.bsky.social @sangerinstitute.bsky.social @maitreya.bsky.social @uwgenome.bsky.social
#VariantEffect26 Register soon for the early bird rate!
ℹ️➡️https://www.mss2026.org
The image is an event flyer for the Mutational Scanning Symposium (MSS) 2026. On the left, the MSS logo features a cluster of squares in shades of orange, green, and gray forming an abstract representation (of Australia), next to the text "MSS 2026 Mutational Scanning Symposium" in orange and gray. Below it, details about the event read: "March 25-27, 2026 in Melbourne, Australia." The phrase "REGISTRATION IS OPEN!" is prominently displayed in orange, followed by information about abstract submissions. A URL in blue text at the bottom provides further information. On the right, six invited speakers are showcased in a grid layout. Each speaker has a photo with their name and affiliation underneath: Prof Matthew Hurles (Wellcome Sanger Institute), Prof Maitreya Dunham (University of Washington), A/Prof Fumitaka Inoue (Kyoto University), Dr Alex Wagner (Nationwide Children's Hospital), A/Prof Melissa Call (WEHI), and Prof Mark Dawson (Peter MacCallum Cancer Centre).
September 18, 2025 at 1:44 PM
Reposted by Lara Muffley
varianteffect.bsky.social
🧬 Out this month in Nature Reviews Cardiology: A powerful look at how multiplexed assays of variant effects (MAVEs) are reshaping our understanding of cardiovascular disease genetics. Contributors include members of the AVE Alliance.
📑 www.nature.com/articles/s41...
#Cardiology #FunctionalGenomics
Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine - Nature Reviews Cardiology
In this Review, Roden and co-workers describe how multiplexed assays of variant effects can be used for high-throughput functional assessment of nearly all coding variants in a target sequence to impr...
www.nature.com
September 19, 2025 at 1:04 PM
Reposted by Lara Muffley
uwgenome.bsky.social
Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP
www.nature.com/articles/s41...
Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP - Nature Structural & Molecular Biology
Multiplexed assays of variant effect can resolve clinical variants but are incompatible with secreted proteins. Here Popp et al. develop MultiSTEP, a generalizable surface-tethering method to assess v...
www.nature.com
September 10, 2025 at 3:55 AM
Reposted by Lara Muffley
varianteffect.bsky.social
MSS is a cornerstone event for the functional genomics community. Did you know that the Mutational Scanning Symposium has been held eight times since 2017? We have an amazing community! Join us next year in Australia! www.mss2026.org (Registration to open soon). #VariantEffect26
The image is divided into two main sections. The top half contains two group photos labeled "Group photo 2024" on the left and "Group photo 2025" on the right. The 2024 group photo shows a large gathering of people indoors with banners featuring red and orange designs in the background. Participants are standing on a beige-tiled floor. The 2025 group photo depicts another gathering of people outdoors on a wooden deck, set against a modern architectural backdrop. The bottom half of the image features an infographic in blue and white, with the text "The Mutational Scanning Symposium has been held 8 times since 2017" prominently displayed. Below this, a timeline of events from 2017 to 2026 is shown with numbered circles indicating each year. Information about each symposium location is provided: Seattle, USA (2017, 2019, 2020), Virtual Only (2021), Toronto, Canada (2022), Hinxton, UK (2023), Boston, USA (2024), Barcelona, Spain (2025), and a planned event in Melbourne, Australia (2026).
September 16, 2025 at 2:18 PM