Myelin Lab
@myelinlab.bsky.social
Lab at Albany Medical College, led by Sophie Belin and Yannick Poitelon.
Sciencing therapeutic strategies for myelin disorders
Sciencing therapeutic strategies for myelin disorders
Reposted by Myelin Lab
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
October 29, 2025 at 2:57 PM
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Reposted by Myelin Lab
Reposted by Myelin Lab
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com/4hj9NNV
go.nature.com/4hj9NNV
Economics Nobel prize won by researchers who showed how science boosts growth
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com
October 13, 2025 at 8:37 PM
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com/4hj9NNV
go.nature.com/4hj9NNV
Reposted by Myelin Lab
NSAIDs are known to alleviate pain by reducing inflammation. A study in Nature Communications shows that selective inhibition of the prostaglandin E2 receptor in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation. #medsky 🧪
Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation - Nature Communications
Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.
go.nature.com
October 13, 2025 at 1:03 AM
NSAIDs are known to alleviate pain by reducing inflammation. A study in Nature Communications shows that selective inhibition of the prostaglandin E2 receptor in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation. #medsky 🧪
Reposted by Myelin Lab
Remyelinated fibers have a distinct lipid profile compared to intact myelin
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain
Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at spatial level using traditio…
www.sciencedirect.com
October 1, 2025 at 11:34 AM
Remyelinated fibers have a distinct lipid profile compared to intact myelin
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Myelin Lab
Paper Alert!! Our collaborative work with Giger Lab at UMich is out now in #ScienceTranslationMedicine Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury | Science Translational Medicine @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury
In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.
www.science.org
October 8, 2025 at 6:22 PM
Paper Alert!! Our collaborative work with Giger Lab at UMich is out now in #ScienceTranslationMedicine Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury | Science Translational Medicine @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Myelin Lab
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues
go.nature.com/48QDdAJ
go.nature.com/48QDdAJ
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
October 6, 2025 at 3:56 PM
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues
go.nature.com/48QDdAJ
go.nature.com/48QDdAJ
Reposted by Myelin Lab
"Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth
Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in …
www.sciencedirect.com
September 30, 2025 at 1:10 PM
"Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Myelin Lab
🚀 Our new paper is out in Nature Communications!
We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination.
Open access link:
www.nature.com/articles/s41...
We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination.
Open access link:
www.nature.com/articles/s41...
Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements - Nature Communications
The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.
www.nature.com
September 27, 2025 at 1:38 PM
🚀 Our new paper is out in Nature Communications!
We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination.
Open access link:
www.nature.com/articles/s41...
We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination.
Open access link:
www.nature.com/articles/s41...
Reposted by Myelin Lab
Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD
Thanks to Nina and all of the team!
Thanks to Nina and all of the team!
Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function
Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...
rdcu.be
August 31, 2025 at 1:03 PM
Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD
Thanks to Nina and all of the team!
Thanks to Nina and all of the team!
Reposted by Myelin Lab
Now online! Transient gene melting governs the timing of oligodendrocyte maturation
Transient gene melting governs the timing of oligodendrocyte maturation
Oligodendrocyte maturation is governed by an SOX6-dependent gene-melted chromatin state at multiple immaturity loci. Reducing SOX6 accelerates maturation, offering a potential strategy to regenerate myelin in diseases like multiple sclerosis.
dlvr.it
August 25, 2025 at 2:59 PM
Now online! Transient gene melting governs the timing of oligodendrocyte maturation
Reposted by Myelin Lab
Reposted by Myelin Lab
Successful networking event for Peripheral Gliaphiles & friends #glia2025 #marseille
July 8, 2025 at 10:17 PM
Successful networking event for Peripheral Gliaphiles & friends #glia2025 #marseille
Reposted by Myelin Lab
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
ki.se/en/about-ki/...
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
ki.se
June 25, 2025 at 2:56 PM
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
ki.se/en/about-ki/...
Reposted by Myelin Lab
Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...
June 14, 2025 at 4:13 PM
Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...
We are extremely proud to announce that in the last weeks we received the support of two terrific associations.
First, Katie Lewis received the 2025 Peripheral Nerve Society Laura Feltri Basic Science fellowship, and will join our team for her postdoc to study axon-Schwann cell interactions 1/3
First, Katie Lewis received the 2025 Peripheral Nerve Society Laura Feltri Basic Science fellowship, and will join our team for her postdoc to study axon-Schwann cell interactions 1/3
June 10, 2025 at 1:26 AM
We are extremely proud to announce that in the last weeks we received the support of two terrific associations.
