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Vanja Tepavcevic

@tepavcevicvanja.bsky.social

390 followers 290 following 52 posts

Neurobiologist.Oligodendrocytes/myelin/remyelination/energy metabolism.

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Vanja Tepavcevic @tepavcevicvanja.bsky.social · Jan 11

Interested in #oligodendrocyte metabolism and/or #multiplesclerosis? Our paper is now at Biorxiv! We show that oligos express MCT2, the high affinity monocarboxylate transporter, well known for supplying neurons with astrocyte-derived lactate (astro-neuron lactate shuttle)👇

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jan 11

Monocarboxylate transporter 2 is required for the maintenance of myelin and axonal integrity by oligodendrocytes https://www.biorxiv.org/content/10.1101/2025.01.10.632306v1

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Vanja Tepavcevic @tepavcevicvanja.bsky.social · 2h

Another evidence for lactate influx, not efflux, in neurons. However, it suggests that in neonates, where levels of circulating lactate are high, lactate used by neurons is blood-derived, and that neonatal astrocytes might also use lactate.
www.nature.com/articles/s41...

Neuronal MCT2 promotes angiogenesis via lactate in the developing mouse neocortex - Cell Death & Differentiation

Cell Death & Differentiation - Neuronal MCT2 promotes angiogenesis via lactate in the developing mouse neocortex

www.nature.com

Reposted by Vanja Tepavcevic

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 1d

Prenatal Acetaminophen Exposure Does Not Disrupt Human Fetal Brain Development in Cortical Organoid Models https://www.biorxiv.org/content/10.1101/2025.10.07.681041v1

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Vanja Tepavcevic @tepavcevicvanja.bsky.social · 1d

Alkalinization of glial cells increases lifespan and healthspan in C. Elegans
www.science.org/doi/10.1126/...

The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in C. elegans

Alkalinization of glial cells mediates longevity, stress resistance, and protection from polyQ aggregation in C. elegans.

www.science.org

Reposted by Vanja Tepavcevic

Joe Sabatino @jsabatino37.bsky.social · 1d

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions

www.science.org/doi/10.1126/...

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions

Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.

www.science.org

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Reposted by Vanja Tepavcevic

Conceicao Bettencourt @saobettencourt.bsky.social · 2d

Interested in #epigenetics #DNAmethylation #omics #Dementia #oligodendrocytes? Join us tomorrow👇

Conceicao Bettencourt @saobettencourt.bsky.social · 7d

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 9th October at 2.30 PM (UK Time). Delighted to have Kate Fodder‬ as invited speaker – “Early #oligodendrocyte dysfunction signature in #Alzheimer’s disease: Insights from DNA #methylomics and #transcriptomics”.
DM for more info

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Reposted by Vanja Tepavcevic

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 2d

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism https://www.biorxiv.org/content/10.1101/2025.10.07.680990v1

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Reposted by Vanja Tepavcevic

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 6d

GlialCAM Cytoplasmic Signaling in Oligodendrocytes and Astrocytes is Essential for White Matter Homeostasis in the Brain https://www.biorxiv.org/content/10.1101/2025.10.03.680331v1

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Reposted by Vanja Tepavcevic

Michael D Kornberg @mdkornberg.bsky.social · 7d

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis | Science Translational Medicine www.science.org/doi/10.1126/...

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis

SV2A-PET reveals cortical synapse loss in multiple sclerosis (MS), highlighting a potential approach for unmasking gray matter pathology.

www.science.org

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Reposted by Vanja Tepavcevic

PLOS Biology @plosbiology.org · 9d

What role does #myelination play in #PrefrontalCortex development? This study shows that juvenile #demyelination disrupts PV #interneuron firing & self-inhibition, revealing a developmental window where myelination is essential for long-term cortical function @plosbiology.org 🧪 plos.io/4mI4lVO

Left: An example image of a filled PV interneuron showing putative autapses with white arrows. Note that all autapses are present in close distance to the soma. Right: Pie charts depicting the percentage of cells showing (1) both structural and physiological autapses, (2) no structural nor physiological autapses, and (3) only structural autapses. Note that only mice that underwent juvenile demyelination have PV interneurons which show structural autapses but no autaptic response.

