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Reposted by Nils Hebach

Wilhelm Palm @wilhelmpalm.bsky.social · 1d

Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

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Reposted by Nils Hebach

Sanjeev Herr @sanjeevherr.bsky.social · 7d

I’m thrilled to report on work I led with Dr. Shawn Hervey-Jumper and Dr. Todd Hollon which shows that we can forecast where glioblastoma will recur even at time of initial resection.

It’s wonderful to see all the work I conducted during my research year @neurosurgucsf.bsky.social come together!

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Nils Hebach @nilshebach.bsky.social · 1d

Very excited to see this out and happy to have contributed!

Winkler Laboratory @winklerlab.bsky.social · 1d

How to disconnect therapy-resistant tumor networks in glioblastoma?

In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...

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Reposted by Nils Hebach

Daniel D. Azorín @danielazorin.bsky.social · 1d

My main PhD project is out in #CancerDiscovery @theaacr.bsky.social

We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.

Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!

Winkler Laboratory @winklerlab.bsky.social · 1d

How to disconnect therapy-resistant tumor networks in glioblastoma?

In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...

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Reposted by Nils Hebach

Michael Platten, MD @michael-platten.bsky.social · 7d

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...

Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

The immunology of brain tumors

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

www.science.org

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Reposted by Nils Hebach

The Venkatesh Lab @venkatesh-lab.bsky.social · 24d

We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature

Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...

www.nature.com

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Reposted by Nils Hebach

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 29d

Check it out! The team at Acepodia reports efficacy of cetuximab-conjugated allogenic gamma/delta-T cells against EGFR+ tumors in mice, off-the-shelf, safer alternative to CAR-T. Currently in phase 1 clinical study (NCT06415487). Cell-surface chemistry for the win 👏

jitc.bmj.com/content/13/7...

Allogeneic cetuximab-armed gamma delta T cells using antibody-cell conjugation technology for the treatment of EGFR-expressing solid tumors

Background Targeting epidermal growth factor receptor (EGFR) has become a strategic approach in cancer therapy, using various modalities including chimeric antigen receptor (CAR)-αβT cell therapies. D...

jitc.bmj.com

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Anna Obenauf @obenaufa.bsky.social · Sep 9

🔥Trio Fatale: Neutrophils, NETs and Necrosis
👉 authors.elsevier.com/a/1lk-k3qNrU...

We summarized for @cp-immunity.bsky.social
"Neutrophils drive vascular occlusion, tumour necrosis and metastasis" published in @nature.com by @megeblad.bsky.social @adrover.bsky.social rdcu.be/eFdau

Congrats!

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Reposted by Nils Hebach

Hans Clevers @hansclevers.bsky.social · Sep 6

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

Epithelial tension controls intestinal cell extrusion

Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

www.science.org

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Reposted by Nils Hebach

Matthia Karreman @matthiakarreman.bsky.social · Sep 4

How do #metastases survive (and thrive!) in the #brain microenvironment?

In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠

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Reposted by Nils Hebach

Hellmut Augustin @hellmutaugustin.bsky.social · Sep 4

Congratulations to Mahak Singhal @uniheidelberg.bsky.social on being awarded an @erc.europa.eu Starting Grant for his project "Vascular-Rhythm" focussing on "DeClocking the vascular rhythmic control of tissue homeostasis and disease initiation". Pioneering a new branch of vascular research!

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Reposted by Nils Hebach

Richard White @whitefishlab.bsky.social · Aug 28

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

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Reposted by Nils Hebach

Jonathan Kipnis @jonykipnis.bsky.social · Jul 24

Excited to share our new work, led by an exceptional graduate student, Tornike Mamuladze, on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || www.cell.com/cell/fulltex...

Mast cells regulate the brain-dura interface and CSF dynamics

Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...

www.cell.com

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Reposted by Nils Hebach

Hellmut Augustin @hellmutaugustin.bsky.social · Jul 14

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...

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Reposted by Nils Hebach

Toni Celià-Terrassa @tceliaterrassa.bsky.social · Jul 10

We’re thrilled to share our latest publication in
@cp-cancercell.bsky.social and very proud of C. Rozalén for this tour de force uncovering how TIM3⁺ breast cancer cells drive immune evasion during micrometastasis. #CancerImmunology #BreastCancer #Metastasis www.cell.com/cancer-cell/...

TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak

Rozalén et al. report that TIM3 in breast cancer drives a specific mechanism of immune escape during micrometastasis. TIM3+ tumor cells exhibit stemness/EMT features and promote immune-evasion by indu...

www.cell.com

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Reposted by Nils Hebach

Winkler Laboratory @winklerlab.bsky.social · Jun 30

Today is the abstract deadline!

Please join us to discuss the next steps and future perspectives of #cancerneuroscience at the @helloeacr.bsky.social conference in Bilbao 🤩

Winkler Laboratory @winklerlab.bsky.social · Jun 8

We’re so excited for the
Cancer Neuroscience EACR conference!
📍Bilbao, Spain
📅 14-16 Oct 2025

‼️Upcoming abstract and travelgrant deadline *June 30th* ‼️

Looking forward to seeing many of you there! 🧠🔬

#cancerneuroscience @helloeacr.bsky.social #neuroscience #cancer

Submit your abstract here 👇

Abstracts and posters | Cancer Neuroscience | The European Association for Cancer Research

eacr.org

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Reposted by Nils Hebach

Nature @nature.com · Jun 25

Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis

https://go.nature.com/46c474I

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature

A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.

go.nature.com

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Winkler Laboratory @winklerlab.bsky.social · Jun 24

We have already received many interesting abstracts for the Cancer Neuroscience EACR Conference in Bilbao, Spain....

...and we are looking forward to reading *yours*! 🧠🔬

📢 Abstract Deadline June 30th 📢

#cancerneuroscience #neuroscience #cancer @helloeacr.bsky.social

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Reposted by Nils Hebach

Eric Topol @erictopol.bsky.social · Jun 20

The pioneer of cancer neuroscience, @michellemonje.bsky.social along w/ Frank Winkler @brainprize.org , profiled @thelancet.com today @stanforduniversity.bsky.social @stanfordmedicine.bsky.social www.thelancet.com/journals/lan...

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Reposted by Nils Hebach

Michelle Monje @michellemonje.bsky.social · Jun 20

Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling: Cell www.cell.com/cell/fulltex...

Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling

Midbrain cholinergic neuronal activity promotes the proliferation of both oligodendrocyte precursor cells and diffuse midline glioma (DMG) cells in a circuit-dependent manner, mediated by muscarinic M...

www.cell.com

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Reposted by Nils Hebach

Christophe 🔬 L @christlet.bsky.social · May 29

Reposting as I hear about a German Pubmed-like initiative: let's build on Europe PMC which is already great

Christophe 🔬 L @christlet.bsky.social · Jan 31

Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed

Prasad Jallepalli, MD, PhD @prasad.bsky.social · Jan 31

I’m very scared to see what happens to PubMed

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Reposted by Nils Hebach

Junhong Choi @choijunhong.bsky.social · May 27

New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)

Lineage recording in monoclonal gastruloids reveals heritable modes of early development

Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...

www.biorxiv.org

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Reposted by Nils Hebach

Manu Saraswat @manusaraswat.bsky.social · May 16

🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇

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Adrienne Boire @adrienneboire.bsky.social · May 14

I am delighted to share that our work focused on anti-tumor immunity in the leptomeningeal space was published today:
www.nature.com/articles/s41...

@meningojan.bsky.social

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Reposted by Nils Hebach

André Nadler @nadlerlab.bsky.social · May 13

Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...

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