First, Katie Lewis received the 2025 Peripheral Nerve Society Laura Feltri Basic Science fellowship, and will join our team for her postdoc to study axon-Schwann cell interactions 1/3
First, Katie Lewis received the 2025 Peripheral Nerve Society Laura Feltri Basic Science fellowship, and will join our team for her postdoc to study axon-Schwann cell interactions 1/3
If you have some interest in Peripheral Glia, join us at the Black Stone on Tuesday July 8th!
RSVP: amc.az1.qualtrics.com/jfe/form/SV_...
RSVP: amc.az1.qualtrics.com/jfe/form/SV_...
June 4, 2025 at 1:04 PM
If you have some interest in Peripheral Glia, join us at the Black Stone on Tuesday July 8th!
RSVP: amc.az1.qualtrics.com/jfe/form/SV_...
RSVP: amc.az1.qualtrics.com/jfe/form/SV_...
Reposted by Myelin Lab
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
www.nature.com
May 14, 2025 at 11:45 AM
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Myelin Lab
🚨 The #GLIA2025 Plenary Lineup is 🔥
7 top scientists, 1 big meeting in sunny 'Marseille ☀️🧠
🧠 Bruno Weber
🧠 Kelly Monk
🧠 Klaus-Armin Nave
🧠 Nathalie Rouach
🧠 Anna Molofsky
🧠 Bart J.L. Eggen
🧠 Maiken Nedergaard
July 8–11 — join us for cutting-edge glial science.
🔗 glia2025.eu
#Neuroscience #glial
7 top scientists, 1 big meeting in sunny 'Marseille ☀️🧠
🧠 Bruno Weber
🧠 Kelly Monk
🧠 Klaus-Armin Nave
🧠 Nathalie Rouach
🧠 Anna Molofsky
🧠 Bart J.L. Eggen
🧠 Maiken Nedergaard
July 8–11 — join us for cutting-edge glial science.
🔗 glia2025.eu
#Neuroscience #glial
May 8, 2025 at 8:33 AM
🚨 The #GLIA2025 Plenary Lineup is 🔥
7 top scientists, 1 big meeting in sunny 'Marseille ☀️🧠
🧠 Bruno Weber
🧠 Kelly Monk
🧠 Klaus-Armin Nave
🧠 Nathalie Rouach
🧠 Anna Molofsky
🧠 Bart J.L. Eggen
🧠 Maiken Nedergaard
July 8–11 — join us for cutting-edge glial science.
🔗 glia2025.eu
#Neuroscience #glial
7 top scientists, 1 big meeting in sunny 'Marseille ☀️🧠
🧠 Bruno Weber
🧠 Kelly Monk
🧠 Klaus-Armin Nave
🧠 Nathalie Rouach
🧠 Anna Molofsky
🧠 Bart J.L. Eggen
🧠 Maiken Nedergaard
July 8–11 — join us for cutting-edge glial science.
🔗 glia2025.eu
#Neuroscience #glial
Reposted by Myelin Lab
Researchers transferred bacteria from the guts of multiple sclerosis patients and their healthy twins to mice. In susceptible mice, the microbes Eisenbergiella tayi and Lachnoclostridium caused multiple sclerosis-like disease. In PNAS: www.pnas.org/doi/10.1073/...
May 1, 2025 at 6:15 PM
Researchers transferred bacteria from the guts of multiple sclerosis patients and their healthy twins to mice. In susceptible mice, the microbes Eisenbergiella tayi and Lachnoclostridium caused multiple sclerosis-like disease. In PNAS: www.pnas.org/doi/10.1073/...
Today we hosted our first Postdoctoral Discovery Forum @AlbanyMed.
👍Great Success!!👍
Congrats to Drs. Deswal, Brace, Kar and Rahtes for best presentation awards!🏆
👍Great Success!!👍
Congrats to Drs. Deswal, Brace, Kar and Rahtes for best presentation awards!🏆
May 1, 2025 at 8:14 AM
Today we hosted our first Postdoctoral Discovery Forum @AlbanyMed.
👍Great Success!!👍
Congrats to Drs. Deswal, Brace, Kar and Rahtes for best presentation awards!🏆
👍Great Success!!👍
Congrats to Drs. Deswal, Brace, Kar and Rahtes for best presentation awards!🏆