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Vanja Tepavcevic @tepavcevicvanja.bsky.social · 9d

Remyelinated fibers have a distinct lipid profile compared to intact myelin
www.sciencedirect.com/science/arti...

Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain

Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at spatial level using traditio…

www.sciencedirect.com

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Reposted by Vanja Tepavcevic

PLOS Biology @plosbiology.org · 9d

How are #circadian rhythms established during development? This study shows that maternal metabolic signals oscillate in the fetal #SCN before the endogenous #clock becomes functional, offering a plausible mechanism for maternal entrainment of the developing clock @plosbiology.org 🧪 plos.io/3VD45fZ

Rhythmic metabolites in the E19 SCN peak during the day. Majority of rhythmic lipids and polar metabolites in the E19 SCN peak during the day, while there are more diverse phase clusters in the developed P28 SCN postweaning. Polar metabolites and lipids identified as rhythmic in E19 SCN (E19 clusters 1, top, and 2, bottom) were divided into subgroups based on hierarchical K-means clustering. Line plots on the left show traces of the normalized level of each rhythmic compound in each corresponding cluster. Bar plots on the right represent the lipid classes and polar metabolites in each rhythmic cluster.

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Reposted by Vanja Tepavcevic

Sarah Moyon @neurosarah.bsky.social · 9d

NeuroMAP @neuromarseille.bsky.social @univ-amu.fr organise une visite de laboratoire sur le campus de la Timone le 14 Novembre ! Venez rencontrer nos chercheurs 👩🏻‍🔬🧑🏽‍🔬

neuro-marseille.org/events/journ...

Matinée NeuroMAP – Visite de laboratoire | NeuroMarseille

neuro-marseille.org

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Vanja Tepavcevic @tepavcevicvanja.bsky.social · 10d

"Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth"
www.sciencedirect.com/science/arti...

Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth

Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in …

www.sciencedirect.com

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Reposted by Vanja Tepavcevic

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 15d

Progenitor Timing Shapes NG2-Glia Fate and Oligodendrocyte Differentiation https://www.biorxiv.org/content/10.1101/2025.09.24.678191v1

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Reposted by Vanja Tepavcevic

PLOS Biology @plosbiology.org · 17d

How do different tissues respond to mitochondrial dysfunction? @candrewfrank.bsky.social &co show that Complex I depletion triggers ROS-driven compensatory signaling in #MotorNeurons, but degeneration in muscles, with implications for #MitochondrialDisease @plosbiology.org 🧪 plos.io/4nLUIGJ

Left: Image of the Drosophila melanogaster third instar larval ventral nerve cord used to examine mitochondrial morphology. Green fluorescence labels neuronal mitochondrial clusters decorated by a transgenically expressed Mito-GFP protein. Magenta fluorescence labels the Drosophila Bruchpilot protein, a component of active zones. Image credit: Bhagaban Mallik. Right: Image of synaptic boutons at the Drosophila melanogaster third instar larval neuromuscular junction rendered into three dimensions to quantify volumes of synaptic mitochondria. Green fluorescence labels neuronal mitochondria localized to the presynaptic boutons. Mitochondria are decorated by a transgenically expressed Mito-GFP protein. Magenta fluorescence labels the Drosophila Discs Large protein, an organizer of the postsynaptic density in the muscle. Image credit: Bhagaban Mallik and Thomas Moninger.

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Reposted by Vanja Tepavcevic

PLOS Biology @plosbiology.org · 20d

Despite recent advances in green genetically encoded #potassium indicators (GEPOs), red-shifted GEPOs have been slower to come. @piatkevich.bsky.social &co present 2 new red #fluorescent #indicators for visualizing neuronal K+ dynamics in culture & in mice @plosbiology.org 🧪 plos.io/42niaSz

Top: Representative single-plane images showing co-expression of RGEPO1/2 and GCaMP6f in layer 2/3 neurons of the primary somatosensory cortex. Bottom: Top panel: Representative individual (light green and light red) and averaged (green and red) fluorescence responses of GCaMP6f and RGEPO1 during KA-induced seizures and subsequent spreading waves. Middle and bottom panels: Vertical projections of fluorescence profiles from neurons expressing GCaMP6f and RGEPO1 during KA-induced seizures and subsequent spreading waves.

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Reposted by Vanja Tepavcevic

Christian Frezza @frezzalab.bsky.social · 22d

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

www.nature.com/articles/s41...

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature

A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...

www.nature.com

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Reposted by Vanja Tepavcevic

PLOS Biology @plosbiology.org · 22d

Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @plosbiology.org 🧪 plos.io/3ViI1qL

AlphaFold model of the complex formed between HK2 and the SOX10 5′UTR (189–204 nts). The predicted RNA structure is shown in cyan, and HK2 protein is shown in green. HK2 residues and SOX10 mRNA nucleotides at the interaction interface are highlighted in red. Inset: schematic representation of the secondary structure of the SOX10 5′UTR (189–204 nts) predicted by Mfold, with the putative HK2-binding region (194–198 nts) marked in red.

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Reposted by Vanja Tepavcevic

Doug Dyer @douglaspdyer.bsky.social · 27d

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix):Oxford Road

Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:

www.jobs.manchester.ac.uk

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Reposted by Vanja Tepavcevic

UK Glia Network @ukglia.bsky.social · 23d

📢 2 PhD positions on the role of GLIA in brain function 📢

Neuronal Clues to Astrocytes in the Developing Brain https://
tinyurl.com/4m3uuf2a
Neuroimmune strategy to treat Alzheimer’s disease https://
tinyurl.com/c7stnur5

#opportunities #neuroscience #neuroskyence #graduates

Neuronal Clues to Astrocytes: Uncovering Hidden Mechanisms in the Developing Brain. MRC GW4 BioMed DTP PhD studentship for 2026/27 Entry, Department of Clinical and Biomedical Science at University of...

PhD Project - Neuronal Clues to Astrocytes: Uncovering Hidden Mechanisms in the Developing Brain. MRC GW4 BioMed DTP PhD studentship for 2026/27 Entry, Department of Clinical and Biomedical Science at...

tinyurl.com

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Reposted by Vanja Tepavcevic

BrunetLab @brunetlab.bsky.social · 23d

Exciting meeting in beautiful Ascona, Switzerland!!

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Reposted by Vanja Tepavcevic

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 24d

Spatial transcriptomics of compartmentalised inflammation in a natural disease multiple sclerosis cohort. https://www.biorxiv.org/content/10.1101/2025.09.10.675210v1

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Reposted by Vanja Tepavcevic

Joe Sabatino @jsabatino37.bsky.social · 24d

Very pleased to publish this new review with Farah Wahbeh on the role of #EBV in #Multiplesclerosis. I learned a lot writing this, I hope others find it useful too

www.neurology.org/doi/10.1212/...

Epstein-Barr Virus in Multiple Sclerosis | Neurology Neuroimmunology & Neuroinflammation

Epstein-Barr virus (EBV) is a very common herpesvirus that infects more than 90% of the general population. Epidemiologic data indicate that EBV is a requisite risk factor for the development of multi...

www.neurology.org

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Reposted by Vanja Tepavcevic

Elaine Emmerson @doctoremmerson.bsky.social · 27d

I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Postdoctoral Research Fellow

An exciting opportunity has arisen to join the Emmerson lab within the Institute for Regeneration and Repair at the University of Edinburgh. This three year, BBSRC-funded postdoctoral research associa...

elxw.fa.em3.oraclecloud.com

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Reposted by Vanja Tepavcevic

Hao Yin @haoyin.bsky.social · 25d

AAV-BI30, an endotheliotropic #AdenoAssociatedVirus for transducing vascular tree in #CentralNervousSystem Brain/Retina/Spinal Cord

👉>AAV-BR1 esp. in artery/vein

👉Also transduce #EndothelialCell in #Aorta/Liver/Lung/Kidney

@natcardiovascres.nature.com 2022
pmc.ncbi.nlm.nih.gov/articles/PMC...

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